Clinical trials: Imaging Guided
Sentinel Lymph Node, Breast Cancer
Sentinel Lymph Node Biopsy in Breast Cancer Surgery Using ICG
This clinical trial is a prospective, multicenter, self-controlled clinical study. In order to meet the requirements of this plan, 130 breast cancer patients need the sentinel lymph node biopsy with novel near-infarred…
- Trial name
- NCT03579979
- Testing
- Methylene Blue, Indocyanine Green
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Chinese Academy of Sciences
Hepatocellular Carcinoma
GPC3 Targeted Fluorescence Image Guided Surgery of Hepatocellular Carcinoma
This study is to evaluate whether intraoperative fluorescence imaging targeting GPC3 can aid improve the surgical accuracy of hepatocellular carcinoma.
- Trial name
- NCT05047510
- Testing
- Anti-GPC3-IRDye800CW
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Prostate Cancer
Advanced Magnetic Resonance Imaging (MRI) in Men With Suspected Prostate Cancer
The clinical trial aims to address the critical challenge of differentiating aggressive from indolent prostate cancers by correlating prospectively collected MultiParametric (MP) Magnetic Resonance Imaging (MRI) data (index test)…
- Trial name
- MULTIPROS (NCT02745496)
- Testing
- TRUS Biopsy, TRUS/FUSION Biopsy
- Where
- United Kingdom
- Volunteers
- 603 people
- Sponsor
- University of Dundee
Heart Failure
Empiric Versus Imaging Guided Left Ventricular Lead Placement in Cardiac Resynchronization Therapy
The aim of this study is to investigate if imaging guided optimal left ventricular (LV) lead placement improves the response rate to cardiac resynchronization therapy (CRT).
- Trial name
- ImagingCRT (NCT01323686)
- Testing
- Imaging guided optimal LV lead placement
- Where
- Denmark
- Volunteers
- 182 people
- Sponsor
- University of Aarhus
Localised Prostate Cancer, Locally Advanced Prostate Cancer
MRI Guided Transurethral HIFU for Various Prostate Diseases
This study assesses feasibility and safety, the primary outcomes, of MRI guided transurethral high intensity focused ultrasound (HIFU) ablation for prostate diseases (PD).
- Conditions
- Localised Prostate Cancer, Locally Advanced Prostate Cancer, Locally Recurrent Prostate Cancer, Benign Prostatic Hyperplasia
- Trial name
- HIFU-PRO (NCT03350529)
- Testing
- MRI guided transurethral HIFU ablation of prostatic tissue
- Where
- Finland
- Volunteers
- 87 people
- Sponsor
- Turku University Hospital
Mesial Temporal Lobe Epilepsy
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
The main goals of this clinical study are to learn if AMT-260 is safe and tolerable and works to reduce the frequency of seizures in adults with unilateral mesial temporal lobe epilepsy (MTLE).
- Trial name
- GenTLE (NCT06063850)
- Testing
- AAV9-hSyn1-miGRIK2
- Where
- 18 sites in United States
- Volunteers
- 12 people
- Sponsor
- UniQure Biopharma B.V.
Paroxysmal Atrial Fibrillation (PAF)
Intracardiac Echocardiography-guided Versus Electroanatomical Mapping-guided Pulsed Field Ablation for Paroxysmal Atrial Fibrillation
This is a prospective, randomized clinical trial, which will be conducted in selected European centers. The objective is to compare two commonly used strategies to guide pulsed-field ablation (PFA) in patients with paroxysmal…
- Trial name
- PFA-VISION (NCT07772518)
- Testing
- In the ICE group, positioning/contact of the ablation catheter will be performed under ICE guidance. In the mapping group, guidance will be performed using three-dimensional electroanatomical mapping.
- Where
- 8 sites in Croatia, Czechia and 6 more
- Volunteers
- 292 people
- Sponsor
- Mitera Hospital
Stroke Hemorrhagic
DTI-guided Minimally Invasive Hematoma Evacuation for Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating disease with high early mortality, unfavorable neurological outcomes, and high cost of care.
- Trial name
- GLAMOR (NCT05891509)
- Testing
- Minimally Invasive Hematoma Evacuation, Best Medical Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhongming Qiu
Neoplasm, Esophageal, Squamous Cell Carcinoma
PET Imaging-guided Chemoradiotherapy in Esophageal Squamous Cell Carcinoma
Since multiple studies have demonstrated that PET can identify responders and non-responders to induction chemotherapy, using FDG-PET imaging to guide treatment decisions has prompted interest in clinical practice.
- Trial name
- NCT03791905
- Testing
- Paclitaxel, Cisplatin, Oxaliplatin
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Mian XI
Regional Anesthesia Morbidity, Postoperative Pain
Local Anesthesia Spread After an Erector Spinae Plane Block.
This a single-center prospective spread-evaluation study where the primary objective is to assess the spread of local anesthesia in an ESPB using magnetic resonance imaging (MRI).
- Trial name
- NCT05012332
- Testing
- Erector Spinae Plane Block
- Where
- Norway
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Head and Neck Squamous Cell Carcinoma, Margin Assessment
Image Guided Surgery for Margin Assessment of Head and Neck Cancer Using Cetuximab-IRDye800CW cONjugate
Surgery remains a main pillar in the treatment of head and neck squamous cell carcinoma (HNSCC). The margin status is the main prognostic factor of local tumor control in surgically treated HNSCC and will determine the…
- Trial name
- ICON (NCT03134846)
- Testing
- Cetuximab-IRDye800CW
- Where
- Netherlands
- Volunteers
- 79 people
- Sponsor
- University Medical Center Groningen
Prostate Neoplasm
Targeted Biopsy or Standard Biopsy for Clinical Significant Prostate Cancer Detection
This randomized controlled trial aims to assess the detection rate of clinically significant and clinically insignificant cancer of mpMRI-targeted biopsy compared to transperineal standard biopsy in men with clinical suspicion of…
- Trial name
- NCT03572946
- Testing
- Targeted prostate biopsy, Standard biopsy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Recurrent Prostate Cancer
MRI-Guided Biopsy of Recurrent Prostate Cancer After Radiotherapy
In this study we will test a new procedure to guide needle biopsies into the prostate gland based on MRI. This study will be conducted in patients who may have recurrence of their cancer in the prostate gland after radiation…
- Trial name
- NCT00775866
- Testing
- MRI-Guided Biopsy
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- University Health Network, Toronto
Severe Pneumonia
Rapid Identification of Infectious Pathogens in Severe Pneumonia Guided by Bronchoscopic Imaging and Lung CT
Severe pneumonia requires rapid and accurate diagnosis for targeted treatment, but single lung CT has limitations in identifying pathogens and distinguishing infectious/non-infectious etiologies.
- Trial name
- IMG-GUIDE-IP (NCT07308340)
- Testing
- Standalone Lung CT for Severe Pneumonia Diagnosis, Bronchoscopic Imaging + Lung CT for Severe Pneumonia diagnosis
- Volunteers
- 400 people
- Sponsor
- The First Hospital of Jilin University
Pancreatic Neoplasms, Pancreatic Cancer
Indocyanine Green-Guided Versus Standard Laparoscopic Distal Pancreatectomy for Pancreatic Body and Tail Lesions
Postoperative pancreatic fistula is the most important complication after laparoscopic distal pancreatectomy for tumors of the body and tail of the pancreas. It can cause infection, bleeding, longer hospital stay, and even death.
- Trial name
- ICG-LDP (NCT07656571)
- Testing
- ICG Fluorescence-Guided Laparoscopic Distal Pancreatectomy, Standard Laparoscopic Distal Pancreatectomy
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Alexandria University
Prostate Cancer, Image Guided Radiotherapy
PINPOINT Feasibility Study
This feasibility study is investigating the application of magnetic resonance imaging (MRI) and transperineal ultrasound (TPUS) to visualise potential sites of relapse and surrounding normal tissue in patient having…
- Trial name
- NCT05481372
- Testing
- Imaging
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Prostate Cancer (CRPC)
Prostate Cancer Postoperative Stereotactic Body Radiotherapy With Adaptive Technology for Minimizing Toxicity
Single-arm, prospective registry study assessing changes in acute patient-reported urinary (GU) and gastrointestinal (GI) quality of life at the 24-month post-treatment time point following magnetic resonance imaging (MRI)-guided…
- Trial name
- MASAMUNE (NCT07077239)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Gynecologic Cancer
High-frequency Ultrasound for Intraoperative Lymph Node Assessment in Gynecological Cancer: From Surgery to Radiomics
Lymph node assessment is crucial in gynecological cancers (ovarian, endometrial, cervical, and vulvar), as nodal involvement significantly impacts prognosis and treatment.
- Trial name
- RHINOCERUS (NCT06906705)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Abdominal Cancer
Magnetic Resonance Imaging (MRI) Guided Stereotactic Adaptive Radiotherapy for Targeting Abdominal Cancer
The aim of this study is to investigate the effect of MRI-guided adaptive stereotactic radiotherapy on local control, survival, and toxicity in the treatment of oligometastatic cancer to the abdomen.
- Trial name
- NCT06604533
- Testing
- Intervention: MRI-Linac SABR
- Where
- 2 sites in Australia
- Volunteers
- 30 people
- Sponsor
- Australasian Gastro-Intestinal Trials Group
Glioblastoma
Phase III Study Comparing 2 Brain Conformational Radiotherapy in Combination With Chemotherapy in the Treatment of Glioblastoma
This is a multi-institutional phase III clinical study of interventional type. The trial will include 220 patients with confirmed unifocal glioblastoma over a period of 3 years + 3 years of follow up.
- Trial name
- SPECTRO GLIO (NCT01507506)
- Testing
- Radiotherapy, Experimental arm
- Where
- 12 sites in France
- Volunteers
- 180 people
- Sponsor
- Institut Claudius Regaud