Clinical trials: Illness, Critical
Intraabdominal Infections, Fluid Balance; Disorder
Intra-Abdominal Sepsis and Relationship Between Cumulative Fluid Balance and Serum Sodium and Chloride Levels and In-Hospital Mortality
Intra-abdominal sepsis and septic shock in critically ill surgical patients have a high mortality rate. Fluid therapy is one of the initial resuscitation measures, but it can contribute to poor treatment outcomes through fluid…
- Conditions
- Intraabdominal Infections, Fluid Balance; Disorder, Sodium Disorder, Chloride Disorder
- Trial name
- NCT06838585
- Testing
- infusion therapy
- Where
- Serbia
- Volunteers
- 100 people
- Sponsor
- Clinical Center of Vojvodina
Critical Illness
Air Suspension Biodegradable Patient Transport Pad
On the one hand, transferring patient from bed to bed is usually handling by the manual lifting of several staffs or utilizing bedsheet, slide sheet , shovel-style stretcher or other devices to move and lift patients.
- Trial name
- NCT03858374
- Testing
- transferred by air-suspending mattress, transferred by slide board, transferred by bedsheet
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Critically Ill, Extubation
Does Tracheal Suction During Extubation in Intensive Care Unit Decrease Functional Residual Capacity
Little is known about the procedure of extubation of patients admitted in Intensive Care Units (ICU). In particular, effects of tracheal suction during extubation have never been evaluated.
- Conditions
- Critically Ill, Extubation, Intensive Care Unit
- Trial name
- NCT03681626
- Testing
- no tracheal suction, tracheal suction
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Cryotherapy Effect
Evaluation of Efficacy of Cryotherapy for Skin Anesthesia During Arterial Puncture
the purpose of this study is to evaluate the cryotherapy effect by vapocoolant spray to reducing pain during puncture for artérial blood gas
- Trial name
- SNOW (NCT03973385)
- Testing
- Cryotherapy
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Versailles Hospital
Invasive Mechanical Ventilation, Critical Illness
Mechanical Ventilation Discontinuation Practices
Background: The requirement for ventilator support is a defining feature of critical illness. Weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Conditions
- Invasive Mechanical Ventilation, Critical Illness, Spontaneous Breathing Trial, Weaning Invasive Mechanical Ventilation
- Trial name
- IOS (NCT03955874)
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,868 people
- Sponsor
- Unity Health Toronto
Acute Kidney Injury, Critical Illness
Predicting Adverse Kidney Events of Cardiac Surgery-Associated Acute Kidney Injury Using Novel Biomarkers
The aim of this study was to identify and validate novel biomarkers for predict acute kidney injury (AKI) subphenotype, major adverse kidney events and other poor outcomes.
- Conditions
- Acute Kidney Injury, Critical Illness, Kidney Failure
- Trial name
- NCT06351813
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Kidney Injury (AKI)
Mitochondrial Health and Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients
Renal replacement therapy is a life-saving treatment for patients who have sudden and severe kidney failure. However, some of these patients blood pressure who receive this treatment could become unstable, thus resulting in more…
- Trial name
- MitoHIRRT (NCT05264285)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Intensive Care Unit Acquired Weakness, Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)
Functional Assessment in Critically Ill Patients
This longitudinal, prospective observational study aims to evaluate functional status in critically ill adult patients in the Intensive Care Unit using the Chelsea Critical Care Physical Assessment Tool (CPAx).
- Trial name
- NCT07191743
- Where
- Brazil
- Volunteers
- 186 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Critical Illness, ICU Patients
Intensive Care Unit Rehabilitation Protocols
The aim of this study was to investigate the effects of NMES combination applied in addition to bicycle ergometry on mobility, functional status, muscle strength and hemodynamic responses in ICU patients.
- Trial name
- ICU-Rehab (NCT07179718)
- Testing
- neuromuscular electrical stimulation, bicycle ergometer
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Hacettepe University
Bacterial Sepsis
Therapeutic Monitoring of Beta-lactams in Critically Ill Patients With Sepsis
Background: Sepsis is a leading cause of morbidity and mortality among critically ill patients and is associated with intensive use of β-lactam antibiotics.
- Trial name
- NCT07270523
- Testing
- Individualized dosing of beta-lactam antibiotics based on therapeutic monitoring
- Where
- Spain
- Volunteers
- 198 people
- Sponsor
- Complexo Hospitalario Universitario de A Coruña
Circulatory Shock
Efficacy of the Use of Vasopressin as a Primary Vasoconstrictor in Critically Ill Patients
Current guidelines recommend the inititaion of noradrenaline and if shock is refractory, then vasopressin should be administered. Data indicate that the earlier use of vasopressin may improve survival.
- Trial name
- NCT06265259
- Testing
- Initiation of vasopressine as a first vasoconstrictive drug, Initiation of noradrenaline as a first vasoconstrictive drug
- Where
- Greece
- Volunteers
- 145 people
- Sponsor
- University of Thessaly
COVID-19 Acute Respiratory Distress Syndrome
Rehabilitation of Critically Ill Patients With SARS-CoV-2 Variants in ICU With Limited Resources
Acute rehabilitation in critically ill patients can improve post-intensive care unit (post-ICU) physical function. Scientific evidence has considered neuromuscular electrical stimulation (NMES) as a promising approach for the…
- Trial name
- NCT05450120
- Testing
- Functional Rehabilitation, Neuromuscular Electrical Stimulation
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Universidade Federal de Sao Carlos
Septic Shock
Meropenem and Ciprofloxacin Dosing in Septic Shock
Patients with septic shock may have altered volume of distribution and metabolism of antibiotics which are crucial medications for treating infections.
- Trial name
- NCT02240277
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Critical Illness, Multi Organ Failure
Parathyroid Hormone Kinetics During CRRT
The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation…
- Conditions
- Critical Illness, Multi Organ Failure, Renal Failure, Circulatory Failure
- Trial name
- NCT03873675
- Testing
- parathyroid hormone
- Where
- 3 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Patients Treated With Methadone
Methadone Administration in Critically Ill Patients in the Intensive Care Unit and Risk of Prolonged QTc and Cardiac Arrythmia
Continuous infusion of short-acting synthetic opioids, primarily remifentanil, is widely used for anesthesia and analgesia in ventilated patients in the intensive care unit (ICU) due to its short half-life, which is independent…
- Trial name
- NCT07892677
- Testing
- ICU patients treated with methadone
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Meir Medical Center
Critical Illness, Heart Arrest
Risk Modelling for Quality Improvement in the Critically Ill: Making Best Use of Routinely Available Data
The aim of the proposed study is to better understand the epidemiology of, risk factors for and consequences of critical illness leading to improvements in the risk models used to underpin national clinical audits for adult…
- Trial name
- NCT02454257
- Volunteers
- 1,007,147 people
- Sponsor
- Intensive Care National Audit & Research Centre
Outcome
Outcome and Predictors of Mortality of Patients on Prolonged Mechanical Ventilation
Prolonged mechanical ventilation (PMV) and weaning failure are factors associated with prolonged hospital length of stay and increased morbidity and mortality.
- Trial name
- NCT06087939
- Testing
- Mechanical ventilation
- Volunteers
- 323 people
- Sponsor
- Wollo University
Lung Microbiota
Lung Microbiota Analysis in Critically Ill Patients Admitted to the Intensive Care Unit.
Our study aims to evaluate the relationship between the heterogeneity of pulmonary microbiota and clinical and outcome variables among critically ill patients admitted to the intensive care unit (ICU).
- Trial name
- NCT04271345
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Disorder of Consciousness, Unresponsive Wakefulness Syndrome
Auditory Processing in DOC Patients
This prospective observational study investigates whether electroencephalography (EEG) can improve the differentiation between unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) in patients with severe…
- Conditions
- Disorder of Consciousness, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- AUD-DOC (NCT07455682)
- Testing
- Coma Recovery Scale-Revised (CRS-R), Electroencephalography (EEG)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Augmented Renal Clearance, Critically Ill
Iohexol Clearance in Critically Ill Patients With Augmented Renal Creatinine Clearance
Evaluation of glomerular filtration rate using iohexol plasma clearance in critically ill patients with augmented renal creatinine clearance
- Trial name
- GFR-ARC (NCT04776486)
- Testing
- Iohexol
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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