Clinical trials: IVF
Poor Responders Undergoing IVF
The Comparison of Effect of Four Different Treatment Protocols on IVF Outcomes in Poor Responders Undergoing in Vitro Fertilization.
The comparison of effect of four different treatment protocols: Antagonist/letrozole protocol, microdose flare-up protocol, Antagonist/clomiphene protocol, Antagonist on IVF outcomes in poor responders undergoing in vitro…
- Trial name
- NCT01948804
- Testing
- GnrH Antagonist/letrozole protocol (Cetrotide; serono + Femara; Novartis Pharma AG), microdose flare-up protocol (Lucrin; Abbott + Gonal F, Serono), Antagonist/clomiphene protocol (Cetrotide; serono + Klomen, Kocak pharma)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pınar Özcan Cenksoy
Infertility, in Vitro Fertilization (IVF)
Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF Outcomes
The use of machine learning techniques using an artificial intelligence tool is proposed to analyze clinical data to predict best possible IVF/ART outcomes.
- Conditions
- Infertility, in Vitro Fertilization (IVF), ART
- Trial name
- AI in ART (NCT04255615)
- Testing
- AI to analyze 3 D ultrasound
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Ovarian Hyperstimulation Syndrome
Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS
This a prospective randomized double blind study involving patients at high risk of OHSS development with peak serum E2 levels < 4,000 pg/ml comparing the ongoing pregnancy rates in patients who receive adjuvant hCG 1,000 IU at…
- Trial name
- NCT01815138
- Testing
- hCG
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- UConn Health
Infertility
Efficacy and Safety of R-hLH (Luveris ®) Priming Prior to R-HFSH Treatment in Infertile Women Undergoing IVF-ET
In programmes of IVF, normal women undergo controlled ovarian stimulation using exogenous FSH injections to obtain multiple eggs.
- Trial name
- NCT00441324
- Testing
- recombinant human LH
- Where
- 3 sites in Denmark, France and 1 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Thyroid Diseases
An Assessment of Aspirin Plus Prednisone Treatment for Euthyroid Women With Thyroid Autoimmunity
Thyroid autoimmunity(TAI) per se have adverse effect on pregnancy outcomes，and aspirin and prednisone were used frequently in antithyroid antibodies(ATA) positive infertile women in clinical practice, but the impact of these…
- Trial name
- NCT04943146
- Testing
- Prednisone 10 MG+aspirin 100MG
- Where
- 2 sites in China
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Vitamin D Status
The Impact of Vitamin D Status on in Vitro Fertilization (IVF) Outcomes
Infertility is a common and psychologically devastating problem for 20% of Canadian couples. Approximately, 20% of infertile couples are diagnosed with unexplained infertility and left without an explanation for their inability…
- Trial name
- NCT01348594
- Where
- Canada
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Infertility
A Clinical Trial to Evaluate the Efficacy and Safety of DR-2011 for In Vitro Fertilization
This is a multi-center study to evaluate the effects of DR-2011 compared to a progesterone gel in women undergoing in vitro fertilization with fresh eggs.
- Trial name
- NCT00615251
- Testing
- DR-2011, Crinone 8%
- Where
- 29 sites in United States
- Volunteers
- 1,297 people, healthy volunteers welcome
- Sponsor
- Duramed Research
Infertility, Female
Exploratory Study Assessing Synchronisation of Egg Sacs With Degarelix
The main purpose of this clinical research study is to investigate if degarelix can synchronise the growth of the egg sacs in the ovaries and if degarelix has any effect on the lining of the womb.
- Trial name
- NCT00434122
- Testing
- Degarelix mid-luteal, 2.5 mg
- Where
- 4 sites in Belgium, Czechia and 1 more
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Ovarian Aging, IVF Outcome
The ROAR Study: Reactive Oxygen Species and Reproduction
This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative…
- Conditions
- Ovarian Aging, IVF Outcome, Oxidative Stress
- Trial name
- ROAR (NCT06831019)
- Testing
- Oxidative stress markers
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
AMH Levels, Inhibin B Levels
Evaluation of Anti-mullerian Hormone Levels as Predictive of IVF Outcomes in Women Over 38 Years Old
The present study is designed to evaluate the basal serum levels of anti-mullerian hormone (AMH) and inhibin B as early predictors of ovarian response, implantation rate, and pregnancy rate in women 38 years old or older that are…
- Conditions
- AMH Levels, Inhibin B Levels, IVF Patients Over 38 Years Old
- Trial name
- NCT01219387
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Poor Response to Ovulation Induction, Infertility, Female
Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders
Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subjected to intracytoplasmic…
- Conditions
- Poor Response to Ovulation Induction, Infertility, Female, Ovarian Insufficiency, Ovarian Failure
- Trial name
- PRPPOR (NCT05181748)
- Testing
- Autologous platelet rich plasma
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Infertility, IVF
Sex Selection of Human Spermatozoa
This study aims to demonstrate a reliable method of selecting gender specific sperm. X-bearing spermatozoa and Y-bearing spermatozoa will be identified from the density gradient layers.
- Trial name
- NCT05500573
- Testing
- Sperm Sorting
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Pre-Eclampsia
At High-risk for Pre-eclampsia After Assisted Reproductive Technology
The overarching goal of the project is to unravel PE etiopathogenesis in high-risk patients (PCOS patients and oocyte acceptors) after assisted reproductive technology (ART) to individualize prenatal care following ART and to…
- Trial name
- HEART (NCT05746793)
- Testing
- endometrium biopsy, Transabdominal ultrasound, Peripheral phlebotomy
- Where
- Belgium
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
In Vitro Fertilization, Frozen Embryo Transfer
Comparison of Thawing Embryos in Advance and on the Day of Transfer on Pregnancy Outcomes in FET Cycle
Respectively for patients with repeated transplant failure and routine patients, Thawing frozen embryos in advance (18h) to extend the duration of embryonic development or thawing embryos on the day of transfer in the frozen…
- Trial name
- NCT04455191
- Testing
- Thawing Embryos in Advance, Thawing Embryos on the Day of Transfer
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jinan Central Hospital
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Infertility, ART
Automation of the In Vitro Fertilization Laboratory
Enrolled patients will undergo an Assisted Reproductive technology (ART) treatment using intracytoplasmic sperm injection (ICSI, the direct injection of a single sperm cell into an oocyte) as the method of insemination.
- Trial name
- NCT06581068
- Testing
- AURA assisted ART treatment
- Where
- 2 sites in Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Conceivable Life Sciences
Infertility
Effect of Influenza Vaccination on IVF Outcomes - IVF
In this study the investigators propose a randomized controlled trial to evaluate the effect of influenza vaccination on clinical pregnancy rates among women undergoing in vitro fertilization.
- Trial name
- IVF-FluVac (NCT02947217)
- Testing
- Influenza Vaccine, Sterile Saline
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility, Female
The Role of ICSI in Non-male Factor Infertility in Advanced Maternal Age
The use of Intracytoplasmic sperm injection (ICSI) has increased in the last decades regardless of the cause of infertility. Despite the increased use there is no clear evidence that ICIS is more effective than conventional in…
- Trial name
- ICSI (NCT03370068)
- Testing
- ICSI, Conventional IVF
- Where
- Israel
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Dr. Tal Miller-Elkan
Infertility, Female
The Effectiveness and Safety of the Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation
Since the first "tube baby", Louise Brown, was born in the United Kingdom in 1978, many infertile couples have been benefitted from in vitro fertilization and embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI).
- Trial name
- NCT03809221
- Testing
- Triptorelin acetate
- Volunteers
- 1,892 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Efficacy of DHEA, Pregnancy Rate
Administration of DHEA in Patients With Poor Response to Ovarian Stimulation for IVF
Poor responders to ovarian stimulation represents one of the most frustrating problems in reproductive medicine. The investigators hypothesize that ovarian response of those patients could improve by treating these patients with…
- Conditions
- Efficacy of DHEA, Pregnancy Rate, Diminished Ovarian Reserve, Changes in AMH
- Trial name
- DHEA (NCT02099916)
- Testing
- gonadotropins plus DHEA, Gonadotropins
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Athens