Clinical trials: INDIVIDUALIZED THERAPY
Sleep Apnea, Obstructive, Exercise Training Therapy
Effects of an Individualized Training Program on Severity Markers of Obstructives Sleep Apnea/Hypopnea Syndrome (OSAS)
There are two types of treatments depending on the severity of Obstructive Sleep Apnea/Hypopnea Syndrome (OSAS): - for the treatment of severe (AHI> 30/h), the standard treatment is Continuous Positive Airway Pressure (CPAP).
- Trial name
- REEVASAS (NCT01256307)
- Testing
- training and educational program, educational program
- Where
- France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Montpellier
Stroke
Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Stroke
Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of stroke patients' motor function by altering the cortical excitability.
- Trial name
- NCT03390192
- Testing
- Dual-mode stimulation
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Melanoma
Comparative Study of Individualized Sensitivity-Directed Chemotherapy Versus DTIC
This phase III trial is aimed to investigate the efficacy of an individualized, sensitivity-directed combination chemotherapy in comparison to the standard regimen DTIC. Two question are aimed to be answered by this study: 1.
- Trial name
- ChemoSensMM (NCT00779714)
- Testing
- DTIC (dacarbazine), paclitaxel + cisplatin, treosulfan + cytarabine
- Where
- 23 sites in Germany
- Volunteers
- 360 people
- Sponsor
- University of Wuerzburg
Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness
Pilot Study of Individualized Treatment for Genitourinary Syndrome of Menopause in Women After Cancer Treatment
This pilot study is designed to evaluate an individualized approach to the treatment of genitourinary syndrome of menopause (GSM) in women who have undergone oncological treatment.
- Conditions
- Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness, Menopause, Female Cancer Survivors
- Trial name
- NCT07420647
- Testing
- Non-ablative vaginal Er:YAG laser therapy, Standard care
- Where
- Slovenia
- Volunteers
- 65 people
- Sponsor
- Institute of Oncology Ljubljana
HCC, Transarterial Chemoembolization
A New Conception About Individualized Treatment Allocation for HCC
The current guidelines on hepatocellular carcinoma (HCC) aimed to build effective prognostic stratification strategies to guide therapeutic allocation; however, the current guidelines did not consider the simultaneous comparison…
- Conditions
- HCC, Transarterial Chemoembolization, Resection
- Trial name
- PTA4HCC (NCT06008548)
- Testing
- TACE
- Volunteers
- 4,991 people
- Sponsor
- Tang-Du Hospital
Alcohol Dependence
Research on Individualized Treatment for Alcoholism
The purpose of this study was to compare the effects of two psychosocial treatments that differed in scope and intensity (Broad Spectrum Treatment and Motivational Enhancement Treatment) combined with 3 or 6 months of treatment…
- Trial name
- RITA (NCT00523133)
- Testing
- naltrexone, Broad Spectrum Treatment, Motivational Enhancement Treatment
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- Indiana University
Acute Coronary Syndrome, STEMI
Efficacy and Safety of Individualized P2Y12 Receptor Antagonists Treatment Based on Agregometry Versus Fixed Dose Regimen in Patients After Acute Myocardial Infarction
The specific goal of this study is to determine whether the individualized approach and adjusting the dosage of the P2Y12 receptor inhibitors will improve the platelet inhibiton and the clinical outcome in patients with an ACS…
- Conditions
- Acute Coronary Syndrome, STEMI, NSTEMI - Non-ST Segment Elevation MI, PLATELET AGGREGATION
- Trial name
- SPARELIFE (NCT04369534)
- Testing
- Clopidogrel, Ticagrelor
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- University of Zagreb
Transplant Recipient (Kidney)
Immune Monitoring-Guided Individualized Tacrolimus Therapy in Renal Transplant Recipients: An Observational Study and PK/PD Modeling
This study aims to resolve the clinical limitation that therapeutic drug monitoring (TDM) alone cannot accurately reflect the net immune status after kidney transplantation.
- Trial name
- NCT07815938
- Testing
- No interventional treatment, only observational data collection without clinical drug adjustment
- Volunteers
- 50 people
- Sponsor
- Zhongnan Hospital
Breast Cancer, Premenopausal Breast Cancer
Role of Individualized Intervention(s) in Hormone-Receptor Positive Early-stage Breast Cancer
Although combination endocrine therapy has been associated with significant reduction in risk of recurrence in younger women with hormone receptor positive breast cancer, it has been associated with more adverse effects and…
- Conditions
- Breast Cancer, Premenopausal Breast Cancer, Hormone Receptor Positive Tumor
- Trial name
- MyCHOICE (NCT03407768)
- Testing
- Individualized interventions
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- University of Saskatchewan
Advanced Non Small Cell Lung Cancer
Individualized Treatment of Patients With Advanced NSCLC: Potential Application for Circulating Tumor Cells (CTC) Molecular and Phenotypical Profiling
The purpose of this study is to determine the percentage of CTC-positive patients and total CTC numbers in patients with advanced Non Small Cell Lung Cancer .
- Trial name
- 2012/52 (NCT02407327)
- Where
- Italy
- Volunteers
- 215 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Adolescent Idiopathic Scoliosis (AIS)
Personalized Prevention and Treatment Strategies for Adolescent Idiopathic Scoliosis Via a Comprehensive Health Management Platform
Spinal cord injury (SCI), leads to functional deficits and complications like neurogenic bladder and deep vein thrombosis, imposing a global annual financial burden.
- Trial name
- NCT06314594
- Testing
- Conventional treatment, intervention treatment
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Hangzhou Medical College
Surgery-Complications
Restrictive- vs Individualized Goal Directed Fluid Therapy in Liver Surgery
"Low central venous pressure (low-CVP) or a restrictive fluid administration strategy is usually used worldwide during major liver resection surgery.
- Trial name
- REVOLUTION (NCT05704387)
- Testing
- individualized GDFT, Restrictive fluid therapy strategy
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebrovascular Disease
Individualized Antithrombotic Therapy for Patients With Ischemic Cerebrovascular Disease
To investigate the therapeutic effect of individualized treatment of antiplatelet in secondary prevention of ischemic stroke.
- Trial name
- NCT03471169
- Testing
- Desirable TEG, Undesirable TEG
- Where
- China
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Hyperthyroidism
Optimization With a Gamma Camera of the Individualized Patient Dosimetry in Radioiodine Therapy of Thyroid Diseases
This is a pilot, single-center, prospective, open-label clinical investigation of a medical device (ambulatory gamma camera " MoTI " (Mobile Therapy Imager)) for patients with hyperthyroidism (Graves' disease, toxic nodule and…
- Trial name
- THIDOS (NCT06371339)
- Testing
- Additional acquisitions with the investigational gamma-camera " MoTI ".
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Institut Claudius Regaud
Mild Cognitive Impairment
Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Mild Cognitive Impairment
Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of mild cognitive impairment (MCI) patients' cognitive function by altering the cortical…
- Trial name
- NCT03647345
- Testing
- High-frequency rTMS on left DLPFC+anodal tDCS on right DLPFC, High-frequency rTMS on left DLPFC+cathodal tDCS on right DLPFC
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Samsung Medical Center
Diabetes Mellitus, Type 2, Patient Education as Topic
Impact of a Multidisciplinary Therapeutic Education Program Being Set up for Patients With Type 2 Diabetes Mellitus
Therapeutic education programs allows in diabetic patients to promote self-care and better perception of the disease The multidisciplinary program of therapeutic education regroups in one day: individual interview, nutritional…
- Trial name
- NCT03192228
- Testing
- Treatment adequacy score
- Volunteers
- 120 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Lung Cancer
Vaccine Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. PURPOSE: This phase II trial is studying vaccine therapy given after standard therapy to see how well it works in treating patients with stage…
- Trial name
- NCT00019929
- Testing
- mutant p53 peptide pulsed dendritic cell vaccine, adjuvant therapy
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Recurrent Glioblastoma
Individualized Systems Medicine Functional Profiling for Recurrent Glioblastoma
A study to determine the feasibility and safety of individualized cancer stem cell targeted therapy based on high-throughput functional profiling of FDA/EMA-approved drugs in patients with GBM that has recurred or progressed…
- Trial name
- ISM-GBM (NCT05043701)
- Testing
- Personalized drug combination
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
COPD, ILD
Individualized Plan for Improving Adherence to Portable Oxygen Therapy in Patients With Respiratory Pathology
Pilot study with patients with prescription of portable oxygen therapy, to test the impact on adherence of a patient-centered empowerment program, with contents on the nature of the respiratory pathology, the symptom of dyspnea…
- Conditions
- COPD, ILD, Dyspnea
- Trial name
- PIMAOX (NCT04691336)
- Testing
- Educational and Training with counselling
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Air Liquide Healthcare Spain
Acute Myeloid Leukemia
Study of SA+X in the Treatment of Newly Diagnosed AML
This is a phase II, open-label, multi-center study evaluating the efficacy and safety of sonrotoclax (SA) in combination with azacitidine (AZA) plus individualized targeted or chemotherapeutic agents in adult participants with…
- Trial name
- NCT07548710
- Testing
- Anthracycline, Ivosidenib, Gilteritinib
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Ruijin Hospital