Clinical trials: Idiopathic Dilated Cardiomyopathy
Dilated Cardiomyopathy
Exercise Stress MRI to Evaluate Aortic Function (Compliance, Distensibility, Pulse Wave Velocity) and Left Ventricular Function : Validation in Healthy Volunteers and in Selected Patients. A Pilot Study.
Detecting abnormalities in the left ventricular mechanical and hemodynamic response to the stress of exercise may offer early diagnostic indicators in patients suffering from valvular disease such as mitral regurgitation.
- Trial name
- NCT02018835
- Testing
- MRI, cardiac echography transthoracic
- Where
- France
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Dilated Cardiomyopathy
Multicenter Exploratory Study of Accelerometry in Dilated Cardiomyopathy
Study evaluates the relationships between daily physical activity levels (PAL) and functional capacity (VO2peak) in patients with dilated cardiomyopathy (DCM)
- Trial name
- MESA-DCM (NCT03207230)
- Testing
- Cardea SOLO, ActiGraph wGT3X-BT, Wavelet Wristband
- Sponsor
- Stanford University
Patients With Ischemic or Idiopathic Dilated Cardiomyopathy
Multihormonal Deficiencies and miRNA Profile in Chronic Heart Failure: Effects of Combined Hormonal Replacement Therapy
The results from this study will be useful to gain detailed information on the correlation related to pathophysiological aspects between endocrine system and clinical status of patients with heart failure, and to identify factors…
- Trial name
- NCT05769387
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- IRCCS SYNLAB SDN
Cardiomyopathy (Ischemic or Non-Ischemic)
Data Analysis and Evaluation of the Incidence of Life-threatening Ventricular Arrhythmias in Patients with Newly Diagnosed Cardiomyopathies of NICM or MI/CAD Origin PROTECTED from SCD by a WCD
SCD-PROTECT is an epidemiological, observational, multicenter study to assess the incidence of sudden cardiac arrest/death (SCA/SCD) in patients with newly diagnosed non-ischemic cardiomyopathy or with myocardial…
- Trial name
- SCD-PROTECT (NCT06883383)
- Where
- Germany
- Volunteers
- 19,598 people
- Sponsor
- Hannover Medical School
Congestive Heart Failure
Regulation of Immunological Cytokines by Qiliqiangxin Capsule in Dilated Cardiomyopathy Patients
Purpose :Research into the impact of Qiliqiangxin capsule on IFN-γ，IL-4，NT-proBNP in dilated cardiomyopathy patients with heart failure.
- Trial name
- NCT02283450
- Testing
- Qiliqiangxin Capsule
- Volunteers
- 30 people
- Sponsor
- Harbin Medical University
Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy
An Integrative-"Omics" Study of Cardiomyopathy Patients for Diagnosis and Prognosis in China
This is a multi-omics research of Chinese cardiomyopathies patients, aiming to determine genetic risk factor and serial biomarkers of cardiomyopathies in diagnosis and prognosis.
- Conditions
- Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy, Left Ventricular Non-compaction
- Trial name
- AOCC (NCT03076580)
- Where
- 3 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM)
Early Identification and Treatment of Rare Cardiomyopathy Cohorts
This study aims to further develop an imaging-guided cohort of rare cardiomyopathies based on the existing database. The investigators will standardize the construction of a cohort that integrates a clinical data repository…
- Conditions
- Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM), Metabolic Cardiomyopathy, Restrictive Cardiomyopathy
- Trial name
- EARLY-MYO-RARE (NCT06794710)
- Testing
- diuretics, ACEIs/ARBs, beta blockers, positive inotropic drugs, MRAs, SGLT2i, retinoids, Close follow-up, early rehabilitation guidance
- Where
- China
- Volunteers
- 300 people
- Sponsor
- RenJi Hospital
Sudden Cardiac Death Due to Cardiac Arrhythmia, Dilated Cardiomyopathy
Arrhythmic Risk Stratification in Nonischemic Dilated Cardiomyopathy
Nonischemic dilated cardiomyopathy is a heterogeneous disease often associated with increased rates of sudden cardiac death. Although many algorithms have been proposed, risk stratification remains suboptimal, and implantable…
- Trial name
- ReCONSIDER (NCT04246450)
- Testing
- Implantable Cardioverter Defibrillator (ICD) insertion
- Where
- Greece
- Volunteers
- 675 people
- Sponsor
- University of Athens
Primary Familial Dilated Cardiomyopathy
Exploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants or Other Causalities
The purpose of this Phase 2a study is to establish safety and preliminary efficacy of treatment with danicamtiv in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants or other causalities.
- Trial name
- NCT04572893
- Testing
- danicamtiv
- Where
- 19 sites in United States, Germany and 2 more
- Volunteers
- 41 people
- Sponsor
- Bristol-Myers Squibb
Cardiomyopathy
Acute Dietary Nitrate in Dilated Cardiomyopathy
Acute consumption of dietary nitrate (as beetroot juice) has been shown to improve exercise capacity in athletes, healthy adults and subjects with both peripheral vascular disease or COPD.
- Trial name
- NCT02471417
- Testing
- Dietary nitrate
- Volunteers
- 12 people
- Sponsor
- Royal College of Surgeons, Ireland
Heart Failure, Left Bundle-Branch Block
Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure Patients
Heart failure (HF) is the most common nosology encountered in clinical practice. Its incidence and prevalence increase exponentially with increasing age and it is associated with increased mortality, more frequent hospitalization…
- Conditions
- Heart Failure, Left Bundle-Branch Block, Ischemic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy
- Trial name
- RECOVER-HF (NCT05769036)
- Testing
- Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Biventricular Pacing, Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Left Bundle Branch Pacing
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Dilated Cardiomyopathy
Evaluation of the CIRCULATE Catheter for Transcoronary Administration of Pharmacologic and Cell-based Agents
Clinical evaluation of the CIRCULATE catheter involves intracoronary administration of a typical medical agent (nitroglycerin) and a shown-to-be-safe cell-based agent (CardioCell) in patients with a diagnosis of dilated…
- Trial name
- NCT04703751
- Testing
- Transcoronary delivery of a pharmacological agent (nitroglycerin) and cell based agent (Cardiocell) using the CIRCULATE Catheter
- Where
- Poland
- Volunteers
- 10 people
- Sponsor
- John Paul II Hospital, Krakow
Dilated Cardiomyopathy
Resveratrol: A Potential Anti- Remodeling Agent in Heart Failure, From Bench to Bedside
The purpose of this study is to determine if resveratrol can improve heart function and quality of life. Although, population studies have revealed that a mild to moderate intake of red wine reduces cardiovascular disease risk in…
- Trial name
- RES-HF (NCT01914081)
- Testing
- Resveratrol
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Boniface Hospital
ARNI, Pediatric Dilated Cardiomyopathy
Comparative Efficacy of ARNI Versus ACE Inhibitor Therapy in Egyptian Children With Dilated Cardiomyopathy
This is a prospective, cohort study designed to evaluate the efficacy and safety of sacubitril/valsartan versus captopril in children with dilated cardiomyopathy (DCM) admitted to Assiut University Children Hospital over a…
- Conditions
- ARNI, Pediatric Dilated Cardiomyopathy, ACE Inhibitor
- Trial name
- NCT07197372
- Volunteers
- 70 people
- Sponsor
- Assiut University
LMNA-Related Dilated Cardiomyopathy
A Rollover Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy
This is a rollover study designed to investigate the safety and effectiveness of investigational study drug ARRY-371797 in patients who previously received ARRY-371797 in a study for patients with LMNA-related dilated…
- Trial name
- NCT02351856
- Testing
- ARRY-371797, p38 inhibitor, oral
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Pfizer
Cardiovascular Diseases, Congestive Heart Failure
Treating Congestive HF With hiPSC-CMs Through Endocardial Injection
Heart failure is the primary cause of morbidity and mortality worldwide. Currently drug treatments for heart failure manage the symptoms, but not restore the loss cardiomyocytes due to the very limited regenerative capability in…
- Conditions
- Cardiovascular Diseases, Congestive Heart Failure, Dilated Cardiomyopathy
- Trial name
- NCT04982081
- Testing
- hiPSC-CM therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- HELP Therapeutics Co., Ltd.
Dilated Cardiomyopathy
Reverse Remodelling and Remission Markers in the Serial Evaluation of Recent-onset Dilated Cardiomyopathy
Approximately 30-40% of patients with non-ischaemic dilated cardiomyopathy (DCM) undergo significant left ventricular reverse remodelling in response to guideline-directed therapies.
- Trial name
- REMIT-DCM (NCT04957147)
- Testing
- 12 months of guideline-directed heart failure therapy
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Nonischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM)
Mainstreaming Genetic Testing for Non-Ischemic Cardiomyopathy in Western Canada
Heart muscle disorders are a common cause of heart failure: a life-threatening condition that can cause dangerous abnormal heart rhythms (arrhythmia) and a buildup of fluid in the body (edema).
- Trial name
- HOGI (NCT07345338)
- Testing
- Health service delivery change
- Where
- 4 sites in Canada
- Volunteers
- 300 people
- Sponsor
- Thomas Roston
Cardiovascular Diseases, Heart Failure
Randomized Study of Coronary Revascularization Surgery With Injection of WJ-MSCs and Placement of an Epicardial Extracellular Matrix
Ischemic heart disease is one of the most important causes of mortality and morbidity in the Western world and is a public health problem.
- Conditions
- Cardiovascular Diseases, Heart Failure, Coronary Artery Disease, Mesenchymal Stem Cell Transplantation
- Trial name
- scorem-cells (NCT04011059)
- Testing
- Wharton's jelly-derived mesenchymal cells
- Where
- Colombia
- Volunteers
- 40 people
- Sponsor
- Hospital San Vicente Fundación
Heart Failure With Reduced Ejection Fraction, Dilated Cardiomyopathy
v4 Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491
The purpose of this Phase 1b/2a study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of MYK-491 in patients with stable heart failure.
- Trial name
- NCT03447990
- Testing
- MYK-491
- Where
- 17 sites in United States, France and 5 more
- Volunteers
- 52 people
- Sponsor
- Bristol-Myers Squibb