Clinical trials: IUD Complication
Malaria, Stillbirths
The Impact of Sulphadoxine-Pyrimethamine Use At Scale on Newborn Outcomes in Nigeria
The purpose of this study is to test the feasibility of the scale-up of sulphadoxine- pyrimethamine (SP) for the preventive treatment of malaria in pregnancy in three Local Government Areas (LGAs) in Sokoto State, Nigeria.
- Trial name
- MIPP-NG (NCT02758353)
- Testing
- Community distribution of SP
- Volunteers
- 31,493 people, healthy volunteers welcome
- Sponsor
- JSI Research & Training Institute, Inc.
IUD Insertion Complication
Role of Vaginal Misoprostol Prior to IUCD Insertion in Women Who Delivered Only by Elective Caesarean Section.
Role of vaginal misoprostol prior to IUCD insertion in women who delivered only by elective caesarean section.
- Trial name
- NCT03939663
- Testing
- misoprostol
- Where
- Egypt
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
BACTERIAL VAGINOSIS
Bacterial Vaginosis Screening at IUD Insertion
A number of studies have shown a higher prevalence of BV among IUD users.13,,14 None, however, have screened women prior to inserting the IUD.
- Trial name
- NCT00802386
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Fetal Death
Mifepristone-misoprostol vs. Misoprostol Alone for Second Trimester Fetal Death
The primary aim of this trial is to compare the efficacy of mifepristone-misoprostol versus misoprostol alone for treatment of intrauterine fetal demise between 14 and 28 weeks LMP.
- Trial name
- NCT02633761
- Testing
- Mifepristone, Misoprostol 200mcg
- Where
- 3 sites in Mexico, Vietnam
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pregnancy, Pregnancy Complications
AI-POCUS for Maternal and Neonatal Health in Ethiopia
Maternal and neonatal health remains one of the most pressing global health challenges, particularly in low- and middle-income countries (LMICs).
- Conditions
- Pregnancy, Pregnancy Complications, Preterm Birth, Fetal Growth Restriction
- Trial name
- AIM-ETH (NCT07171086)
- Testing
- AI-POCUS (BabyChecker, Delft Imaging), AI-POCUS (Edan, China)
- Where
- Ethiopia
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Contraceptive Device; Complications
Vaginal Misoprostol Before IUD Insertion in Women With Cesarean Scar
Groups of study: 120 candidates for Cu T 380A IUD insertion were enrolled in the study. They were divided into two groups: Group 1: Sixty women received 600 micrograms of misoprostol vaginally as deep as possible six hours before…
- Trial name
- NCT03081442
- Testing
- Misoprostol, Intrauterine contraceptive device IUCD
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
IUD Insertion Complication
Different Analgesics Prior to Intrauterine Device (IUD) Insertion: Is There Any Evidence?
Different ways of reducing pain during IUD insertion have been explored. So a randomized study will be conducted to test their role
- Trial name
- NCT02522130
- Testing
- Lidocaine, oral misoprostol, naproxen
- Where
- 2 sites in Egypt, Saudi Arabia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Al Hayat National Hospital
Labor Induction
A Randomized Trial of Two Regimens of Misoprostol for Second Trimester Termination for Intrauterine Fetal Death
Misoprostol (Cytotec®) is a synthetic prostaglandin E1 analog that has been marketed in the United States since 1988 as a gastric cytoprotective agent.
- Trial name
- NCT00141895
- Testing
- Misoprostol
- Where
- Lebanon
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Small for Gestational Age at Delivery, Hypoxic-Ischemic Encephalopathy
Umbilical Cord Abnormalities in the Prediction of Adverse Pregnancy Outcomes
The objective of our study is to investigate the association of umbilical cord abnormalities with adverse pregnancy outcomes. The umbilical cord parameters that will be investigated as part of this study include the umbilical…
- Conditions
- Small for Gestational Age at Delivery, Hypoxic-Ischemic Encephalopathy, Stillbirth, Admission to Neonatal Unit
- Trial name
- ULOOP (NCT05901688)
- Testing
- Umbilical cord measurements & observations
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Medway NHS Foundation Trust
Stillbirth
Revealed Versus Concealed Cerebroplacental Ratio
The purpose of this study is to evaluate the role of an integrated strategy at selecting fetuses for delivery at term based on a combination of fetal biometry and cerebroplacental ratio (CPR) to reduce stillbirth rate and adverse…
- Trial name
- NCT02907242
- Testing
- Revealment
- Where
- 9 sites in Chile, Czechia and 4 more
- Volunteers
- 11,582 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Early Pregnancy Failure, Miscarriage
MiMi: A Randomized Trial of Mifepristone and Misoprostol for Treatment of Early Pregnancy Failure
The purpose of this study is to compare two combinations of drugs (mifepristone and misoprostol versus placebo and misoprostol) used for medical treatment for early pregnancy failure.
- Conditions
- Early Pregnancy Failure, Miscarriage, Fetal Demise, Anembryonic Pregnancy
- Trial name
- MiMi (NCT00468299)
- Testing
- Mifepristone and misoprostol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boston University
IUD Insertion Complication
Pain Relief During IUD Insertion in Women Delivered Only by Elective Cesarean Section
The aim of the work is to assess the effect of combined misoprostol 200 mcg and isosorbide mononitrate 40 mg versus misoprostol 200 mcg and placebo as local vaginal tablet on the successful IUD insertion.
- Trial name
- NCT03587077
- Testing
- Misoprostol, isosorbide mononitrate
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Assiut University
IUD Insertion Complication, Pain Control
Study of Local Anesthesia as a Method to Decrease IUD Insertion Related Pain
Despite the high efficacy of intrauterine devices (IUDs), some women choose not to receive IUDs secondary to the pain associated with insertion.
- Trial name
- NCT01967017
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Stillbirth, Neonatal Respiratory Depression
Newborn Heart Rate as a Catalyst for Improved Survival
Heart rate (HR) is not routinely assessed during newborn resuscitations in low- and lower-middle income countries (LMICs). Many non-breathing newborns classified as fresh stillbirths have a heartbeat and are live born.
- Conditions
- Stillbirth, Neonatal Respiratory Depression, Neonatal Bradycardia, Neonatal Resuscitation
- Trial name
- NCT03799861
- Testing
- Epoch 2: HBB with NeoBeat, Epoch 3: HR-guided HBB
- Where
- 3 sites in Democratic Republic of the Congo
- Volunteers
- 24,034 people, healthy volunteers welcome
- Sponsor
- American Academy of Pediatrics
Venous Thromboembolism, Fetal Death
Fetal Loss in Women With Unprovoked Thromboembolism (FLUTE)
The purpose of this study is to determine the risk of fetal loss in women with unprovoked venous thromboembolism (VTE) who do not have identifiable inherited thrombophilia compared with women who have the diagnosis of venous…
- Trial name
- NCT00149357
- Testing
- Thrombophilia Testing
- Where
- 5 sites in Australia, Canada
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mechanical Complication of Intrauterine Device
Immediate Post-placental Insertion of IUCD During Cesarean Delivery Versus 6 Week Post-Cesarean Insertion
The aim of current study is to compare the rates of IUCD expulsion and complications in immediate post-placental insertion versus delayed IUCD insertion (6-weeks after cesarean delivery)
- Trial name
- NCT03404622
- Testing
- IUCD
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- ALshaimaa Aboalhassan Ali
Stillbirths and Infant Mortality
Oral Azithromycin to Prevent Stillbirths and Infant Mortality in Mali
The double blind randomized controlled trial will assess the efficacy of oral azithromycin administered to pregnant women and/or infants during routine care in preventing stillbirths and mortality through 6-12 months of age in…
- Trial name
- SANTE (NCT03909737)
- Testing
- Azithromycin to pregnant women, Azithromycin to infants, No intervention to pregnant women
- Where
- Mali
- Volunteers
- 99,700 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Decreased Fetal Movements Affecting Care of Mother, Pregnancy
Promoting Awareness Fetal Movements to Reduce Fetal Mortality Stillbirth, a Stepped Wedge Cluster Randomised Trial.
Rates of stillbirth in Scotland are among the highest in resource rich countries. The majority of stillbirths occur in normally formed infants, with (retrospective) evidence of placental insufficiency being the commonest clinical…
- Conditions
- Decreased Fetal Movements Affecting Care of Mother, Pregnancy, Stillbirth
- Trial name
- AFFIRM (NCT01777022)
- Testing
- A package of interventions
- Where
- 29 sites in Ireland, United Kingdom
- Volunteers
- 430,830 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
IUD, IUD Insertion Complication
IUD Placement Without Sounding
The purpose of this study is to determine the feasibility of a uterine sound sparing technique for levonorgestrel 52 mg intrauterine device (IUD) placement. This study will be conducted in three phases.
- Conditions
- IUD, IUD Insertion Complication, IUD; Complications
- Trial name
- NCT05700812
- Testing
- Sound sparing levonorgestrel 52 mg IUD placement
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cardiovascular Diseases
Continuation of the nuMoM2b Heart Health Study
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and large knowledge gaps exist in CVD predictive and preventative strategies for women.
- Trial name
- nuMoM2b-HHS2 (NCT05472597)
- Where
- 14 sites in United States
- Volunteers
- 4,048 people, healthy volunteers welcome
- Sponsor
- RTI International