Clinical trials: IVF
Quality of Life, IVF
CALM IVF (Creating Affiliations, Learning, and Mindfulness for In Vitro Fertilization Patients)
The investigators have designed a psychoeducational group curriculum specifically for new in vitro fertilization (IVF) patients (both male and female) to improve their treatment knowledge, to allow them to engage more in their…
- Conditions
- Quality of Life, IVF, Patient Satisfaction, Patient Engagement
- Trial name
- NCT04048772
- Testing
- CALM IVF, Standard of Care
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Recurrent Implantation Failure, Infertility (IVF Patients)
Endometrial Immune Profile in Recurrent Implantation Failure
The goal of this observational study is to learn whether differences in the immune cells of the womb lining (endometrium) help explain why some women do not become pregnant despite several IVF attempts using good-quality embryos…
- Trial name
- NCT07848399
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- King's College London
Infertility (IVF Patients), BMI
BMI Versus Body Fat Percentage - Which is the Better Predictor of Fertility Outcomes in IVF Cycles?
The goal of this prospective observational cohort study is to evaluate whether body composition measured using bioelectrical impedance analysis (BIA) (including measures of body fat% and visceral fat) serve as a better predictor…
- Conditions
- Infertility (IVF Patients), BMI, Bioelectrical Impedance Analysis, IVF Outcomes
- Trial name
- NCT07765368
- Testing
- Measurement of BIA (Body Fat and Visceral Fat Percentage)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Infertility (IVF Patients), Clinical Pregnancy After Single Embryo Transfer
Correlation Of Clinical Outcomes After Transfer Of Good-Quality Morphology Embryos In Patients With A Favorable Prognosis And Non-Invasive Preimplantation Genetic Testing For Aneuploidy (NiPGT-A) Results
Non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A) is an emerging approach that analyzes embryonic cell-free DNA (cfDNA) released into the spent culture medium (SCM) to assess chromosomal status without…
- Conditions
- Infertility (IVF Patients), Clinical Pregnancy After Single Embryo Transfer, Embryo Diagnosis and Selection
- Trial name
- NCT07700602
- Where
- Vietnam
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
Infertility, IVF
Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?
A-PRP (Autologous Platelet Rich Plasma) is becoming widely used in a variety of medical procedures seeking tissue remodeling and/or healing as an intervention.
- Conditions
- Infertility, IVF, Premature Ovarian Failure, Anti-Mullerian Hormone Deficiency
- Trial name
- NCT04381299
- Testing
- autologous platelet rich plasma, saline solution
- Where
- United Arab Emirates
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Quantifying Uterine Elastography in Menstruating Women
This study is aiming to characterize the elasticity of the female reproductive tract including the uterus, cervix and ovary using shear wave elastography at different times during the menstrual cycle and define the standard…
- Trial name
- QUEST (NCT06816381)
- Testing
- Shear wave elastography measurements
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
GnRH Antagonist IVF Protocol, Fresh Embryo Transfer
GnRH for Luteal Support - Mechanism of Action
This prospective observational study will include women undergoing IVF treatment with a GnRH antagonist protocol and fresh embryo transfer at the IVF unit of Shaare Zedek Medical Center.
- Conditions
- GnRH Antagonist IVF Protocol, Fresh Embryo Transfer, Administration of Hormonal Luteal Support
- Trial name
- NCT07620067
- Testing
- GnRH agonist, Progesterone
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Heli Alexandroni
Infertility, IVF
Sex Selection of Human Spermatozoa
This study aims to demonstrate a reliable method of selecting gender specific sperm. X-bearing spermatozoa and Y-bearing spermatozoa will be identified from the density gradient layers.
- Trial name
- NCT05500573
- Testing
- Sperm Sorting
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Severe Oligoasthenoteratozoospermia, Sperm Quality
PRP Improves Blastocyst Formation in ICSI Cycles
The goal of this clinical trial is to learn if platelet rich plasma (PRP) works to improve embryo development rates and embryo quality in IVF cycles, involving male adult patients with severe sperm disorders.
- Conditions
- Severe Oligoasthenoteratozoospermia, Sperm Quality, Spermatazoa Disorders, Sperm Parameters in Fertile and Infertile Men
- Trial name
- PRP ICSI SOAT (NCT07579858)
- Testing
- Platelet Rich Plasma
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stella Maris Women and Children Hospital
Stimulation in the Ovary, IVF Outcome
Comparing IVF/ICSI Cycle Outcomes of Post Ovulation Ovarian Stimulation Protocol With Elonva Without GnRH Antagonist to Follicular Phase Day 2 Stimulation Fixed Day 5 Antagonist Protocol
There are several approaches to the timing of antagonist administration in IVF/ICSI cycles. The primary goal is indeed to prevent premature ovulation, which could jeopardize the success of the cycle There is an emerging concept…
- Trial name
- NCT06879002
- Testing
- Ovarian stimulation with menstruation or after ovulation
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
IVF
Efficacy of Micronized Natural Progesterone vs GnRH Antagonist in the Prevention of LH Peak During Ovarian Stimulation.
This study aims to investigate if the use of oral micronized natural progesterone is not inferior to the use of subcutaneous antagonist in preventing LH peak in controlled ovarian stimulation.
- Trial name
- PRO_NAT (NCT05954962)
- Testing
- Progesterone 200 MG, Ganirelix Acetate
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
IVF Outcomes
HELIOS Advanced: Human Oocyte Illumination to Enhance Development
Oocytes need a lot of energy to complete meiosis and fertilize successfully. As women get older, the "power plants" of the cells (called mitochondria) don't work as well.
- Trial name
- HELIOS-A (NCT07425080)
- Testing
- Photobiomodulation
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Columbia University
Ovarian Aging, IVF Outcome
The ROAR Study: Reactive Oxygen Species and Reproduction
This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative…
- Conditions
- Ovarian Aging, IVF Outcome, Oxidative Stress
- Trial name
- ROAR (NCT06831019)
- Testing
- Oxidative stress markers
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
IVF
Non-Invasive Preimplantation Genetic Screening for Aneuploidies and Clinical Outcomes in Egg Donation Patients
Preimplantation genetic testing for aneuploidies (PGT-A) is commonly used in IVF but requires embryo biopsy and shows limited benefit in egg donation cycles.
- Trial name
- niPGTAdon (NCT07364526)
- Where
- Spain
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Infertility, in Vitro Fertilization (IVF)
Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF Outcomes
The use of machine learning techniques using an artificial intelligence tool is proposed to analyze clinical data to predict best possible IVF/ART outcomes.
- Conditions
- Infertility, in Vitro Fertilization (IVF), ART
- Trial name
- AI in ART (NCT04255615)
- Testing
- AI to analyze 3 D ultrasound
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
In Vitro Fertilization (IVF), Embryo Transfer
Dual Trigger With HCG and GnRH Agonist on Thawed Modified Natural Cycle Embryo Transfer
Impact of dual trigger using recombinant human chorionic gonadotropin (HCG) and gonadotropin-releasing hormone (GnRH) agonist on thawed modified natural cycle outcomes: an open-label multi-center randomized controlled trial.
- Trial name
- NCT07269392
- Testing
- GnRH agonist
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Infertility (IVF Patients)
An Advanced Decision Support Tool for Personalized Medicine for IVF Using Modeling and Optimization for Provera
A clinical trial will determine the effectiveness of using the Opt-IVF decision support tool for each patient's personalized and optimal drug dosage profile in the United States.
- Trial name
- NCT07148999
- Testing
- Opt-IVF, Control
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Urmila DIwekar
Infertility (IVF Patients)
The Role of hCG in Thawed Embryo Transfer
This prospective randomized trial will assess the relevance, if any, of a corpus luteum induced by hCG in transfers of thawed embryos.
- Trial name
- NCT07004192
- Testing
- HCG injection, No intervention
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
IVF Outcomes
Comparison of Two Protocols in Frozen Embryo Transfer
This randomized clinical trial evaluates two different endometrial preparation protocols-hormone replacement therapy (HRT) and natural cycle-for frozen embryo transfer (FET) in infertile women undergoing assisted reproductive…
- Trial name
- NCT07003373
- Testing
- hormone replacement therapy (HRT) group
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Malihe Mahmoudinia
IVF, Frozen Embryo Transfer (FET)
Maternal Cardiovascular Adaption to Pregnancy in IVF Patients Following Frozen Embryo Transfer (FET)
Aim of the study is to explore the effect of a lacking corpus luteum on maternal cardiovascular and metabolic adaption to pregnancy by the use of magnetic resonance imaging (MRI).
- Conditions
- IVF, Frozen Embryo Transfer (FET), Cardiovascular Adaption, Magnetic Resonance Imaging (MRI)
- Trial name
- NCT06471140
- Testing
- magnetic resonance imaging (MRI)
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital