Clinical trials: IVF Treatment
Endometriosis, IVF
The Effect of Endometrial Scratching on Patients With Endometriosis
We aimed to investigate whether endometrial scratching could improve IVF outcomes by enhancing endometrial receptivity in patients with endometriosis.
- Trial name
- NCT05360875
- Testing
- Endometrial scratching
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking Union Medical College Hospital
Infertility
Study to Estimate Seedchrony's Predictive Capacity in the Success of Embryo Implantation.
In Vitro Fertilization (IVF) success is below 40%, with Embryo Transfer the leading cause of IVF failure. This clinical investigation aims to evaluate if the levels of an intrauterine biomarker dissolved in the uterine fluid…
- Trial name
- Seedchrony02 (NCT06259084)
- Testing
- Seedchrony
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Manina Medtech
Immunomodulatory Drugs, Killer-cell Immunoglobulin-like Receptors (KIRs)
Effect of Immunomodulatory Treatment on IVF (in Vitro Fertilization) Outcomes in Patients With KIR AA Genotype
The aim of the study is to investigate the immune cause of recurrent implantation failure (RIF) and the role of immunomodulatory treatment in IVF (in vitro fertilization) patients that have a KIR AA genotype.
- Conditions
- Immunomodulatory Drugs, Killer-cell Immunoglobulin-like Receptors (KIRs), KIR Alleles (KIR AA)
- Trial name
- NCT06264206
- Testing
- Killer-cell immunoglobulin-like receptors (KIRs) testing
- Where
- Romania
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Calla IVF Center
Infertility, In-vitro Fertilization
NuvaRing vs. Oral Contraceptive Pills (OCP) for In-Vitro Fertilization (IVF) Pre-treatment
The newly designed contraceptive ring, Nuvaring has a lower total steroid dose, and medications are delivered locally. It has been proven to be as safe and effective as the combined OCP in ovarian suppression and preventing…
- Trial name
- NCT01298128
- Testing
- NuvaRing, marvelon
- Volunteers
- 70 people
- Sponsor
- University of Toronto
Polycystic Ovary Syndrome
Metformin in Assisted Reproduction-MET-AR-study
Aim of study: To investigate whether four months of metformin treatment before IVF (in-vitro-fertilisation) or ICSI (intra-cytoplasmic-sperm-injection) might increase clinical pregnancy rate in normal-weight (body mass index…
- Trial name
- NCT00159575
- Where
- 2 sites in Norway
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Infertility
The Effect of LH-Priming During Early Follicular Phase in IVF Treatment.
To evaluate the effect of LH-activity supplementation during the early follicular phase in GnRHa down-regulated women undergoing IVF in terms of S-Estradiol levels on hCG day by comparing different combinations with HP-HMG and…
- Trial name
- NCT00334425
- Testing
- MENOPUR; GONAL-F
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Central Jutland Regional Hospital
Polycystic Ovary Syndrome
Metformin Treatment Before in Vitro Fertilization (IVF) in Women With Ultrasound Evidence of Polycystic Ovaries
The aim of study was to investigate whether pre-treatment with metformin before and during IVF increases the live birth rate compared to placebo in women with sonographic evidence of polycystic ovaries (PCO), but without any…
- Trial name
- NCT01046032
- Testing
- Metformin
- Where
- 3 sites in United Kingdom
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Luteal Hormone Supplementation
A Phase III Study of FE 999913 in Japanese Female Patients Undergoing Fertility Treatment
The purposes of the study are to verify sufficient supplementation of luteal hormone after administrating FE999913 Vaginal Tablet twice a day (BID) or three times a day (TID) and to determine the efficacy and safety of FE999913…
- Trial name
- NCT01710514
- Testing
- FE 999913 vaginal tablet
- Where
- 6 sites in Japan
- Volunteers
- 108 people
- Sponsor
- Ferring Pharmaceuticals
Failure After Assisted Reproductive Technology
Observation on the Curative Effect of Assisted Reproduction by TCM Multi-channel Interventional Therapy
Objective: To evaluate the curative effect of TCM multi-channel interventional therapy on women with ART Failure; to compare the curative effect of the dual therapy and triple therapy on women with ART Failure; to choose the best…
- Trial name
- NCT03078205
- Testing
- The dual therapy, The triple therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Anxiety
Randomised Controlled Trial of the Effect of Music on Women Undergoing Assisted Reproductive Technology Treatments.
To investigate whether listening to music at the time of embryo transfer reduces anxiety levels in women undergoing assisted conception treatment.
- Trial name
- NCT02223845
- Testing
- Music
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- University of Southampton
Recurrent Implantation Failure, Endometrial Receptivity Disorders
Experimental Study on the Use of Intrauterine Infusion of Autologous Platelet-rich Plasma (PRGF-IUI) in Patients With Recurrent Implantation Failure and/or Refractory Thin Endometrium
Endometrial receptivity is a key determinant of success in assisted reproductive technology (ART). A significant proportion of patients experience repeated implantation failure despite euploid embryos and adequate laboratory…
- Conditions
- Recurrent Implantation Failure, Endometrial Receptivity Disorders, Embryo Implantation, Platelet-Rich Plasma
- Trial name
- PMA_PREPAIRE (NCT07455773)
- Testing
- Intrauterine Platelet-Rich Plasma (PRP) Infusion, Hormone Replacement Therapy (HRT)
- Volunteers
- 80 people
- Sponsor
- Azienda Sanitaria Locale di Asti
Infertility, Fertilization in Vitro
Low Molecular Weight Heparin in Recurrent Implantation Failure
Recurrent implantation failure is the failure to achieve a pregnancy after multiple attempts with in vitro fertilization treatment. The reason is usually obscure.
- Conditions
- Infertility, Fertilization in Vitro, Recurrent Implantation Failure
- Trial name
- NCT00750451
- Testing
- low molecular weight heparin (enoxaparine sodium), crinone 8% gel
- Where
- Turkey (Türkiye)
- Sponsor
- V.K.V. American Hospital, Istanbul
Amount of FSH Units During Ovarian Stimulation Protocols
Inositols and FSH in IVF
Ovarian hyperstimulation syndrome (OHSS), although quite uncommon, represents the most serious complication of ovulation induction during in-vitro fertilization (IVF) protocols.
- Trial name
- NCT04576546
- Testing
- D-chiro-inositol, Myo-inositol
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Lo.Li.Pharma s.r.l
Infertility, In Vitro Fertilization
Video-Supported Medication Education for Women Undergoing In Vitro Fertilization (IVF): Quality of Life and Psychosocial Effects
Reproductive health problems, particularly infertility, affect 48 million couples globally, ranking as the fifth most serious global obstacle for women.
- Conditions
- Infertility, In Vitro Fertilization, Psychosocial Support Systems, Quality of Life
- Trial name
- NCT06515275
- Testing
- Education via video (QR code links)
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Infertility
Recombinant FSH Investigation in the Treatment of Infertility With Assisted Reproductive Technology (ART) (RITA-1)
This trial investigates the effects of FE 999049 compared to placebo.
- Trial name
- RITA-1 (NCT03740737)
- Testing
- Follitropin delta
- Where
- 23 sites in United States
- Volunteers
- 579 people
- Sponsor
- Ferring Pharmaceuticals
Infertility, Female
The Difference Seen in Granulosa Cells and Immature Oocytes in IVF Treated Patients Sorted by Body Mass Index (BMI)
This study aims to discover the connection between BMI and oocyte and granulosa consistencies.
- Trial name
- NCT03020173
- Testing
- Laboratory study
- Volunteers
- 100 people
- Sponsor
- Hillel Yaffe Medical Center
Infertility
Phase 3 Placebo Controlled Study of Nolasiban to Improve Pregnancy Rates in Women Undergoing IVF/ICSI
The primary objective of this study is to confirm the efficacy of a single oral 900mg dose of nolasiban to increase the ongoing clinical pregnancy rate at 10 weeks post embryo transfer (ET) day.
- Trial name
- IMPLANT2 (NCT03081208)
- Testing
- Nolasiban 900mg
- Where
- 43 sites in Belgium, Czechia and 7 more
- Volunteers
- 810 people
- Sponsor
- ObsEva SA
Poor Ovarian Response
Novel Therapy for Poor Responders Management
Unfortunately for some infertile women, gonadotrophin administration results in a desultory ovarian response. While this is commonly due to diminished ovarian reserve, as indicated by advanced age and/or elevated basal day 3 FSH…
- Trial name
- NCT04310293
- Testing
- Femara,Grotwth hormone,HMG
- Where
- Bahrain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Al Baraka Fertility Hospital
Ovarian Hyperstimulation Syndrome
Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS
This a prospective randomized double blind study involving patients at high risk of OHSS development with peak serum E2 levels < 4,000 pg/ml comparing the ongoing pregnancy rates in patients who receive adjuvant hCG 1,000 IU at…
- Trial name
- NCT01815138
- Testing
- hCG
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- UConn Health
Infertility
Oral Microdose Lupron Versus Luteal Estradiol Trial in Poor Responder In Vitro Fertilization (IVF) Patients
Hundreds of thousands of couples in the United States experience infertility each year. When initial measures do not help, some couples require a process called ovarian stimulation and in vitro fertilization (IVF).
- Trial name
- OMLET (NCT00826839)
- Testing
- Oral contraceptive pill and microdose lupron, E2 patch/antagonist
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University