Clinical trials: Illness, Critical
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension
Patients with cirrhosis patients have a high incidence of sepsis which can trigger decompensation and may result in prolonged hospital stay and increased mortality.
- Conditions
- Cirrhosis, Liver, Acute-On-Chronic Liver Failure, Shock, Septic, Shock Hypovolemic
- Trial name
- NCT05441878
- Testing
- 20% albumin, Balanced salt solution
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
COVID-19, Critical Illness
Analysis of Mortality of Critically Ill Patients With COVID-19
The recent pandemic of the COVID-19 disease has caused a national health emergency due to its severity and the clinical and social consequences of the disease. Crude mortality in Spain is 9.2%.
- Conditions
- COVID-19, Critical Illness, Effectiveness, Outcome, Fatal
- Trial name
- NCT04379258
- Where
- Spain
- Volunteers
- 868 people
- Sponsor
- Hospital Universitario Getafe
Gastroparesis
Nutritional Adequacy Therapeutic Enhancement in the Critically Ill. The NUTRIATE Study
This is a multi-center, parallel group, placebo-controlled and active-compared, randomized study to assess the ability of GSK962040 to enhance the delivery of enteral feed to critically ill subjects that are predisposed to…
- Trial name
- NCT01934192
- Testing
- GSK962040 50 mg, Metoclopramide 10 mg
- Where
- 19 sites in United States, Australia and 1 more
- Volunteers
- 91 people
- Sponsor
- GlaxoSmithKline
Metabolic Acidosis
Meglimine Sodium Succinate for Correction of Metabolic Acidosis in Critically Ill Patients
An acid-base imbalance, called metabolic acidosis (acid-base disorder lasting from several minutes to several days, caused by a decrease in serum bicarbonate ion (HCO3) concentration), is often observed in critically ill patients…
- Trial name
- NCT05147051
- Testing
- Meglumine Sodium Succinate
- Where
- 6 sites in Russia
- Volunteers
- 140 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Critically Ill Children
Evaluating Processes of Care & the Outcomes of Children in Hospital (EPOCH)
The purpose of this study is to evaluate the impact of Bedside Paediatric Early Warning System (Bedside-PEWS) on early identification of children at risk for near and actual cardiopulmonary arrest, hospital mortality, processes…
- Trial name
- EPOCH (NCT01260831)
- Testing
- Implementation of Bedside Paediatric Early Warning System, Hospital Standard of Care
- Where
- 22 sites in Belgium, Canada and 5 more
- Volunteers
- 144,539 people
- Sponsor
- The Hospital for Sick Children
Hypoglycaemia
Mechanisms of Insulin Resistance in Critical Illness: Role of Systemic Inflammation and GLP-1
The purpose of this study is to determine the role of inflammation and the insulin regulating hormone GLP-1 during critical illness.
- Trial name
- NCT01347801
- Testing
- GLP-1, TNF-alfa, OGTT
- Where
- 2 sites in Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obstetric Complication, Gynecologic Cancer
Lung Ultrasound in Critically Ill Obstetrics and Gynecological Patients
Pulmonary dysfunction aggravates the illness of critically ill obstetrics and gynecological patients. Early identification with bedside technique and prompt management may improve the outcome of critical care in this vulnerable…
- Conditions
- Obstetric Complication, Gynecologic Cancer, Lung Diseases, Ultrasound
- Trial name
- POLUS (NCT06728709)
- Testing
- ultrasound detection of any abnormal ultrasonographical findings.
- Where
- Egypt
- Volunteers
- 280 people
- Sponsor
- Ain Shams University
SARS-CoV-2, Covid19
Pathological Findings of Fatal COVID-19
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new coronavirus discovered in December 2019 in Wuhan, China and currently responsible of a worldwide outbreak and the death of more than 55,000 patients in…
- Conditions
- SARS-CoV-2, Covid19, Pathology, Intensive Care Units
- Trial name
- HISTOCOVID (NCT04675281)
- Testing
- 2 post-mortem transcutaneous lung biopsies (1 anterior ; 1 posterior) using anatomical landmarks
- Where
- 44 sites in France
- Volunteers
- 170 people
- Sponsor
- Nantes University Hospital
Light Sedation, Mechanical Ventilation
Long-term Sedation With Remimazolam Besylate in Critically Ill Patients
A randomized non-inferior trial comparing remimazolam besylate with propofol for long-term sedation during invasive mechanical ventilation in critically ill patients
- Trial name
- LOSREB (NCT05555667)
- Testing
- Remimazolam besylate, Propofol
- Where
- China
- Volunteers
- 728 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Critical Illness
Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU
Renal dysfunction is a frequent complication in patients admitted to intensive care units (ICUs), associated with high morbidity and mortality.
- Trial name
- NOVA-AKI (NCT06547892)
- Testing
- Vasopressin, 0,9% saline solution
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital do Coracao
Severe Sepsis
Zinc Therapy in Critical Illness
Sepsis is a clinical syndrome often caused by a bloodstream infection that results in a common set of symptoms termed systemic inflammatory response syndrome (SIRS).
- Trial name
- NCT01162109
- Testing
- Zinc sulfate
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Corona Virus Infection, Critical Illness
The Change of Critical Patient Managements and Subsequent Influences Under Epidemic of Coronavirus Disease 19 (COVID-19)
In the ER of National Taiwan University Hospital, the critical patients are treated (including tracheal intubation and cardiopulmonary resuscitation) in either resuscitation area or negative pressure isolation rooms based on the…
- Trial name
- NCT04479332
- Testing
- Tracheal intubation and cardiopulmonary resuscitation
- Where
- Taiwan
- Volunteers
- 198 people
- Sponsor
- National Taiwan University Hospital
Effect of RBC Transfusions on Cerebral Oxygen Saturation
Monitoring the Effect of Red Blood Cell Transfusion on Cerebral Oxygen Saturation With Near Infrared Spectroscopy (NIRS) in Critically Ill Patients
Critically ill patients are frequently transfused with red blood cell (RBC) units with the predominant intention to increase arterial oxygen content and thus oxygen delivery to the tissues.
- Trial name
- NCT02232412
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Respiratory Failure, Tracheostomy Complication
Expert-Guided Early Tracheostomy Pathway
The optimal timing of tracheostomy insertion remains uncertain. We hypothesized that a clinical pathway including expert-informed risk assessment regarding predicted duration of mechanical (MV) would enhance the effectiveness of…
- Trial name
- NCT05595707
- Testing
- Expert-Guided Early Tracheostomy
- Where
- Jordan
- Volunteers
- 104 people
- Sponsor
- Denver Health and Hospital Authority
Critically Ill Patients
Ultrasound Assessment of Residual Gastric Content in Critically Ill Patients
This prospective observational study aims to assess whether ultrasound assessment of gastric content may be useful for the monitoring of the gastric residual content in critically ill patients
- Trial name
- GastrICU (NCT03205592)
- Testing
- Ultrasound examination of the antrum
- Where
- 3 sites in France
- Volunteers
- 61 people
- Sponsor
- Hôpital Edouard Herriot
Cardiac Output, Critically Ill
Arterial Tone Influence on Cardiac Output Measured by PRAM
This study evaluates the role of arterial tone in the accuracy of cardiac output (CO) measurement by Pressure Recording Analytical Method (PRAM).
- Trial name
- NCT03900546
- Testing
- MostCare
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- Università Politecnica delle Marche
Critical Illness, Metabolism Disorders
Blood-Interstitial Fluid Glucose Gap
Metabolic monitoring is fundamental to guiding nutritional therapy in critically ill patients. Although indirect calorimetry is the established gold standard for measuring resting energy expenditure, its routine clinical use is…
- Trial name
- NCT07240103
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Chinese Medical Association
Critical Illness, Catheter-Related Infections
Efficacy and Safety of Peripherally Inserted Central Venous Catheters
Central venous access is critical for administering intravenous medications, parenteral nutrition, and fluid therapy in intensive care units (ICUs).
- Conditions
- Critical Illness, Catheter-Related Infections, Upper Extremity Deep Vein Thrombosis, Catheter Obstruction
- Trial name
- NCT07834996
- Volunteers
- 60 people
- Sponsor
- Assiut University
Vitamin D Deficiency, Sarcopenia
Effect of Vitamin D3 Supplementation on Muscle Mass in ICU Patient
A randomized double blind placebo control trial study will be conducted in critically ill patients with vitamin D deficiency. Investigator aimed to study the effect of oral vitamin D3 supplementation, compare to placebo, on…
- Conditions
- Vitamin D Deficiency, Sarcopenia, Critical Illness
- Trial name
- NCT02594579
- Testing
- Vitamin D3
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Central Venous Pressure
Central Venous Pressure (CVP) Assessment by Ultrasound and Physical Examination
Ultrasound may be useful for noninvasively determining the central venous pressure. We intend to compare the clinical examination of the neck veins; ultrasound delineation of the internal jugular vein; and the central venous…
- Trial name
- NCT01099241
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Iowa
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