Clinical trials: Illness, Critical
Consciousness, Near Death Experience
Episodes of (Dis)Connected Consciousness in ICU Survivors
This single-center observational study aims to describe the incidence of episodes of connected consciousness and disconnected consciousness (including near-death experience (NDE) and out-of-body experiences) in patients who…
- Conditions
- Consciousness, Near Death Experience, ICU, Critical Illness
- Trial name
- CONSCIOUS-ICU (NCT07048951)
- Testing
- The Near-Death Experience Content (NDE-C) scale, Threat perception measure, Interview about the participant's memories of the ICU
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University of Liege
Psychotic Disorders
Critical Time Intervention in the Transition From Hospital to Community in People With Severe Mental Illness
This study will evaluate the effectiveness of a psychosocial treatment, Critical Time Intervention, in easing the transition from hospital to community in people with severe mental disorders.
- Trial name
- NCT00621465
- Testing
- Critical Time Intervention (CTI), Usual care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York State Psychiatric Institute
Augmented Renal Clearance, Critical Illness
Fluorescent Probe for Assessment of Renal Elimination
Accurate measures of kidney function is important for precision dosing of many medications. The current methods of determining kidney function largely hinge on the use of equations that use common laboratory values such as serum…
- Trial name
- FLARE (NCT07643467)
- Testing
- Relmapirazin, Iohexol, Medibeacon tGFR monitor
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Aaron Cook
Critical Illness, Near-Death Experience
Near-death Experience in ICU Survivors
This observational study aims to describe the incidence of near-death experience (NDE) in patients who survived a critical illness.
- Trial name
- NCT04279171
- Testing
- Greyson NDE scale, DES dissociation scale, WHOQOL-SRPB
- Where
- Belgium
- Volunteers
- 126 people
- Sponsor
- University of Liege
Acute Pulmonary Embolism (PE)
Prognostic Factors for Acute Pulmonary Embolism in Critically Ill Patients
Acute pulmonary embolism (PE) is an important cause of in-hospital mortality and may be rapidly fatal if not diagnosed and treated.
- Trial name
- NCT01839266
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Critical Illness, Intensive Care (ICU) Myopathy
Muscle Dysfunction in Critical Illness
Patients surviving critical illness suffered significant skeletal muscle dysfunction and weakness that impacts their functionality and independence.
- Conditions
- Critical Illness, Intensive Care (ICU) Myopathy, PICS, Muscle Weakness
- Trial name
- NCT03717831
- Testing
- Observational study of standard of care
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Kentucky
Sepsis, Acute Lung Injury(ALI)
Recovery of Physical Function After Critical Illness In Older Adults
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially.
- Trial name
- RETURN (NCT07225257)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Critical Illness, Sepsis
The Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)
The purpose of the study is to test whether the health care provider access and training in CERTAIN (Checklist for Early Recognition and Treatment of Acute Illness), would facilitate timely and error free best-practice delivery…
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, Shock
- Trial name
- NCT01973829
- Testing
- Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)
- Where
- 30 sites in Belarus, Bosnia and Herzegovina and 15 more
- Volunteers
- 5,215 people
- Sponsor
- Mayo Clinic
Hypotension, Shock
Trendelenburg as a First-line Intervention in Critically Ill, Sedated, Invasively Mechanically Ventilated, Hypotensive Patients
A pilot randomized controlled trial to evaluate the efficacy and safety of Trendelenburg position in critically ill patients with hypotension, mainly patients with septic shock and post operative vasoplegia.
- Trial name
- Trend (NCT05209737)
- Testing
- Trendelenburg position, Semirecumbent position
- Where
- 2 sites in Russia
- Volunteers
- 10 people
- Sponsor
- Negovsky Reanimatology Research Institute
Critical Illness Polyneuromyopathy (CIPNM), ICU Acquired Weakness (ICUAW)
Electrical Muscle Stimulation (EMS), a Preventive and Therapeutic Tool for Critical Illness Polyneuromyopathy (CIPNM)
The purpose of this study is to investigate the role of EMS as a preventive and therapeutic tool of CIPNM. The investigators hypothesized that EMS will prevent the development of CIPNM or have a beneficial role as a therapeutic…
- Trial name
- NCT00882830
- Testing
- EMS
- Where
- Greece
- Volunteers
- 52 people
- Sponsor
- University of Athens
COVID-19 Respiratory Infection
Respiratory Muscles Electromyography in Patients With Covid-19
This research was characterized as a cross-sectional observational study, following the recommendations of the STROBE instrument.
- Trial name
- EMG-COVID (NCT05572853)
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- University of Pernambuco
Critical Illness
Infusion Set Replacement Intervals for Critically Ill Patients
This study aimed to evaluate the efficacy of 24-hour versus 96-hour infusion set replacement to prevent central line-associated bloodstream infection (CLABSI) in critically ill adults with central venous access devices.
- Trial name
- NCT05359601
- Testing
- Infusion set replacement intervals
- Where
- China
- Volunteers
- 1,240 people
- Sponsor
- Zhongnan Hospital
Sepsis, Severe Sepsis
Vitamin D Status in Patients With Severe Sepsis
Sepsis is a clinical entity that complicates infection. Without early recognition and timely management, it can rapidly progress to severe sepsis, septic shock, and culminate in multiple organ dysfunction syndrome.
- Conditions
- Sepsis, Severe Sepsis, End Organ Damage, Multi Organ Failure
- Trial name
- ViDISS (NCT02684487)
- Testing
- vitamin D3
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Metabolic Acidosis, Acid-Base Imbalance
Frequency of Metabolic Acidosis in the Pediatric Intensive Care Unit
Metabolic acidosis is one of the most common acid-base disturbances encountered in critically ill children and often reflects underlying disease severity.
- Conditions
- Metabolic Acidosis, Acid-Base Imbalance, Critical Illness in Children
- Trial name
- NCT07803263
- Volunteers
- 140 people
- Sponsor
- Assiut University
Critically Ill Child, Nutritional Status
Height Measurement in Critically Ill Children
Height/length has to be assessed accurately in critically ill children, as its value is required to assess nutritional status, to calculate nutritional requirements, to calculate body surface area (involved in drug…
- Conditions
- Critically Ill Child, Nutritional Status, Height, Length
- Trial name
- EvTaRéaP (NCT03572504)
- Testing
- critically ill children
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Strasbourg, France
Shock, Right Ventricular Dysfunction
Right Ventriculo-Arterial Coupling During Fluid Loading in ICU Patients
Preload responsiveness and venous congestion have largely been investigated independently in recent literature. However, recent data report a similar incidence of venous congestion regardless of fluid responsiveness status…
- Conditions
- Shock, Right Ventricular Dysfunction, Venous Congestion
- Trial name
- RVPA-FLICU (NCT07537621)
- Testing
- Echography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Pancreatitis
Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube
The purpose of this study is to assess the effect of erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube.
- Trial name
- NCT00999232
- Testing
- Erythromycin
- Sponsor
- Canisius-Wilhelmina Hospital
Hospital Infection, Multi-antibiotic Resistance
Colistin Intravenous Administration in Critically Ill Patients Suffering From Hospital Infections Caused by Multi-antibiotic-resistant Germs.
Colistin is an antibiotic active against several classes of multi-resistant gram-negative bacteria; the drug should be used in high doses in patients on continuous renal replacement therapy, since the drug is eliminated through…
- Conditions
- Hospital Infection, Multi-antibiotic Resistance, Critically Ill
- Trial name
- NCT04995133
- Testing
- Colistin
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Iatrogenic Anaemia
The Influence of Blood Sampling Technique on the Total Amount of Blood Collected for Laboratory Testing Critically Ill Pediatric Patients
The aim of this prospective randomized study is to evaluate blood loss caused by laboratory blood draws in patients in the paediatric ICU (Intensive Care Unit) of a tertiary hospital among two groups of patients with established…
- Trial name
- PEDPBM (NCT06376747)
- Testing
- In line sampling, Standard blood sampling technique
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Critical Illness, Enteral Feeding
Tolerance and Efficacy of a Predigested, High Protein, High Omega 3 Fat Enteral Feeding Formula Versus a Standard Formula In Multiple Intensive Care Unit Settings
The purpose of this pilot study is to assess the efficacy, safety and tolerance profile of the enteral feeding product VITAL AF (a semi-elemental, high protein, and high omega-3 fish oil) when compared to Osmolite 1.2, a standard…
- Trial name
- NCT01448135
- Testing
- VITAL AF, Osmolite 1.2
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
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