Clinical trials: Idiopathic Macular Hole
Macular Holes
Foveal Cone Outer Segment Resumption to Predict Visual Recovery After Macular Hole Surgery
Spectral domain optical coherence tomography (SD-OCT) was used to determine whether the repair of photoreceptor cone outer segment tips defect is significantly correlated with the visual outcomes after macular hole surgery.
- Trial name
- NCT01381965
- Testing
- Vitreous surgery for macular hole
- Where
- Japan
- Volunteers
- 72 people
- Sponsor
- Kyorin University
Idiopathic Macular Hole, Surgery
Study of Surgery in Patients With Idiopathic Macular Hole
The purpose of this study is to determine the effects of two different internal limiting membrane peeling with distinct diameters after macular hole surgery on anatomical closure grades.
- Trial name
- NCT02905409
- Testing
- ILM peeling surgery
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Peking University People's Hospital
Macular Hole Surgery, ILM Peeling
Comparison Between Outcomes of Closure of Idiopathic Macular Hole Using Autologus Tenon Capsule Graft and Internal Limiting Membrane Flap Techniques (Pilot Study)
The aim of this study is to compare the functional visual outcomes, anatomical closure rate and macular perfusion changes assessed by OCT and OCTA after surgical repair of macular hole using Tenon capsule graft versus ILM flap.
- Conditions
- Macular Hole Surgery, ILM Peeling, Tenon Capsule, ILM Flap
- Trial name
- NCT07633457
- Testing
- vitrectomy under topical anesthesia [Proparacaine HCL (Alcaine®)]
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Internal Limiting Membrane Peeling
Internal Limiting Membrane Peeling on Retinal Displacement
The purpose of this study is to investigate displacement of the retina after idiopathic macular hole surgery with different internal limiting membrane peeling patterns.
- Trial name
- NCT04655781
- Testing
- idiopathic macular hole (MH) surgery
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Idiopathic Macular Holes
Brillant Blue Versus Indocyanine Green for Macular Hole Surgery
Macular Hole Surgery with two different Dyes
- Trial name
- NCT00757471
- Testing
- Brillant Blue, Indocyanine Green
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Idiopathic Macular Hole
Outcome of Surgery for Idiopathic Macular Holes
Retrospective medical chart review of patients undergoing surgical repair of idiopathic macular hole
- Trial name
- TROMAC (NCT02895594)
- Volunteers
- 59 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Macular Holes
Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular Holes
The human amniotic membrane (hAM) patch, introduced by Rizzo et al. in 2018, showed a 100% anatomical success rate for large or failed macular holes over a 6-month follow-up.
- Trial name
- MACROHOLE (NCT06433284)
- Testing
- 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade, 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling with amniotic membrane hydrogel filling and SF6 tamponade
- Where
- Thailand
- Volunteers
- 26 people
- Sponsor
- Walailak University
Idiopathic Macular Hole
ILM Inverted Flap Size in Macular Hole
In the current study, the investigators described the results of a randomized, comparative clinical trial that was conducted to study the impact of the size of internal limiting membrane (ILM) inverted flap on rate and timing of…
- Trial name
- NCT04683276
- Testing
- pars plana vitrectomy with ILM inverted flap
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Mansoura University
Macular Hole, Surgery
Internal Limiting Membrane Peeling-reposition to Treat Idiopathic Macular Holes
To compare the morphologic and functional outcomes of internal limiting membrane peeling-reposition versus peeling in idiopathic macular holes
- Trial name
- NCT03020459
- Testing
- peeling-reposition, peeling, Brilliant Blue G
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Macular Hole
Effects of Different Area of Internal Limiting Membrane Peeling (ILM) Peeling on Anatomical Outcomes in Macular Hole Surgery
The purpose of this study is to determine the effects of two different internal limiting membrane (ILM) peeling area on anatomical closure outcomes after macular hole surgery measured by optical coherence tomography (OCT).
- Trial name
- NCT02930369
- Testing
- ILM peeling surgery
- Volunteers
- 128 people
- Sponsor
- Peking University People's Hospital
Idiopathic Macular Hole, Effective Prone Time
Analysis of Novel Positioning Sensor-assisted Postoperative Position Correction and Effective Prone Time Recorded in Patients With Different Prone Times After Macular Hole Surgery
Idiopathic macular hole (IMH) is a fundus disease without clear etiology, most often seen in healthy women over 50 years of age, and is often associated with ocular manifestations such as loss of central vision and visual…
- Trial name
- NCT05757349
- Testing
- Face-down position time 1-day, Face-down position time 3-day
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Tianjin Medical University Eye Hospital
Macular Holes, Optical Coherence Tomography
Optical Coherence Tomography Angiography Characteristics of Patients With Surgically Closed Full-thickness Idiopathic Macular Holes < 600 μm With Air Versus 10% SF6 Tamponade
State of the art treatment for idiopathic macular holes consists of pars plana vitrectomy, internal limiting membrane staining with a blue colouring dye, internal limiting membrane peeling and filling of the vitrectomized space…
- Trial name
- NCT05223205
- Testing
- Air, 10% SF6 and 90% air
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Macular Holes
Clinical Study of Translocated Internal Limiting Membrane Flap Reposition for the Treatment of Idiopathic Macular Hole
The main objective of this study is to evaluate the therapeutic effectiveness of the internal limiting membrane (ILM) peeling and translocation surgery compared to the conventional surgical approach for treating large idiopathic…
- Trial name
- NCT06063005
- Testing
- Translocation ILM Flap, ILM Peeling
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Macular Disease
Epiretinal Proliferation in Eyes With Full Thickness Macular Hole
We evaluated preoperative and postoperative optical coherence tomograpghic images in eyes with full thickness macular hole (FTMH) whether the epiretinal proliferation (EP) was detected and detection of EP was correlated to the…
- Trial name
- NCT03376776
- Testing
- Vitrectomy
- Where
- Japan
- Volunteers
- 390 people
- Sponsor
- Kyorin University
Macular Hole, Visual Acuity
Combined Versus Successive Macular Hole and Cataract Surgery
The purpose of this study is to compare functional and anatomical results of a combined surgery and two time surgery for macular hole and cataract extraction in one hundred and twenty patients (120 eyes) with idiopathic Macular…
- Trial name
- NCT01069029
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Idiopathic Macular Hole
Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole Surgery
To evaluate the anatomical and visual outcomes after vitrectomy and internal limiting membrane (ILM) peeling with indocyanine green (ICG) or trypan blue (TB) for idiopathic macular hole repair in a prospective randomized trial.
- Trial name
- NCT00419185
- Testing
- Delamination of the Internal limiting membrane
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Luebeck
Idiopathic Macular Hole
Outcome of Idiopathic Macular Hole
The purpose of this study is to evaluate the role of cataract surgery and cystoid macular edema (CME) on reopening of idiopathic macular holes (IMH).
- Trial name
- NCT00941291
- Where
- France
- Volunteers
- 135 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Macular Holes
ILM Peeling Versus Inverted Flap Technique for Treatment of Macular Hole: Near Visual Acuity Outcomes
A prospective randomised study comparing the near visual acuity outcomes using Salzburg Reading Desk in pseudophakic patients with idiopathic full-thickness macular hole treated with pars plana vitrectomy with internal limiting…
- Trial name
- NCT04698226
- Testing
- 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling and SF6 tamponade, 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Macular Holes
Compare the Healing Process of Idiopathic Macular Hole With Different Surgical Techniques
To compare anatomic and functional results, and to evaluate postoperatively the healing process in 2 different techniques for the closure of the macular holes (MH)
- Trial name
- NCT03888625
- Testing
- Conventional ILM Peeling, Inverted ILM Peeling
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Macular Hole, Macular Hole Surgery
Minimal Vitrectomy and ILM Flap with Sodium Hyaluronate Gel for MH
The purpose of this clinical trial is to compare the prognostic validity of two different surgical approaches: minimal posterior pole vitrectomy combined with a sodium hyaluronate gel-covered internal limiting membrane(ILM) flap…
- Conditions
- Macular Hole, Macular Hole Surgery, Idiopathic Macular Hole, Macular Hole of Left Eye (Disorder)
- Trial name
- ILM MH (NCT06685328)
- Testing
- minimal posterior pole vitrectomy combined with a sodium hyaluronate gel-covered internal limiting membrane(ILM) flap with balanced saline filling and postoperative supine position, Conventional vitrectomy combined with inner limiting membrane flap flip coverage with sterile air filling and postoperative prone position
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Jie Zhong