Clinical trials: Illness, Critical
Critical Illness, Enteral Nutrition
Optimizing Enteral Nutrition Regimen for Critically Ill Patients
Clinical Trial The goal of this clinical trial is to learn whether different enteral feeding cycles (18-hour, 20-hour, or standard 24-hour continuous feeding) improve outcomes for critically ill ICU patients who need tube…
- Conditions
- Critical Illness, Enteral Nutrition, Ventilator Associated Pneumonia, Hyperglycemia
- Trial name
- NCT07270939
- Testing
- 20-Hour Cycled Enteral Nutrition with a 4-Hour Fasting Window, 18-Hour Cycled Enteral Nutrition with a 6-Hour Fasting Window
- Volunteers
- 150 people
- Sponsor
- Hamad Medical Corporation
Critical Illness, Intensive Care Unit
Intensive Care Unit Activity in France From the National Database Between 2013 and 2019
Using data from the French National Uniform Hospital Discharge Database (systematically collecting administrative and medical information related to all hospitalized patients in France for care reimbursement purposes), the…
- Trial name
- ICU_ACTIVITY (NCT05353023)
- Where
- France
- Volunteers
- 1,594,801 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Delirium, Critical Illness
Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery
"Postoperative delirium is a common and serious complication following cardiac surgery, particularly among older adults who require intensive care.
- Conditions
- Delirium, Critical Illness, Aged, Cardiopulmonary Bypass
- Trial name
- NCT07265128
- Testing
- Midazolam, Remimazolam
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Critical Illness
Effect of Combined IV Bolus Amino Acid Supplementation and Mobilisation on Skeletal Muscle During the First 10 Days in the ICU: A RCT
A single-centre, two-arm, parallel randomised controlled trial (RCT) to compare the combined effect of early intravenous bolus amino acid supplementation and mobilisation versus standard of care on changes in muscle mass over the…
- Trial name
- ProMob-ICU (NCT04099108)
- Testing
- Combined cycle ergometry and bolus amino acid supplementation
- Where
- South Africa
- Volunteers
- 50 people
- Sponsor
- University of Stellenbosch
Pneumonia, Viral, Critically Ill
French Multicentre Observational Study on SARS-Cov-2 Infections (COVID-19) ICU Management Study
Since December 2019, a new agent, the SARS-Cov-2 coronavirus has been rapidly spreading from China to other countries causing an international outbreak of respiratory illnesses named COVID-19.
- Conditions
- Pneumonia, Viral, Critically Ill, Corona Virus Infection
- Trial name
- FRENCH CORONA (NCT04340466)
- Testing
- No intervention
- Where
- France
- Volunteers
- 1,003 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Fluid Therapy, Vasopressor Therapy
Practice of Fluid Therapy in Critically Ill Invasively Ventilated Patients
The goal of this woldwide observational study is to investigate various aspects of fluid and vasopressor therapy in critically ill invasively ventilated patients.
- Conditions
- Fluid Therapy, Vasopressor Therapy, Critical Illness, Invasive Ventilation
- Trial name
- PRoFLUID (NCT05968066)
- Where
- Netherlands
- Volunteers
- 2,508 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Delirium, Delirium in Old Age
Eyecontrol coMmunication Platform for dEliRium manaGemEnt in Intensive Care Units (EMERGE)
The purpose of this research is to investigate whether addition of the EyeControl-Pro platform as an adjunct to standard guideline-based intensive care unit management of critically ill patients is effective in reducing delirium…
- Conditions
- Delirium, Delirium in Old Age, Critical Illness, Intensive Care Unit Delirium
- Trial name
- EMERGE (NCT06029244)
- Testing
- EyeControl-Pro, Control
- Where
- 3 sites in United States, Israel
- Volunteers
- 160 people
- Sponsor
- Beth Israel Deaconess Medical Center
Critical Illness
Predictive Model for Mortality in Older People With Critical Illness
The present study aims to develop a predictive model to identify elderly patients with the highest likelihood of mortality upon admission to an intensive care unit.
- Trial name
- VITA (NCT06727903)
- Testing
- laboratory biomarker analysis
- Where
- 15 sites in Spain
- Volunteers
- 450 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Critical Illness, Ventilation
Wise Choices in the Intensive Care Unit
Aim: to evaluate if the Choosing Wisely campaign can be introduced without harming critically ill patients. Background: Each year, around 45,000 patients are admitted to Sweden's 81 ICUs (intensive care units), costing 6-7…
- Conditions
- Critical Illness, Ventilation, Outcome, Dialysis
- Trial name
- WICH-ICU (NCT07013175)
- Testing
- Choosing wisely protocol
- Where
- 2 sites in Sweden
- Volunteers
- 10,000 people
- Sponsor
- Karolinska Institutet
Intraabdominal Infections
Multicentre Observational Study on Community Acquired Intraabdominal Infections Management
Intraabdominal infection require rapid care management including antibiotic therapy and source control. Morbidity and mortality associated with Intraabdominal infections remain high.
- Trial name
- PERICOM (NCT03544203)
- Where
- 14 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Critical Illness, Intensive Care Units (ICUs)
Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit
The goal of this observational study is to measure effort using esophageal pressure measurements, oxygen consumption and diaphragm activity in mechanically ventilated Intensive Care Unit patients during a Spontaneous Breathing…
- Conditions
- Critical Illness, Intensive Care Units (ICUs), Weaning Failure, Mechanical Ventilation
- Trial name
- SERA-Effort (NCT07109570)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Critical Illness, Metabolism Disorders
The Blood-Interstitial Glucose Gap
Metabolic monitoring is fundamental to guiding nutritional therapy in critically ill patients. Although indirect calorimetry is the established gold standard for measuring resting energy expenditure, its routine clinical use is…
- Trial name
- NCT07251764
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Chinese Medical Association
Critical Illness
Physiotherapy and Optimised Nutrition in Survivors of Critical Illness
The goal of this randomised controlled feasibility study is to assess the feasibility and acceptability of individualised physiotherapy and optimised nutrition, delivered on the ward following discharge from intensive care to…
- Trial name
- PHOENIX (NCT06159868)
- Testing
- Structured physiotherapy and rehabilitation, Standard care
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Intensive Care Units
Immediate Effects of Automatic Lateralization in Critically Ill Patients
New devices have been used in intensive care to optimize respiratory function in critically ill patients, such as automatic lateralization therapy.
- Trial name
- NCT07087600
- Testing
- Automatic lateralization therapy, Supine Positioning
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Pernambuco
Underdosing of Aminoglycosides, Critical Illness
An International Survey on Aminoglycoside Practices in Critically Ill Patients: AMINO III Survey
This is an international observational cohort study on current aminoglycoside practices in intensive care units. Clinical and demographic data, dosing and therapeutic drug monitoring data will be collected during the first week…
- Trial name
- NCT02850029
- Testing
- Observational study, no intervention
- Where
- 85 sites in Australia, Chile and 3 more
- Volunteers
- 964 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Critical Illness, Communication
Time Limited Trials to Reduce Non-Beneficial Intensive Care Unit Treatments
Overutilization of intensive care unit (ICU) treatments among patients with advanced medical illnesses and poor prognosis places them at risk for prolonged suffering with minimal anticipated benefit.
- Trial name
- NCT04181294
- Testing
- Family meetings using time limited trials as default ICU communication and care planning approach, Usual practice
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Critical Illness, Postoperative Complications
General Surgery Patients at the Intensive Care Unit
Introduction: high-risk surgical patients in the intensive care unit (ICU) are a unique population that has yet to be carefully monitored.
- Trial name
- TraViII (NCT06731296)
- Testing
- Presence of a risk factor
- Where
- 2 sites in Colombia
- Volunteers
- 1,000 people
- Sponsor
- Hospital Departamental de Villavicencio
Sepsis, Respiratory Failure
Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients
This observational study aims to determine whether three blood test ratios - lactate-to-albumin, CRP-to-albumin, and procalcitonin-to-albumin - can predict in-hospital mortality among critically ill adults.
- Conditions
- Sepsis, Respiratory Failure, Cardiac Arrest, Circulatory Failure
- Trial name
- LAR-CAR-PAR (NCT07242027)
- Where
- Poland
- Volunteers
- 212 people
- Sponsor
- Medical University of Silesia
Circulatory Failure, Shock
Brachial-radial Pressure Gradient Phenomenon in Critically Ill Patients Treated With Vasoactive Agents
The goal of this observational study is to observe brachial-to-radial pressure gradient in critically-ill patients receiving vasoactive agents. The main questions it aims to answer are: 1.
- Conditions
- Circulatory Failure, Shock, Vasopressor Agents, Blood Pressure
- Trial name
- NCT07061457
- Where
- 3 sites in Poland
- Volunteers
- 300 people
- Sponsor
- Jagiellonian University
Critical Illness, Metabolism Disorders
Blood-Interstitial Fluid Glucose Gap
Metabolic monitoring is fundamental to guiding nutritional therapy in critically ill patients. Although indirect calorimetry is the established gold standard for measuring resting energy expenditure, its routine clinical use is…
- Trial name
- NCT07240103
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Chinese Medical Association