Clinical trials: Idiopathic Overactive Bladder
Overactive Bladder
Standard Injections Versus Reduced Injections for Intravesical onabotulinumtoxinA Treatment of Overactive Bladder
OnabotulinumtoxinA is an effective treatment for both idiopathic and neurogenic overactive bladder and was FDA approved for this indication in 2013.
- Trial name
- NCT04020510
- Testing
- onaBoNT-A
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Overactive Bladder, Incontinence, Urge
Noninvasive Spinal Cord Stimulation for Neurogenic and Idiopathic Overactive Bladder
Overactive bladder (OAB) affects 12-30% of the world's population. The accompanying urinary urgency, urinary frequency and incontinence can impair the ability to work, interact in social activities and can result in poor social…
- Conditions
- Overactive Bladder, Incontinence, Urge, Neurogenic Bladder
- Trial name
- NCT03753750
- Testing
- Noninvasive spinal cord stimulation
- Where
- United States
- Sponsor
- University of Southern California
Urinary Bladder, Overactive
Transcutaneous Medial Plantar Nerve Stimulation in Women With Idiopathic Overactive Bladder
The investigators conducted a prospective, randomized double-blind, placebo-controlled study based on a placebo technique to evaluate the efficacy of T-MPNS vs placebo in women with idiopathic OAB.
- Trial name
- NCT06390488
- Testing
- Transcutaneous medial plantar nerve stimulation (T-MPNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Pamukkale University
Idiopathic Overactive Bladder, Electrical Stimulation
Intravaginal Electrical Stimulation in Idiopathic Overactive Bladder
Overactive bladder (OAB) is a symptom complex defined as urgency, with or without urge urinary incontinence (UUI), usually with frequency and nocturia, in the absence of urinary tract infection.
- Conditions
- Idiopathic Overactive Bladder, Electrical Stimulation, Bladder Training
- Trial name
- NCT04389307
- Testing
- Electrical stimulation (IVES), Bladder Training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Pamukkale University
Overactive Bladder, Urge Incontinence
Effects of Transcutaneous and Percutaneous PTNS on Idiopathic OAB
The purpose of this study is to determine if Transcutaneous Tibial Nerve Stimulation (TENS) is as effective as Percutaneous Tibial Nerve Stimulation (PTNS) as therapeutic option for subjects with Idiopathic Overactive Bladder…
- Conditions
- Overactive Bladder, Urge Incontinence, Overactive Detrusor
- Trial name
- NCT02657057
- Testing
- PTNS, TENS SNS
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Instituto Médico Tecnológico SL
Overactive Bladder
Effect of Pelvic Floor Down-training on Women With Idiopathic Overactive Bladder
This study will be conducted to investigate the effect of pelvic floor down-training on women with idiopathic overactive bladder
- Trial name
- NCT06662565
- Testing
- Behavioral modification, Pelvic floor down-training
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Urinary Bladder, Overactive
Comparison of the Efficacy of Perineal and Intravaginal Electrical Stimulation in Women With Idiopathic Overactive Bladder
The investigators conducted a prospective, randomized double-blind, placebo-controlled study based on a placebo technique to evaluate the efficacy of IVES vs perineal ES in women with idiopathic OAB.
- Trial name
- NCT07366918
- Testing
- Intravaginal ES, BT, Perineal ES
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Pamukkale University
Overactive Bladder
Evaluation of the Link Between Bladder Sensation and Changes in Skin Electrical Conductance and Heart Rate.
Measuring sympathetic skin response or heart rate variability can provide an objective biomarker of bladder sensation and its modulation by drug with potential to treat overactive bladder.
- Trial name
- NCT00481728
- Testing
- Tolterodine, Filling cystometry, Intravesical neurostimulation
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Overactive Bladder (OAB)
RELIEVE Study: NT 201 Intravesical Administration Using Vibe System (ViXe Combination Product) for the Treatment of Idiopathic Overactive Bladder
This Phase 2b study is a prospective, multicenter, double blind, randomized, placebo and sham controlled trial to assess the safety, efficacy and dose response of NT 201 delivered by the Vibe System in participants with…
- Trial name
- RELIEVE (NCT07553065)
- Testing
- NT 201 200U and Vibe System, NT 201 300U and Vibe System
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- Vensica Therapeutics Ltd.
Bladder, Overactive
Evaluation of Professional Practices in the Treatment of Refractory Idiopathic Overactive Bladder at the Dose of 50 Units (TOX50IUU)
Considering that the 2013 Hermieu's guidelines differs from the product marketing authorization delivered in November 2014, the primary endpoints is to evaluate life quality by questionnaires at the baseline time, and after two…
- Trial name
- TOX50IUU (NCT04075578)
- Testing
- OnabotulinumtoxinA / Botox®, Allergan Ltd, Irvine, CA, United-States
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Idiopathic Overactive Bladder
Effectiveness of HYPNOsis Masks During Botulinum TOXin Injections in Idiopathic Overactive Bladder(HypnoTox)
Monocenter, prospective, randomized, parallel group study (1:1) evaluating the efficacy of self-hypnosis performed by mask on pain and anxiety in patients receiving botulinum toxin injections in the treatment of idiopathic…
- Trial name
- HypnoTox (NCT05352945)
- Testing
- HyPNOS self-hypnosis mask from DREAMINZZ
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier de Roubaix
Overactive Bladder
Clinical Trial for the Assessment of Safety, Usability and Efficacy of the Vixe Combination for OAB in Female Subjects
The goal of this interventional clinical trial is to assess the safety, usability and initial efficacy of Xeomin and Vibe combination (ViXe) compared to placebo + sham in female subjects with idiopathic Overactive Bladder.
- Trial name
- XAVIER (NCT06345677)
- Testing
- ViXe Xombination
- Where
- 8 sites in Portugal
- Volunteers
- 48 people
- Sponsor
- Vensica Therapeutics Ltd.
Over Active Bladder
Stimulating Percutaneous Array for Urinary Reflex Control (SPARC)
The Confidanz Smart Patch System consists of a Smart Patch containing one transcutaneous gel electrode and one percutaneous microneedle array electrode that sits directly superficial to the posterior tibial nerve.
- Trial name
- NCT07149103
- Testing
- Percutaneous Tibial Nerve Stimulation
- Where
- 2 sites in Australia
- Volunteers
- 40 people
- Sponsor
- Australis Scientific PTY LTD
Overactive Bladder
Study of Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence
The purpose of this study is to assess the safety and effectiveness of botulinum toxin type A (onabotulinumtoxinA) in treating patients with idiopathic overactive bladder with urinary incontinence.
- Trial name
- NCT00910845
- Testing
- onabotulinumtoxinA, normal saline
- Where
- 2 sites in United States, Canada
- Volunteers
- 557 people
- Sponsor
- Allergan
Overactive Bladder
Efficacy and Safety Study of Botulinum Toxin Type-A (Dysport®) in Continent Female Subjects Suffering From Idiopathic Overactive Bladder
The purpose of this study is to determine the optimal dose of botulinum toxin type A injected in the detrusor muscle to improve urinary symptoms, urodynamic parameters and quality of life of continent women suffering from…
- Trial name
- NCT00578097
- Testing
- Botulinum toxin type A
- Where
- 34 sites in Belgium, Czechia and 6 more
- Volunteers
- 81 people
- Sponsor
- Ipsen
Idiopathic Overactive Bladder With Urinary Incontinence
Safety and Tolerability of TAR-302-5018 in Subjects With Idiopathic Overactive Bladder
The purpose of this study is to determine if TAR-302-5018, an investigational drug-delivery system, is safe and tolerable in patients with idiopathic overactive bladder and urinary incontinence.
- Trial name
- NCT03109379
- Testing
- Trospium-Releasing Intravesical System (TAR-302-5018)
- Where
- 12 sites in United States
- Volunteers
- 43 people
- Sponsor
- Taris Biomedical LLC
Urologic Diseases, Overactive Bladder Syndrome
Trigonal vs Non Trigonal Botox Injection in OAB.
The investigators attend to conduct a prospective randomized study to assess safety and efficacy of trigonal-involved vs. trigonal-sparing botox injection technique, quality of life measurement and post-injection anticholinergics…
- Conditions
- Urologic Diseases, Overactive Bladder Syndrome, Quality of Life, Anticholinergic Syndrome
- Trial name
- NCT03533062
- Testing
- botulinum toxin A
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Overactive Bladder Syndrome
TTNS Versus Sham Therapy for Children With iOAB (TaPaS Part I)
Part I of the TaPaS trial forms part of a twofold clinical RCT: Part 1) A prospective RCT comparing the efficacy of transcutaneous tibial nerve stimulation (TTNS) with TTNS sham therapy for children with idiopathic overactive…
- Trial name
- TaPaS (NCT04256876)
- Testing
- TTNS
- Where
- Belgium
- Volunteers
- 6 people
- Sponsor
- University Hospital, Ghent