Clinical trials: Idiopathic Infertility
Infertility, Female
Clinical Trials Evaluating the Effect of Metformin Treatment on Function Endometrium in Women Diagnosed With Idiopathic Infertility
Randomized, controlled, double-blind, three-arm clinical trial in which 75 women will be randomized to treatment with metformin, 75 women to treatment with placebo and 50 women to the observation group.
- Trial name
- METIN (NCT06012682)
- Testing
- Metformin Hydrochloride
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Asthenozoospermia
Alpha Lipoic Acid Plus Coenzyme Q10 Versus Coenzyme Q10 Alone in Asthenozoospermia
The goal of the clinical trial is to learn if Alpha-lipoic acid plus Coenzymeq10 work to treat asthenozoospermia in subfertile male. It will also learn about the safety of drug Alpha-lipoic acid plus Coenzymeq10.
- Trial name
- CoQ10 ALA (NCT07455890)
- Testing
- ALA 500mg once daily for 3 month, CoenzymeQ10
- Where
- Bangladesh
- Volunteers
- 40 people
- Sponsor
- Mst.Sumyara Khatun
Idiopathic Infertility, Infertility Unexplained
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility
The goal of this clinical trial is to determine whether telomere profiling and other biological aging hallmarks can help identify underlying mechanisms of persistent infertility in women with post-treatment unexplained…
- Conditions
- Idiopathic Infertility, Infertility Unexplained, Infertility (IVF Patients), Infertility Assisted Reproductive Technology
- Trial name
- TECMI (NCT07404969)
- Testing
- 1. Aging Hallmarks Biomarker Profiling (Telomere-Based), 2. Integrative Botanical and Nutraceutical Intervention, 3. Natural Conception or Assisted Reproductive Technologies
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- BEYOND GENOMiX SA, AG, Ltd
Infertility, Male
Clomiphene Citrate in Infertile Men With Idiopathic Oligoasthenozoospermia
The goal of this clinical trial is to learn if drug clomiphene citrate improves sperm parameters in infertile men with idiopathic oligoasthenozoospermia. It will also learn about the safety of clomiphene citrate.
- Trial name
- NCT06564961
- Testing
- Clomiphene Citrate
- Where
- Bangladesh
- Volunteers
- 50 people
- Sponsor
- Shakeela Ishrat
Male Infertility
A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0
The purpose of this study is to determine if elevations in oxidative stress, as measured by oxidation-reduction potential (ORP), can distinguish between semen samples from men with abnormal semen parameters from those with normal…
- Trial name
- NCT02839447
- Testing
- Diagnostic
- Where
- 6 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aytu BioPharma, Inc.
Infertility
Next Generation DNA Sequencing in Patients With Idiopathic Male Infertility
Hypothesis: To identify new gene mutations that can be related to patients with idiopathic male factor infertility. Primary Objective: To detect possible genetic abnormalities in families with more than one sibling with male…
- Trial name
- NCT02021721
- Where
- Qatar
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Infertility, Female, Recurrent Miscarriage
Immune Cell Populations in the Endometrium
Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood.
- Conditions
- Infertility, Female, Recurrent Miscarriage, Gynecologic Disease
- Trial name
- NCT06826365
- Testing
- Percentage distribution of immune system cells in peripheral blood, Percentage distribution of immune system cells in endometrium
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Jagiellonian University
Infertility, Male
Assessment of TetraSOD® Efficacy to Improve Semen Parameters in Men With Idiopathic Infertility
TetraSOD® is a unique marine phytoplankton (Tetraselmis chuii) SOD-rich ingredient that is grown under patent-protected technology exclusively designed by the company Fitoplancton Marino, S.L. (Spain).
- Trial name
- NCT04864314
- Testing
- Marine microalgae Tetraselmis chuii with high Superoxide Dismutase (SOD) activity
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Fitoplancton Marino, S.L.
Idiopathic Oligoasthenoteratozoospermia, Male Infertility
Comparative Evaluation of the Efficacy of Letrozole, L-Carnitine, and Their Combination on Sperm Quality, Oxidative Stress, and ART Outcomes in Men With Idiopathic Oligoasthenoteratozoospermia.
This is a randomized clinical trial evaluating the efficacy of Letrozole, L-Carnitine, and their combination on sperm quality, oxidative stress, and ART outcomes in men with idiopathic oligoasthenoteratozoospermia.
- Trial name
- NCT07669402
- Testing
- Letrozole 2.5mg, L-carnitine
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Tehran University of Medical Sciences
Infertility Unexplained, Infertility, Male
Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle
Infertility affects about 10% of all couples and is defined by a failure to achieve a clinical pregnancy within a year of regular unprotected sexual intercourse.
- Conditions
- Infertility Unexplained, Infertility, Male, DNA Damage
- Trial name
- NCT03319654
- Testing
- DNA fragmentation by TUNEL assay
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Infertility
Androxal in Male Infertility
This is an exploratory, single center, randomized, parallel, double-blind placebo- and active-controlled trial in adult males ages 18 to 35 years of age who have male infertility of unknown cause.
- Trial name
- NCT02160704
- Testing
- Enclomiphene citrate
- Where
- United States
- Sponsor
- Baylor College of Medicine
Idiopathic Infertility
Neotililty Trial: Effect of Coenzyme Q10 on Semen Parameters in Men With Idiopathic Infertility
To study the effect of coenzyme Q10 on semen parameters in men with idiopathic infertility
- Trial name
- Neotility (NCT03104998)
- Testing
- Coenzyme Q10
- Where
- Pakistan
- Sponsor
- PharmEvo Pvt Ltd
Sperm DNA Fragmentation
HMG Treatment Reduces Sperm DNA Fragmentation
Male factors account for approximately 50% of infertility cases. The principal etiologies of male infertility include sexual dysfunction, semen abnormalities arising from various etiologies, and idiopathic infertility.
- Trial name
- NCT07873502
- Testing
- Human Menopausal Gonadotropin (hMG), Vitamin E
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Jinling Hospital, China
Infertility, Male
The Effect of Combination of Red and White Bahman Retrieved of Iranian Traditional Medicine on Semen Parameters in Idiopathic Oligospermic Men
This study is a prospective double blind randomized controlled trial to investigate the effect of red and white bahman on semen parameters, sexual hormones and DNA defragmentation in idiopathic oligospermic men .Include patients…
- Trial name
- NCT02998593
- Testing
- Bahman capsules
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Royan Institute
Infertility
Human MATER and Idiopathic Infertility
Approximately 15 percent of couples experience infertility, yet no abnormalities can be detected in the man or the woman. In a number of couples, their embryos unexpectedly slow down growth or stop growth completely.
- Trial name
- NCT00361816
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Oligospermia
The Effect and Safety of Lisinopril in Non-hypertensive Men With Infertility From Low Sperm Count
This study was conceived in order to explain what the investigators previously observed suggesting that lisinopril, a drug normally used to treat patients with high blood pressure and heart failure, may be effective in treating…
- Trial name
- NCT01409837
- Testing
- Lisinopril
- Where
- Nigeria
- Volunteers
- 33 people
- Sponsor
- University Of Nigeria Teaching Hospital
Insulin Resistance, Oligospermia
Insulin Resistance in Idiopathic Oligospermia and Azoospermia
Insulin resistance in men can be the underlying major factor in reproductive abnormalities ( chronic hypospermatogenesis ) as well as metabolic abnormalities similar to polycystic ovarian syndrome ( PCOS ) in women.
- Conditions
- Insulin Resistance, Oligospermia, Azoospermia
- Trial name
- NCT01509482
- Testing
- blood samples
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Egyptian IVF-ET Center
Osteonecrosis of Femoral Head, Osteonecrosis; Aseptic, Idiopathic
Aspirin in the Prevention of Collapse in Osteonecrosis of the Hip
The purpose of this study is to determine if prolonged administration of low-dose aspirin will prevent the progression of early-stage osteonecrosis of the femoral head and may even reduce the extent of involvement of the femoral…
- Trial name
- NCT03405974
- Testing
- Aspirin
- Where
- Canada
- Volunteers
- 114 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Abortion, Spontaneous, Abortion in First Trimester
Application of Lactobacillus Salivarius CECT5713 in Infertility of Unknown Origin
In this study, we aimed to assess the cervicovaginal environment (pH, Nugent score, soluble immune factors and bacterial profile) in women with reproductive failure because of either repetitive abortion or infertility of unknown…
- Conditions
- Abortion, Spontaneous, Abortion in First Trimester, Infertility Unexplained
- Trial name
- NCT04446572
- Testing
- Lactobacillus salivarius CECT5713
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Universidad Complutense de Madrid
Infertility, Female, Infertility Unexplained
Pro-inflammatory Cytokines and Implantation Process in Women With Primary Idiopathic Infertility
Infertility is a common, worldwide problem. In about 20% of couples, the causative agent of infertility cannot be identified after routine diagnostic tests.
- Conditions
- Infertility, Female, Infertility Unexplained, Inflammatory Response
- Trial name
- NCT05190250
- Testing
- Pipelle biopsy
- Where
- Poland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University