Clinical trials: IVM, open to volunteers
Infertility, In Vitro Maturation of Oocytes
Aspire In Vitro Maturation Study
A study to assess the Capacitation - in-vitro maturation (CAPA-IVM) system as an option for patients with a good ovarian reserve to achieve pregnancy.
- Conditions
- Infertility, In Vitro Maturation of Oocytes, Assisted Reproduction Technologies
- Trial name
- AIM (NCT07789730)
- Testing
- CAPA-IVM
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Inception Fertility Research Institute, LLC
Healthy, PCOS
In Vitro Maturation of Human Eggs
CCRM Fertility, a global pioneer in fertility treatment, research and science, is seeking participants for a new study on in vitro maturation (IVM).
- Conditions
- Healthy, PCOS, PCOS (Polycystic Ovary Syndrome), Ovarian Reserve
- Trial name
- NCT06633120
- Testing
- IVM
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Colorado Center for Reproductive Medicine
In Vitro Fertilization
Effect of Super-GDF9 on CAPA-IVM of COCs From Small Antral Follicles
CAPA-IVM (In Vitro Maturation) technology is an assisted reproductive method offering significant benefits in terms of safety and treatment costs, particularly for high-risk patients.
- Trial name
- sGDF-9 (NCT06766604)
- Testing
- Super-GDF9 supplementation during CAPA-IVM, Conventional CAPA-IVM
- Where
- Vietnam
- Volunteers
- 9 people
- Sponsor
- Mỹ Đức Hospital
Healthy Adult Females, Healthy Adult Male
Apply Biphasic IVM for POSEIDON Group 1
The goal of this clinical trial is to learn if biphasic In Vitro Maturation (IVM) works to help young women who produce very few oocytes after controlled ovarian stimulation.
- Trial name
- POSEIDON-Ia (NCT07632300)
- Testing
- Biphasic-IVM
- Where
- Vietnam
- Volunteers
- 25 people
- Sponsor
- Mỹ Đức Hospital
PCOS (Polycystic Ovary Syndrome)
The Physical and Mental Impact of ART: IVM vs Conventional Ovarian Stimulation
Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine conditions, affecting around 10% of women in reproductive age (ESHRE PCOS guideline, 2023).
- Trial name
- QolART (NCT07274202)
- Testing
- Questionnaires
- Volunteers
- 84 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
Implementing IVM for Fertility Treatment in Clinical Practice
The ovarian reserve consists of a finite pool of follicles that gradually declines throughout a woman's reproductive life. During conventional IVF, exogenous gonadotropins are administered for 10-14 days to support the growth and…
- Trial name
- IVM-DK 2-0 (NCT07894952)
- Testing
- In vitro maturation
- Where
- Denmark
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Oocyte Maturation, Infertility
OSC Co-culture for Rescue IVM of Human GV Oocytes
This single-center randomized sibling-oocyte controlled trial evaluates whether co-culture with induced pluripotent stem cell (iPSC)-derived ovarian support cells (OSCs) improves rescue in vitro maturation (r-IVM) outcomes of…
- Trial name
- OSC-rIVM (NCT07559357)
- Testing
- Conventional rescue in vitro maturation, Rescue in vitro maturation with iPSC-derived ovarian support cell co-culture
- Where
- Vietnam
- Volunteers
- 102 people
- Sponsor
- Hung Vuong Hospital
Solid Tumor, Adult, Clinical Stage IV Gastric Cancer AJCC v8
Intravital Microscopy in Human Solid Tumors
This study will investigate the tumor-associated vasculature of patients with solid tumors. The investigators will use a technology known as intravital microscopy (IVM) in order to visualize in real-time the vessels associated…
- Conditions
- Solid Tumor, Adult, Clinical Stage IV Gastric Cancer AJCC v8, Malignant Solid Neoplasm, Metastatic Colorectal Carcinoma
- Trial name
- NCT03823144
- Testing
- Diagnostic Microscopy, Fluorescein Sodium Injection
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Mayo Clinic
Vaginismus
Immersive Visual Modulation and Ambient Music Therapy During Transvaginal Ultrasonography in Women With Vaginismus
Vaginismus is a sexual dysfunction characterized by involuntary contractions of the pelvic floor muscles that prevent vaginal penetration. This condition is often associated with intense fear, anxiety, and avoidance behaviors.
- Trial name
- NCT07734454
- Testing
- Standard Care, Immersive Visual Modulation (IVM), Ambient Music Therapy (AMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Demet Mutlu
Infertility (IVF Patients), Infertility
Intra-ovarian CAPA-IVM vs Standard IVM
This prospective study compares two approaches to obtaining mature oocytes for fertility treatment within the same participant. Immature oocytes are first retrieved from the right ovary and matured in the laboratory using a…
- Conditions
- Infertility (IVF Patients), Infertility, Infertility Female
- Trial name
- IO-CAPA (NCT07858435)
- Testing
- CAPA-IVM, In-House CAPA-IVM Pre-Maturation Medium, Minimal-Stimulation OS-IVF
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New Hope Fertility Center
Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes
IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women
Assisted Reproductive Technologies (ART) aim to increase success rates while minimizing patient risks. For women with high AFC or PCOS, conventional IVF carries a high risk of OHSS (Ho et al., 2019).
- Conditions
- Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes, Fresh Embryo Transfer
- Trial name
- SAIGON-PTC (NCT07171970)
- Testing
- IVM-Fresh (No gonadotropin + Fresh embryo transfer), IVF-FET (GnRH-Antagonist - Agonist Trigger - Frozen embryo transfer)
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- Mỹ Đức Hospital
Glaucoma, Open-Angle, Ocular Hypertension
Inflammatory Biomarkers in Ocular Surface in Primary Open Angle Glaucoma or Ocular Hypertension Under Topical Prostaglandins
Glaucoma is a chronic optic neuropathy whose main modifiable risk factor is an abnormally elevated intraocular pressure. The aim of glaucoma treatment is to slow the progression of the disease by reducing intraocular pressure.
- Trial name
- NCT05039684
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
In Vitro Maturation of Oocytes
Fertilo In Vitro Research Study and Trial
The goal of this clinical trial is to evaluate the safety and efficacy of using Fertilo for In vitro maturation (IVM) in participants 18-35 years of age.
- Trial name
- FIRST (NCT06858111)
- Testing
- Fertilo, Medicult IVM
- Where
- 16 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Gameto, Inc.
Ovulatory Infertile Women
CAPA - IVM in Ovulatory Infertile Women
In vitro maturation (IVM) is an assisted reproductive technology (ART) using minimal or no ovarian stimulation. In IVM, immature oocytes at the germinal vesical (GV) or metaphase I (MI) stage retrieved from small antral follicles…
- Trial name
- NCT06744881
- Testing
- CAPA-IVM
- Where
- Vietnam
- Volunteers
- 20 people
- Sponsor
- Mỹ Đức Hospital
Infertility
Hormone-free Antral Retrieval for Viable Embryo Storage & Transfer
This study is testing whether eggs can be collected from small follicles without using the usual ovarian stimulation medications. Participants will have up to three egg retrieval procedures.
- Trial name
- HARVEST (NCT07801105)
- Testing
- CAPA-IVM System, Serial Unstimulated Transvaginal Oocyte Retrieval, ICSI, Blastocyst Culture, PGT-A, Embryo Vitrification/Accumulation, and Single Euploid Embryo Transfer
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kevin Doody
Polycystic Ovary Syndrome
IVM With Low Cost Priming, Enhanced Oocyte Recovery, and Delayed Transfer
A protocol was developed to improve pregnancy results after IVM compared to results from studies in the literature. Differences from most published protocols include the use of the Steiner-Tan needle to optimize oocyte…
- Trial name
- IVMprt (NCT04149496)
- Testing
- in vitro maturation of oocytes
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Bruce Rose, MD
PCOS (Polycystic Ovary Syndrome), Cumulus Cell
Transcriptomic Profiling of Cumulus Cells From CAPA-IVM
Capacitation in vitro maturation (CAPA-IVM) has improved oocyte maturation and resulted in live births. Because cumulus cells (CCs) communicate bidirectionally with the oocyte, their transcriptomic profile may serve as a…
- Conditions
- PCOS (Polycystic Ovary Syndrome), Cumulus Cell, Capacitation IVM, Transcriptomic Profiling
- Trial name
- NCT07197255
- Where
- Vietnam
- Volunteers
- 10 people
- Sponsor
- Mỹ Đức Hospital
Hematological Neoplasm, Endothelial Dysfunction
The Endothelial Cell Dysfunction and Outcome Project for Hematological Neoplasms
The endothelium is a semipermeable monolayer of endothelial cells (EC) organized as a complex biological interface that separates all tissues from circulating blood.
- Trial name
- EndoCDO-H (NCT05502887)
- Testing
- Sublingual in vivo microscopy with the Glycocheck microscope
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Prof. Dr. Thomas Luft