Clinical trials: IVF Poor Responders
Infertility
Mild Versus Conventional Ovarian Stimulation for Poor Responders Undergoing In Vitro Fertilisation
The investigators will examine the balance between IVF success in terms of outcome parameters, using a mild ovarian stimulation protocol, opposing it to the conventional stimulation regimens in poor responders undergoing IVF.
- Trial name
- NCT01319708
- Testing
- mild ovarian stimulation, conventional ovarian stimulation
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- National and Kapodistrian University of Athens
Infertility, Poor Responder to IVF Treatment
Study of Dehydroepiandrosterone Treatment for Poor Responders in In Vitro Fertilization Patients
The aim of this study is to show solid evidences of the efficacy of DHEA in improving the success rates of in-vitro fertilization (IVF) patients facing poor ovarian reserve.
- Trial name
- NCT01535872
- Testing
- Dehydroepiandrosterone
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- KK Women's and Children's Hospital
Androgen Receptor Gene Overexpression, Normal Responders
Androgen Receptor mRNA Expression is Positively Associated With Live Birth in Women Undergoing IVF Independently of the Type of Ovarian Response
AR is a steroid hormone receptor that regulates various genes' expression and affects cellular proliferation and differentiation.
- Conditions
- Androgen Receptor Gene Overexpression, Normal Responders, Poor Ovarian Response, Bologna Criteria
- Trial name
- NCT03433768
- Testing
- Real time PCR
- Volunteers
- 67 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility Assisted Reproductive Technology, Oocyte Retrieval
ART Cycle Outcomes When Only 1 to 3 Oocytes Are Retrieved
This is a monocentric retrospective observational study. The study focuses on the women who underwent Assisted Reproductive Technology (ART) cycles with poor ovarian response (POR), defined as <4 oocytes retrieved.
- Trial name
- POR (NCT06950476)
- Testing
- Oocyte Retrieval
- Volunteers
- 3,761 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Infertility
Study of Optimal Posology of Gonadotrophins in Patients With Insufficient Ovarian Response Due to Age
In In vitro fertilization (IVF) treatment, poor responder patients of more than 38 years old are randomized prospectively into two dosages of gonadotrophins. The outcome of treatment will be analyzed.
- Trial name
- NCT00575302
- Testing
- Gonal-f®: follitropin alpha
- Where
- 4 sites in Belgium
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Chretien
Female Infertility Due to Diminished Ovarian Reserve
IVF/ICSI Protocols in Poor Responders With Growth Hormone
in this study, we are trying to monitor the effect of the addition of growth hormone on the different down regulation protocols ( long, short, antagonist and microflare).
- Trial name
- NCT01897324
- Testing
- Growth hormone (Norditropin, Novo nordisk)
- Where
- Egypt
- Volunteers
- 287 people
- Sponsor
- Woman's Health University Hospital, Egypt
Infertility
The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders
The supplementation of Dehydroepiandrosterone (DHEA) has been used in some centers for patients with previous poor ovarian reserve and response in an attempt to improve pregnancy outcomes.
- Trial name
- DHEA (NCT02357472)
- Testing
- dehydroepiandrosterone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Infertility, Premature Ovarian Failure
Flexible GnRH Antagonist vs Flare up GnRH Agonist Protocol in Poor Responders
The purpose of this study is to compare ovulation induction using a flexible GnRH antagonist protocol and flare up GnRH agonist protocol in IVF patients with poor response to ovarian stimulation.
- Trial name
- NCT00417066
- Testing
- Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands), Arvekap 0.1mg (Triptorelin, Ipsen, France)
- Where
- Greece
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Eugonia
Infertility
Follicular Flushing Outcomes in Singles Versus Double Lumen Oocyte Retrieval Needles in Poor Responding Patients
In this study, the investigators aimed to evaluate to the efficacy of the needle type used in follicular flushing in oocyte retrieval in the poorest responders undergoing IVF.
- Trial name
- needles(opu) (NCT02391155)
- Testing
- single lumen needle in oocyte retrieval, double lumen needle in oocyte retrieval
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Baskent University
Infertility
Dydrogesterone Versus GnRH Antagonist in Poor Responders Undergoing Double Ovarian Stimulation
The aim of this randomized controlled trial is to compare the efficacy and cost-effectiveness of using progestin with GnRH antagonist to prevent premature LH surge in poor responders undergoing double stimulation protocol.
- Trial name
- NCT06212102
- Testing
- Progestin primed ovarian stimulation, GnRH antagonist
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Bedaya Hospital
Poor Responders Undergoing IVF
The Comparison of Effect of Four Different Treatment Protocols on IVF Outcomes in Poor Responders Undergoing in Vitro Fertilization.
The comparison of effect of four different treatment protocols: Antagonist/letrozole protocol, microdose flare-up protocol, Antagonist/clomiphene protocol, Antagonist on IVF outcomes in poor responders undergoing in vitro…
- Trial name
- NCT01948804
- Testing
- GnrH Antagonist/letrozole protocol (Cetrotide; serono + Femara; Novartis Pharma AG), microdose flare-up protocol (Lucrin; Abbott + Gonal F, Serono), Antagonist/clomiphene protocol (Cetrotide; serono + Klomen, Kocak pharma)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pınar Özcan Cenksoy
Female Infertility, Poor Responder
Long Acting FSH Plus Antagonist Versus Daily FSH Plus Antagonist Versus Short Agonist Protocol in Poor Responders Undergoing IVF
Despite the progression in assisted reproductive technology (ART), poor ovarian response to controlled ovarian stimulation remains a challenge for clinicians and a source of distress for patients.
- Trial name
- NCT02070198
- Testing
- Long acting FSH and GnRH antagonist, Daily FSH and GnRH antagonist, Triptorelin and recombinant FSH
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Bioroma
Infertility, Female
Efficacy of Growth Hormone Supplementation With Gonadotrophins in IVF/ICSI for Poor Responders
The objective of this study is to assess the effectiveness of adjuvant growth hormone injection during controlled ovarian stimulation, in poor responder women undergoing intracytoplasmic sperm injection (ICSI) procedures.
- Trial name
- NCT03759301
- Testing
- Growth Hormones Somatropin Recombinant
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- ClinAmygate
Poor Ovarian Reserve, Infertility (IVF Patients)
Drospirenone-Primed Ovarian Stimulation Versus GnRH Antagonist Protocol in Poor Ovarian Responders Undergoing Freeze-All IVF/ICSI
Participants will: Take either drospirenone (a daily pill) or the standard daily injection during their ovarian stimulation cycle, alongside their regular fertility hormone injections Undergo egg retrieval, with all resulting…
- Trial name
- PPOS (NCT07736261)
- Testing
- Drospirenone drug, Cetrorelix 0.25 mg
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ahmed Saad
Infertility
Testosterone Gel in Poor Responders Undergoing IVF
The main purpose of this study is to compare the number of oocytes retrieved after using transdermal testosterone gel 10 mg per day or Dehydroepiandrosterone (DHEA) 75mg per day for 6-8 weeks as pre-treatment for poor ovarian…
- Trial name
- NCT02549690
- Testing
- Testosterone gel, DHEA
- Where
- Vietnam
- Sponsor
- Vietnam National University
Infertility
Dual Ovarian Stimulation in the Same IVF/ICSI Cycles for Treatment of Poor Ovarian Responders
This study is a prospective before \& after clinical trial to investigate the efficacy of double stimulations during both the follicular and luteal phases in patients with poor ovarian response undergoing IVF and intracytoplasmic…
- Trial name
- NCT02732808
- Testing
- Ovulation stimulation
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Royan Institute
ICSI
Luteal Phase Support With Estradiol In Poor Responders Undergoing In Vitro Fertilization
The role of progesterone (P) supplementation in the luteal phase of in vitro fertilization (IVF) cycles is well established world-wide , but the influence of the luteal phase estradiol level on implantation is not clearly defined…
- Trial name
- NCT03788681
- Testing
- Estradiol Valerate
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Ain Shams University
Fertility Disorders
Prospective Randomized Trial Comparing Corifollitropin-alfa Late Start vs. Corifollitropin-alfa Standard Start in Expected Poor, Normal and High-responders Undergoing IVF
To compare the number of retrieved oocytes in the late start CF-alfa (day 4) versus standard CF-alfa protocols (day 2) in patients undergoing IVF.
- Trial name
- NCT03816670
- Testing
- Corifollitropin Alfa
- Where
- Italy
- Volunteers
- 113 people
- Sponsor
- University of Turin, Italy
Infertility
RCT of Low-dose Clomiphene vs. High Dose Gonadotropin Protocol for IVF Poor Responders
The purpose of this study is compare two commonly-used medication protocols ( low-dose clomiphene citrate and high dose gonadotropin protocols) for the treatment of patients with diminished ovarian reserve (decreased number of…
- Trial name
- CLOVANT (NCT01577199)
- Testing
- Low-dose Clomiphene, High dose gonadotropins
- Sponsor
- Weill Medical College of Cornell University
Poor Responders, IVF
Clomiphene Citrate Plus Gonadotropins and GnRH Antagonist Versus Flexible GnRH Antagonist Protocol Versus Microdose GnRH Agonist Protocol in Poor Responders Undergoing IVF
Poor ovarian response to stimulation in IVF cycles is a challenging and frustrating condition, due to its poor prognosis in terms of chances of pregnancy and live births.
- Conditions
- Poor Responders, IVF, Clomiphene Citrate, GnRH Agonist
- Trial name
- NCT02201914
- Testing
- Clomiphene citrate, Daily FSH and LH plus Cetrorelix, Triptorelin plus daily FSH anh LH
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Bioroma