Clinical trials: Image Guided Radiotherapy
Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Busulfan, Etoposide, and Intensity-Modulated Radiation Therapy Followed By Donor Stem Cell Transplant in Treating Patients With Advanced Myeloid Cancer
RATIONALE: Giving chemotherapy drugs, such as busulfan and etoposide, and intensity-modulated radiation therapy before a donor stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
- Trial name
- NCT00540995
- Testing
- busulfan, etoposide, intensity-modulated radiation therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- City of Hope Medical Center
Lung Cancer
3-Dimensional Conformal Radiation Therapy Versus Intensity Modulated Radiation Therapy
Primary Objective: Developing Common Toxicity Criteria (CTC) 3.0 grade > 3 treatment related pneumonitis (TRP) or Developing local-regional recurrence among patients treated with 3D conformal radiation therapy (CRT) (Arm 1) or…
- Trial name
- NCT00520702
- Testing
- Intensity Modulated Radiation Therapy, 3-Dimensional Conformal Radiation Therapy
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- M.D. Anderson Cancer Center
Glioma
Image Guided Therapy in the Treatment of Gliomas
RATIONALE: New imaging techniques using magnetic resonance imaging give better tumor definition, thus may lead to better tumor targeting and avoid damaging critical parts of normal brain.
- Trial name
- NCT01263821
- Testing
- Diffusion-weighted magnetic resonance imaging, Perfusion-weighted magnetic resonance imaging, Functional magnetic resonance imaging
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
Head and Neck Cancer, Lung Cancer
Evaluation of a Cone-beam CT Scanner for Image Guided Radiotherapy
This is a feasibility study investigating the image quality of a new, high-performance cone beam CT (CBCT) used for on-couch imaging during radiotherapy treatments.
- Conditions
- Head and Neck Cancer, Lung Cancer, Breast Cancer, Abdominal Cancer
- Trial name
- CONFIGURE (NCT05524454)
- Testing
- Novel CBCT Imaging
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Varian, a Siemens Healthineers Company
Prostate Cancer
Tumor-directed Radiation Therapy for Patients With the Highest Risk Category of Localized Prostate Cancer
HYPO-RT-PC boost is is an open-label, multicentre, phase II trial evaluating safety and efficacy of real-time image-guided tumor-directed ultra-hypofractionated radiation boost and lymph node irradiation for patients with…
- Trial name
- NCT06220435
- Testing
- Ultra-hypofractionated radiotherapy regimen.
- Where
- 2 sites in Sweden
- Volunteers
- 76 people
- Sponsor
- Region Skane
Pancreatic Ductal Adenocarcinoma, Gastric Cancer
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Phase I/IIa image-guided, alpha-particle therapy study of [203Pb]Pb-PSV359 and [212Pb]Pb-PSV359 in patients with solid tumors that are known to be Fibroblast Activation Protein (FAP)-positive.
- Conditions
- Pancreatic Ductal Adenocarcinoma, Gastric Cancer, Esophageal Cancer, Colorectal Cancer
- Trial name
- NCT06710756
- Testing
- [203Pb]Pb-PSV359, [212Pb]Pb-PSV359
- Where
- 16 sites in United States
- Volunteers
- 112 people
- Sponsor
- Perspective Therapeutics
Radiotherapy, Spine Metastases
Stereotactic Radiotherapy and Image-guided Intensity Modulated Radiotherapy for Spinal Metastatic Tumors
Data of 100 patients with spinal metastatic tumor who received stereotactic radiotherapy or conventionally-fractionated image-guided intensity-modulated radiotherapy in the multi-center of the research group from July 2019 to…
- Conditions
- Radiotherapy, Spine Metastases, Radiosurgery
- Trial name
- SCIRSM (NCT03963713)
- Testing
- Stereotactic radiotherapy, Conventionally-fractionated image- guided Intensity modulated radiotherapy
- Where
- 10 sites in China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Small Cell Lung Carcinoma
Two Schedules of Hyperfractionated Thoracic Radiotherapy in Limited Disease Small Cell Lung Cancer
The majority of patients with limited disease small cell lung cancer (SCLC) experience recurrent disease despite receiving concurrent chemoradiotherapy.
- Trial name
- THORA (NCT02041845)
- Testing
- 45 Gy in 30 fractions, 60 Gy in 40 fractions
- Where
- 22 sites in Denmark, Norway and 1 more
- Volunteers
- 177 people
- Sponsor
- Norwegian University of Science and Technology
Radiotherapy, Repositonning Pelvic
Assessing the Ompact of Neutral Pelvic Positioning on Bone Repositioning Quality in Pelvic Radiotherapy Patients
This study explores whether achieving a neutral pelvic position improves bone repositioning quality for patients undergoing pelvic radiotherapy.
- Conditions
- Radiotherapy, Repositonning Pelvic, Neutral Pelvic Positioning
- Trial name
- Pelvtilt-RT (NCT06687200)
- Testing
- Setup with neutral pelvic positioning technique, Standard setup
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Leon Berard
Prostate Cancer
Evaluation of Late Toxicity Following Intensity-Modulated Radiotherapy and Two Image-Guided Strategies With Corresponding Treatment Margins.
The Calypso® System (Varian Medical Systems, Inc., Palo Alto, CA) is a recent technology using electromagnetic transponders implanted within the prostate.
- Trial name
- RCMIGI (NCT03254420)
- Testing
- Calypso beacon implant, moderate hypofractionation Radiotherapy
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Tumor, Effects of; Movement
Evaluation of Intrafractional Motion of Liver Tumors Using Markers
Radioopaque fiducial markers or electro-magnetic transponders will be implanted into or in close proximity of the tumor. During a radiotherapy treatment session image and/or signal acquisition will be performed by ultrasound…
- Conditions
- Tumor, Effects of; Movement, Radiation; Lesion
- Trial name
- ESMERALDA (NCT02095236)
- Testing
- organ motion
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Carcinoma, Glioblastoma
MRinRT: Swansea University and SWWCC Collaboration Study.
The aim of this study is to learn whether using MRI (magnetic resonance imaging) scans to plan radiotherapy is better than using CT (computed tomography) scans alone.
- Conditions
- Carcinoma, Glioblastoma, Radiotherapy, MRI
- Trial name
- MRinRT (NCT07365124)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Swansea Bay University Health Board
Head and Neck Cancer, Recurrence
BNCT and IG-IMRT for Recurrent Head and Neck Cancer
This is a boron neutron capture therapy (BNCT) combined with image-guided intensity modulation radiotherapy (IG-IMRT) for patients with previously irradiated and locally recurrent head and neck cancer.
- Trial name
- NCT02004795
- Testing
- BNCT + IG-IMRT
- Where
- Taiwan
- Volunteers
- 28 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Head and Neck Cancers, Breast Cancer
Feasibility Study of CBCT for IGRT in Cancer Patients
Cone beam computed tomography (CBCT) is an imaging technology that is incorporated into many modern radiation therapy systems. The quality of conventional CBCT is good enough to align patients for their daily radiation therapy…
- Conditions
- Head and Neck Cancers, Breast Cancer, Thoracic Cancers, Liver Cancer
- Trial name
- NCT06681233
- Testing
- Comparison of HyperSight CBCT imaging to conventional CBCT imaging.
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Varian, a Siemens Healthineers Company
Metastatic Disease
Study Using High-Dose Single Fraction Image-Guided Radiotherapy for Metastatic Lesions to Soft Tissue Masses, Lymph Node, or Bone
The purpose of this research study is to find out what IG-IMRT radiation dose works best for treatment of disease in bone or soft tissues. This protocol will study what dose level may work most effectively.
- Trial name
- NCT00678158
- Testing
- intensity modulated radiation therapy
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bladder Cancer
Study of Weekly Radiotherapy for Bladder Cancer
Background Localised muscle invasive bladder cancer (MIBC) is life-threatening and can cause significant symptoms. Around 50% of patients with MIBC who are referred for radiotherapy are unfit for standard radical treatment…
- Trial name
- HYBRID (NCT01810757)
- Testing
- Standard planning radiotherapy, Adaptive planning radiotherapy
- Where
- 11 sites in United Kingdom
- Volunteers
- 65 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Recurrent Melanoma (Skin), Metastatic Melanoma
MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
In this first-in human, phase I/IIa study, the safety and efficacy of [212Pb]VMT01, an alpha-particle emitting therapeutic agent targeted to melanocortin sub-type 1 receptor (MC1R) is being evaluated as a monotherapy and in…
- Conditions
- Recurrent Melanoma (Skin), Metastatic Melanoma, Melanoma Stage IV, Melanoma Stage III
- Trial name
- NCT05655312
- Testing
- [203Pb]VMT01, [212Pb]VMT01, Nivolumab
- Where
- 16 sites in United States
- Volunteers
- 300 people
- Sponsor
- Perspective Therapeutics
Prostate Cancer
Image-guided, Tumor-focused Radiotherapy Treatment in Intermediate and High-risk Prostate Cancer
This is a phase II non-blinded randomized controlled trial of image-guided, tumor-focused radiotherapy in patients with intermediate- or high-risk prostate cancer planning to undergo definitive radiotherapy with or without…
- Trial name
- RadTARGET (NCT06990542)
- Testing
- Image-guided tumor-focused radiation therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Diego
Central Nervous System Tumors, Brain Tumors
A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects
The purpose of the study was to determine if treating a limited volume of normal tissue surrounding the tumor or tumor bed using conformal radiation therapy would achieve similar rates of disease control compared to standard…
- Trial name
- NCT00187226
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- St. Jude Children's Research Hospital
Lung Neoplasm, Pelvic Neoplasm
Personalized Estimation of Doses Delivered During Image Guided Radiation Therapy Tests
In image-guided radiotherapy (IGRT), the repeated and increasingly intensive use of on-board positioning imaging, using 2D or 3D Mega-Volt (MV) or kilo-Volt (kV) imaging devices (cone-beam or CBCT scanners), is leading the…
- Conditions
- Lung Neoplasm, Pelvic Neoplasm, Breast Cancer, Cancer, Otorhinolaryngeal
- Trial name
- ELISA (NCT05258383)
- Testing
- 3D maps of physical doses
- Where
- 9 sites in France
- Volunteers
- 320 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris