Clinical trials: IL6
Anxiety
Biological and Psychological Markers After Intervention in Adults With GAD
This clinical trial inestigates the effects of transcranial direct current stimulation (tDCS) on anxiety symptoms in adult women with clinically relevant anxiety levels.
- Trial name
- AnsitDCS (NCT07116980)
- Testing
- 'Transcranial Direct Current Stimulation - tDCS
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Advanced Cancer, Solid Tumor
STAT3 Inhibitor for Solid Tumors
The goal of this clinical research study is to find the highest tolerable dose of OPB-31121 that can be given to patients with an advanced solid tumor. The safety of this drug will also be studied.
- Trial name
- NCT00955812
- Testing
- OPB-31121
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Postoperative Cognitive Dysfunction, Postoperative Pain, Acute
Propofol and Dexmedetomidin vs Midazolam Intraoperative Sedation and POCD
This study will examine the effect of intraoperative sedation with midazolam, propofol and dexemdetomidine on the occurrence of postoperative cognitive impairment in patients undergoing surgical treatment of pertrochanteric…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Pain, Acute, Pertrochanteric Fracture
- Trial name
- ProDex-POCD (NCT05398757)
- Testing
- Mini mental state exame (MMSE), Digit Symbol Substitution Test (DSST), Numeric rating Scale (NRS)
- Where
- Croatia
- Sponsor
- Osijek University Hospital
Obesity, Healthy
IL-6 Regulation of Substrate Metabolism and Influence of Obesity
The aim of the study is to investigate the effects of blocking IL-6 signaling with tocilizumab on lipid, glucose and protein metabolism during rest and exercise in healthy and obese humans.
- Trial name
- NCT03967691
- Testing
- Tocilizumab infusion, Saline 0.9%
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Multiple Myeloma
A Study of the Safety and Efficacy of CNTO 328 and Bortezomib to Bortezomib Alone in Patients With Relapsed or Refractory Multiple Myeloma
The purpose of Part 1 of the study is to determine the safety of the combination of Siltuximab (CNTO 328) and bortezomib (Velcade).
- Trial name
- NCT00401843
- Testing
- Siltuximab, Bortezomib, Dexamethasone
- Where
- 80 sites in United States, Belgium and 16 more
- Volunteers
- 307 people
- Sponsor
- Janssen Research & Development, LLC
Chronic Kidney Disease on Hemodialysis, Thyroid Gland Disease
Interleukin-6 and Thyroid Dysfunction in Hemodialysis Patients
Chronic kidney disease (CKD) is often associated with multiorgan complications, including thyroid hormone dysfunction. Interleukin-6 (IL-6), a pro-inflammatory cytokine, has been proposed as a marker of inflammation that may…
- Trial name
- NCT07328113
- Testing
- Thyroid hormone
- Where
- Indonesia
- Volunteers
- 65 people
- Sponsor
- Dr. Soetomo General Hospital
Autoimmune, Lupus Erythematosus, Systemic
Effect of Green Tea on Treatment of Lupus
This randomized double blind clinical trial performed on 68 patients (32 in intervention and 36 in control group) diagnosed with SLE.
- Trial name
- NCT02875691
- Testing
- green tea extract
- Where
- Iran
- Volunteers
- 68 people
- Sponsor
- Ahvaz Jundishapur University of Medical Sciences
Immune Function, Immunity
Effects of TM02® Supplementation on Immune Function in Children
This randomized, double-blind, placebo-controlled clinical study evaluated the effects of 12 weeks of TM02® supplementation on immune-related outcomes in generally healthy children aged 2 to 12 years.
- Trial name
- NCT07853573
- Testing
- TM02®
- Where
- Malaysia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ligno Biotech Sdn. Bhd.
Surgical Stress Response, Inflammation
CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy
This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy.
- Conditions
- Surgical Stress Response, Inflammation, Anesthesia, Perioperative Care
- Trial name
- CORESTRESS (NCT07571473)
- Testing
- propofol, CoreSys Monitor, Remifentanil (Target-Controlled Infusion)
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Hospital Provincial de Rosario
Diabetic Macular Edema
Changes in Inflammatory Biomarkers Including Soluble CD14 and Hyperreflective Foci in DME Patients Treated With Aflibercept (FORESIGHT)
This study evaluates the effect of aflibercept on the change of cytokines incluing sCD14, MCP-1, IL-6, and ICAM-1 in the aqueous humor of DME patients.
- Trial name
- FORESIGHT (NCT03780361)
- Testing
- Aflibercept Injection
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Hyewon Chung
Nonalcoholic Steatohepatitis (NASH)
Comparing the Effects of Vitamin E, Ursodeoxycholic Acid and Pentoxyfylline on Egyptian Non-alcoholic Steatohepatitis (NASH) Patients
We conducted a 3-month, randomized, single-blind study in 102 Egyptian NASH patients who were divided into three groups; group 1 included 34 patients received Vit.
- Trial name
- NCT04977661
- Testing
- Vitamin E, Ursodeoxycholic acid, Pentoxifylline
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Kafrelsheikh University
Meconium Aspiration Syndrome
Interleukin-6 in the Development of Meconium Aspiration Syndrome in Newborn
This trial is intended to assess the serum levels of interleukin-6 as a predictive factor for the occurrence of meconium aspiration syndrome in infants born with MSAF.
- Trial name
- NCT07394322
- Testing
- serum interleukin 6
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Benha University
Preterm Labor, Immunochromatographic Assay
Diagnostic Tests in the Context of Threatened Preterm Labour
The primary purpose of the protocol is to compare the diagnostic accuracy in terms of positive and negative predictive values of Premaquick © (combined detection of IL-6 / IGFBP-1 total / IGFBP-1 native) and Quikcheck fFN ™…
- Conditions
- Preterm Labor, Immunochromatographic Assay, Predictive Value of Tests, Preterm Delivery
- Trial name
- PREMAQUICK (NCT03608995)
- Testing
- Premaquick (Diagnostic test), Quikcheck fFN ™
- Where
- France
- Volunteers
- 221 people
- Sponsor
- University Hospital, Clermont-Ferrand
Prematurity, Late-onset Sepsis
A Trial on Different Dosages of Vitamin D in Preterm Infants With Late-onset Sepsis
This is a randomized controlled trial (RCT) to evaluate the influence of different doses of vitamin D3 (800 IU/d versus 400 IU/d), on serum levels of interleukin (IL)-6, TNF-alpha and C- reactive (CRP) in premature infants with…
- Trial name
- NCT02273843
- Testing
- High-dose vitamin D 3, Conventional-Dose Vitamin D 3
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University Children Hospital
Inflammatory Changes in Epithelial Lining Fluid Sampled Non-invasively by Nasal Lavage in CF Patients With G551D Receiving Kalydeco
Effects of Kalydeco on Upper Airway and Paranasal Sinus Inflammation Measured by Nasal Lavage and on Symptoms
The aim of the proposed trial in assessment of effects of Kalydeco™ treatment on sinonasal involvement in CF patients with at least one mutation of G551D receiving a new therapy with the CFTR potentiator.
- Trial name
- KPNSI (NCT02311140)
- Testing
- nasal lavage (routine diagnostic procedure in our centre), assessment of symptoms
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Jena
Postoperative Cognitive Dysfunction, Postoperative Delirium
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)
Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Frailty
- Trial name
- POCD (NCT04837391)
- Testing
- Near Infrared Spectroscopy (NIRS), Blood sample, Addenbrooke Cognitive Examination III (ACE-III)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istanbul University
Aortic Diseases, Osteoarthritis, Hip
Pro-inflammatory Cytokines in Blood From Orthopedic Surgery Compared to Abdominal Aneurysm Repair
The purpose of this study is to investigate the contents in blood sampled from surgery site during hip replacement compared with blood sampled from abdominal aortic surgery.
- Trial name
- KEEP-HB (NCT00851149)
- Testing
- Sangvia blood sampling system
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Sykehuset i Vestfold HF
Intrathecal Infection, External Ventricular Drainage Associated Infection
Cerebrospinal Fluid IL-6, IL-8 and PCT as Early Marker of an Intrathecal Infection in Neurosurgical Patients
The value of CSF IL-6, IL-8 and Procalcitonin in detecting an early diagnosis of intrathecal infection in neurosurgical patients with an external ventricular drainage is evaluated.
- Trial name
- NCT02875808
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Medicine Greifswald
Acute Gastroenteritis, Acute Diarrhea
Evaluation of Serum Interleukin 6 and 8 in Children With Acute Gastroenteritis
Cytokines, such as IL-6 and IL-8 can be used as markers of acute infections, including acute gastroenteritis. This study aims to evaluate serum levels of interleukins 6 and 8 in children with acute gastroenteritis.
- Trial name
- NCT05213325
- Testing
- Evaluation of serum levels of IL-6 and IL-8
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Elective Surgical Procedures, Postoperative Pain
Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair
Open Abdominal Aortic Aneurysm (AAA) repair is a high-risk surgical procedure accompanied by intense endocrine and metabolic responses to surgical stress, with subsequent activation of the inflammatory cascade, cytokine and…
- Conditions
- Elective Surgical Procedures, Postoperative Pain, Anesthesia, Opioid Use
- Trial name
- NCT04894864
- Testing
- Opioid-Based Anesthesia-Analgesia Strategy, Opioid-free Anesthesia-Analgesia Strategy
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of Crete