Clinical trials: Ileal Brake
Obesity, Overweight
The Effect of Different Macronutrients on Ileal Brake Activation
The purpose of this study is to determine whether ileal infusion of casein and sucrose can activate the ileal brake.
- Trial name
- NCT01509469
- Testing
- Casein, Sucrose, Saline
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Eating, Obesity
Repetitive Brake Activation
The appearance of intact macronutrients in the small intestine induces an intestinal brake; a negative feedback mechanism from different parts of the intestine to the stomach, the small intestine and to the central nervous…
- Conditions
- Eating, Obesity, Ileal Brake
- Trial name
- NCT02511366
- Testing
- Ileal infusion of casein, Ileal infusion of tap water
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity, Diabetes Mellitus, Type 2
Slowly Digestible Carbohydrates and the Ileal Brake
The ileal brake is a feedback mechanism controlling stomach-mediated transit of a meal, for which gastric emptying can be used as an indicator.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Appetitive Behavior
- Trial name
- NCT03630445
- Testing
- Isomaltooligosaccharides (IMOs), Xtend® sucromalt, Combination of IMOs and Xtend® sucromalt
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Purdue University
Appetite Regulation
Lipid Encapsulation for Ileal Brake Activation
This study evaluates the ability of encapsulation of orally applied lipids in a yoghurt snack to modify ad libitum food intake and satiety, without GI symptoms.
- Trial name
- NCT03025997
- Testing
- Active yoghurt
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Ileal Brake, Satiety
Location Specific Differences in Intestinal Brake Activation
The appearance of intact macronutrients in the small intestine can result in the activation of an intestinal brake; a negative feedback mechanism from different parts of the intestine to the stomach, the small intestine and to…
- Conditions
- Ileal Brake, Satiety, Overweight, Obesity
- Trial name
- NCT02500069
- Testing
- Casein (in duodenum), Casein (in jejunum), Casein (in ileum)
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Body Weight Decreased
Proof of Concept Study; The Effect of an Encapsulated Nutrient Mixture on Ileal Brake Activation
Intraileal infusion of nutrients results in a reduction in food intake. A previous study by our group showed that both sucrose and casein infusion resulted in an increase in satiety and release of gastrointestinal peptides and a…
- Trial name
- NCT02635659
- Testing
- Encapsulated nutrients
- Where
- Netherlands
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center