Clinical trials: Illness, Critical
COVID-19 Pandemic, ICU
Chronic Pain in COVID-19 Patients Discharged From Intensive Care Unit
More than six million French were affected by SARS-COV2 epidemic. About 20% of infected peoples were hospitalized, and about 5% were admitted to the intensive care units (ICU) for severe SARS-COV2 acute respiratory distress…
- Conditions
- COVID-19 Pandemic, ICU, Pain, Chronic, Post Intensive Care Unit Syndrome
- Trial name
- NCT04940208
- Testing
- Pain and neuropsychological questionnaires, Quantitative Sensory testing
- Where
- 3 sites in France
- Volunteers
- 143 people
- Sponsor
- Mikhail Dziadzko, MD, PhD
Intensive Care Unit Syndrome
High Protein Intake in Critically Ill Ventilated Patients
This prospective interventional randomized control study was conducted on forty patients with respiratory failure; all patients were intubated and mechanically ventilated for at least three days.
- Trial name
- NCT04977440
- Testing
- Whey protein
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Critical Illness
Assessment of Hemodynamic Responses at Adequate Depth of Anesthesia Using Bispectral Index During Rapid Sequence Intubation in the Emergency Department
Rapid sequence intubation (RSI) is the standard approach for emergency airway management in critically ill patients requiring endotracheal intubation.
- Trial name
- NCT07722897
- Testing
- Bispectral Index (BIS) Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Akdeniz University Hospital
Critical Illness, Post Intensive Care Unit Syndrome
pEEG Monitoring Effect on Delirium, Ventilator Days, and PICS
The goal of this multi-site observational study is to compare delirium rates, days on mechanical ventilation, and Post Intensive Care Syndrome (PICS) rates in adult Intensive Care Unit (ICU) patients.
- Conditions
- Critical Illness, Post Intensive Care Unit Syndrome, Post Intensive Care Syndrome, Mechanical Ventilation Complication
- Trial name
- NCT06019078
- Testing
- SedLine
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Fraser Health
Critical Illness, Discomfort
Discomfort in Intensive Care Patients - IPREA-N
The purpose of this study is to investigate discomforts experienced by intensive care patients during their critical illness period.
- Trial name
- NCT06091046
- Volunteers
- 250 people
- Sponsor
- Oslo University Hospital
Critical Illness, Palliative Care
Improving Needs Among Older Adults
Millions of older adults receive care in intensive care units (ICUs) annually. However, the quality and accessibility of ICU-based palliative care is highly variable across hospitals and clinicians, due in part to specialists'…
- Conditions
- Critical Illness, Palliative Care, Older Adults, Informal Caregivers
- Trial name
- ICUconnect 2 (NCT06588556)
- Testing
- ICUconnect, Usual care
- Where
- 4 sites in United States
- Volunteers
- 350 people
- Sponsor
- Duke University
Weaning Failure, Fluid Overload
Fluid unLoading On Weaning (FLOW)
The purpose of this study is to determine if testing preload responsiveness, the normal physiologic state that means that changes in preload determine changes in cardiac output, allows an earlier and physiologically safer weaning…
- Conditions
- Weaning Failure, Fluid Overload, Cardiac Failure Acute
- Trial name
- FLOW (NCT04496583)
- Testing
- Fluid depletion strategy
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Obesity, Obesity With Complications
Prevalence, Determinants and Consequences of Dyspnea During Weaning in Critically Ill Obese Patients
ICU patients encounter numerous discomforts, with dyspnea (the sensation of breathlessness) being among the most distressing and impactful.
- Conditions
- Obesity, Obesity With Complications, Weaning From Mechanical Ventilation in Care Unit, Dyspnea
- Trial name
- WEAN OBESE (NCT06867354)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury, Sepsis
Phosphate-Containing Replacement Fluid for Patients Undergoing CRRT
Brief Summary: Evaluating a New Phosphate-Containing Fluid for Blood Purification (CRRT) Why is this study being done? Patients in the Intensive Care Unit (ICU) often need a treatment called Continuous Renal Replacement Therapy…
- Conditions
- Acute Kidney Injury, Sepsis, Critically Ill Patients Requiring Continuous Renal Replacement Therapy
- Trial name
- PHOS-CRRT (NCT07550894)
- Testing
- Phosphate-containing Replacement Fluid, Standard Phosphate-free Replacement Fluid
- Where
- 15 sites in China
- Volunteers
- 220 people
- Sponsor
- Sun Yat-sen University
Sepsis
Procalcitonin-Guided Antimicrobial Discontinuation
The current study aims to validate the diagnostic use of PCT assessing its capability to individualize and shorten the duration of antibiotic therapy in critically ill patients with suspected or confirmed sepsis.
- Trial name
- NCT00250666
- Testing
- PCT measurement
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Geneva
Respiratory Failure
Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial
The use of a written, pre-procedure checklist and positioning the patient with the head of the bed elevated have been proposed as interventions capable of preventing complications during non-elective intubation and are used…
- Trial name
- Check-UP (NCT02497729)
- Testing
- Written Checklist, Head of Bed Up
- Where
- 5 sites in United States
- Volunteers
- 260 people
- Sponsor
- Vanderbilt University
Critically Ill Patients
Correlation Between Intestinal Blood Flow and Intestinal Dysfunction in Critically Ill Patients
Currently in the field of critical care, altered intestinal blood flow in critically ill patients has been a hot research topic in recent years.
- Trial name
- NCT06049979
- Testing
- Acute gastrointestinal injury
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Bronchoalveolar Lavage Fluid, Sensitivity and Specificity
Aspergillosis Detection Via EBC-GM in Ventilated Patients
Brief Research Proposal: Non-Invasive Detection of Invasive Pulmonary Aspergillosis in ICU Patients Background: Invasive Pulmonary Aspergillosis (IPA) is a critical threat to patients in ICUs, especially those undergoing…
- Conditions
- Bronchoalveolar Lavage Fluid, Sensitivity and Specificity, Critical Illness, Respiration Failure
- Trial name
- NCT06333379
- Testing
- Compare the levels of Galactomannan (GM) levels in exhaled breath condensate (EBC) and BALF
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Lin Chen
Gastrointestinal Dysfunction, Critical Illness
Effect of Different Feeding Method on Gastrointestinal Function of Critical Patients
The intestine is the most vulnerable target organ in septic patients and is the first to be damaged organ in multiple organ dysfunction syndrome(MODS).Therefore, improving intestinal motility and mucosal barrier function is…
- Conditions
- Gastrointestinal Dysfunction, Critical Illness, Nutrition Disorders
- Trial name
- DFM-GFC (NCT04224883)
- Testing
- Continuously feeding, 16-hours feeding, intermittent feeding
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Critically Ill Patients
Disease Severity, Mortality Risk, and Muscle Function in Intensive Care Unit Patients
Intensive Care Units are specialized, technologically advanced hospital units that provide continuous monitoring and care from multiple healthcare disciplines for patients who are critically ill and face a high risk of death or…
- Trial name
- NCT07124442
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istinye University
ICU Survivors
Integrated Recovery Program for Critical Illness
This study aims to investigate the effects of the Integrated Critical Illness Aftercare and Recovery Enhancement (I-CARE) program on reducing healthcare burden and improving functional outcomes in ICU survivors.
- Trial name
- iCARE (NCT06997822)
- Testing
- LINE Bot-Based Remote Care Combined with In-Person Post-ICU Clinic
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- National Taiwan University Hospital
Weakness Acquired in the ICU, Muscle Wasting
Muscle and Subcutaneous Tissue Variation by Ultrasound and Impedance Linked to Fluid Balance in ICU Patients
This cross-sectional study aims to investigate the relationship between variations in muscle thickness and subcutaneous tissue, measured by ultrasound, and fluid compartments, evaluated using bioelectrical impedance analysis…
- Conditions
- Weakness Acquired in the ICU, Muscle Wasting, Edema, Fluid Overload
- Trial name
- NCT06697470
- Testing
- Ultrasound and Bioelectrical Impedance Analysis for Muscle Thickness and Fluid Balance Assessment Translation
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Dr F Duprez
Investigation Time
Comparison of Two Endoscopically Placed Nasojejunal Probes
A direct application of jejunal tube feeding is necessary especially in patients with gastroparesis due of existing diabetes mellitus, postoperative or severe underlying disease.
- Trial name
- NCT02705027
- Testing
- Freka®-Trilumina versus Freka®-EasyIn
- Where
- 2 sites in Germany
- Volunteers
- 64 people
- Sponsor
- Ruhr University of Bochum
Traumatic Brain Injury
TBI-Prognosis Multicenter Prospective Study
Severe traumatic brain injury (TBI) is the leading cause of death and disability among people under 45 years of age and a major public health problem.
- Trial name
- NCT02452541
- Testing
- Prognostic tests
- Where
- 17 sites in Canada
- Volunteers
- 315 people
- Sponsor
- CHU de Quebec-Universite Laval
Respiratory Failure
Mode Of Ventilation During Critical IllnEss Pilot Trial
Landmark trials in critical care have demonstrated that, among critically ill adults receiving invasive mechanical ventilation, the use of low tidal volumes and low airway pressures prevents lung injury and improves patient…
- Trial name
- MODE (NCT05563779)
- Testing
- Volume Control mode, Pressure Control mode, Adaptive Pressure Control mode
- Where
- United States
- Volunteers
- 566 people
- Sponsor
- Vanderbilt University Medical Center
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