Clinical trials: IL6
Periodontal Health, Gingivitis
Salivary and GCF Biomarkers in Periodontal Health, Gingivitis and Periodontitis
This observational cross-sectional study aims to compare the levels of irisin, interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α) in saliva and gingival crevicular fluid (GCF) among individuals…
- Conditions
- Periodontal Health, Gingivitis, Periodontitis
- Trial name
- NCT07881406
- Testing
- Clinical periodontal examination, ELISA-based biomarker analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Immune Function, Immunity
Effects of TM02® Supplementation on Immune Function in Children
This randomized, double-blind, placebo-controlled clinical study evaluated the effects of 12 weeks of TM02® supplementation on immune-related outcomes in generally healthy children aged 2 to 12 years.
- Trial name
- NCT07853573
- Testing
- TM02®
- Where
- Malaysia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ligno Biotech Sdn. Bhd.
Suicidal Ideation
Correlation of Campbell Score With Suicidal Ideation
The Campbell Score is a blood based means of assessing molecules believed to be associated with suicidal ideation and in some cases successful suicide.
- Trial name
- NCT04606875
- Testing
- Campbell Score
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Therapeutic Solutions International
Cardiac Arrest
Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
Acute myocardial infarction complicated with cardiogenic shock trigger IL-6, the strong inflammatory response, result in multiple organ failure, even death.
- Trial name
- NCT02633358
- Testing
- Therapeutic hypothermia group
- Where
- Taiwan
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Migraine, Tension-Type Headache
Salivary Inflammatory Markers in Tension Type Headache and Migraine
Data role of salivary inflammatory markers in migraine and Tension Type headache (TTH) are lacking. Τhe investigators studied whether headache attacks are associated with changes in C reactive protein (CRP), Interleukin -1β and…
- Trial name
- SalHead (NCT03727672)
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Polycystic Ovary Syndrome
Adipocytokines and Polycystic Ovary Syndrome (PCOS)
Inflammation may play a role in the development of polycystic ovary syndrome (PCOS). In this study, the investigators investigated the expression of different mediators of inflammation in fatty tissue and in blood in women with…
- Trial name
- NCT00975832
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity, Healthy
Meal-regulated Substrate Metabolism, Influence of Obesity and IL-6
The overall purpose of this explorative yet quantitative study project is to understand how blocking IL-6 signaling leads to the expansion of adipose tissue mass in humans in vivo.
- Trial name
- NCT04687540
- Testing
- Tocilizumab, Saline 0.9%
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Periodontitis, Smoking
Relationships Between Tenascin C, Smoking and Periodontal Status
The goal of this observational study is to determine if there is a relationship between different periodontal conditions (gingival healthy, stage 2 grade B, stage 2 grade C, stage 3 grade B, stage 3 grade C) and the levels of…
- Conditions
- Periodontitis, Smoking, Periodontal Diseases
- Trial name
- NCT06523205
- Testing
- Clinical Measurements and Saliva Sample Collection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Depression, Postpartum
Multimodal Biomarkers and Precision TMS for Postpartum Depression
The purpose of this study is to identify multimodal biological markers associated with postpartum depression (PPD) and to evaluate the effectiveness of precision brain stimulation treatment.
- Trial name
- MOTHER-TMS (NCT07757815)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 2 sites in Macau
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Macau
Apical Periodontitis, Inflammatory Markers
The Efficacy of Two Different Irrigation Methods on PGE2, NO and IL-6 Levels
Today, debates about the effectiveness of Passive Ultrasonic Irrigation (PUI) and Sonically Activated Irrigation (SAI) techniques used to increase the success of endodontic treatment in chronic apical periodontitis (AP) are still…
- Trial name
- NCT06629545
- Testing
- irrigation activation with PUI, irrigation with sonic activation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Healthy Volunteers
A Safety and Pharmacokinetic Study of Complarate (Tocilizumab Biosimilar) and Actemra® in Healthy Volunteers
This is a randomized double-blind comparative parallel group study of the safety, pharmacokinetics and pharmacodynamics of Complarate and Actemra® in healthy volunteers.
- Trial name
- NCT06481202
- Testing
- Complarate®, Actemra®
- Where
- 2 sites in Russia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- AO GENERIUM
Periodontitis
Effects of PRF and i-PRF on Clinical and Biochemical Parameters in Non-Surgical Periodontal Therapy
The goal of this clinical trial is to learn if adding platelet-rich fibrin (PRF) or injectable platelet-rich fibrin (i-PRF), obtained from the participant's own blood, to standard non-surgical periodontal treatment helps improve…
- Trial name
- PRF-NSPT (NCT07525531)
- Testing
- Non-surgical periodontal therapy (NSPT), Platelet-rich fibrin (PRF), Injectable platelet-rich fibrin (i-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Preeclampsia
Analyses of Interleukin-6, Presepsin and Pentraxin-3 in the Diagnosis and Severity of Late-onset Preeclampsia
Introduction: The etiology/pathophysiology of preeclampsia remains an enigma. Cellular immunity is a key factor in the etiology of late-onset preeclampsia (L-PrE).
- Trial name
- Presepsin&PE (NCT04126902)
- Testing
- interleukin-6, presepsin and pentraxin-3
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Treatment-Resistant Major Depressive Disorder
Triple-Blind Randomized Clinical Trial of Tocilizumab vs Placebo: Potential Use of an IL-6 Antagonist as an Adjuvant to Standard Treatment for Treatment-Resistant Major Depression in the Brazilian Public Health System (SUS)
Clinical trial aimed at evaluating whether a single infusion of tocilizumab, a medication that blocks the action of an inflammatory molecule called interleukin-6 (IL-6), can reduce symptoms of treatment-resistant major depression…
- Trial name
- NCT07052058
- Testing
- Tocilizumab, Normal Saline (0.9% NaCl)
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Obesity, Periodontitis
Chemerin and Interleukin-6 Levels of Gingival Crevicular Fluid in Obese Individuals Following Periodontal Treatment
The objective in this case-control intervention study, therefore, was to explore the effect of nonsurgical periodontal therapy on the GCF levels of chemerin and IL-6 in patients with chronic periodontitis in order to determine…
- Trial name
- NCT02660814
- Testing
- Non-surgical periodontal treatment, Gingival crevicular fluid collection
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Umut BALLI
Periodontitis, Periodontal Disease
Investigation of the Relationship Between Periodontitis and Sleep Quality
This project aims to investigate the relationship between periodontitis and sleep quality. Its originality lies in evaluating the association between periodontal status and sleep quality together with salivary interleukin-6…
- Conditions
- Periodontitis, Periodontal Disease, Sleep Quality, Fatigue
- Trial name
- RBPSQ (NCT07421960)
- Testing
- Periodontal examinations, Collection of saliva samples, Pittsburgh Sleep Quality Index
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Cognitive Impairment, Aging
Influence of Overground Walking on Biomarkers, Cognitive Function, and Quality of Life in Elderly With Mild Cognitive Impairment
The purpose of this research is to investigate the impact of overground walking as a part of a rehabilitation program on the increase in Brain-derived neurotrophic factor (BDNF) levels, decrease in IL-6 levels, decrease in hs-CRP…
- Trial name
- NCT06029920
- Testing
- Overground Walking
- Where
- Indonesia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Metabolic Syndrome, Overweight
Systematic Review and Meta-analysis of the Differential Effects of DHA and EPA on Inflammation
According to the World Health Organization, cardiovascular diseases (CVDs) are the number 1 cause of death globally. Systemic and local tissue inflammation is now recognized as a key etiological process leading to CVD.
- Conditions
- Metabolic Syndrome, Overweight, Obesity, Chronic Inflammation
- Trial name
- NCT03520556
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Laval University
Genetic Alteration, Low Back Pain
Genetic Alterations From Physical Therapy in Low Back Pain and Disc Degeneration
Background and Scientific Rationale: This prospective randomized controlled trial examines the combined effect of physiotherapy and vitamin D supplementation on pain, disability, interleukin-6 (IL-6) expression, and vitamin D…
- Conditions
- Genetic Alteration, Low Back Pain, Physiotherapy
- Trial name
- Low back pain (NCT07439874)
- Testing
- Interferential therapy
- Where
- Saudi Arabia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Tabuk
End-Stage Kidney Disease (ESKD), Hemodialysis
Cardiovascular and Bone Mineral Markers in Dialysis Patients and Healthy Controls
This observational study will compare cardiovascular status, bone mineral metabolism, systemic inflammation, body composition, functional status, quality of life, pruritus, and pain among patients receiving different renal…
- Conditions
- End-Stage Kidney Disease (ESKD), Hemodialysis, Peritoneal Dialysis (PD)
- Trial name
- NCT07686978
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gazi University