Clinical trials: IVF Poor Responders
Poor Responders
Comparison of Treatment Modalities in Poor Responders Undergoing IVF
The accurate identification and efficient management of poor responders remains one of the most enigmatic challenges in assisted reproductive technology (ART).
- Trial name
- NCT02158689
- Testing
- Letrozole, human menopausal gonadotropin (hMG)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ercan Bastu
Other Complications Associated With Artificial Fertilization
Delayed Start Versus Conventional Antagonist Protocol in Poor Responders Pretreated by Estradiol in Luteal Phase
40 patients attending IVF center during 2013 \&2014 were fulfilling criteria of poor response and they failed to go through OPU as they gave <3 mature follicles on a dose of 300U GN or more.
- Trial name
- NCT02333253
- Testing
- cetrotide
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Subfertility
Transdermal Testosterone Pretreatment in Poor Responders Undergoing IVF
Ιt has been suggested that the accumulation of androgens in the micro milieu of the primate ovary, plays a critical role in early follicular development and granulosa cell proliferation.
- Trial name
- NCT01961336
- Testing
- Testosterone
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility
Cumulative Live Birth After Double Stimulation Protocol Versus Antagonist Protocol for Poor Ovarian Responders
To compare the difference in cumulative live birth rates within one year between double stimulations protocol and two-cycle antagonist protocol in poor ovarian responders.
- Trial name
- NCT05765968
- Testing
- Double Stimulation Protocol, Antagonist Stimulation Protocol
- Where
- China
- Volunteers
- 1,198 people, healthy volunteers welcome
- Sponsor
- Shandong University
Infertility
Protocols for Improved in Vitro Fertilization (IVF) Outcomes
Many infertile patients have a decreased chance of becoming pregnant when using in vitro fertilization (IVF). For these patients, many different treatments are available, but none of them have been shown to be better than the…
- Trial name
- NCT00334243
- Testing
- Microflare protocol for IVF, Antagonist protocol for IVF, Demi-halt protocol for IVF
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco
Infertility
Growth Hormone in Poor Responders to IVF Trial
This study (the "Adjuvant Growth Hormone Study") is being done to see the effects of adding Growth Hormone (GH) during fertility treatment (also called in vitro fertilization or IVF).
- Trial name
- NCT01616225
- Testing
- Saizen (Human Growth Hormone), No Saizen Control (Standard IVF Protocol)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Pacific Centre for Reproductive Medicine
Poor Response to Ovulation Induction, PCOS
The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment
According the World Health Organization (WHO), infertility is a disease of the male or female reproductive system defined by the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse.
- Conditions
- Poor Response to Ovulation Induction, PCOS, Endometriosis, Infertility, Female
- Trial name
- NCT05298657
- Where
- United Arab Emirates
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fatima College of Health Sciences
Infertility
Extended Letrozole Regimen Co-treatment With Gonadotropin Releasing Hormone Antagonist Protocol Versus Gonadotropin Releasing Hormone Antagonist Protocol in Poor Responders Undergoing IVF-ET
The object of this study is to evaluate the efficacy of extended letrozole co-treatment with GnRH-antagonist protocol in ovarian stimulation of poor responder patients undergoing IVF-ET.
- Trial name
- NCT04268927
- Testing
- GnRH ant/letrozole, GnRH ant
- Where
- 2 sites in Egypt
- Volunteers
- 106 people
- Sponsor
- Cairo University
Fertilization in Vitro
Poor Ovarian Responders Undergoing IVF Using Luteal Ovarian Stimulation Versus Follicular Ovarian Stimulation
The investigators attempted to compare the clinical outcomes and cumulus genes expression in poor ovarian responders undergoing luteal ovarian stimulation or follicular ovarian stimulation in in vitro fertilization cycles.
- Trial name
- NCT03238833
- Testing
- luteal ovarian stimulation, follicular ovarian stimulation
- Where
- Taiwan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Poor Response to Ovulation Induction
Effect of LH Supplementation on the Endometrial Gene Expression Profile in Poor Ovarian Responders
This is a prospective randomized open-label cross-over study. Poor responder patients will undergo two ovarian stimulation cycles.
- Trial name
- NCT05405686
- Testing
- Lutropin alfa, Follitropin alfa, Endometrial biopsy
- Sponsor
- CRG UZ Brussel
Infertility, Female
Can Antioxidants Affect Pregnancy Rate in Patients With Expected Low Number of Egg Retrieval in IVF Cycles?
The aim of the study is to evaluate the effect of antioxidants on IVF outcome in infertile patients undergoing IVF who are expected to produce low number of eggs compared to a control group.
- Trial name
- NCT03085030
- Testing
- Antioxidant Formula
- Where
- Egypt
- Volunteers
- 593 people
- Sponsor
- Cairo University
Poor Responders in IVF
Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients
Poor ovarian response population of ART are considered the biggest challenge for providers. Hitherto, no one protocol has been proven to be effect in this subgroup of IVF patients.
- Trial name
- NCT03560583
- Testing
- Metoclopramide
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
Infertility, Female
Transdermal Testosterone for Poor Responder Patients Undergoing Controlled Ovarian Stimulation Prior to IVF
This study evaluates the efficacy of pre- IVF treatment with transdermal testosterone to enhance ovarian response in poor responders.
- Trial name
- NCT03078569
- Testing
- Testosterone gel
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Fertilization in Vitro
The Comparison of Granulosa Cell Apoptosis Rates With or Without Luteinizing Hormone Administration in Poor Responders.
In Zeynep Kamil Women and Children's Education and Research Hospital which is a tertiary referral hospital, the investigators perform microdose flare-up gonadotropin-releasing hormone (GNRH) analogue or GNRH antagonist protocol…
- Trial name
- NCT03527823
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sebnem Alanya Tosun
In Vitro Fertilization, Poor Ovarian Response
Impact of Melatonin on IVF/ICSI Outcomes in Prospective Poor Responders
The purpose of this study is to investigate the impact of melatonin administration on in vitro fertilization (IVF/ICSI) outcomes namely the total number and quality of the oocytes and embryos in the prospective poor responders.
- Trial name
- NCT02993588
- Testing
- Melatonin
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University