Clinical trials: Imaging Guided
Malignant Tumors
PET/CT-Guided Biological Target Volume Delineation and Dose Optimization for Radioactive Seed Implantation Therapy in Malignant Tumors
This prospective, open-label Phase I/II trial evaluates a PET/CT-guided planning strategy for radioactive seed implantation therapy in malignant solid tumors.
- Trial name
- NCT07327515
- Testing
- CT-Guided Radioactive Seed Implantation, PET/CT-Guided Radioactive Seed Implantation, PET/CT-Guided Radioactive Seed Implantation (Biological Dose Optimization)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Li Min
Kidney Cancer, Metastatic Cancer
Magnetic Resonance Imaging-guided Thermal Radiofrequencey Ablation of Primary Renal Cell Carcinoma, Hepatic Metastasis, and Other Sites of Solid Organ Tumor and Metastases
RATIONALE: Radiofrequency ablation uses high-frequency electric current to heat and kill tumor cells. Magnetic resonance imaging-guided radiofrequency ablation may an effective treatment for primary kidney cancer, liver…
- Conditions
- Kidney Cancer, Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00006255
- Testing
- radiofrequency ablation, thermal ablation therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer Screening, PSMA-PET
PSMA PET/MRI-Guided Prostate Biopsy for PI-RADS ≤3 and Prior Negative Biopsy
The goal is to provide more accurate diagnostic tools and optimized diagnostic workflows for clinically suspected prostate cancer patients with prior negative biopsies, improving early detection rates for csPCa and reducing…
- Trial name
- NCT06923657
- Testing
- PSMA PET/MRI-TRUS guided prostate targeted combined saturation biopsy, TRUS guided transperineal saturation biopsy
- Where
- China
- Volunteers
- 230 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
STEMI, Intravascular Imaging
Intravascular ULTRAsound-Guided PCI in Patients With ST-Elevation Myocardial Infarction
The main goal of the ULTRA-STEMI trial is to investigate the prognostic impact of IVUS-guided PCI in patients with STEMI and correlate IVUS measurements with clinical, procedural, imaging and follow-up outcomes of interest.
- Conditions
- STEMI, Intravascular Imaging, IVUS
- Trial name
- ULTRA-STEMI (NCT05974930)
- Testing
- IVUS imaging for primary PCI guidance
- Volunteers
- 80 people
- Sponsor
- Aristotle University Of Thessaloniki
Obsessive-Compulsive Disorder
Imaging-Guided Low Intensity Focused Ultrasound (LIFU)
This research study is to investigate the safety, feasibility, and possible therapeutic benefits of a technology called Low Intensity Focused Ultrasound (LIFU) in patients with obsessive- compulsive disorder (OCD).
- Trial name
- LIFU (NCT05467085)
- Testing
- BX Pulsar 1002
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Breast-Conserving Surgery
A Novel Intraoperative Fluorescence-guided System for Evaluating Margins During Breast-conserving Surgery for Breast Cancer
The goal of this clinical trial is to learn if a novel intraoperative fluorescence-guided system (EndoSCell Scanner) can help surgeons more accurately remove all cancerous tissue during breast-conserving surgery in female…
- Trial name
- NCT07352930
- Testing
- EndoSCell Scanner (ES Scanner) System
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Guangdong Provincial People's Hospital
Uterine Fibroids
Clinical Test of the MRgHIFU System on Uterine Fibroids
The objectives of this program are to verify the safety and effectiveness of the MRgHIFU system developed by the division of Medical Engineering of National Health Research Institutes (NHRI)
- Trial name
- MRgHIFU (NCT02283502)
- Testing
- MRgHIFU system
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Chin-Jung Wang
Malignant Neoplasms of Lip Oral Cavity and Pharynx, Oropharyngeal Cancer
Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer
The goal of this clinical research study is to compare the use of MRI simulations to plan different doses of intensity modulated radiotherapy (IMRT) to the standard IMRT dose in patients with low risk human papilloma virus…
- Trial name
- NCT03224000
- Testing
- Modified Barium Swallow (MBS), Swallowing Questionnaire, Symptom Questionnaire
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- M.D. Anderson Cancer Center
Locally Advanced Cervical Cancer, Brachytherapy
This is a Multicentre International Study Evaluating CT-based IGABT With / Without Either TRUS During BT/Pre BT MR as Per IBS-GECESTRO-ABS Recommendations for Target contouring-as an Alternative to MRIGABT for Cervical Cancer From Implementation Perspectives Under EMBRACE-III:TRIPLET IMPACT Study.
Title: Integration of Multi-modality Imaging Protocols with Emphasis on CT in Image-Guided Adaptive Brachytherapy (IGABT) for Cervical Cancer - EMBRACE III-TRIPLET : IMPACT Study Locally advanced cervical cancer (LACC) remains a…
- Conditions
- Locally Advanced Cervical Cancer, Brachytherapy, CT, Transrectal Ultrasound
- Trial name
- IMPACT (NCT07249021)
- Testing
- CT IGABT
- Where
- India
- Volunteers
- 1,200 people
- Sponsor
- Homi Bhabha Cancer Hospital & Research Centre
Prostate Cancer
Imaging Guided Surgery to Improve the Detection of Lymph Node Metastases in Prostate Cancer Patients
The project aims at assessing the role of radio-guided surgery in the detection of lymph node invasion (LNI) in prostate cancer (PCa) patients undergoing radical prostatectomy (RP) by using an intraoperative gamma probe and a…
- Trial name
- NCT04832958
- Testing
- 99m-TC-PSMA-I&S
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- IRCCS San Raffaele
Brain and Central Nervous System Tumors
Imaging Procedure Using ALA in Finding Residual Tumor in Grade IV Malignant Astrocytoma
RATIONALE: Imaging procedures that use aminolevulinic acid (ALA) may help find and diagnose residual tumor in participants with grade IV malignant astrocytoma who are undergoing surgery to remove the tumor.
- Trial name
- NCT00752323
- Testing
- aminolevulinic acid, Surgical Resection
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Andrew Sloan, MD
Heart Failure
Image Guided Mapping for Cardiac Pacing Intervention
Patients with heart failure and cardiomyopathy that have been referred for Cardiac Resynchronization Therapy (CRT) will have their CRT devices implanted using an image guided treatment plan for optimal lead delivery.
- Trial name
- MAPIT-TOO (NCT01638754)
- Testing
- Image guided Cardiac Resynchronization Therapy (CRT) device lead placement., optimizing myocardial lead placement for Cardiac Resynchronization Therapy (CRT) devices
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression - Major Depressive Disorder
Feasibility, Safety, and Preliminary Clinical Efficacy of Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression: A Randomized, Double-Blind, Controlled Pilot Study
This study aims to assess the feasibility, safety, acceptability, and preliminary efficacy trends of a Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) intervention for adolescent depression…
- Trial name
- NCT07185438
- Testing
- Experimental target rTMS treatment, Conventional target rTMS treatment
- Where
- China
- Volunteers
- 45 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Inverted Papilloma, Molecular Fluorescence Imaging
Image Guided Surgery in Sinonasal Inverted Papilloma
In sinonasal inverted papilloma (SNIP) it is very challenging to discriminate between tumor and surrounding tissue. Local recurrence is a frequent phenomenon as it occurs in 16.5% of the cases.
- Trial name
- SNIPER (NCT03925285)
- Testing
- Bevacizumab-800CW
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- University Medical Center Groningen
Breast Cancer
MEthods for LOcalization of Different Types of Breast Lesions
In the last decades, the proportion of breast cancer (BC) patients receiving breast-conserving surgery has increased steadily, reaching 70-80% in developed countries.
- Trial name
- MELODY (NCT05559411)
- Where
- Germany
- Volunteers
- 7,416 people
- Sponsor
- European Breast Cancer Research Association of Surgical Trialists
Localized Prostate Cancer
Prospective Clinical Safety and Efficacy Study of Lesion-targeted MRI-TULSA for Localized Prostate Cancer
Magnetic resonance imaging (MRI) has improved detection of clinically significant prostate cancer (PCa). MRI-guided transurethral ultrasound ablation (MRI-TULSA) system incorporates precise diagnosis and simultaneous ablation of…
- Trial name
- PRO-TULSA-PC (NCT03814252)
- Testing
- MRI-TULSA
- Where
- Finland
- Volunteers
- 62 people
- Sponsor
- Turku University Hospital
Cancer Pain, Intractable Pain
MRI Evaluation of Spinal Cord Edema After CT-Guided Percutaneous Cordotomy in Cancer Pain Patients
This observational study aims to evaluate changes in the spinal cord following CT-guided percutaneous cervical cordotomy performed for the treatment of intractable cancer-related pain.
- Conditions
- Cancer Pain, Intractable Pain, Spinal Cord Edema, Neuropathic Pain
- Trial name
- CORD-MRI (NCT07400055)
- Testing
- CT-guided Percutaneous Cervical Cordotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Mersin University
Esophageal Cancer, Gastrointestinal Cancers
Single Dose Investigator Initiated Pilot Study to Investigate CYTALUX (Pafolacianine) for Intraoperative Detection of Malignant Tissue in Subjects Undergoing Surgical Resection for Cancer.
The goal of clinical trial is to test an FDA approved drug called Pafolacianine that attaches to cancer cells and lights up when seen through a special camera system in adults with a suspected primary diagnosis, or a high…
- Conditions
- Esophageal Cancer, Gastrointestinal Cancers, Gynecologic Cancers
- Trial name
- NCT07039526
- Testing
- CYTALUX™ (pafolacianine) injection preoperatively
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Waters
Cancer
MR Imaging Study Using the Northern Alberta Linac-MR (Northern LIGHTs - 1)
Cancers are often treated with external beam radiotherapy. Current radiotherapy treatments are performed using computed tomography (also known as CT) scans which may not always clearly identify the cancer.
- Trial name
- NCT04358913
- Testing
- MR scan with the Alberta linac-MR P3 system
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- AHS Cancer Control Alberta
Breast Cancer
Real-Time Near-infrared (NIR) Mapping of Sentinel Lymph Nodes in Breast Cancer
The objective of this Phase II study is to assess the diagnostic accuracy of sentinel lymph node (SLN) identification in patients with breast cancer using near-infrared (NIR) fluorescence optical imaging.
- Trial name
- NCT01468649
- Testing
- NIR Imaging with FLARE and Mini-FLARE Imaging System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center