Clinical trials: Idiopathic Dilated Cardiomyopathy
Heart Failure, Dilated Cardiomyopathy
Myocardial Telomere Recapping Study for Dilated Cardiomyopathy
The aim of this study is to determine the safety and feasibility of giving an adeno-associated viral vector expressing a modified telomerase protein (TERT), driven by cardiac troponin T promoter (AAV9-cTnT-modTERT), to 12 dilated…
- Trial name
- MERCURY-DCM (NCT05837143)
- Testing
- JV001
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Shanghai East Hospital
Idiopathic Cardiomyopathy, Left Ventricular (LV) Systolic Dysfunction
Performance of the Cardiac Microcurrent (C-MIC) System With a Less Invasively Placed Left Ventricular Lead
Patients with idiopathic dilated cardiomyopathy in heart failure (NYHA class III - IV) with a baseline left ventricular ejection fraction between ≥25% and ≤35%, and patients with non-ischemic cardiomyopathy in heart failure (NYHA…
- Conditions
- Idiopathic Cardiomyopathy, Left Ventricular (LV) Systolic Dysfunction, Non-ischemic Cardiomyopathy
- Trial name
- NCT06920030
- Testing
- Subcutaneous cardiac microcurrent treatment
- Where
- 4 sites in Bosnia and Herzegovina, Serbia
- Volunteers
- 22 people
- Sponsor
- Berlin Heals GmbH
Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic
Association of Insulin Resistance and FGF21 on Cardiac Function in Pediatric Dilated Cardiomyopathy
This study will investigate whether there is an association between insulin resistance and cardiac function in children with dilated or hypertrophic cardiomyopathy.
- Conditions
- Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic, Insulin Resistance
- Trial name
- NCT04222101
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Le Bonheur Children's Hospital
Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy
Genotype-Phenotype Associations in Pediatric Cardiomyopathy (PCM GENES)
Cardiomyopathy in children is a serious disease which can result in death, disability, heart transplantation or serious heart rhythm disorders. Doctors know little about the causes of cardiomyopathy but would like to learn more.
- Conditions
- Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy
- Trial name
- NCT01873963
- Where
- 12 sites in United States, Canada
- Volunteers
- 544 people
- Sponsor
- Wayne State University
Cardiomyopathies, Dilated Cardiomyopathy
Pediatric Cardiomyopathy Mutation Analysis
The goal of this protocol is to obtain information from individuals with cardiomyopathy and from their families in order to elucidate the molecular genetics of this disorder.
- Conditions
- Cardiomyopathies, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy
- Trial name
- NCT02432092
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Dilated Cardiomyopathy
Respiratory Muscles Training in Patients With Dilated Cardiomyopathy
The aim of this study was to determine the effects of respiratory muscles training on cardiopulmonary parameters and quality of life in patients with dilated cardiomyopathy (DCM).
- Trial name
- NCT04307823
- Testing
- Treadmill training, Treadmill protocol and Respiratory training
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Dilated Cardiomyopathy (DCM)
Prognostic Values of Coronary Microvascular Dysfunction in Patients With Dilated Cardiomyopathy
The goal of this observational study is to learn about the long-term prognostic of coronary microvascular dysfuction in Patients with Dilated Cardiomyopathy.
- Trial name
- NCT07293338
- Testing
- coronary angiography
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Dilated Cardiomyopathy, Heart Failure
Repetitive Intramyocardial CD34+ Cell Therapy in Dilated Cardiomyopathy (REMEDIUM)
The goal of REMEDIUM project is to develop personalized stem cell therapy for patients with chronic heart failure due to dilated cardiomyopathy (DCM).
- Trial name
- REMEDIUM (NCT02248532)
- Testing
- Stem cell therapy
- Where
- Slovenia
- Volunteers
- 66 people
- Sponsor
- University Medical Centre Ljubljana
Cardiomyopathy, Congestive, Cardiovascular Diseases
Mapping Novel Disease Genes for Dilated Cardiomyopathy
To identify new dilated cardiomyopathy genes by genetic linkage and mutational analyses.
- Conditions
- Cardiomyopathy, Congestive, Cardiovascular Diseases, Heart Diseases, Heart Failure, Congestive
- Trial name
- NCT00046618
- Sponsor
- Mayo Clinic
Heart Failure, Dilated Cardiomyopathy
A Pivotal Trial to Establish the Efficacy and Safety of Algisyl in Patients With Moderate to Severe Heart Failure
AUGMENT-HF II is a study to evaluate the efficacy and safety of the Algisyl device. The purpose of this study is to investigate Algisyl employed as a method of left ventricular augmentation and restoration in patients with…
- Conditions
- Heart Failure, Dilated Cardiomyopathy, Heart Failure With Reduced Ejection Fraction
- Trial name
- AUGMENT-HFII (NCT03082508)
- Testing
- Algisyl, Standard Medical Therapy
- Volunteers
- 240 people
- Sponsor
- LoneStar Heart, Inc.
CARDIOMYOPATHY
Combined Effect of Aerobic and Resistance Exercise in Non Ischemic Dilated Cardiomyopathy Patients
This study explores the effects of combined aerobic and resistance exercise in patients with non-ischemic dilated cardiomyopathy (NIDCM).
- Trial name
- NCT07062874
- Testing
- Combined Aerobic and Resistance Exercise, Aerobic Exercise Only
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Riphah International University
Breast Cancer
MarginProbe, a Device for Intraoperative Assessment of Margin Status in Breast Conservation Surgery
The purpose of this study is to show that addition of device use to a routine breast cancer tumor excision procedure is beneficial and assists the surgeon in correctly determining the extent of excision.
- Trial name
- Pivotal (NCT00749931)
- Testing
- MarginProbe, Lumpectomy
- Where
- 21 sites in United States, Israel
- Volunteers
- 664 people
- Sponsor
- Dune Medical Devices
Dilated Cardiomyopathy, Left Ventricular Systolic Dysfunction
Cardiovascular Magnetic Resonance GUIDEd Insertion of Implantable Cardiac Defibrillator in Dilated CardioMyopathy
CMR GUIDE DCM is a randomized controlled trial with a registry for non-randomized patients. Patients enrolled will have non-ischemic cardiomyopathy (NICM) with mild to severe Left Ventricular (LV) systolic dysfunction with…
- Conditions
- Dilated Cardiomyopathy, Left Ventricular Systolic Dysfunction, Fibrosis Myocardial
- Trial name
- CMR GUIDE DCM (NCT03993730)
- Testing
- ICD, ILR
- Volunteers
- 1,880 people
- Sponsor
- Flinders University
Shock, Sepsis
Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCO
The purpose of this study is To assess the value of dynamics (SVV, PPV) and static indices (GEDVI, ITBVI, CVP) of preload and its combination with contractility (CI,SV, ventricular power, dP/dtmax, CFI, GEF) and lung water…
- Conditions
- Shock, Sepsis, Systemic Inflammatory Response Syndrome, Low Cardiac Output
- Trial name
- PreloaDren (NCT01157299)
- Where
- 7 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario La Paz
Chronic Systolic Heart Failure (Dilated Cardiomyopathy)
NORDIC: Nitric Oxide-Derived Oxidants and Regional Endothelial and Diastolic Dysfunction in Dilated Cardiomyopathy
The principal aim is to investigate the safety and efficacy of rosiglitazone in patients with chronic systolic heart (Dilated cardiomyopathy).
- Trial name
- NORDIC (NCT00293137)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Dilated Cardiomyopathy
Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells by Mini-Thoracotomy
Bone marrow mononuclear cells (BMMC) transplantation is a promising therapy for treating ischemic disease, however the effect in non-ischemic dilated cardiomyopathy is unknown.This study describes a technique of BMMC…
- Trial name
- STEMDILCARD (NCT00615394)
- Testing
- intramyocardial bone marrow stem cells implantation
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
BAG3 Mutation Associated Dilated Cardiomyopathy
ALXN2350 in Adult Participants With BAG3-Associated Dilated Cardiomyopathy
This Phase 1/2 study is an open-label, dose finding and dose expansion study investigating the safety, tolerability, and efficacy of a single IV infusion of ALXN2350 in adult participants with BAG3 associated DCM.
- Trial name
- DCMRestore (NCT07218887)
- Testing
- ALXN2350
- Where
- 11 sites in United States, Italy and 2 more
- Volunteers
- 6 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Cardiovascular Diseases, Heart Diseases
Epidemiology of Idiopathic Dilated Cardiomyopathy (Washington, DC Dilated Cardiomyopathy Study)
To identify risk factors for idiopathic dilated cardiomyopathy and to examine prognostic factors over a follow-up period of two to three years.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Diseases, Asthma
- Trial name
- NCT00005262
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Healthy Adults (Full Study and Extension Phase), Hypertrophic Cardiomyopathy or Dilated Cardiomyopathy
A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare
The MedSeq™ Project seeks to explore the impact of incorporating information from a patient's whole genome sequence into the practice of clinical medicine.
- Trial name
- NCT01736566
- Testing
- Family History + Whole Genome Sequencing, Family History Only
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
LMNA-Related Dilated Cardiomyopathy
A Rollover Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy
This is a rollover study designed to investigate the safety and effectiveness of investigational study drug ARRY-371797 in patients who previously received ARRY-371797 in a study for patients with LMNA-related dilated…
- Trial name
- NCT02351856
- Testing
- ARRY-371797, p38 inhibitor, oral
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Pfizer