Clinical trials: Illness, Critical
Nutrition Therapy, Critical Illness
Efficacy and Safety of SmofKabiven Extra Nitrogen for Parenteral Nutrition in Patients Receiving Intensive Care
The aim of this clinical trial is to assess the efficacy and safety of the investigational product SmofKabiven extra Nitrogen in patients requiring parenteral nutrition (PN) to achieve the target protein dose.
- Trial name
- NCT05257031
- Testing
- SmofKabiven extra Nitrogen
- Where
- Russia
- Volunteers
- 56 people
- Sponsor
- Fresenius Kabi
Cardiac Output
Comparison of Techniques for Assessing Cardiac Output and Preload in Critically Ill Pediatric Patients
The ability to measure cardiac output (CO) accurately and reproducibly at frequent intervals remains elusive to the clinician caring for critically ill pediatric patients even though a large proportion of these children are known…
- Trial name
- GCH (NCT00853437)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Transonic Systems Inc.
Critical Illness
Optimal Protein Supplementation for Critically Ill Patients
It is well accepted that during critical illness there is an increase in protein breakdown and loss of lean body mass. Previous studies have shown that during critical illness muscle breakdown increases dramatically.
- Trial name
- NCT01934595
- Testing
- Beneprotein
- Where
- United States
- Sponsor
- University of Oklahoma
Ventilator Associated Tracheobronchitis, Tracheobronchitis
Ventilator-associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation
The Ventilator Associated tracheobronchitis Initiative to Conduct Antibiotic evaluation (VATICAN) trial is a national, multicenter, non-inferiority trial in ICU patients comparing antibiotic treatment for 7 days versus clinical…
- Trial name
- VATICAN (NCT05266066)
- Testing
- Clinical observation without antibiotic therapy for VAT, 7 day antibiotic course for VAT
- Where
- 16 sites in Brazil
- Volunteers
- 590 people
- Sponsor
- Hospital Sirio-Libanes
Delirium, Critical Illness
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs.
- Conditions
- Delirium, Critical Illness, Sedation Complication, Executive Dysfunction
- Trial name
- mini-MENDS (NCT04801589)
- Testing
- Dexmedetomidine, Midazolam
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- Vanderbilt University Medical Center
Critical Illness, Covid19
Psychological Impact of COVID-19 Outbreak on Caregivers
Based on the experience of previous pandemics, countries reacted by applying different upgrade strategies to prevent or delay the widespread of the disease.
- Conditions
- Critical Illness, Covid19, Stress Disorders, Post-Traumatic
- Trial name
- PSY-CO-ICU (NCT04511780)
- Testing
- questionnaire filling
- Where
- 51 sites in France
- Volunteers
- 701 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Critical Illness
Healthcare and Community Service Utilisation in Older Survivors of Critical Illness
This prospective observational study will describe healthcare and community service utilisation among older adults who survive critical illness and return to the community following hospital discharge.
- Trial name
- NCT07870343
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Monash University
Antimicrobial Treatment
Target-controlled Infusion Model for Cefepime
For this study, a previously developed population pharmacokinetic (popPK) model for cefepime (Jonckheere et al., submitted to JAC) was programmed in Rugloop vII, which is a software program to drive an infusion pump.
- Trial name
- NCT02688582
- Testing
- TCI group
- Volunteers
- 21 people
- Sponsor
- Onze Lieve Vrouw Hospital
Sepsis, Critical Illness
Methionine Metabolism in Parenterally Fed Pediatric Sepsis
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while synthesis of muscle and structural…
- Trial name
- NCT01891682
- Testing
- Observational
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Skin Abnormalities, Skin; Injury, Superficial
Assessment of an Innovative Air Mattress on Critically Ill Infants
The permanent bedding of critically ill neonates and infants in the pediatric intensive care unit (PICU) for an extended amount of time can result in the development of pressure injuries (PI).
- Conditions
- Skin Abnormalities, Skin; Injury, Superficial, Skin; Ulcer, Decubitus
- Trial name
- Prepicare (NCT06425068)
- Testing
- Exposure of the patient to a novel air mattress., Exposure of the patient to a conventional foam mattress.
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Simon Annaheim
ICU Ill Patients, Critical Illness
Evolution of Physical and Emotional Distress in ICU
Emotional distress is prevalent in ICU patients and may be influenced by physical symptoms such as dyspnea and pain, yet its evolution and interactions during ICU stay remain insufficiently explored.
- Trial name
- CARE-ICU (NCT07153380)
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Corporacion Parc Tauli
Critical Illness
Antibiograms of Intensive Care Units at an Egyptian Tertiary Care Hospital
The burden of antimicrobial resistance is high in ICUs and antibiotic therapy must continue to be used to improve health and save lives.
- Trial name
- NCT04318613
- Where
- Egypt
- Volunteers
- 45,221 people
- Sponsor
- Zagazig University
Sepsis, Trauma
BIA Assessment of Polymyoneuropathy in Critically Ill Patients
The aim of the study is to monitor and evaluate changes in body composition, with a special emphasis on muscle mass, in the context of polyneuromyopathy of critically-ill patients at ICU, on artificial ventilation (duration of…
- Conditions
- Sepsis, Trauma, Respiratory Insufficiency, Surgery
- Trial name
- NCT04758676
- Testing
- Nutritional and physiotherapy protocol, BIA, Standard of care
- Where
- 2 sites in Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
Critical Illness
Determination of Risk Factors and Mortality for Pediatric Chronic Critical Illness in Turkey
It is predicted that the number of Pediatric Chronic Critical Illness increases similar to adult all over the world. The prevalence of Pediatric Chronic Critical Illness in Turkey is unknown.
- Trial name
- NCT03308513
- Where
- Turkey (Türkiye)
- Volunteers
- 888 people
- Sponsor
- Yuzuncu Yil University
COVID-19 Respiratory Infection, Aspergillosis
Posaconazole Prophylaxis for CAPA Prevention in Critically-Ill Patients
COVID-19 associated pulmonary aspergillosis (CAPA) is considered a potentially life-threatening infection in critically ill COVID (Corona Virus disease)-19 patients.
- Trial name
- POSACOVID (NCT05065658)
- Testing
- Posaconazole
- Where
- 3 sites in Austria, France and 1 more
- Volunteers
- 249 people
- Sponsor
- Medical University of Graz
Critical Illness, Surgery
Diluted and Undiluted Enteral Nutrition
Adult patients after elective major abdominal surgeries who are planned to be admitted to the Intensive Care Unit (ICU) can be included in the trial. Each patient will be fed via the gastrointestinal tract.
- Conditions
- Critical Illness, Surgery, Enteral Feeding Intolerance, Gastro-Intestinal Disorder
- Trial name
- NCT06516835
- Testing
- Enteral fluid, Intravenous fluid
- Where
- 5 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lublin
Critical Illness, Sleep Deprivation
Improving the Sleep and Circadian Rhythms of Mechanically Ventilated Patients
The goal of this project is to determine whether the sleep and circadian rhythms of critically ill patients undergoing mechanical ventilation can be improved through practical strategies that can be employed at the bedside.
- Conditions
- Critical Illness, Sleep Deprivation, Respiratory Failure, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT01284140
- Testing
- Sleep and circadian rhythm promotion, Usual care
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Brian Gehlbach
Simulation of Physical Illness, COVID-19 Respiratory Infection
In Situ Simulation Training in Transferring Critically Ill COVID-19 Patients
This study aimed to determine the role of in situ simulation training during a pandemic by using standard and high-fidelity mannequins to improve interprofessional communication, skills, and teamwork in transferring critically…
- Trial name
- NCT05113823
- Testing
- Simulation Training
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Acute Respiratory Distress Syndrome, Hemodynamic Instability
Thoracic Fluid Content by Bioimpedance-based Starling System
The Starling system is a completely non-invasive hemodynamic monitoring technique. It is able to measure the thoracic fluid content (TFC). The TFC is supposed to reflect the total content of fluid in the thorax.
- Conditions
- Acute Respiratory Distress Syndrome, Hemodynamic Instability, Shock, Fluid Overload Pulmonary Edema
- Trial name
- TFC-Bio (NCT05676723)
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Bicetre Hospital
Covid19, Respiratory Disease
COVID-19 Longitudinal Biomarkers in Lung Injury
Profile known and novel biomarkers in blood in COVID19 patients to characterize the host response to SARS-CoV-2 over time and in response to treatment. The investigators aim to: Better understand the disease.
- Conditions
- Covid19, Respiratory Disease, Critical Illness
- Trial name
- COLOBILI (NCT04747782)
- Testing
- no interventions performed. Just collecting data, blood samples and post-mortem biopsies.
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dr. Andrew Baker
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