Clinical trials: Imaging Guided
Atrial Fibrillation (AF)
Non-invasive Mapping-Guided Atrial Fibrillation Ablation
The goal of this pilot study is to test if noninvasive global mapping can guide catheter ablation defining personalized targets and improve the therapy of atrial fibrillation. It will also test the safety of such an approach.
- Trial name
- ELISA-AF (NCT07358611)
- Testing
- Non-invasive mapping-guided ablation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Clinic of Barcelona
Atrial Fibrillation
Intra-Cardiac Echocardiography Guided Cardioversion(ICE-CHIP) Study
This is a sequential phase 1 and phase 2 study to evaluate the efficacy of intracardiac echocardiography to detect septal and left atrial pathology as compared to transesophageal echocardiography (Phase 1) and its value in a…
- Trial name
- ICE-CHIP (NCT00281073)
- Testing
- Intra-Cardiac Echocardiography guided Cardioversion, Intracardiac Echo, ICE
- Where
- 6 sites in United States, Netherlands
- Volunteers
- 95 people
- Sponsor
- EP MedSystems
Coronary Artery Stenosis
Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease
The objective of this randomized study was to compare outcomes of imaging-and physiology-guided state-of-the-art percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in patients with diabetes and…
- Trial name
- DEFINE-DM (NCT05831085)
- Testing
- State-of-the-Art Percutaneous Coronary Intervention, standard CABG
- Where
- 39 sites in United States, Australia and 12 more
- Volunteers
- 1,500 people
- Sponsor
- Duk-Woo Park, MD
Surgery Site Fistula
Hypopharynx ICG to Reduce the Fistula Rate in Patients Undergoing Salvage Laryngectomy
A laryngectomy involves removing the voice box from the throat. After the voice box has been removed from the throat, the surgeon sews the throat closed.
- Trial name
- NCT05350540
- Testing
- ICG dye
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Uterine Fibroids
Sonalleve Fibroid Ablation Pivotal Clinical Trial for MR-HIFU of Uterine Fibroids
The purpose of this clinical study is to determine whether treatment with the Philips Sonalleve Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) system is effective in the treatment symptomatic uterine…
- Trial name
- SOFIA (NCT01504308)
- Testing
- MR-HIFU treatment
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 49 people
- Sponsor
- Philips Healthcare
Squamous Cell Carcinoma of the Head and Neck, Oral Cancer
Fluorescence-guided Surgery Using cRGD-ZW800-1 in Oral Cancer
This is a two-staged clinical trial to investigate the feasibility of intraoperative Fluorescence Imaging (FLI) to adequately assess tumor margins in patients with oral cancer using cRGD-ZW800-1.
- Conditions
- Squamous Cell Carcinoma of the Head and Neck, Oral Cancer, Squamous Cell Carcinoma of the Oral Cavity
- Trial name
- GuidedbyLight (NCT04191460)
- Testing
- cRGD-ZW800-1.
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- Erasmus Medical Center
Stress Disorders, Post-Traumatic
Salience Network Informed rTMS for PTSD
The proposed study will test whether magnetic resonance imaging (MRI)-guided transcranial magnetic stimulation (TMS) can reduce posttraumatic stress disorder (PTSD) symptoms in Veterans.
- Trial name
- NCT07886840
- Testing
- Active MRI-Guided intermittent theta burst stimulation (iTBS)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- VA Office of Research and Development
Sentinel Lymph Node
Bronchial NIR Image-guided Resection
This is a clinical trial to evaluate the use of peritumoral injection of near-infrared dye indocyanine green to identify lung lesions and sentinel lymph nodes.
- Trial name
- NCT03097575
- Testing
- ICG Intervention, Near Infrared Imaging
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Solid Neoplasm
An Investigational Device (Millar Mikro-Tip Catheter) and Imaging Scan (Shear Wave Elastography) in Measuring Tumor Pressure and Stiffness in Patients With Solid Tumors Undergoing Ultrasound-Guided Biopsy
This trial studies how well a Millar Mikro-tip catheter and shear wave elastography measure pressure and stiffness inside tumors among patients with solid tumors undergoing an ultrasound-guided biopsy.
- Trial name
- NCT04054154
- Testing
- Shear Wave Elastography, Tumor Interstitial Fluid Pressure Measurement
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- M.D. Anderson Cancer Center
Coronary Artery Disease, Atherosclerosis
Intravascular Imaging- Versus Angiography-Guided Percutaneous Coronary Intervention For Complex Coronary Artery Disease
The aim of the study is to compare clinical outcomes between intravascular imaging-guided versus angiography-guided percutaneous coronary intervention (PCI) in complex lesions.
- Trial name
- RENOVATE (NCT03381872)
- Testing
- Percutaneous coronary intervention for complex lesion, Drug-eluting stent, Intravascular imaging (IVUS or OCT)
- Where
- South Korea
- Volunteers
- 1,639 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
OPTIMIZE-APT: Tailored Versus Conventional Antiplatelet Therapy After Intravascular Imaging-guided Drug-eluting Stent Implantation
Objectives: To assess the safety of tailored antiplatelet therapy (short DAPT followed by P2Y12 inhibitor alone strategy) in patients who received optimized DES implantation guided by intravascular imaging (IVUS or OCT)…
- Trial name
- OPTIMIZE-APT (NCT05418556)
- Testing
- aspirin
- Where
- 33 sites in South Korea
- Volunteers
- 3,944 people
- Sponsor
- Asan Medical Center
Major Depressive Episode
Personalized Repetitive Transcranial Magnetic Stimulation Treatment for Major Depressive Episode
Adolescents and young adults with mood disorders experiencing major depressive episode have poor efficacy of medication treatment.
- Trial name
- PRTMSTMDEAYA (NCT05465928)
- Testing
- Active rTMS
- Where
- China
- Volunteers
- 219 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Neurosurgery, Neuro-Oncology
Intraoperative Hyperspectral Imaging for Fluorescence Guided Surgery in Low Grade Gliomas
The purpose of this study is to obtain images of brain tumours during surgery using a new type of surgical camera. The study will assess how the information obtained from the images during surgery matches the removed tissue.
- Conditions
- Neurosurgery, Neuro-Oncology, Brain Tumor
- Trial name
- Neuro-qFHSI (NCT05397574)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College London
Prostate Cancer
Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) Guided Biopsy in Men With Elevated PSA
In 22% of patients with elevated Prostate-specific antigen (PSA) MRI guided biopsy will not detect significant prostate cancer (PCA) (defined as either: Gleason score (GS) ≥ 3+4 or tertiary pattern 5, or final stage ≥ pT3a and/or…
- Trial name
- NCT03187990
- Testing
- [68Ga]PSMA-11, [18F]PSMA-1007
- Where
- Switzerland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Irene Burger
Primary Progressive Aphasia
Transmagnetic Stimulation Pilot in Primary Progressive Aphasia
Frontotemporal degeneration (FTD) is a non-Alzheimer's dementia that is the 2nd most common cause of dementia in the United States.
- Trial name
- TMS in PPA (NCT05860647)
- Testing
- Intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- HealthPartners Institute
Breast Cancer
Fluorescence Guided Surgery in Breast Cancer
A need for further investigation for fluorescence image-guided surgery in breast conserving surgery (BCS) has arisen following the results obtained from a phase I feasibility breast cancer trial (BIRDYE study: ABR NL…
- Trial name
- MARGIN (NCT02583568)
- Testing
- Bevacizumab-800CW
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- University Medical Center Groningen
Prostate Cancer
Radiolabeled Gallium-68 (68Ga-PSMA) for PET/CT Imaging to Detect Prostate Cancer
The purpose of the study is to find out whether imaging of the prostate with a new molecule called 68Ga-PSMA can find prostate cancer.
- Trial name
- NCT03689582
- Testing
- 68Ga-PSMA
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Michigan Rogel Cancer Center
Squamous Cell Carcinoma of the Head and Neck
Early Response Evaluation of Proton Therapy by PET-imaging in Squamous Cell Carcinoma Located in the Head and Neck
The goal of this project is to develop and characterise an imaging strategy for biology-guided individualisation of the proton therapy plan to improve patient outcome and quality-of-life.
- Trial name
- ERM-PT-HNSCC (NCT03513042)
- Testing
- Intensity Modulated Proton Therapy (IMPT) +/- Chemotherapy
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Leiden University Medical Center
Arrhythmia
Radiation-free Anatomical Direct Imaging Approach for No-fluoroscopy Cardiac Electrode Implantation
Permanent pacemaker implantation is traditionally performed under fluoroscopic (X-ray) guidance. Although effective, fluoroscopy exposes patients and medical staff to ionizing radiation.
- Trial name
- RADIANCE (NCT07458724)
- Testing
- Permanent Pacemaker Implantation
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Carpal Tunnel Syndrome
Cerebral Changes Following CTS Treated With Guided Plasticity
70 patients with mild to moderate Carpal tunnel Syndrome (CTS) including 24 patients with unilateral CTS were randomized to treatment with ipsilateral cutaneous forearm deafferentation with an anesthetic cream (EMLA®) or placebo…
- Trial name
- NCT06016049
- Testing
- EMLA® adjuvant, Sensory training
- Volunteers
- 70 people
- Sponsor
- Region Skane