Clinical trials: Iatrogenic Injury
Biliary Tract Injuries
Endoscopic Treatment of Post Surgical Biliary Tract Injury
The objective of this study is to determine the technical and clinical success rate of endoscopic treatment in a population presenting only with iatrogenic injuries of the bile ducts, excluding the cystic duct.
- Trial name
- EpSB (NCT07345936)
- Where
- France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Strasbourg, France
Bladder Cancer, Infections
Infectious Complications After Cystectomy: A Prospective Observational Study
Patients undergoing cystectomy for either oncological or non-oncological indications are prospectively enrolled following informed consent.
- Conditions
- Bladder Cancer, Infections, Infection, Bacterial, Infection, Hospital
- Trial name
- NCT05153694
- Testing
- Cystectomy
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Hand Hygiene, Surgical Wound Infection
Surgical Handwashing: Drying With One or Two Surgical Towels
This study aims to determine whether the use of two sterile towels for drying after surgical handwashing results in fewer contamination events compared to the use of only one towel among healthcare personnel.
- Conditions
- Hand Hygiene, Surgical Wound Infection, Healthcare Associated Infection, Medical Errors
- Trial name
- NCT06420934
- Testing
- Drying procedure after surgical handwashing
- Where
- Colombia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Instituto de Ortopedia Infantil Roosevelt
Head Injury, Traumatic Brain Injury
Outcomes of Early Versus Late Tracheostomy in Critically Ill Patients Due to Head Injury: A Randomized Controlled Trial
Tracheostomy is a surgical procedure that involves creating an opening in the trachea and bringing it to the skin surface to form a stoma. It may be performed as an emergency or elective operation.
- Trial name
- NCT07872865
- Testing
- Tracheostomy
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- University Of Anbar
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Intraoperative Ureter Visualization, Abdominolpelvic Surgery
A Study to Find Out if ASP5354 Can Clearly Help Show the Ureter During Surgery
The ureter was the tube that carries urine from the kidneys to the bladder. It was difficult for surgeons to see the ureter during abdominal surgery. This could lead to injuring the ureter which, although rare, could be serious.
- Trial name
- NCT05754333
- Testing
- pudexacianinium chloride
- Where
- 6 sites in United States
- Volunteers
- 107 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Hip Fractures (ICD-10 72.01-72.2)
Pre- and Postoperative Chest Therapy With Positive Expiratory Pressure (PEP) to Prevent Hospital-acquired Pneumonia
The goal of this clinical trial is to investigate whether pre- and postoperative treatment with systematic PEP therapy can prevent hospital-acquired pneumonia in patients with hip frac-ture.
- Trial name
- NCT07189260
- Testing
- positive expiratory pressure
- Where
- 2 sites in Denmark
- Volunteers
- 566 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Lung Transplant; Complications, Ventilator-Induced Lung Injury
Inspiratory Work of Breathing Before and After Extubation
Critically ill patients who (1) are not able to maintain their airway, (2) cannot breathe on their own, or (3) both, are ones who often require tracheal intubation and support from a breathing machine (mechanical ventilator).
- Conditions
- Lung Transplant; Complications, Ventilator-Induced Lung Injury, Ventilator Associated Pneumonia
- Trial name
- INTEGRATION (NCT07017608)
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- University Health Network, Toronto
Iatrogenic Injury
Identifying Adverse Events After Discharge From a Community Hospital
The purpose of this study is to: -Determine the incidence of adverse events, preventable adverse events, and ameliorable adverse events, and the timeliness of post-discharge ambulatory appointments, affecting urban and rural…
- Trial name
- NCT01536340
- Where
- United States
- Volunteers
- 684 people
- Sponsor
- Florida State University
Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD)
National Surveillance and Prevention of Neonatal VAP
The goal of this observational study is to improve how hospital-acquired lung infections (called ventilator-associated pneumonia, or VAP) are diagnosed, treated and prevented in very low birth weight (VLBW) infants, babies born…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD), Antibiotic-Resistant Organisms (AROs), Health-Care Associated Infection (HAI)
- Trial name
- NCT07109791
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- University of Alberta
Coronavirus, Iatrogenic Disease
Adverse Events Related to Treatments Used Against Coronavirus Disease 2019
The outbreak of Covid-19 started several clinical trials and treatment experiments all over the world in the first months of 2020.
- Conditions
- Coronavirus, Iatrogenic Disease, Acute Kidney Injury, ARDS, Human
- Trial name
- CovidTox (NCT04314817)
- Testing
- Any drug used to treat Covid-19
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Cholecystectomy, Common Bile Duct Diseases
A Comparison of Bile Duct Injuries Following Open Cholecystectomy Versus Laparoscopic Cholecystectomy
In this prospective study the investigators compared common bile duct injuries (CBDI) following laparoscopic cholecystectomy (LC) and open cholecystectomy (OC) procedures, 35 patients in each group.
- Conditions
- Cholecystectomy, Common Bile Duct Diseases, Major Bile Duct Injury
- Trial name
- NCT00840138
- Testing
- Surgical reconstruction
- Volunteers
- 70 people
- Sponsor
- Centre of Postgraduate Medical Education
Acute Kidney Injury
Iatrogenic Deficiencies in ICU Patients With Prolonged Continuous Renal Replacement Therapy
ICU patients are recruited after at least 5 days treatment with continuous renal replacement therapy. Blood samples are drawn at time of recruitment and then every 3-5 days until ceseation of renal replacement therapy.
- Trial name
- IBRIST (NCT06983197)
- Testing
- blood test
- Volunteers
- 30 people
- Sponsor
- Karolinska University Hospital
Chest Tube Management, Chest Tube Withdrawal
The Buzdar Technique
Chest tube thoracostomy remains a lifesaving intervention in trauma and thoracic surgery, used for the management of pneumothorax, hemothorax, empyema, and pleural effusions.
- Conditions
- Chest Tube Management, Chest Tube Withdrawal, Iatrogenic Injury
- Trial name
- NCT07338019
- Testing
- Gradual chest tube removal
- Where
- Pakistan
- Volunteers
- 300 people
- Sponsor
- University of Health Sciences Lahore
Acute Respiratory Distress Syndrome, Ventilator Associated Pneumonia
Macrophage Programing in Acute Lung Injury: MiniBAL
The goal of this observational clinical trial is to learn about the role white blood cells (macrophages) play in lung inflammation in people with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- NCT05767671
- Testing
- Non-Bronchoscopic Mini Bronchoalveolar Lavage
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- William Janssen, MD
Respiratory Distress Syndrome, Adult, Pneumonia
Comparison Study of High Frequency Percussive Ventilation With Conventional Ventilation
This study is designed to exam the effects of early management with high frequency percussive ventilation (HFPV) on patients with lung injury.
- Conditions
- Respiratory Distress Syndrome, Adult, Pneumonia, Mechanical Ventilation
- Trial name
- NCT00308022
- Testing
- High Frequency Percussive Ventilation
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Cardiac Surgery, Infection, Postoperative Wound
Management Practices and the Risk of Infection Following Cardiac Surgery
The purpose of the study is to determine the best ways to prevent infections after heart surgery. Participation in the study will last at most 3 months after heart surgery.
- Conditions
- Cardiac Surgery, Infection, Postoperative Wound, Postoperative Wound Infection, Infections, Nosocomial
- Trial name
- NCT01089712
- Where
- 10 sites in United States, Canada
- Volunteers
- 5,158 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Surgical Site Infections, Nosocomial Infection
Nasal Photodisinfection in All Patients Presenting for Surgery for a Wide Range of Surgical Procedures
This is a Phase 2 single-center, open-label, single-arm, study of a microbiological endpoint using antimicrobial photodynamic therapy (aPDT) for nasal disinfection in all patients (universal) presenting for surgery at an acute…
- Conditions
- Surgical Site Infections, Nosocomial Infection, Healthcare Associated Infections
- Trial name
- BENEFIT-PDT (NCT05090657)
- Testing
- methylene blue 0.01%/chlorhexidine gluconate 0.25% + light activation
- Where
- United States
- Volunteers
- 322 people
- Sponsor
- Ondine Biomedical Inc.
Iatrogenic Hypocalcemia, Iatrogenic Hypoparathyroidism
Post-thyroidectomy Vocal Cord Paralysis Along With Hypocalcemia: STROBE - Guided Prospective Cohort
In the present study, the severity of recurrent laryngeal nerve injury (RLNI) and hypocalcemia (H) will be followed-up and the probable interrelation between them will be proposed considering the clinical situation of patients…
- Conditions
- Iatrogenic Hypocalcemia, Iatrogenic Hypoparathyroidism, Vocal Cord Paralysis, Vocal Cord Paresis
- Trial name
- NCT04396912
- Testing
- Total thyroidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Umraniye Education and Research Hospital
Nosocomial Infection, Respiratory Tract Infection
Prevention of Nosocomial Infection by Decontamination of the Naso- and Oropharynx With Chlorhexidine (NONI Trial)
Does chlorhexidine gluonate, a simple broad-spectrum antimicrobial agent with virtually no adverse-effects lower the incidence of NI after cardiac surgery, especially with respect to LTI and SSI?
- Conditions
- Nosocomial Infection, Respiratory Tract Infection, Surgical Site Infection
- Trial name
- NCT00272675
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)