Clinical trials: Idiopathic Cardiomyopathy
Heart Failure
IVIg Therapy for Patients With Idiopathic Cardiomyopathy and Endomyocardial Biopsy Proven High PVB19 Viral Load
Rationale: Parvovirus B19 (PVB19) persistence in the heart has been associated with progressive cardiac dysfunction and evolution to dilated cardiomyopathy.
- Trial name
- NCT00659386
- Testing
- Intravenous immunoglobulin therapy
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Myocarditis, ANCA Associated Vasculitis
EACVI Study on Multimodality Cardiovascular Imaging of Inflammatory Cardiovascular Diseases
Inflammatory Cardiovascular Diseases and Autoimmune Rheumatic Diseases (ICARDs) encompass cardiovascular involvement in connective tissue diseases, vasculitis, and primary inflammatory cardiac processes affecting all layers of…
- Conditions
- Myocarditis, ANCA Associated Vasculitis, Pericarditis, Systemic Sclerosis
- Trial name
- EACVI-INFLAME (NCT07077304)
- Testing
- observational study
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Idiopathic Dilated Cardiomyopathy
Infusion Intracoronary of Mononuclear Autologous Adult no Expanded Stem Cells of Bone Marrow on Functional Recovery in Patients With Idiopathic Dilated Cardiomyopathy and Heart Failure.
Clinical trial phase IIb, double-blind, randomized, controlled with placebo. There is sufficient preliminary evidence to consider intracoronary injection of bone marrow progenitor cells as a viable, safe and beneficial treatment…
- Trial name
- NCT02033278
- Testing
- Infusion of autologous mononuclear bone marrow cells
- Where
- 9 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Idiopathic Dilated Cardiomyopathy
Honey in Idiopathic Dilated Cardiomyopathy
Background: Honey, as a natural product produced by honey bees, has anti-oxidant, anti-microbial, anti-inflammatory and immunomodulator properties.
- Trial name
- NCT02987322
- Testing
- honey
- Volunteers
- 50 people
- Sponsor
- mamdouh abdulmaksoud abdulrhman
Cardiomyopathy
Arrhythmogenic Substrate in Primary Cardiomyopathies and/or Channellopathies
This study assesses the value of arrhythmogenic substrate identification and elimination by catheter ablation to prevent recurrent ventricular arrhythmias and sudden cardiac death in a series of selected patients with primary…
- Trial name
- NCT03304847
- Testing
- ablation
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- IRCCS Policlinico S. Donato
Cryptogenic Stroke
Cardiac Abnormalities in Stroke Prevention and Risk of Recurrence
This is a multi-center retrospective analysis of consecutive adult patients with cryptogenic stroke patients following a comprehensive workup for the underlying stroke etiology.
- Trial name
- CASPR (NCT06398366)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- The Cooper Health System
Dilated Cardiomyopathy
Defining the Role of Insulin Resistance in 'Idiopathic' Dilated Cardiomyopathy
This study will investigate the effects of rosiglitazone, a medicine commonly used to treat type 2 diabetes, on the utilization of glucose by the heart in patients with heart failure which is not due to heart attacks.
- Trial name
- NCT00466713
- Testing
- Rosiglitazone therapy
- Where
- United States
- Sponsor
- Stanford University
Premature Ventricular Beats, Premature Ventricular Complexes
Flecainide in Idiopathic Premature Ventricular Contractions and Related Cardiomyopathy
The UNIFLECA study is a prospective, single-arm, observational cohort evaluating the efficacy, safety, and tolerability of flecainide (in the form of Sanocard) in adults with frequent idiopathic premature ventricular contractions…
- Conditions
- Premature Ventricular Beats, Premature Ventricular Complexes, Premature Ventricular Contraction (PVC), Arrhythmia Ventricular
- Trial name
- UNIFLECA (NCT06949748)
- Testing
- Flecainide (monotherapy)
- Where
- 6 sites in Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Athens
Healthy Volunteers
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects
Berlin Cures develops BC 007 to treat patients suffering from diseases (chronic heart failure, pulmonary hypertension, chronic fatigue syndrome etc.) which are associated with functional autoantibodies (AAB) directed against…
- Trial name
- NCT02955420
- Testing
- BC 007, NaCl 0.9 %
- Where
- Germany
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Berlin Cures GmbH
Heart Failure, Left Ventricular Dysfunction
Microvascular Dysfunction Assessment to Predict Left Ventricular Reverse Remodeling
Patients presenting with idiopathic dilated cardiomyopathy and left ventricle dysfunction (LVEF <40%), naive of anti-remodeling cardiac medical therapy, will undergo invasive coronary microvascular assessment based on…
- Conditions
- Heart Failure, Left Ventricular Dysfunction, Idiopathic Dilated Cardiomyopathy
- Trial name
- MICROREV (NCT06356727)
- Testing
- Thermodilution based assessment of coronary microcirculation
- Where
- 12 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Patients With Idiopathic Dilated Cardiomyopathy
18F-deoxyglucose (FDG) PET-CMD
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) may have application in a promising tool for identification of myocardial inflammation in patients with dilated cardiomyopathy (DCM).Therefore, the purpose of the…
- Trial name
- NCT02078141
- Testing
- 18F-deoxyglucose (FDG)
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Congestive Heart Failure, Ischemic Cardiomyopathy
Study Tests Whether a Standardized LVR Performed With the Blue Egg Device Improves Cardiopulmonary Exercise Capacity
The purpose of the present prospective, randomized study is to investigate the clinical effectiveness of standardized left ventricular reconstruction surgery (LVR).
- Conditions
- Congestive Heart Failure, Ischemic Cardiomyopathy, Coronary Artery Disease, Myocardial Diseases
- Trial name
- NCT00326690
- Testing
- Blue Egg Device
- Where
- 10 sites in United States, Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- BioVentrix
Dilated Cardiomyopathy
Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is a poorly understood cause of systolic heart failure and is the most common indication for heart transplantation worldwide.
- Trial name
- NCT01917149
- Testing
- Benazepril, Valsartan, Metoprolol
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Xijing Hospital
Cardiomyopathy, Dilated
Vitamin D Supplementation Can Improve Heart Function in Idiopathic Cardiomyopathy
Vitamin D deficiency could be a high risk for cardiovascular diseases. It has been recently reported that vitamin D deficiency is another cause of heart failure and cardiomyopathies.
- Trial name
- NCT02517814
- Testing
- Vitamin D
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hillel Yaffe Medical Center
Fabry Disease
Screening of Fabry Disease in Portuguese Patients With Idiopathic Cardiomyopathies
In Portugal, the prevalence of Fabry disease is largely unknown as recently has been stressed by the Portuguese hypertrophic cardiomyopathy registry investigators.
- Trial name
- F-CHECK (NCT05409846)
- Testing
- Alfa-galactosidase activity and genetic testing for Fabry diagnosis
- Where
- 11 sites in Portugal
- Volunteers
- 409 people
- Sponsor
- Universidade do Porto
Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic
Pulse Reduction On Beta-blocker and Ivabradine Therapy
Heart failure with reduced left ventricular ejection fraction (HFrEF) is the most common form of chronic heart failure in subjects ≤ 75 years of age.
- Conditions
- Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic, Ventricular Remodeling, Electrical Remodeling
- Trial name
- PROBE-IT (NCT02973594)
- Testing
- Ivabradine
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Colorado, Denver
Dilated Cardiomyopathy
Intracoronary Infusion of Autologous Bone Marrow Cells for Treatment of Idiopathic Dilated Cardiomyopathy
The main aim of the study is to determine whether intracoronary infusion of autologous bone marrow mononuclear cells can improve the ventricular function of patients with idiopathic dilated cardiomyopathy.Secondary end-points…
- Trial name
- NCT00629096
- Testing
- Intracoronary infusion of autologous bone marrow cells
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Myocardial Diseases, Parvovirus B19, Human
Intravenous Immunoglobulin (IVIg) for Parvovirus B19(PVB19) Mediated Cardiomyopathy
A prospective randomized double-blind placebo-controlled trail to investigate the effect of high doses of IVIg on cardiac functional capacity and virus presence in a subgroup of patients with chronic symptomatic ICM and a high…
- Trial name
- NCT00892112
- Testing
- Intravenous Immunoglobulins, plasma volume expander
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Prothya Biosolutions
Primary Idiopathic Dilated Cardiomyopathy
Mesenchymal Stem Cells for Idiopathic Dilated Cardiomyopathy
The purpose of this study is to assess the safety, the feasibility and the efficacy of transendocardial injection of bone marrow-derived mesenchymal stem cells (MSCs) in patients with dilated idiopathic cardiomyopathy.
- Trial name
- NCT01957826
- Testing
- bone marrow-derived MSCs injection
- Where
- 2 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Dilated Cardiomyopathy with Conduction Defect, Left Bundle-Branch Block
Conduction System Pacing Versus Biventricular Pacing for Cardiac ResYNChronization
Cardiac resynchronization therapy (CRT) with biventricular pacing (BiV) is the cornerstone treatment for heart failure patients with ventricular dyssynchrony.
- Conditions
- Dilated Cardiomyopathy with Conduction Defect, Left Bundle-Branch Block, Heart Failure, Resynchronization Therapy
- Trial name
- CSP-SYNC (NCT05155865)
- Testing
- Resynchronization with conduction system pacing, Cardiac resynchronization therapy with biventricular stimulation
- Where
- Slovenia
- Volunteers
- 62 people
- Sponsor
- University Medical Centre Ljubljana