Clinical trials: Illness, Critical
Acetaminophen,Mechanical Ventilation,Critically Ill Children
Clinical Efficacy of Acetaminophen in Mechanical Ventilation in Children With New Coronary Pneumonia
Patients were randomized to receive either paracetamol during mechanical ventilation. When patients were randomized to receive paracetamol (40 mg/kg per day in 4 doses), a placebo infusion of normal saline was administered…
- Trial name
- NCT05691088
- Testing
- Paracetamol injection
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Second Clinical Medical College of Jinan University
Medical Device Site Erosion
Nursing Interventions on Prevention Medical Device Related Pressure Injury (MDRPI)
This study aims to assess the effect of implementing nursing interventions on preventing medical device related pressure injury in critically ill patients.
- Trial name
- MDRPI (NCT06513936)
- Testing
- The skin care Bundle, Routine care
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Critically Ill, Extubation
Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity
Little is known about the procedure of extubation of patients admitted in Intensive Care Units (ICU). In particular, effects of tracheal suction during extubation have never been evaluated.
- Conditions
- Critically Ill, Extubation, Intensive Care Unit
- Trial name
- NCT03681626
- Testing
- no tracheal suction, tracheal suction
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Critical Illness, Sars-CoV2
Anxiety and Work Resilience Among Tertiary University Hospital Workers During the COVID-19 Outbreak: An Online Survey
For limiting COVID-19 spreading, the World Health Organisation (WHO) recommended worldwide confinement on 2010. In France, unessential institutions were closed on March 14th and population confinement was decided on March 17th.
- Conditions
- Critical Illness, Sars-CoV2, SARS Pneumonia, Coronavirus Infection
- Trial name
- PSY_CO_CHU (NCT04358640)
- Where
- France
- Volunteers
- 1,784 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Ventilation Modes, Mechanical Ventilation
Effectiveness of Ventilation Modes in Intensive Care: A Comparison of Mandatory Minute Ventilation and Synchronized Intermittant Mandatory Ventilation Using Bioelectrical Impedance Tomography
Synchronized Intermittent Mandatory Ventilation (SIMV) is a commonly used ventilatory mode available in many modern ventilators, frequently applied in intensive care units for patients requiring invasive mechanical ventilation.
- Conditions
- Ventilation Modes, Mechanical Ventilation, Critical Illness, Respiratory Support
- Trial name
- NCT06961227
- Testing
- No investigational intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Harran University
Critical Illness
Decision Support Among Surrogate Decision Makers of the Chronically Critically Ill (INVOLVE)
Each year, millions of Americans are admitted to an intensive care unit (ICU). For more than half of them, ICU admission initiates a cascade of decisions about treatment and end-of-life care.This is particularly the case for…
- Trial name
- INVOLVE (NCT03099746)
- Testing
- INVOLVE, Informational Support, Usual Care
- Where
- United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Clinical Reasoning, Critical Illness
The Effect of Case-Based Education on the Development of Nursing Students' Clinical Reasoning Skills
Aim: This study was conducted to determine the effect of case-based education on the development of clinical reasoning skills of nursing students in critical illnesses.
- Trial name
- NCT05504824
- Testing
- Case-based education
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ankara University
Deep Sedation
Clinical Performance of the Automated Closed-loop Minimum Viable Prototype
The goal of this clinical trial is to evaluate a minimum viable prototype for automated closed-loop administration of propofol in deep sedated patients under invasive mechanical ventilation in the ICU.
- Trial name
- NCT06187545
- Testing
- Minimum viable prototype, Usual care
- Where
- 3 sites in Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chile
Peripheral Perfusion
Assessment of Peripheral Perfusion in the Critically Ill Patient
The purpose of this study is to evaluate PPI as a surrogate for clinical signs of peripheral perfusion in patients in septic shock and after cardiac surgery.
- Trial name
- CRTPPI (NCT02771002)
- Testing
- Peripheral Perfusion index by Carescape Patientenmonitor
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pre-Eclampsia, Critical Illness
Homocysteine in Critically Ill Preeclampsia
Preeclampsia is a disorder characterized by the new onset of hypertension and proteinuria typically presenting after 20 weeks of gestation.
- Trial name
- NCT06413576
- Testing
- homocysteine measurement
- Where
- 2 sites in Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Gram-Positive Bacterial Infections, Nephrotoxicity
Effect of Intermittent Infusion Versus Continuous Infusion of Vancomycin on Kidney Failure in Critically Ill Patients
This is a randomized, controlled multicenter clinical trial. The purpose of this study is to compare the continuous infusion of vancomycin with intermittent infusion regarding the effectiveness to reach the target serum level and…
- Conditions
- Gram-Positive Bacterial Infections, Nephrotoxicity, Sepsis
- Trial name
- ETERNITY (NCT03438214)
- Testing
- Vancomycin Continuous infusion, Vancomycin Intermittent infusion
- Where
- Brazil
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Sedation
Impact of a Nurse Implemented Sedation and Analgesia Algorithm in Surgical Intensive Care Unit
To show that the nurse implementation of a sedation and analgesia algorithm is beneficial to the patient in terms of sedative drugs reduction and thus overall decrease in duration of mechanical ventilation and the morbidity and…
- Trial name
- ALGOSEDA (NCT03186521)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Critical Illness
Evaluation of Oxidative Stress Induced by Iron Injection in Healthy Volunteers and Critical Care Patients
The purpose of this study is to evaluate the pro-oxidant toxicity of iron injections in critically ill patients and in healthy volunteers.
- Trial name
- SOFI (NCT01443624)
- Testing
- critical care patients venofer
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nutrition, Critical Illness
Micronutrients in Critically Ill Patients
Nutritional support is an important component of modern critical care. The practice of vitamin and micronutrient supplementation is variable and official guidelines are not consistent.
- Conditions
- Nutrition, Critical Illness, Vitamin Supplementation
- Trial name
- MiNuCrit (NCT04136119)
- Testing
- questionnaire
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Critical Illness Polyneuromyopathy
Reference Values for Compound Muscle Action Potential Amplitude Obtained by Direct Muscle Stimulation
Direct muscle stimulation (DMS) method is one of the electrodiagnostic methods used in the diagnosis of critical illness myopathy (CIM) and critical illness neuropathy (CIN).
- Trial name
- NCT04227548
- Testing
- needle electromyography
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Adana City Training and Research Hospital
Critical Illness, Delirium in the Intensive Care Unit
Pilot Feasibility Study of a Pragmatic Mixed-Methods Randomized Controlled Trial on a Follow-Up Bundle of Care for ICU Survivors and Caregivers
~80% of ICU survivors experience profound long-term cognitive, physical, and psychiatric impairments known as post-intensive care syndrome (PICS).
- Trial name
- IMPACT-ICU (NCT06681649)
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Queen's University
Heart Defects, Congenital, Critical Illness
Leuven Growing Into Deficit Follow-up Study
The key objective of the Leuven growing-into-deficit (GID) follow-up-study is to test the hypothesis that children with a congenital heart disease (CHD) show more neurocognitive impairment at the second follow-up at 7 years old…
- Conditions
- Heart Defects, Congenital, Critical Illness, Mental Processes, Child
- Trial name
- Leuven-GID (NCT01632813)
- Where
- Belgium
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- KU Leuven
ICU Acquired Weakness
ICU CONNECT: Study Comparing EMG in Healthy Volunteers and ICU Patients.
This study is testing whether a non-invasive nerve monitoring device (TetraGraph) can accurately detect early signs of ICU-acquired weakness by comparing readings from the device with standard nerve conduction/EMG tests done by a…
- Trial name
- ICU CONNECT (NCT07699562)
- Testing
- TetraGraph, Electromyography, Nerve conduction studies
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Autonomic Nervous System Dysfunction in Critically Ill
Transplanted-like Heart in Critical Ill Patients
The purpose of this study is to measure the dysfunction of the autonomic nervous system in modulating the heart rate variability and baroreflex control in critically ill.
- Trial name
- NCT01930669
- Testing
- Gravitational sympathetic stimulus
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Liver Cirrhoses
Indirect Calorimeter Based Study in Patients With Liver Cirrhosis
Part I- Observational study In the first part , investigator would investigate and compare the energy requirements and substrate utilization in healthy subjects and in patients with liver cirrhosis of various etiologies across…
- Trial name
- METALIC (NCT03871894)
- Testing
- Indirect calorimetry based nutritional intervention till patient in ICU(Intensive care unit), Standard and fixed nutritional intervention till patient in ICU
- Where
- India
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India