Clinical trials: Illness, Critical
ICU Delirium, Critical Illness
Exogenous Ketone Supplementation in ICU Delirium
Delirium is a common syndrome in intensive care unit (ICU) patients. Those experiencing delirium may suddenly feel confused, have trouble thinking clearly, struggle to pay attention, or see and hear things that are not real.
- Trial name
- KETONES-ICU (NCT07364162)
- Testing
- Ketone monoester
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Intellectual Disability, Perceptual Disorders
Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood
The purpose of this study is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes.
- Conditions
- Intellectual Disability, Perceptual Disorders, Memory Disorders
- Trial name
- RESTORE-cog (NCT02225041)
- Where
- 31 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Frailty, Critical Illness
Prevalence and Long Term Effects of Frailty in Elderly Intensive Care Patients
The primary aim is to study change of critical frailty scale (CFS) and health related quality of life (EQ-5D-5L) in a long-term follow-up of ICU survivors.
- Trial name
- SkrInt (NCT06012942)
- Where
- 5 sites in Norway
- Volunteers
- 300 people
- Sponsor
- University Hospital of North Norway
Refeeding Syndrome, Syndrome, Refeeding
Refeeding Syndrome in Critically Ill Children
Refeeding syndrome (RFS) is the a metabolic disturbance which occurs as a result of reinstitution of nutrition in people who are starved, severely malnourished, or metabolically stressed because of severe illness.
- Trial name
- NCT06583928
- Volunteers
- 54 people
- Sponsor
- Assiut University
Critical Illness
The ICALIC International Multicentric Study
This study will evaluate the ease of use of the new calorimeter (Q-NRG (COSMED, Italy)) in intensive care unit (ICU) patients compared to currently used calorimeters (i.e.
- Trial name
- ICALIC (NCT02796430)
- Testing
- Time needed to start indirect calorimetry measurement, Indirect calorimetry measurement
- Where
- 7 sites in Austria, Belgium and 4 more
- Volunteers
- 272 people
- Sponsor
- University Hospital, Geneva
Ventilator-Associated Pneumonia, Severe Pneumonia
Fiberoptic Bronchoscopy in Severe Ventilator-associated Pneumonia
This randomized controlled trial evaluated the clinical effect of fiberoptic bronchoscopy in the management of adult patients with severe ventilator-associated pneumonia (VAP).
- Conditions
- Ventilator-Associated Pneumonia, Severe Pneumonia, Critical Illness
- Trial name
- NCT07149909
- Testing
- Other (Conventional Therapy), Fiberoptic Bronchoscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Obstetric Complication, Lung Injury, Acute
Lung Ultrasound to Detect Pulmonary Complications in Critically Ill Parturients
This study aims at describing the frequency, timing and type of pulmonary complications detected with lung ultrasound in critically-ill parturients in admitted to a high-dependency unit in Freetown, Sierra Leone.
- Conditions
- Obstetric Complication, Lung Injury, Acute, Pulmonary Disease, Acute Respiratory Distress Syndrome
- Trial name
- LUSIP (NCT03828630)
- Where
- Sierra Leone
- Volunteers
- 168 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Secondary Hypothyroidism
Thyroid Function in Critically Ill Patients With Acute Kidney Injury
The objective of this study was to assess the changes in thyroid hormones and its activity during CRRT in patients with Acute Kidney Injury.
- Trial name
- NCT04767763
- Testing
- Assessment of TSH, fT3, fT4,TRH, TT3, TT4, rT3 in patients with CVVHDF
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- Medical University of Gdansk
Pharmacokinetics, Sedation
Pharmacokinetics of Dexmedetomidine During Prolonged Infusion in ICU
The study will examine dexmedetomidine levels in the blood of critically ill intensive care patients to understand how it is broken down by the body.
- Trial name
- DEX PK (NCT00747721)
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 13 people
- Sponsor
- Orion Corporation, Orion Pharma
CGM, Intensive Care (ICU)
Evaluate the Performance of the Dexcom G7 Continuous Glucose Monitoring (CGM) System in Critically Ill Patients Undergoing Major Abdominal Surgery and Solid Organ Transplantation Which Require Blood Glucose Monitoring for Intensive Insulin Therapy.
Main objective: The goal is to to determine the accuracy of Dexcom G7 Continuous glucose monitor system in critically ill patients, undergoing major abdominal surgery and solid organ transplantation, in the intensive care unit.
- Conditions
- CGM, Intensive Care (ICU), Liver Transplant Surgery, Solid Organ Transplantation
- Trial name
- DREAM-ICU (NCT07611721)
- Testing
- Continuous glucose monitor
- Where
- Czechia
- Volunteers
- 62 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Sepsis, Septic Shock
Ultrasound-guided Blood Sampling Drawing for Microbiological Analysis in the Critically Ill
This study will test the feasibility of ultrasound-guided sterile blood sampling for critically ill patients with suspected sepsis requiring blood culture.
- Conditions
- Sepsis, Septic Shock, Infections, Diagnosis
- Trial name
- ECOVEN (NCT06156072)
- Testing
- Ultrasound-guided venipuncture
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gastrointestinal Manifestations in Critically Ill Children
Gastrointestinal Manifestations in Critically Ill Children Admitted in PICU of Children's Hospital Assuit University
Gastrointestinal complications are common in critically ill children. GIC are commonly observed, as either a primary reason for admission or as a part of multiple organ dysfunction syndromes MODS in children admitted in the…
- Trial name
- NCT06235528
- Volunteers
- 83 people
- Sponsor
- Assiut University
Anemia, Iron Deficiency, Anemia of Chronic Disease
Anemia of Inflammation and Deficiency Anemia
Critical patients which requiring admission to intensive care (IT) are a special group of patients. In these patients the prevalence of anemia reported in studies is 75%.
- Trial name
- AIDA (NCT04071067)
- Where
- 2 sites in Romania
- Volunteers
- 1,000 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Status Epilepticus
Status Epilepticus in the Critically Ill Patients
Convulsive and Non Convulsive Status Epilepticus (SE) and Pseudo Status Epilepticus prospective registry. Data collection using a standardized form : demographic data and data related to the SE, including circumstances of onset…
- Trial name
- NCT03457831
- Where
- 20 sites in France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ictal Group
Critical Illness, Geriatric Assessment
Geriatric Assessment at Discharge From the Intensive Care Unit in Patients Aged 75 Years and Older: a Feasibility Study
The number of patients aged over 75 continues to grow, and, according to INSEE, will represent almost 10% of the French population in 2021, an increase of 2.4 points since 2000.
- Conditions
- Critical Illness, Geriatric Assessment, Older People, Frailty
- Trial name
- PreGEDI (NCT06513130)
- Testing
- Geriatric assessment in the 7 days following ICU discharge., No geriatric assessment in the 7 days following ICU discharge.
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Strasbourg, France
Cognitive Impairment, Apolipoprotein E, Deficiency or Defect of
Perioperative Research Into Memory, Genomics in the Intensive Therapy Unit: Alzheimer's
The current central dogma of long-term cognitive impairment after intensive care admission suggests an underlying neuroinflammatory dysregulation affecting neuronal function.
- Conditions
- Cognitive Impairment, Apolipoprotein E, Deficiency or Defect of, Critical Illness, Burns
- Trial name
- PRIMoGenITA (NCT03393130)
- Testing
- APOE genotyping
- Volunteers
- 150 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Respiration, Artificial, Critical Illness
Development of a Rehabilitation Strengthening and Mobility Program for Ventilator Dependent Older Patients
As the general population ages and technology advances, many who suffer from catastrophic critical illness (i.e. septic shock, respiratory failure, Acute Respiratory Disease Syndrome) survive only to find themselves severely…
- Conditions
- Respiration, Artificial, Critical Illness, Chronic Disease, Exercise Therapy
- Trial name
- NCT03195127
- Testing
- multimodal physical therapy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Maryland, Baltimore
Severe Sepsis
Glutamine Supplementation in Critically Ill Patients With Severe Sepsis
Severe sepsis is a common condition with high mortality and morbidity. A previous meta-analysis has demonstrated the safety of glutamine supplementation with suggestion of mortality and morbidity benefits in critically ill…
- Trial name
- CGH-GLU (NCT03048994)
- Testing
- Glutamine
- Where
- Singapore
- Volunteers
- 39 people
- Sponsor
- Changi General Hospital
Delirium
Brief Delirium Assessments in Non-Intensive Care Unit (ICU) Patients
Delirium is an acute confusional state characterized by fluctuating mental status, inattention, and either disorganized thinking or an altered level of consciousness.
- Trial name
- NCT01162369
- Where
- 2 sites in United States
- Sponsor
- Vanderbilt University Medical Center
Hypokalemia, Intensive Care Unit (ICU)
Management of Hypokalemia in Intensive Care Patients
Hypokalemia is a common electrolyte disorder in critically ill patients and may contribute to substantial morbidity and mortality if inadequately managed.
- Conditions
- Hypokalemia, Intensive Care Unit (ICU), Intensive Care Unit (ICU) Patients
- Trial name
- NCT07833722
- Testing
- Implementation of hypokalemia treatment algorithm
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Anadolu University
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