Clinical trials: Illness, Critical
Mechanical Ventilation, Critically Ill Patients
Saline Instillation Before Tracheal Suctioning and the Incidence of Ventilator Associated Pneumonia
Compare the incidence of ventilator associated pneumonia with or without tracheal isotonic saline instillation before tracheal suctioning
- Trial name
- NCT00432718
- Testing
- Saline Instillation before Tracheal Suctioning
- Where
- Brazil
- Volunteers
- 260 people
- Sponsor
- Hospital do Cancer, Sao Paulo
Acute Lung Injury, Acute Respiratory Distress Syndrome
Airway Pressure Release Ventilation in Acute Lung Injury
The purpose of this study is to compare airway pressure release ventilation (APRV) to conventional mechanical ventilation (MV) in patients with acute lung injury (ALI) to determine if APRV can reduce agitation, delirium, and…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Mechanical Ventilation
- Trial name
- NCT00750204
- Testing
- APRV, Conventional MV
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Septic Shock
Acute Intestinal Failure in Critically Ill Patients and Microbial Translocation
The hypothesis of the investigators is that patients with septic shock in ICU have acute intestinal insufficiency favoring subclinical microbial translocation, which is the consequence of alterations of the epithelium, and is…
- Trial name
- IGA-TM (NCT03861325)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Kidney Injury
Furosemide Stress Test Guiding Initiation of Renal Replacement Therapy
Does Early Initiation of Renal Replacement Therapy Have an Impact on 7-day Fluid Balance in Critically Ill Patients with Acute Kidney Injury with Positive Furosemide Stress Test?: a Multicenter Randomized Controlled Trial
- Trial name
- NCT02730117
- Testing
- Dialysis with continuous renal replacement therapy, Mechanical ventilator, Anti-Bacterial Agents
- Where
- Thailand
- Volunteers
- 118 people
- Sponsor
- Chulalongkorn University
COVID-19
Safety of Short-term Hydroxychloroquine Plus Azithromycin Treatment in Critically Ill Patients With Severe COVID-19
Hydroxychloroquine and azithromycin have been proposed as treatment of COVID-19 patients, but few reports have assessed this combination therapy in critically ill COVID-19 patients.
- Trial name
- NCT04452617
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Institut Mutualiste Montsouris
Critical Illness, Enteral Nutrition
Trial of Enteral Glutamine on Intestinal Permeability in Critically Ill Patients
Glutamine-induced recovery in intestinal barrier function by reducing bacterial translocation was demonstrated in previous studies.
- Conditions
- Critical Illness, Enteral Nutrition, Intestinal Permeability
- Trial name
- NCT03113240
- Testing
- Glutamin, Maltodextrin
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University
Pneumonia, Resistant Pneumonia
Flexible Bronchoscopy in Resistant Pneumonia in PICU
Pneumonia remains a leading cause of morbidity and mortality among critically ill children admitted to Pediatric Intensive Care Units (PICUs).
- Conditions
- Pneumonia, Resistant Pneumonia, Resistant Pneumonia in Critically Ill Pedaitric Patients
- Trial name
- FFP-RP PICU (NCT07421440)
- Testing
- Flexible fiberoptic bronchoscopy with bronchoalveolar lavage (BAL)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansour Gomaa Mohammed Saleh
Post-Resuscitation Syndrome, Critical Illness
Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest
This retrospective observational cohort study aims to identify early predictors of short- and mid-term mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest.
- Conditions
- Post-Resuscitation Syndrome, Critical Illness, Cardiac Arrest, Hypoxic-Ischemic Encephalopathy
- Trial name
- PROM-ROSC (NCT07020091)
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Ahmet Düzgün
Critical Illness
Optimization Dose Study on Pharmacokinetics and Pharmacodynamics of Colistin in Critically Ill Patients
Phase II clinical trial, open-labelled, prospective and single-center study directed to obtain blood samples in experimental detailed conditions in order to compare and optimize the dose of colistin in critically ill patients…
- Trial name
- COLPHAR (NCT02408185)
- Testing
- Colistin 6 million units + 240mg/8h, Colistin 6 million units + 360mg/12h
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Critically Ill, Continuous Renal Replacement Therapy
Filter Lifespan in Continuous Renal Replacement Therapy
The only supportive therapy for patients with AKI is renal replacement therapy (RRT). In the ICU setting, continuous RRT (CRRT) is mostly favored.
- Conditions
- Critically Ill, Continuous Renal Replacement Therapy, Infections
- Trial name
- CRRTInfO (NCT05450185)
- Testing
- Critically ill patients with continuous renal replacement therapy
- Where
- 5 sites in Austria, Brazil and 1 more
- Volunteers
- 600 people
- Sponsor
- University Hospital Muenster
Critically Ill, Enterobacteriaceae Infections
Infections and Colonization With the Third Group of Enterobacteriaceae in the Intensive Care Unit
There is a lack of data whether colonization and infection with Enterobacteriaceae of the third group (EB3) affect the outcomes for ICU patients.
- Conditions
- Critically Ill, Enterobacteriaceae Infections, Antibiotic Resistant Infection
- Trial name
- EB3REA (NCT04528043)
- Where
- France
- Volunteers
- 179 people
- Sponsor
- Central Hospital, Nancy, France
Blood Transfusion
Oxygen Extraction-guided Transfusion
In critically ill patients, optimized strategies for red blood cells transfusion (RBCT) are still controversial. Most recent guidelines suggest that clinical practice in ICU setting should follow a restrictive approach to RBCT…
- Trial name
- OXYTRIP (NCT06102590)
- Testing
- Individualized red blood cell transfusion strategy, European guidelines red blood cell transfusion strategy
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 324 people
- Sponsor
- Università degli Studi di Ferrara
Infection
Colistin Pharmacokinetics in Continuous Renal Replacement Therapy
The blood concentration of the antibiotic colistin is determined in patients in whom kidney function is reduced such that a renal replacement therapy is needed.
- Trial name
- NCT02081560
- Testing
- Colistin
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University of Zurich
Transpulmonary Pressure, Pressure.Rate Product
Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation
Typically doctors adjust the settings on the ventilator to ensure that children receive enough help to decrease the work they perform to breathe, receive enough oxygen through the machine to pass into the blood and to the organs…
- Conditions
- Transpulmonary Pressure, Pressure.Rate Product, Guide to Mechanical Ventilator Management, Extubation Readiness
- Trial name
- NCT02354365
- Testing
- Transpulmonary Pressure measurement
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Children's Hospital Los Angeles
Critical Illness
Predicting Early Circulatory Deterioration After Short-Acting Beta-Blocker Treatment in Intensive Care Patients
This retrospective observational study used existing intensive care records to examine whether heart rate and blood pressure measured before short-acting beta-blocker treatment could help predict early signs of worsening…
- Trial name
- NCT07846995
- Testing
- Esmolol, Landiolol
- Where
- China
- Volunteers
- 2,541 people
- Sponsor
- Shanghai Zhongshan Hospital
Delirium, Acute Kidney Injury
Neurocognitive Outcomes for ICU Patients With Acute Kidney Injury
Introduction. Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and is associated with increased morbidity and mortality.
- Conditions
- Delirium, Acute Kidney Injury, Critical Illness, Cognitive Impairment
- Trial name
- INCOGNITOAKI (NCT04722939)
- Testing
- Cerebral oxygenation
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Dr. Gordon Boyd
Mortality, Muscle Loss
Mortality and Muscle Mass Loss in Critically Ill Patients.
The aim of the study is to monitor changes in muscle mass in critically ill patients and to verify whether a decrease in muscle mass of ≥10% during the first 7 days of hospitalization is associated with increased 28-day…
- Trial name
- MUSIC 2 (NCT07280039)
- Where
- Czechia
- Volunteers
- 386 people
- Sponsor
- Brno University Hospital
Deep Sedation, Ventilators, Mechanical
Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive…
- Conditions
- Deep Sedation, Ventilators, Mechanical, Critical Illness
- Trial name
- NCT02903407
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
To Determine If Blood Level (NGAL) Could Accurately Early Detect Acute Renal Damage in All Patients Requiring Critical Care
NGAL in Prediction of AKI and Patient Outcomes
This single-center prospective non-randomized observational research included 120 critically ill persons, at Sohag University hospital's critical care unit.
- Trial name
- NGAL AKI (NCT06691607)
- Testing
- Serum NGAL level
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Sohag University
Fluid Responsiveness, Echocardiography
Echocardiography Guided Fluid Resuscitation in Critically Ill Patients.
To compare between the impact of echocardiography guided fluid resuscitation and clinically guided fluid resuscitation on critically ill patients in hospital outcome.
- Trial name
- NCT03296319
- Testing
- Echocardiography
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.