Clinical trials: IOL
Aphakia
Comparison of Safety and Efficacy of Four-Point Scleral Intraocular Lens Fixation and Yamane Techniques
Comparison of safety and efficacy of two scleral fixation intraocular lens (IOL) methods of four-point scleral fixation ( Akreos AO60) and the Yamane technique (AcrySof MA60AC)
- Trial name
- NCT06389643
- Testing
- Four-point scleral fixation of Akreos AO60 IOL, Sutureless scleral fixation of AcrySof MA60AC IOL with Yamane technique
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Military Institute od Medicine National Research Institute
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies
This phase II trial studies how well cyclophosphamide works in preventing chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplant in patients with hematological malignancies.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Myeloid Leukemia in Remission
- Trial name
- NCT01427881
- Testing
- cyclophosphamide, cyclosporine, peripheral blood stem cell transplantation
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Fred Hutchinson Cancer Center
Cataract
Evaluation the TECNIS IOL in Both Eyes VS the ReZoom IOL in One and TECNIS IOL in the Opposite
The purpose of this study is to evaluate the visual performance of two cohorts of patients who received multifocal intraocular lenses following cataract and clear lens extraction surgeries.
- Trial name
- NCT01253239
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Frank A. Bucci, Jr., M.D.
Cataract
Evaluation of Stability After Implantation of Two Different Lens Models: FEMTIS-study
In this study the investigators will investigate the stability of lens position and the visual outcome after implantation of the new FEMTIS-IOL using FLACS capsulotomy compared to conventional placement of the IOL in the capsular…
- Trial name
- NCT03152500
- Testing
- FEMTIS 313G IOL, Acrysof SN60WF IOL
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cataract
Evaluation of Binocular Visual Acuity and Refractive Stability in the Alcon Clareon Intraocular Lens
The objective is to evaluate refractive stability (spherical equivalent change ≤ 0.50D from 1-month to 3-months).
- Trial name
- NCT04936256
- Testing
- Clareon
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Gainesville Eye Associates
Cataract
Vivinex Impress XY1-EM vs RayOne EMV
Comparison of the outcomes of bilateral implantation of extended depth of vision (EDOF) intraocular lenses (IOLs): the Rayone EMV and the Vivinex Impress XY1-EM in patients with cataract
- Trial name
- NCT06891092
- Testing
- RayOne EMV, Vivinex Impress
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Bialystok
Visual Acuity
Comparative Study of Photopic and Mesopic Distance, Intermediate and Near Visual Acuity, and Spectacle Independence
The purpose of this study is to evaluate visual acuity in different lighting conditions (daylight and night time) and distances (distance, near and intermediate), and the independence of glasses, in patients who have had…
- Trial name
- NCT01191502
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Cataract, Astigmatism
Observational Prospective Clinical Investigation on Monofocal Toric Intraocular Lens
Evaluation, at least one-year long-term, of the clinical performance and safety of Mini Toric Ready Intraocular Lens (IOL), a monofocal toric intraocular lens.
- Trial name
- NCT06250855
- Testing
- Mini Toric IOL
- Where
- 2 sites in Romania
- Volunteers
- 105 people
- Sponsor
- SIFI SpA
Cataract
Clinical Investigation of Expanded Designs of a Multifocal IOL
The purpose of this clinical trial is to evaluate the safety and effectiveness of the TECNIS Multifocal 1-Piece Intraocular Lens (IOLs), Models ZKB00 and ZLB00 which will each provide statistically better distance-corrected near…
- Trial name
- NCT01714635
- Testing
- Tecnis Multifocal Intraocular Lens, Monofocal Intraocular Lens
- Where
- 18 sites in United States, United Kingdom
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Cataract
Post-refractive IOL Outcomes With Clareon TruPlus
This is a prospective, single-arm, single-center, single-surgeon study evaluating the Clareon TruPlus IOL in post-refractive cataract patients. Subjects will be assessed up to 3 months post-operatively.
- Trial name
- NCT07610226
- Testing
- Clareon TruPlus
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Laser Defined Vision
Cataract
Clinical Evaluation Study for Assessing the Visual Performance of Hanita Lenses Trifocal IOL
Hanita Lenses Trifocal IOL, SeeLens AFR (Intensity IOL).Prospective, single-arm single-center, open-label study.
- Trial name
- NCT04843748
- Testing
- cataract surgery and intraocular lens implantation - both eyes
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hanita Lenses
Lymphoma, Small Intestine Cancer
Combination Chemotherapy With or Without Biological Therapy in Treating Patients With Refractory Solid Tumor or Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug, giving the drugs in different ways, and combining biological therapy with…
- Conditions
- Lymphoma, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00005021
- Testing
- filgrastim, carboplatin, paclitaxel
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Fox Chase Cancer Center
Lymphoma, Small Intestine Cancer
BMS-247550 in Treating Patients With Advanced Cancers
Phase I trial to study the effectiveness of BMS-247550 in treating patients who have malignant solid tumors or lymphoma. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Lymphoma, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00006221
- Testing
- ixabepilone
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- National Cancer Institute (NCI)
Cataract
Clinical Investigation of a New Intraocular Lens
The purpose of this clinical trial is to evaluate the safety and effectiveness of the TECNIS Symfony Extended Range of Vision IOL.
- Trial name
- NCT02203721
- Testing
- TECNIS Symfony Extended Range of Vision IOL, Model ZXR00, TECNIS Monofocal IOL, Model ZCB00
- Where
- 15 sites in United States
- Volunteers
- 324 people
- Sponsor
- Abbott Medical Optics
Cataract
Safety and Efficacy of the Bi-Aspheric Monofocal IOL
This is an observational, single-center, non-control, open-label post-marketing study. Patients implanted with an aspicio™ Monofocal Intraocular Lens will be scheduled for a follow-up visit at least 3 months after the surgery to…
- Trial name
- NCT06380478
- Testing
- aspicio Monofocal IOL
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- ICARES Medicus, Inc.
Cataracts
AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric Intraocular Lens (IOL) Clinical Study in Japan
The purpose of this study is to evaluate safety and effectiveness of AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL Models SND1T3, SND1T4, SND1T5, and SND1T6 when implanted to replace the natural lens in Japanese cataract…
- Trial name
- NCT01323777
- Testing
- AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL
- Where
- 2 sites in Japan
- Volunteers
- 65 people
- Sponsor
- Alcon Research
Myopia, Myopic Astigmatism
Post-Market Evaluation of the EVO ICL
The objective of this study is to assess the rate of early intraocular pressure (IOP) increases following implantation of EVO/EVO+ Implantable Collamer Lens (ICL).
- Trial name
- NCT05538754
- Testing
- EVO ICL
- Where
- 8 sites in United States
- Volunteers
- 205 people
- Sponsor
- Staar Surgical Company
Astigmatism
Visual Performance With Clareon® Vivity® Intraocular Lenses (IOLs)
The purpose of this study is to generate clinical data to quantify the impact of residual astigmatism on the overall visual performance during distance, intermediate, and near viewing in patients implanted with Clareon Vivity…
- Trial name
- NCT06784063
- Testing
- Clareon Vivity Extended Vision IOL
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Alcon Research
Cataract Bilateral, Astigmatism Bilateral
Symfony Toric Intraocular Lens Visual Outcomes
In July 2016, the FDA approved an extended depth of focus (EDOF) IOL (Tecnis Symfony, Abbott Medical Optics) helping to improve the sharpness of vision at near, intermediate and far distances reducing the need of glasses after…
- Trial name
- NCT03082599
- Testing
- Presbyopia and astigmatism correcting intraocular lens
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Carolina Eyecare Physicians, LLC
Cataract, Fuchs Endothelial Corneal Dystrophy
Partial Range Of Field IOLs in DMEK-Enabled Procedures
Study Overview This study aims to evaluate the visual outcomes, quality of vision, and patient satisfaction after receiving an extended range PRoF intraocular lens (IOL) during triple Descemet Membrane Endothelial Keratoplasty…
- Trial name
- PROFIDE (NCT07441616)
- Testing
- combined cataract and lamellar endothelial keratoplasty
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel