Clinical trials: Illness, Critical
Critically Ill Patients
Influence of Tightly Glucose Control on Hyperglycemic Toxicity and Protein Catabolism in Critically Ill Patients
To compare the differences of urinary nitrogen excretion, nitrogen balance and clinical outcomes between tightly insulin therapy and conventional insulin therapy in the ICU.
- Trial name
- NCT01227148
- Testing
- Tightly glucose control, Conventional glucose control
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Critical Illness, Invasive Candidiasis
Pharmacokinetics of Micafungin in Critically Ill Patients
A study of micafungin in ICU versus non-ICU patients showed a significantly lower treatment success in ICU patients compared with non-ICU patients.
- Trial name
- NCT01716988
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- University Medical Center Groningen
Mechanical Ventilation
Optimization of Serum Phosphorus Level and Weaning From Mechanical Ventilation
The goal of this clinical trial is to test the impact of serum phosphorus level optimization on weaning from mechanical ventilation in adult ICU patients in Alexandria University Hospitals.
- Trial name
- NCT05682846
- Testing
- Sodium glycerophosphate pentahydrate solution
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Alexandria University
Critical Illness, Cancer
Mean Platelet Volume (MPV) as an Early Predictor of Mortality in Intensive Care Patients With Cancer
This study aims to investigate whether Mean Platelet Volume (MPV) and other blood count parameters measured at admission can predict mortality in cancer patients admitted to the intensive care unit (ICU).
- Conditions
- Critical Illness, Cancer, Mortality
- Trial name
- MPV-CICU (NCT07656311)
- Where
- Turkey (Türkiye)
- Volunteers
- 425 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Critical Illness, Enteral Nutrition
TARGET-Metabolic Effects
The estimation of calorie needs during routine practice in critically ill patients is highly variable and the thermogenic effect of continuous delivery of enteral nutrition (EN) on overall calorie utilisation in critically ill…
- Trial name
- TARGET-ME (NCT03793244)
- Testing
- TARGET protocol EN 1.5 kcal/mL
- Where
- Australia
- Volunteers
- 42 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Trauma Injury, Sepsis
Pathological Myeloid Activation After Sepsis and Trauma
The goal of this observational study is to better understand what happens to circulating blood after a patient experiences severe trauma injury.
- Conditions
- Trauma Injury, Sepsis, Immunosuppression, Chronic Critical Illness
- Trial name
- NCT05616130
- Testing
- Data Collection, Bone marrow collection and blood collection, Serial interviews to complete surveys and questionnaires
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of Florida
Severe Influenza
Early Oseltamivir Carboxylate Low Plasma Concentration in Patients Admitted to Intensive Care for Severe Influenza
Introduction Pandemic and seasonal influenza epidemics can be associated with a high degree of morbidity and mortality, especially in patients developing severe influenza pneumonitis with the acute respiratory distress syndrome…
- Trial name
- OPTIFLU (NCT05375864)
- Testing
- Absorption test
- Where
- France
- Volunteers
- 155 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Sepsis
Adiposity and Immunometabolism in Sepsis
Obesity has been shown to increase adverse outcomes in some critically ill patients e.g. those with COVID-19. For patients with sepsis this association is less clear cut but there is evidence that body fat distribution, resulting…
- Trial name
- AIMS (NCT06307509)
- Testing
- Diagnosis of sepsis
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS Greater Glasgow and Clyde
External Effectiveness Validation of Model
Evaluation of U-AKIpredTM for Predicting AKI in Critically Ill Patients Within 12 Hours: a Multicenter Prospective Cohort Study
The goal of our study is to evaluate U-AKIpredTM for predicting AKI in critically ill patients within 12 h by the multicenter prospective cohorts. AKI was diagnosed by Kidney Disease Improving Global Outcomes (KDIGO) criteria.
- Trial name
- NCT06496555
- Where
- China
- Volunteers
- 2,100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Vitamin D3 Deficiency
Vitamin D3 Supplementation in Critically Ill Patients Undergoing CRRT
Patients hospitalized in intensive care units (ICU) are particularly susceptible to vitamin D3 deficiencies. This can be due to the severity of their underlying disease, the type of treatment they are on, malnutrition before and…
- Trial name
- NephroD (NCT05657678)
- Testing
- Vitamin D3 - 750 000 IU, Vitamin D3 - 500 000 IU
- Where
- 4 sites in Poland
- Volunteers
- 138 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Burned Children, Ceftazidime Treatment
Ceftazidime in Burn Children
Concentrations and effects of Ceftazidime in critically ill burn children are unpredictable and the risk of under-exposure may be associated with poor clinical outcomes.
- Trial name
- CEFTAZOPTIM (NCT03881800)
- Testing
- titration- blood sample
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tracheostomy Complication, Critical Illness
PUSH-IT Continuing Enteral Feeds for Tracheostomy
The goal of this clinical trial is to evaluate nutrition administration in the time around the tracheostomy in patients with breathing tubes.
- Conditions
- Tracheostomy Complication, Critical Illness, Nutritional Deficiency
- Trial name
- NCT05906472
- Testing
- Feeds continued, Feeds held
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- State University of New York at Buffalo
Critically Ill
Ultrasound Guided Central Venous Vascular Access - Novel Needle Navigation Technology Compared With Conventional Method
Background: Central venous catheter (CVC) insertion is a very common procedure in the intensive care setting. A recent international guidelines advocated the use of ultrasound for routine internal jugular CVC insertion.
- Trial name
- NCT03214575
- Testing
- Conventional method, GPS Method
- Volunteers
- 100 people
- Sponsor
- University of Malaya
Critically Ill Patients, Cardiac Surgery
Impact Of Antioxidant Micronutrients On Intensive Care Unit (ICU) Outcome
Critically ill patients are generally exposed to an increased oxidative stress, which is proportional to the severity of their condition.
- Conditions
- Critically Ill Patients, Cardiac Surgery, Trauma, Subarachnoid Hemorrhage
- Trial name
- Etude-AOX (NCT00515736)
- Testing
- Selenium (Se), Zinc (Zn), Vitamin C, Vitamin B1, Vitamin E
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Critically Ill
Testing of a New Therapeutic Vibration Device to Reduce Neuromuscular Weakness in Hospitalized Patients (Hospital Testing)
Objective: Test the ability of vibration to produce physiologic, biochemical, and anatomic changes consistent with exercise that would help prevent the development of muscle weakness that occurs when patients are immobile for…
- Trial name
- NCT05352100
- Testing
- Therapeutic Vibration Device
- Where
- United States
- Sponsor
- University of Michigan
Critical Illness
Impact of Gender on Hospitalized Patients
The purpose of this study is to better understand the relationship between gender (being a man or a woman), infections caught in the hospital, and serious illness.
- Trial name
- NCT00843557
- Where
- United States
- Volunteers
- 2,400 people
- Sponsor
- University of Virginia
Critical Illness, Safety Issues
TraceBook: the Clinical Proof of Concept on the Intensive Care.
The effectiveness of current checklists is hampered by lack of acceptance and compliance. Recently, a new type of checklist with dynamic properties has been created to provide more specific checklist items for each individual…
- Trial name
- TraceBook (NCT03599856)
- Testing
- TraceBook
- Where
- Netherlands
- Volunteers
- 408 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Cardiogenic Shock, Septic Shock
Levosimendan Versus Dobutamine in Shock Patients
The purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock).
- Trial name
- NCT00093301
- Testing
- Levosimendan, Dobutamine
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Wentworth Area Health Services
Premature Neonates
Optimizing the Use of Morphine in Pre-Term Neonates
The purpose of this study is to improve the dosing of morphine in critically ill premature neonates.
- Trial name
- NCT00494429
- Testing
- Morphine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- John van den Anker
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.