Clinical trials: Illness, Critical
Respiratory Failure, Critical Illness
Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation
Sedation is frequently required in critically ill patients admitted to the intensive care unit (ICU), including those receiving non-invasive respiratory support such as high-flow nasal cannula (HFNC), non-invasive ventilation…
- Trial name
- CALM-ICU (NCT07536750)
- Where
- China
- Volunteers
- 1,680 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Delirium, Trauma
Early Delirium Prediction Via Serial EEG Trajectories and Machine Learning
The goal of this observational study is to develop a machine learning model that can predict delirium in trauma patients before it clinically appears.
- Conditions
- Delirium, Trauma, Brain Dysfunction, Critical Illness
- Trial name
- NCT07536854
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Ajou University School of Medicine
Respiratory Failure, Critical Illness
Double Triggering Asynchrony in Mechanically Ventilated Patients.
This observational study examined double triggering asynchrony in28ICU patients on mechanical ventilation. Researchers collected data on patient characteristics, health conditions, and outcomes to understand how this problem…
- Conditions
- Respiratory Failure, Critical Illness, Mechanical Ventilation
- Trial name
- NCT07380607
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Mansoura University
Critical Illness, Recovery Outcomes
UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping.
Persistent Critical Illness (PCI) is a condition that affects some patients who remain in the Intensive Care Unit (ICU) for a long time, usually more than 10-14 days. It is estimated to occur in 5-20% of critically ill patients.
- Conditions
- Critical Illness, Recovery Outcomes, Critical Care, Intensive Care, Critical Care
- Trial name
- UPSt_UCI (NCT07510776)
- Where
- 7 sites in Portugal
- Volunteers
- 7,000 people
- Sponsor
- Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa
Post-Intensive Care Syndrome (PICS), Critical Illness Recovery
Integrated Rehabilitation in HDU for Post-Intensive Care SyndromeLiberation in Patients With PICS
Post-intensive care syndrome (PICS) is characterized by persistent physical, cognitive, and psychological impairments among survivors of critical illness.
- Conditions
- Post-Intensive Care Syndrome (PICS), Critical Illness Recovery, Mechanical Ventilation
- Trial name
- NCT07521540
- Testing
- Integrated Multidisciplinary Rehabilitation
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Hongying Jiang, MD
Cardiac Surgery Associated - Acute Kidney Injury, Critical Illness
Prognostic Value of Metabolic Characteristics in High-Risk Populations for Acute Kidney Injury After Cardiac Surgery
This project aims to explore the metabolic characteristics of adverse renal outcomes in high-risk populations after cardiac surgery by using multi-omics techniques, in order to understand the metabolic changes in patients during…
- Trial name
- NCT07521787
- Testing
- Standard care "bundle"
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Shanghai Zhongshan Hospital
Critical Illness, Enteral Nutrition Intolerance
Predictive Value of Gastrointestinal Blood Flow for Enteral Nutrition Intolerance in Critically Ill Patients
This study aims to explore the correlation between gastrointestinal blood flow and the incidence of enteral nutrition intolerance (ENI) and its symptoms in critically ill patients, construct and compare predictive models…
- Conditions
- Critical Illness, Enteral Nutrition Intolerance, Enteral Nutrition Feeding, Prediction Models
- Trial name
- NCT07521111
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Fibrinolytic Defect, Sepsis
Point of Care Evaluation of Fibrinolysis in Sepsis
Impaired fibrinolysis in septic patients is associated with worse outcome. The present study investigates fibrinolysis shutdown in septic patients, defined as prolonged ClotPro® TPA lysis time at 30 minutes.
- Conditions
- Fibrinolytic Defect, Sepsis, Critical Illness
- Trial name
- POCEFIS (NCT06312488)
- Testing
- Clot Pro
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Pediatrics, Intensive Care Unit
Asia Pediatric Intensive Care Epidemiology and Outcomes Study
The overall objective of this study is to improve the standard of care of critically ill pediatric patients. The specific aims are to describe the clinical profile and outcomes of all admissions to Asian pediatric ICUs, determine…
- Conditions
- Pediatrics, Intensive Care Unit, Critical Illness
- Trial name
- AsiaPedIC (NCT06481644)
- Where
- 2 sites in Singapore, Thailand
- Volunteers
- 10,000 people
- Sponsor
- KK Women's and Children's Hospital
Heart Arrest, Out-Of-Hospital, Wounds and Injuries
Pediatric Prehospital Airway Resuscitation Trial
This study is a Phase 3, multi-center, Bayesian Adaptive Sequential Platform Trial testing the effectiveness of different prehospital airway management strategies in the care of critically ill children.
- Conditions
- Heart Arrest, Out-Of-Hospital, Wounds and Injuries, Respiratory Insufficiency in Children, Child, Only
- Trial name
- Pedi-PART (NCT06364280)
- Testing
- BVM, SGA, ETI
- Where
- 10 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Ohio State University
Pre-Eclampsia, Critical Illness
Homocysteine in Critically Ill Preeclampsia
Preeclampsia is a disorder characterized by the new onset of hypertension and proteinuria typically presenting after 20 weeks of gestation.
- Trial name
- NCT06413576
- Testing
- homocysteine measurement
- Where
- 2 sites in Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Wound Heal, Critical Illness
Medical Honey for Wound Treatment in Intensive Care. (MICARéa) Randomized, Controlled, Single-center Pilot Study.
Wound management is a real public health issue in France. To date, a wide range of devices exists to treat these wounds, depending on their nature and stage of evolution.
- Trial name
- MICAREA (NCT06150326)
- Testing
- medical honey Activon® 25g Tube, standard of care
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Anaemia
ScvO2-Centered Optimisation of RED Blood Cell Transfusions
This clinical trial aims to personalise red blood cell transfusion strategies in the crtitically ill patients. The amount of transfusions needs to be minimised in order to prevent adverse events and organ dysfunctions linked to…
- Trial name
- SCORED (NCT07509203)
- Testing
- Measurement of central venous saturation
- Where
- 2 sites in Hungary
- Volunteers
- 600 people
- Sponsor
- Semmelweis University
Acute Kidney Injury
PREVENTion With Sglt-2 Inhibition of Acute Kidney Injury in Intensive Care
Background Acute Kidney Injury (AKI) is a potentially life-threatening condition caused by unsafe levels of fluid and waste products accumulating in the body.
- Trial name
- PREVENTS-AKI (NCT05468203)
- Testing
- Dapagliflozin 10mg Tab
- Where
- 3 sites in Australia
- Volunteers
- 51 people
- Sponsor
- The George Institute
Acute Respiratory Failure
Randomized Trial of Sedative Choice for Intubation
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death.
- Trial name
- RSI (NCT05277896)
- Testing
- Ketamine, Etomidate
- Where
- 6 sites in United States
- Volunteers
- 2,367 people
- Sponsor
- Vanderbilt University Medical Center
Sedation, Critical Illness
Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patients
This randomized clinical trial evaluates the effects of a musical intervention on hormonal and inflammatory biomarkers in sedated adult patients undergoing invasive mechanical ventilation in an intensive care unit.
- Conditions
- Sedation, Critical Illness, Respiration, Artificial, Inflammation
- Trial name
- NCT06120660
- Testing
- Music Therapy
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- University of Oviedo
Mechanical Ventilation, Critical Illness
Neuromuscular Electrical Stimulation in a Patient on Invasive Mechanical Ventilation (MOVCARE)
This clinical study aims to compare the effects of conventional physical therapy alone versus conventional physical therapy combined with neuromuscular electrical stimulation (NMES) in patients admitted to the ICU and undergoing…
- Conditions
- Mechanical Ventilation, Critical Illness, Intensive Care Unit Patients, Muscle Weakness Condition
- Trial name
- MOVCARE (NCT07188350)
- Testing
- Conventional Physical Therapy, Neuromuscular Electrical Stimulation (NMES)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital Moinhos de Vento
Critical Illness, Sepsis
Systemic Immune-Inflamation Index and Mortality in ICU Patients
Systemic Immune-Inflammation Index (SII) is a hemogram-derived biomarker reflecting the balance between systemic inflammation and immune response.
- Trial name
- NCT07493759
- Testing
- Systemic Immune-Inflammation Index (SII)
- Where
- Turkey (Türkiye)
- Volunteers
- 570 people
- Sponsor
- Ataturk University
Delirium
Melatonin for Treatment of Delirium in Critically Ill Adult Patients
The purpose of this study is to determine the feasibility of conducting a randomized controlled trial (RCT) with melatonin for treatment of delirium in critically ill adult patients.
- Trial name
- DELIRE-ICU (NCT05713877)
- Testing
- Melatonin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Circadian Dysrhythmia, Sleep Disturbance
PICU-related Sleep and Circadian Dysregulation Pilot Study
A single center pilot trial investigating the feasibility of using actigraphy and salivary melatonin levels to measure the sleep and circadian rhythm of critically ill children aged 3 to 6 years old.
- Conditions
- Circadian Dysrhythmia, Sleep Disturbance, Critical Illness, Children, Only
- Trial name
- NCT06505447
- Testing
- Daytime light exposure, Daytime restricted feeding
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo