Clinical trials: IVF-ET
OHSS
Cabergoline Versus GnRH Antagonist Rescue and Cabergoline in the Prevention of Ovarian Hyperstimulation Syndrome
The aim of study is to compare the efficacy of GnRH antagonist rescue combined with cabergoline with cabergoline in the prevention of ovarian hyperstimulation syndrome in high risk patients undergoing ovarian stimulation for…
- Trial name
- NCT02461875
- Testing
- Cabergoline, GnRH antagonist rescue & cabergoline
- Where
- Egypt
- Volunteers
- 236 people
- Sponsor
- Aljazeera Hospital
Infertility Implantation Failure
A Multicentre, Randomised, Double-blind, Placebo-controlled Proof of Concept Study to Compare the Efficacy and Safety of r-hLIF (Emfilermin) for Improving Embryo Implantation Following in Vitro Fertilization (IVF) and Embryo Transfer (ET) in Women With Recurrent Implantation Failure
The primary objective of the study was to provide further clinical and statistical evidence of the efficacy of r-hLIF, in comparison with placebo, administered during the luteal phase after IVF and ET for improving embryo…
- Trial name
- NCT00504608
- Testing
- Emfilermin, recombinant human leukemia inhibitory factor (r-hLIF)
- Volunteers
- 150 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility Implantation Failure
r-hLIF for Improving Embryo Implantation in IVF
This study was designed to obtain pilot clinical evidence of the efficacy, safety and acceptability of r-hLIF administered during the luteal phase after IVF/intra-cytoplasmic sperm injection (ICSI) and ET for improving embryo…
- Trial name
- NCT00504530
- Testing
- Emfilermin, recombinant human leukemia inhibitory factor (r-hLIF)
- Volunteers
- 50 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Pregnancy Result Rape
The Effect of Luteinizing Hormone (LH) Supplementation Following Gonadotropin-releasing Hormone (GnRH) Antagonist Administration in Advanced Reproductive Ageing Women Undergoing IVF and Embryo Transfer (IVF/ET)
To explore whether recombinant LH (rLH) supplementation (Leuveris) to recombinant follicle stimulating hormone (rFSH) following GnRH antagonist treatment has an advantage in infertile women with advanced reproductive ageing…
- Trial name
- NCT01016210
- Testing
- Leuveris
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Infertility
Application of Two Different Synthetic Sequential Media for the Human IVF-Embryo Transfer (IVF-ET) Program
Quality-controlled commercial media have been used in many in-vitro fertilization (IVF) laboratories. However, commercial media are costly and difficult to compare directly because their exact compositions are not clearly…
- Trial name
- NCT01356238
- Testing
- MRC media, Sydney IVF media
- Where
- South Korea
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Maria Fertility Hospital
IVF, IVF Treatment
A New Website for Australian IVF Patients: 'Evidence-based IVF'
IVF 'add-ons' are extra procedures, techniques, or medicines offered alongside standard IVF treatments, often marketed to improve success rates. Examples include EmbryoGlue, endometrial scratching, and acupuncture.
- Conditions
- IVF, IVF Treatment, IVF-ET, IVF/ICSI
- Trial name
- NCT06885151
- Testing
- Evidence-based IVF website content, Control
- Where
- Australia
- Volunteers
- 1,217 people
- Sponsor
- University of Melbourne
Infertility
Effect of LMWH on Pregnancy Outcome in Women With Multiple Failures of IVF-ET
Low-Molecular-Weight-Heparin (LMWH) has been used empirically in patients undergoing in-vitro fertilization embryo transfer (IVF-ET) with the purpose to aid in improving pregnancy outcomes.
- Trial name
- NCT03701750
- Testing
- Low Molecular Weight Heparin (enoxaparin sodium)
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- Shenzhen Zhongshan Urology Hospital
Hydrosalpinx
Coil Hysteroscopic Tubal Occlusion in the Treatment of Hydrosalpinx
this study is to investigate the success rate of proximal tubal occlusion with coil devices in women with hydrosalinx and to observe there pregnancy rate with IVF-ET.
- Trial name
- NCT03395301
- Testing
- Coil
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Wenzhou Medical University
Infertility (IVF Patients)
Triggering Ovulation in Normo-responders Using a Modified Dual Trigger Protocol or HCG Trigger
The aim of this randomized controlled study is to compare the efficacy of a modified dual trigger protocol [a single bolos of HCG combined with two successive doses of a GnRH agonist ] with HCG [a single bolos administered 36…
- Trial name
- NCT07569302
- Testing
- Modified dual trigger, HCG
- Where
- Egypt
- Volunteers
- 196 people
- Sponsor
- Bedaya Hospital
Infertility, Female
Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF
The purpose of this study is to investigate the effect of G-CSF on endometrial thickness in women who have failed reaching minimal endometrial thickness by standard treatments, to assess how many reach embryo transfer and what…
- Trial name
- NCT01202643
- Testing
- G-CSF, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility
Triggering Oocyte Maturation in POSEIDON Group 3 and 4 Poor Responders Using Double Trigger or HCG Trigger
The aim of this randomized controlled study is to compare the efficacy of double trigger protocol [ the co-administration of GnRH agonist with HCG ( 38 - 39 and 35 - 36 h prior to ovum pick-up, respectively ] with HCG in…
- Trial name
- NCT07569289
- Testing
- Double trigger, HCG trigger
- Where
- Egypt
- Volunteers
- 164 people
- Sponsor
- Bedaya Hospital
Ovarian Hyperstimulation Syndrome
Clinical Study of Recombinant Human Follitropin for Injection Assisted in COH Assisted IVF-ET
The aim of this study was to evaluate the efficacy and safety of domestic recombinant human follicle stimulating hormone (rhFSH) stimulating ovarian to promote follicular development before assisted reproductive technology, which…
- Trial name
- NCT03071172
- Testing
- Triptorelin for Injection, Recombinant Human Choriogonadotropin alfa Solution for Injection, Progesterone Soft Capsules
- Where
- 7 sites in China
- Volunteers
- 252 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Infertility, Female, Endometriosis
Predicting Endometrial Receptivity for Optimal Reproductive Management
The purpose of this study is to understand why some women are infertile (unable to conceive a child). The investigators hope to learn if an endometrial biopsy after egg retrieval is feasible for detecting biomarkers for…
- Trial name
- PERFORM (NCT04107129)
- Testing
- Endometrial Biopsy, Euploid embryo transfer, Blood sample
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Stanford University
Infertility
Dydrogesterone Versus GnRH Antagonist in Poor Responders Undergoing Double Ovarian Stimulation
The aim of this randomized controlled trial is to compare the efficacy and cost-effectiveness of using progestin with GnRH antagonist to prevent premature LH surge in poor responders undergoing double stimulation protocol.
- Trial name
- NCT06212102
- Testing
- Progestin primed ovarian stimulation, GnRH antagonist
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Bedaya Hospital
Repeated Implantation Failure
Atosiban Improves Implantation and Pregnancy Rates in Patients With Repeated Implantation Failure
Atosiban, administered at embryo transfer, can improve the implantation rate and the clinical pregnancy rate in patients with repeated implantation failure undergoing IVF-ET (in-vitro fertilization and embryo transfer).
- Trial name
- NCT01493440
- Testing
- atosiban
- Where
- Vietnam
- Volunteers
- 71 people
- Sponsor
- An Sinh Hospital
Infertility
NATural Ovarian Stimulation
To overcome unsuitable effects of controlled ovarian hyperstimulation (COH )while maintaining large oocyte availability, investigators elaborated an innovative protocol (NATural Ovarian Stimulation) that dissociates E2 production…
- Trial name
- NATOS (NCT02892942)
- Testing
- Gonal-F®, Cetrotide®
- Where
- France
- Volunteers
- 129 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Weight Loss
The Impact of Lifestyle Intervention on Weight and Fertility in Obese Males
Obesity, defined by WHO standards as having a body mass index (BMI) equal to or greater than 30 kg/m², affects approximately 800 million people worldwide.
- Conditions
- Obesity, Weight Loss, Male Fertility, Artificial Insemination
- Trial name
- NCT06339840
- Testing
- Low-carbohydrate diet group, Health Education Group
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Third Affiliated Hospital of Zhengzhou University
Infertility
Triggering Oocyte Maturation in Normoresponders Using Double Trigger or HCG Trigger
The aim of this study is to compare the efficacy double trigger [ co-administration of GnRH agonist with HCG 40 and 34 h prior to ovum pick-up, respectively] with HCG trigger in inducing oocyte maturation.
- Trial name
- Doubtrig (NCT06146413)
- Testing
- Double trigger, HCG trigger
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Bedaya Hospital
Endometrial Receptivity
The ERA Test as a Diagnostic Guide for Personalized Embryo Transfer
This project seeks to demonstrate the clinical value of the personalised diagnosis of the endometrial factor in infertility.
- Trial name
- ERA RCT (NCT01954758)
- Testing
- personalized Embryo Transfer (pET), Frozen Embryo Transfer (FET), Fresh Embryo Transfer (ET)
- Where
- 16 sites in Belgium, Brazil and 5 more
- Volunteers
- 569 people
- Sponsor
- Igenomix
Infertility, Female
The Role of Erzhi Tiangui Formula in Expected POR Women Undergoing IVF-ET
This randomized controlled trial aims to determine whether Erzhi Tiangui Formula can optimize the reproductive outcomes of elderly patients with expected poor ovarian response, and to provide a new approach to traditional Chinese…
- Trial name
- NCT05698550
- Testing
- Erzhi Tiangui Granule
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine