Clinical trials: Illness, Critical
Airway Clearance, Mechanical Insufflation-exsufflation
Mechanical Insufflation-Exsufflation in Critically Ill Patients
Mechanical insufflation-exsufflation (MI-E) is an established airway clearance technique for patients with chronic conditions like neuromuscular diseases.
- Conditions
- Airway Clearance, Mechanical Insufflation-exsufflation, Mechanical Insufflation-exsufflation Session ( With Cough Assist), Delphi Study
- Trial name
- DELMI-E (NCT07420946)
- Testing
- Delphi Questionnaire
- Where
- 4 sites in Italy, Spain and 1 more
- Volunteers
- 30 people
- Sponsor
- Medipol University
Chronic Respiratory Failure With Acute Decompensation Requiring Mechanical Ventilation for More Than 48 Hours
Early Chair Sitting Exercise in Mechanically Ventilated Critically Ill Patients
The occurrence of an acute respiratory failure necessitates mostly admission to ICU and mechanical ventilation (MV). Rapid and safe discontinuation of MV should be the objective for the majority of patients.
- Trial name
- RehabVent (NCT02021227)
- Testing
- Early chair sitting exercise
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Montpellier
Coma, Critical Illness
Effectiveness of Familiar Voices and Nature Sounds Among Critically Ill Comatose Patients
The goal of this clinical trial is to compare the effectiveness of auditory stimulation using familiar voices (FV) versus nature sounds (NS) on awakening critically ill comatose persons in the intensive care unit (ICU), reduce…
- Conditions
- Coma, Critical Illness, Unconsciousness
- Trial name
- NCT06470802
- Testing
- Familiar voice, Nature sounds, Control
- Where
- 2 sites in Vietnam
- Volunteers
- 90 people
- Sponsor
- Vo Thi Hong Nhan
Covid19, Critically Ill
Risk Factors for Mortality for COVID-19 Admitted to an Intensive Care Unit
Studying clinical characterization of critically ill COVID-19 patients in a single center Studying Risk factors for Day 28 Mortality in COVID-19 patients admitted to intensive care unit
- Trial name
- ICUCOVID-KK (NCT04805645)
- Testing
- No intervention (Retrospective Cohort Observational)
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- Clinical Research Centre, Malaysia
Delirium, Delirium in Old Age
Eyecontrol coMmunication Platform for dEliRium manaGemEnt in Intensive Care Units (EMERGE)
The purpose of this research is to investigate whether addition of the EyeControl-Pro platform as an adjunct to standard guideline-based intensive care unit management of critically ill patients is effective in reducing delirium…
- Conditions
- Delirium, Delirium in Old Age, Critical Illness, Intensive Care Unit Delirium
- Trial name
- EMERGE (NCT06029244)
- Testing
- EyeControl-Pro, Control
- Where
- 3 sites in United States, Israel
- Volunteers
- 160 people
- Sponsor
- Beth Israel Deaconess Medical Center
Critical Illness
Blood Glucose Control With A Software-Algorithm In Intensive Care Unit (ICU) Patients
Hyperglycemia is common in critically ill patients and associated with an adverse outcome. Recently, large randomized controlled trials have demonstrated that tight glycaemic control (TGC) reduces morbidity and mortality in this…
- Trial name
- Aldea _01 (NCT00735163)
- Testing
- enhanced model predictive control algorithm (eMPC)
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- B. Braun Melsungen AG
Critical Illness, Family
Psychosocial Outcomes in Families of COVID-19 ICU Patients
During the first part of the SRAS-COV2 pandemic, families were not allowed to visit the patients in ICU. We know that families can develop "Family-PICS" after their relatives' ICU stay.
- Conditions
- Critical Illness, Family, Psychological Stress, Covid19
- Trial name
- NCT04498507
- Testing
- HADS questionnaire
- Where
- Belgium
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Liege
Corona Virus Infection, Critical Illness
The Change of Critical Patient Managements and Subsequent Influences Under Epidemic of Coronavirus Disease 19 (COVID-19)
In the ER of National Taiwan University Hospital, the critical patients are treated (including tracheal intubation and cardiopulmonary resuscitation) in either resuscitation area or negative pressure isolation rooms based on the…
- Trial name
- NCT04479332
- Testing
- Tracheal intubation and cardiopulmonary resuscitation
- Where
- Taiwan
- Volunteers
- 198 people
- Sponsor
- National Taiwan University Hospital
Coronavirus Infection
Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19
Multicenter observational/registry study of the clinical features and outcomes of critically ill patients with COVID-19.
- Trial name
- STOP-COVID (NCT04343898)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 5,154 people
- Sponsor
- Brigham and Women's Hospital
Critically Ill
Health and Quality of Life One Year After Discharge From the Intensive Care Unit (ICU)
The goal is to capture the Quality of life and survival of patients one year after the stay at ICU. Data will be collected during the stay in the ICU and evaluated.
- Trial name
- QoL_ICU (NCT02671916)
- Testing
- questionnaire
- Where
- Switzerland
- Volunteers
- 55 people
- Sponsor
- Prof. Dr. med. Cristoph Haberthür
Critically Ill, Deep Sedation
Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation
The purpose of this study is to evaluate the efficacy and safety of remimazolam besylate compared to propofol for sedation in critically ill patients with deep sedation.
- Trial name
- NCT05539521
- Testing
- Remimazolam Besylate, Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Intensive Care Unit, Mechanical Ventilation
Calibration of Esophageal Balloon Catheter in Spontaneous and Mandatory Mechanical Ventilation
Calibration of the esophageal balloon catheter (Pes catheter) is important for the right measurement of the esophageal pressure (Pes) and subsequent interpretation of the derived transpulmonary pressures during mechanical…
- Conditions
- Intensive Care Unit, Mechanical Ventilation, Critical Illness
- Trial name
- PESCA (NCT06584604)
- Testing
- There is no intervention
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Leiden University Medical Center
Adult ICU Patients, Pain, Acute
Incidence of Inadequate Pain Treatment in Ventilated Critically Ill Surgical Patients
In SICU, Siriraj hospital there were no protocols place for the management of pain. All decisions were made according the attending physicians.
- Trial name
- NCT03641911
- Where
- Thailand
- Volunteers
- 118 people
- Sponsor
- Mahidol University
Hereditary Diseases, Critical Illness
UW ISeqU: Clinical Impact of Whole-genome Sequencing in Adults
The goal of this study is to learn how clinical whole genome sequencing can help identify diagnoses and guide medical care in adults.
- Trial name
- NCT07718971
- Testing
- Genome sequencing
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Washington
SARS-CoV-2
Interferon Lambda Therapy for COVID-19
The main purpose of this research study is to test the safety and effectiveness of an investigational drug peginterferon lambda-1a in treating COVID-19.
- Trial name
- NCT04388709
- Testing
- Peginterferon Lambda-1A
- Sponsor
- Icahn School of Medicine at Mount Sinai
COVID-19
Brainstem Dysfunction in COVID-19 Critically Ill Patients: a Prospective Observational Study
The purpose of this study is to determine the prevalence of brainstem dysfunction in critically ill ventilated and deeply sedated patients hospitalized in the Intensive Care Unit (ICU) for a SARS-CoV-s2 infection.
- Trial name
- BRAINSTEM-COV (NCT04527198)
- Testing
- Brainstem Responses Assessment Sedation Score (BRASS), Electroencephalogram with EKG lead
- Where
- 2 sites in France
- Volunteers
- 52 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Malnutrition, Critical Illness
Anabolic Steroids for Nutritional Rehabilitation of Critically Ill Patients
This prospective, double-blinded study will determine the feasibility of determining the efficacy of a weekly intramuscular injection of nandrolone (an anabolic steroid) in malnourished ICU patients.The data from this study will…
- Trial name
- NCT00242463
- Testing
- Nandrolone (anabolic steroid)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Critical Illness
Clinical Trial on Individual Characteristics Affecting Pain Drug Therapy in Neonates
Children differ from adults with respect to growth and development but also immaturity of various pharmacological mechanisms. Dosing schemes in children are usually derived in an empirical manner from clinical trials in adult…
- Trial name
- NeoPopGen (NCT02426463)
- Testing
- propofol, oxycodone
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- Turku University Hospital
Wound Heal, Critical Illness
Medical Honey for Wound Treatment in Intensive Care. (MICARéa) Randomized, Controlled, Single-center Pilot Study.
Wound management is a real public health issue in France. To date, a wide range of devices exists to treat these wounds, depending on their nature and stage of evolution.
- Trial name
- MICAREA (NCT06150326)
- Testing
- medical honey Activon® 25g Tube, standard of care
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Critical Illness Sepsis, Severe
Treatment of IL-6 and Its Receptor Antagonists in Children's Severe Sepsis.
In severe infective patients who survive the initial inflammatory storm, the immune response often evolves toward a state of immunosuppression, which contributes to increased mortality and severe secondary hospital-acquired…
- Trial name
- NCT04850443
- Sponsor
- Children's Hospital of Fudan University
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