Clinical trials: IVM
IVM
IVM Survey Among Reproductive Medicine Specialists
Although IVM as a laboratory technology in reproductive medicine has existed for many decades, there is a lack of well-designed studies comparing the efficiency and the patient satisfaction related to IVM as compared to standard…
- Trial name
- NCT04488211
- Testing
- Survey
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Trichuriasis
Efficacy and Safety of IVM/ALB Co-administration
This study is a double-blind randomized clinical trial conducted with two settings in Africa and one in Asia, namely Côte d'Ivoire, Pemba (Zanzibar, Tanzania) and Lao PDR.
- Trial name
- NCT03527732
- Testing
- Albendazole, Albendazole and Ivermectin
- Where
- 3 sites in Côte d’Ivoire, Laos and 1 more
- Volunteers
- 1,673 people
- Sponsor
- Jennifer Keiser
Polycystic Ovary Syndrome, Infertility
New Application of Sequential in Vitro Muturation System for Infertility Patients With Polycystic Ovary Syndrome
Oocyte in vitro maturation (IVM) is an artificial reproductive technologies (ART) in which cumulus-oocyte complex (COC) are collected at the immature germinal vesicle (GV) stage from unstimulated or FSH-primed ovaries and matured…
- Trial name
- NCT03773263
- Testing
- sequential IVM system, intracytoplasmic sperm injection (ICSI), Thawed embryo transfer (TET)
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-sen University
Onchocerciasis
Ocular Changes After Ivermectin - (DOLF IVM/Oncho)
The DOLF Ocular Changes after Ivermectin study will investigate the kinetics of O. volvulus microfilaria (Mf) in the eye following treatment with ivermectin.
- Trial name
- NCT03517462
- Testing
- Ivermectin 3Mg Tab
- Where
- Ghana
- Volunteers
- 231 people
- Sponsor
- Washington University School of Medicine
Drug Combination, Pharmacokinetics
Pharmacokinetic and Mosquito-Lethal Effects of Ivermectin (IVM), Primaquine (PQ), Dihydroartemisinin-Piperaquine (DHA-PQP) and Albendazole (ABZ) in Healthy Subjects
Primary Objective To evaluate the safety and tolerability of co-administered single dose Dihydroartemisinin-Piperaquine (DHA-PQP), Ivermectin (IVM), Primaquine (PQ), and Albendazole (ABZ) in healthy subjects.
- Conditions
- Drug Combination, Pharmacokinetics, Healthy
- Trial name
- NCT02568098
- Testing
- IVM, IVM and PQ, IVM and DHA-PQP, IVM and DHA-PQP and PQ, PQ and DHA-PQP and PQ, DHA-PQP
- Where
- Thailand
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Oocyte Maturation, Infertility
OSC Co-culture for Rescue IVM of Human GV Oocytes
This single-center randomized sibling-oocyte controlled trial evaluates whether co-culture with induced pluripotent stem cell (iPSC)-derived ovarian support cells (OSCs) improves rescue in vitro maturation (r-IVM) outcomes of…
- Trial name
- OSC-rIVM (NCT07559357)
- Testing
- Conventional rescue in vitro maturation, Rescue in vitro maturation with iPSC-derived ovarian support cell co-culture
- Where
- Vietnam
- Volunteers
- 102 people
- Sponsor
- Hung Vuong Hospital
Loiasis
Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis
Background: Loa loa is a small worm that infects people in West and Central Africa. It is spread by the bite of a fly. Adult worms live under the skin and can cause swelling in the arms, legs, and face.
- Trial name
- NCT01593722
- Testing
- Diethylcarbamazine, Ivermectin
- Where
- Cameroon
- Volunteers
- 155 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Infertility
Hormone-free Antral Retrieval for Viable Embryo Storage & Transfer
This study is testing whether eggs can be collected from small follicles without using the usual ovarian stimulation medications. Participants will have up to three egg retrieval procedures.
- Trial name
- HARVEST (NCT07801105)
- Testing
- CAPA-IVM System, Serial Unstimulated Transvaginal Oocyte Retrieval, ICSI, Blastocyst Culture, PGT-A, Embryo Vitrification/Accumulation, and Single Euploid Embryo Transfer
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kevin Doody
Infertility, IVF
Health of Babies Born From IVF Versus IVM at 5 Years Old
The investigators conduct a long-term follow-up at five years on offspring born from our randomized controlled trial (RCT) to investigate whether or not there is any difference in developmental outcomes in children born after…
- Conditions
- Infertility, IVF, IVM, Development, Child
- Trial name
- FM-BABIES-5Y (NCT06369415)
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3 and behavioural screening according to Strength and Difficulties Questionnaires (SDQ's)
- Where
- Vietnam
- Volunteers
- 214 people
- Sponsor
- Mỹ Đức Hospital
Infertility (IVF Patients), Infertility
Intra-ovarian CAPA-IVM vs Standard IVM
This prospective study compares two approaches to obtaining mature oocytes for fertility treatment within the same participant. Immature oocytes are first retrieved from the right ovary and matured in the laboratory using a…
- Conditions
- Infertility (IVF Patients), Infertility, Infertility Female
- Trial name
- IO-CAPA (NCT07858435)
- Testing
- CAPA-IVM, In-House CAPA-IVM Pre-Maturation Medium, Minimal-Stimulation OS-IVF
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New Hope Fertility Center
Polycystic Ovarian Syndrome
In Vitro Maturation (IVM) for Polycystic Ovary Syndrome (PCOS)
This pilot study will be a prospective investigation to study the efficacy and safety of In-Vitro Maturation (IVM) for women with Polycystic Ovarian Syndrome (PCOS). There will be 10 subjects total in this Study.
- Trial name
- NCT01237106
- Testing
- IVM
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Reproductive Associates
Infertility, IVF
Health of IVF Versus IVM Children (FM-BABIES)
The investigators conduct a follow up of our randomized controlled trial (RCT) to investigate the development of children born from In-vitro fertilization (IVF) and In-vitro maturation (IVM), in order to give strong evidence…
- Conditions
- Infertility, IVF, IVM
- Trial name
- FM-BABIES (NCT04296357)
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3, Physical development and General Health, Developmental Red flags
- Where
- Vietnam
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
Infertility
Implementing IVM for Fertility Treatment in Clinical Practice
The ovarian reserve consists of a finite pool of follicles that gradually declines throughout a woman's reproductive life. During conventional IVF, exogenous gonadotropins are administered for 10-14 days to support the growth and…
- Trial name
- IVM-DK 2-0 (NCT07894952)
- Testing
- In vitro maturation
- Where
- Denmark
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
IVM, IVF
Children Born From IVM-CAPA vs IVF or Natural Conception
CAPA-IVM is a new promising IVM technique involving the use of a new compound to facilitate the oocyte and embryo competence. CAPA-IVM preserved the maintenance of trans-zonal projections and significantly improved maturation…
- Trial name
- NCT04048486
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3, Physical development and General Health, Developmental Red flags
- Where
- Vietnam
- Volunteers
- 66 people
- Sponsor
- Mỹ Đức Hospital
Helminthiasis
Bioavailability and Safety of Two Oral Fixed Dose Preparations Containing 18 mg Ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) Versus Reference Dosing (Weight Based) Containing 6 mg Ivermectin (REVECTINA®, Abbott Laboratórios do Brasil Ltda, Brazil)
Evaluation of the bioavailability and safety of one oral preparation containing fixed dose 18 mg ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) or two oral preparations containing fixed dose 18 mg ivermectin (IVM 36 MG…
- Trial name
- NCT03173742
- Testing
- T1, T2, T3, T1,T3,T2, T2,T1,T3
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
In Vitro Fertilization
Effect of Super-GDF9 on CAPA-IVM of COCs From Small Antral Follicles
CAPA-IVM (In Vitro Maturation) technology is an assisted reproductive method offering significant benefits in terms of safety and treatment costs, particularly for high-risk patients.
- Trial name
- sGDF-9 (NCT06766604)
- Testing
- Super-GDF9 supplementation during CAPA-IVM, Conventional CAPA-IVM
- Where
- Vietnam
- Volunteers
- 9 people
- Sponsor
- Mỹ Đức Hospital
PCOS, IVF
IVM Versus IVF in High Antral Follicle Count Patients
In vitro maturation (IVM) is postulated to be an alternative to conventional in vitro fertilization (IVF) to avoid ovarian hyperstimulation syndrome.
- Conditions
- PCOS, IVF, IVM
- Trial name
- NCT03405701
- Testing
- IVM, IVF
- Where
- Vietnam
- Volunteers
- 546 people
- Sponsor
- Mỹ Đức Hospital
No Condition
Comparison of Clinical Outcomes Between IVM and Minimal Stimulation IVF in Patients With PCOS
Polycystic ovarian syndrome (PCOS) is most common endocrinologic disease in women of reproductive age with incidence of 6.6 ~ 8%.
- Trial name
- NCT03134482
- Testing
- IVM, Minimal stimulation IVF
- Where
- 2 sites in South Korea
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- CHA University
IVM, PCOS
A Pilot Study to Determine the Feasibility, Acceptance, and Effectiveness of In-vitro Maturation in Patients Without IVF Coverage
The specific aim of this pilot study is to test the hypothesis that estrogen stimulated IVM will be non-inferior to traditional IVF, to determine the feasibility and acceptance of estrogen-stimulated in vitro maturation (IVM)…
- Trial name
- IVM (NCT05793931)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Vaginismus
Immersive Visual Modulation and Ambient Music Therapy During Transvaginal Ultrasonography in Women With Vaginismus
Vaginismus is a sexual dysfunction characterized by involuntary contractions of the pelvic floor muscles that prevent vaginal penetration. This condition is often associated with intense fear, anxiety, and avoidance behaviors.
- Trial name
- NCT07734454
- Testing
- Standard Care, Immersive Visual Modulation (IVM), Ambient Music Therapy (AMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Demet Mutlu