Clinical trials: Iatrogenic Disorder
Ventilator-Associated Pneumonia, Acute Respiratory Distress Syndrome
Clinical and Biological Markers in Acute Respiratory Failure
In a recent experimental study, the investigators showed that the growth factor Activin A is expressed in the lungs of rats with the acute respiratory distress syndrome (ARDS) at levels that are comparable with those determined…
- Trial name
- NCT02019095
- Testing
- Bronchoscopy for the sampling of bronchoalveolar lavage (BAL) fluid
- Where
- 2 sites in Greece
- Volunteers
- 55 people
- Sponsor
- University of Athens
Mobility Limitation, Frailty
Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients
The investigator proposes to conduct a randomized trial of supervised ambulation delivered by mobility technician (MT) up to three times daily, including weekends, to hospitalized medical patients.
- Conditions
- Mobility Limitation, Frailty, Hospital Acquired Condition, Weakness, Muscle
- Trial name
- NCT05725928
- Testing
- Mobility technician
- Where
- 5 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- The Cleveland Clinic
Wounds and Injuries
Effect of Leukoreduced Blood Transfusions on Infection Following Trauma
The purpose of this study is to determine if leukoreduced blood transfusions reduce the risk of infection following trauma. Specifically, the investigators intend to evaluate whether there are clinically relevant differences in…
- Trial name
- NCT00135291
- Testing
- Leukoreduced blood transfusion
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pemphigoid, Bullous, Adrenal Insufficiency
Screening for Adrenal Insufficiency During Dermocorticoid Reduction in Bullous Pemphigoid (BP)
The braking of the corticotropic axis is well established during the induction phase of superpotent topical corticosteroid therapy (clobetasol propionate) in bullous pemphigoid (BP).
- Trial name
- PB-DEPIST (NCT06148090)
- Testing
- clobetasol decreasing measurement
- Where
- 5 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Hospital Acquired Pneumonia
Early Mobility Bundle to Prevent Hospital Acquired Pneumonia (HAP) in Medical Inpatients
Hospital acquired pneumonia (HAP) is a common complication of extended hospital stay. In surgical specialities and critical care early physiotherapy is a recognised way of preventing such infections, and reducing length of…
- Trial name
- NCT01769742
- Testing
- Early mobility bundle
- Where
- United Kingdom
- Volunteers
- 1,178 people
- Sponsor
- University of Birmingham
Type 1 Diabetes Mellitus, Glucokinase-Maturity Onset Diabetes of the Young (GCK-MODY)
Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
This study aims to understand the heart and blood sugar health benefits of using an adjunctive therapy to lower high insulin levels in people with type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus, Glucokinase-Maturity Onset Diabetes of the Young (GCK-MODY), MODY2 Diabetes, Healthy Volunteer
- Trial name
- ACT T1D (NCT06609356)
- Testing
- Study Visit 1, Study Visit 2, Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Staphylococcus Aureus
Mupirocin-Iodophor ICU Decolonization Swap Out Trial
The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the non-inferiority of two decolonization regimens: Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in…
- Trial name
- NCT03140423
- Testing
- Arm 1. Routine Care (Mupirocin/CHG), Arm 2. Iodophor/CHG Decolonization
- Where
- 137 sites in United States
- Volunteers
- 353,323 people
- Sponsor
- Harvard Pilgrim Health Care
Ventilator-Associated Pneumonia
The Pharmacodynamics of Meropenem in Patient With Ventilator-associated Pneumonia
The study was a randomized three-way crossover study. Each subject received meropenem in three regimens at room temperature consecutively: (i) bolus injection of 1 g of meropenem over 10 min every 8 h for 24 h, (ii) 3-h infusion…
- Trial name
- NCT02615041
- Testing
- Meropenem
- Where
- Thailand
- Volunteers
- 9 people
- Sponsor
- Sutep Jaruratanasirikul
Evidence-based Practices, Nursing Education
Effect of Selected Evidence-based Practices and Related Nurses' Education on the Incidence and Severity of Ventilator-associated Pneumonia
Background: Invasive mechanical ventilation (MV) is used as a cornerstone in the treatment plan of intensive care units (ICUs) patients to provide adequate tissue oxygenation to support the body during the treatment course.
- Conditions
- Evidence-based Practices, Nursing Education, Incidence, Ventilator-associated Pneumonia
- Trial name
- NCT05877105
- Testing
- Ventilator-associated pneumonia prevention Evidence-based practices (VAPPEBP) which consists of ten items bundle
- Where
- Egypt
- Volunteers
- 99 people
- Sponsor
- Cairo University
Pneumonia, Ventilator-Associated, Coronavirus Infection
Convalescent Antibodies Infusion in Critically Ill COVID 19 Patients
The 2019 outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID 19), which originated in Wuhan, China, has become a major concern all over the world.
- Trial name
- NCT04346589
- Testing
- Anti-coronavirus antibodies (immunoglobulins)obtained with DFPP from convalescent patients
- Where
- 5 sites in Italy
- Volunteers
- 9 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Nosocomial Infection
Achromobacter Xylosoxidans (ACHX) Infections
Data extraction from bacteriological laboratory of Martinique University hospital to determine the frequency and the distribution of nosocomial infections due to Achromobacter xylosoxidans (ACHX), an emerging multi-resistant…
- Trial name
- ACHX (NCT03429283)
- Testing
- descriptive retrospective epidemiological study
- Where
- Martinique
- Volunteers
- 120 people
- Sponsor
- University Hospital Center of Martinique
Severe Pneumonia, Community-acquired Pneumonia
Efficacy of Intravenous Amboxol Hydrochloride as an Adjunct Therapy for Severe Pneumonia in Critically Ill Patients
Ambroxol is a mucolytic containing an active N-desmethyl metabolite of bromhexine. It is approved by both the U.S. FDA and EMA to be marketed under several formulations including oral, nasal, oro-mucosal, rectal and intravenous…
- Conditions
- Severe Pneumonia, Community-acquired Pneumonia, Hospital-acquired Pneumonia, Critical Illness
- Trial name
- NCT05663905
- Testing
- Ambroxol Hydrochloride, Standard Therapy
- Where
- Malaysia
- Volunteers
- 32 people
- Sponsor
- National University of Malaysia
Traumatic Brain Injury, Deep Vein Thrombosis
Traumatic Brain Injury Associated Radiological DVT Incidence and Significance Study
Whilst deep vein thrombosis (DVT) is common following traumatic brain injury (TBI), optimal timing and safety of pharmacological prophylaxis is uncertain. Paradoxically the harm associated with the occurrence of is also unclear.
- Conditions
- Traumatic Brain Injury, Deep Vein Thrombosis, Acute Lung Injury, Ventilator Associated Pneumonia
- Trial name
- TARDIS (NCT03937947)
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- NHS Lothian
Community-associated Infections, Health-care Acquired Infections
Optimal Antibiotic Treatment of Moderate to Severe Bacterial Infections
Severe bacterial infections are associated with mortality of about 30%. Patients with moderate to severe bacterial infections given early and appropriate empirical antibiotic treatment are at a lesser risk for a fatal outcome…
- Conditions
- Community-associated Infections, Health-care Acquired Infections, Nosocomial Infections
- Trial name
- CDSS (NCT01338116)
- Testing
- antibiotic treatment of by TREAT/PCR
- Where
- Israel
- Volunteers
- 600 people
- Sponsor
- Rabin Medical Center
Malnutrition, Infection
VA Nutrition Study on Immune Function
Hospital-acquired infections can occur five times as frequently in rehabilitation patients than in other hospital admissions. We postulate that this high infection rate may be due to nutritional problems frequently experienced in…
- Conditions
- Malnutrition, Infection, Nosocomial Infection
- Trial name
- NCT00105625
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- US Department of Veterans Affairs
Enterobacteriaceae Infections
Efficacy of Piperacillin-tazobactam as Empirical Antimicrobial Therapy for VAP Among ESBL-E Carriers.
Antimicrobial resistance is a major threat worldwide and now concerns last-ressource antibiotics such as carbapenems. As the resistance to carbapenems is directly due to their use, their spare has become a public health…
- Trial name
- PROBATAZO (NCT04276480)
- Testing
- Piperacillin-tazobactam
- Where
- 2 sites in France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Bordeaux
Pneumonia
Doripenem in the Treatment of Hospital-Acquired Pneumonia
The purpose of this study is to compare the safety and effectiveness of doripenem in patients with hospital-acquired pneumonia (HAP).
- Trial name
- NCT00211003
- Testing
- doripenem
- Volunteers
- 240 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Hospital Acquired Condition, Frailty
Effect of a Multicomponent Exercise Program With Virtual Reality (MEP-VR) vs Standard Approaches on Functional and Cognitive Domains in Hospitalized Geriatric Patients: Study Protocol for a Randomized Controlled Trial.
The goal of this clinical trial is to test the effectiveness of a Multicomponent Exercise Program with Virtual Reality (MEP-VR) compared to a Multicomponent Exercise Program (MEP-only) or usual care, in terms of functional and…
- Trial name
- MEP-VR (NCT06469554)
- Testing
- MEP-only group, MEP-VR group
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Fundacion Miguel Servet
Urinary Tract Infection, Nosocomial Infection
Effect of Chlorhexidine on Bacteriuria
This study is conducted to determine and compare the effect of applying Povidone-iodine and Chlorhexidine solutions for perinea washing on bacteriuria rate and type in patients with urinary catheter in intensive care unit.
- Conditions
- Urinary Tract Infection, Nosocomial Infection, Bacteriuria
- Trial name
- NCT02032394
- Testing
- Povidone-iodine, Chlorhexidine, Normal saline
- Where
- Iran
- Volunteers
- 105 people
- Sponsor
- Mashhad University of Medical Sciences
Ventilator-associated Pneumonia, Traumatic Brain Injury
Closed Versus Open Endotracheal Suctioning and Ventilator-Associated Pneumonia in Severe Traumatic Brain Injury
This randomized controlled trial will compare closed versus open endotracheal suctioning techniques for preventing ventilator-associated pneumonia (VAP) in adults with severe traumatic brain injury (TBI) who need mechanical…
- Trial name
- NCT07883083
- Testing
- Closed endotracheal suction system, Open endotracheal suction
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Minia University