Clinical trials: Illness, Critical
Critical Illness, Pain
Treatment of Procedural Pain Associated With Turning in Patients With Mechanical Ventilation
Background: Few studies have addressed the situation of procedural pain and the use of preemptive analgesia for turning in patients under mechanical ventilation.
- Trial name
- NCT01950000
- Testing
- Fentanyl
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Critically Ill Patient
Effect of a Music Therapy Intervention on Mood
The hypothesis is that the music therapy intervention has a positive impact on the critical patients' mood as it has a reassuring effect that allows a connection with emotions, helps to communicate and affects the welfare of…
- Trial name
- NCT04127344
- Testing
- Music Therapy Intervention
- Where
- Spain
- Volunteers
- 164 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Critical Illness, Death, Sudden
Critical Health Assessment and Outcomes Score/Study
CHAOS is based on the investigator's new and exciting results from pre-clinical and large longitudinal multi-center observational clinical studies of critically ill patients and asymptomatic community-based adults with little or…
- Trial name
- CHAOS (NCT02766166)
- Where
- 3 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
COVID-19, ARDS, Human
Cardiac Dysfunction in Critically Ill Covid-19 Patients
We conducted an observation sub-study of the prospective randomized controlled trial "High Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure", in which we analysed the echocardiographic data collected both at…
- Conditions
- COVID-19, ARDS, Human, Cardiac Failure, Right Ventricular Dysfunction
- Trial name
- NCT06197256
- Where
- Sweden
- Volunteers
- 39 people
- Sponsor
- Region Stockholm
Critical Illness, Muscle Loss
Investigating the Anabolic Response to Resistance Exercise During Critical Illness
ICU patients often suffer from rapid and severe muscle loss. It is not known if physical therapy can mitigate the muscle wasting associated with critical illness.
- Trial name
- ARTIST-1 (NCT05197231)
- Testing
- Resisted knee extension exercise, IV amino acids
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Karolinska University Hospital
Critical Illness, Hyperglycemia
Multicentre LOGIC-Insulin Algorithm-guided Versus Nurse-directed Blood Glucose Control During Critical Illness (LOGIC-2)
Most critically ill patients are confronted with hyperglycaemia, which is associated with an increased mortality and morbidity risk.
- Conditions
- Critical Illness, Hyperglycemia, Hypoglycemia
- Trial name
- LOGIC-2 (NCT02056353)
- Testing
- LOGIC-Insulin algorithm, Paper protocol
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 1,550 people
- Sponsor
- KU Leuven
Critically Ill Patients, Indication for Stress Ulcer Prophylaxis
Gastric pH in Critically Ill Patients
H2-receptor antagonists are the gold standard for stress ulcer prophylaxis in critically ill patients. Various studies demonstrated superiority of proton pump inhibitors over H2-receptor antagonists in increasing gastric pH and…
- Trial name
- NCT00590928
- Testing
- esomeprazole, ranitidine
- Where
- Austria
- Volunteers
- 75 people
- Sponsor
- Medical University of Vienna
Critically Ill
The Diagnosis and Treatment System of Transesophageal Echocardiography in ICU
Transesophageal ultrasound offers imaging through the esophagus on the surface of the heart, with good image quality and unique advantages.
- Trial name
- NCT03811730
- Testing
- Transesophageal echocardiography
- Where
- 5 sites in China
- Volunteers
- 200 people
- Sponsor
- Kang Yan
Feasibility of Virtual Reality Stimulation for Critically Ill Patients
Virtual Reality on the IMC
The goal of this substudy (main study NCT04498585) is to determine the feasibility of applying virtual reality stimulation to patients in the intermediate care unit.
- Trial name
- NCT05380700
- Testing
- Virtual Reality Stimulation
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sleep
The Effect of Ear Plug and Eye Mask on Sleeping Quality in Critically Ill Patients
Sleep is a complex physiologic and behavioral process essential for rest, repair, well-being, and survival. Sleep is defined as a periodic, reversible state of cognitive and sensory disengagement from the external environment.
- Trial name
- sayed (NCT02612636)
- Testing
- ear plug, eye mask
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Necrotizing Enterocolitis
Application of Transcriptome Sequencing Combined With Family-Based Whole Genome Sequencing in Improving Precise Diagnosis of Critically Ill Newborns in Northeast China
Background: Birth defects and genetic diseases are major threats to infant health. Many genetic diseases present atypically in newborns, who often have critical conditions, rapid progression, and high mortality.
- Trial name
- NCT06990334
- Testing
- Whole genome sequencing analysis
- Volunteers
- 1,000 people
- Sponsor
- The First Hospital of Jilin University
Severe Sepsis, Critical Illness
Ultrasound Measurement of Reactive Hyperemia in Critical Care
The investigators hypothesize that doctors and nurses can undergo a brief period of training and then use ultrasound to accurately measure blood flow in a forearm artery after a brief period when this flow is interrupted with a…
- Trial name
- URHC (NCT01726595)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Fatigue
Fatigue One Year After ICU Discharge
The investigators contacted consecutive adult patients admitted to intensive care unit (ICU) and mechanically ventilated for at least 72 hours to invite them to an interview at hospital.
- Trial name
- NCT02684877
- Testing
- Questionnaire
- Volunteers
- 56 people
- Sponsor
- Università degli Studi di Ferrara
Post Intensive Care Syndrome, Intensive Care Unit Acquired Weakness
Validity and Reliability of Korean Version of AM-PAC Inpatient Short Form (Low Function) in Critically Ill Patients
The Activity Measure for Post Acute Care (AM-PAC) inpatient short form (low function) evaluates the level of assistance a patient requires another person to provide for distinct functional mobility and daily activities.
- Trial name
- AM-PAC (NCT06440265)
- Testing
- AM-PAC inpatient short form (low function)
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Seoul National University Hospital
Sepsis, Critical Illness
Provider Perspectives on Beta-lactam Therapeutic Drug Monitoring Programs in the Critically Ill
The purpose of the study is to characterize various healthcare practitioners' perspectives on implementation of beta-lactam therapeutic drug monitoring in critical care practice.
- Trial name
- NCT04755777
- Where
- 3 sites in United States, Australia
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Critical Illness
The Use of Sugammadex in the Critically Ill
Moderate and Deep neuromuscular blockade (rocuronium administered to a train of four count 0 and post-tetanic count of 1-2) in critically ill patients needing intubation or procedures can be reversed immediately and effectively…
- Trial name
- NCT03791801
- Testing
- Sugammadex, Neostigmine, Rocuronium
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Burns
Timing of Surgery And Outcome in Burn Patients ( EARLYBURN )
The prognostic of burn patients has improved over the last decades. Early excision of full thickness burns is thought to be one of the key factors which have led to prognostic improvement.
- Trial name
- EARLYBURN (NCT02940171)
- Testing
- Early Excision of full thickness burn, Late Excision of full thickness burn
- Where
- France
- Volunteers
- 470 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Maternal Death
Critically-Ill Women Admitted to an Obstetric High Dependency Unit in a Resource-Limited Setting
Sierra Leone faces the highest maternal mortality ratio in the world. Despite this extreme burden, the potential roles of obstetric critical care and high dependency units (HDUs) in this and other resource-limited settings remain…
- Trial name
- NCT04121234
- Testing
- Exposure: " being admitted to HDU with a red code to OEWS"
- Where
- Sierra Leone
- Volunteers
- 523 people
- Sponsor
- Doctors with Africa - CUAMM
Fever, Hyperthermia
The Fever and Antipyretic in Critically Illness Evaluation Study
The purpose of this multination multicenter observational study is to determine the impact of fever and antipyretic on outcomes in critically ill patients.
- Trial name
- FACE (NCT00940654)
- Testing
- Antipyretic therapy
- Where
- 2 sites in Japan, South Korea
- Volunteers
- 1,426 people
- Sponsor
- Japanese Society of Intensive Care Medicine
Acute Respiratory Failure
INtubation With Sedation Only to Preserve Independent Respiratory Effort Trial
The INtubation with Sedation Only to Preserve Independent Respiratory Effort (INSPIRE) trial is a pragmatic, non-blinded, parallel-group, randomized clinical trial comparing the effect of intubation with sedation only…
- Trial name
- INSPIRE (NCT07845305)
- Testing
- Intubation with a sedative medication only, Intubation with a sedative medication and neuromuscular blockade agent
- Where
- United States
- Volunteers
- 228 people
- Sponsor
- Vanderbilt University Medical Center
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