Clinical trials: Immediate Effect
Anaphylaxis, Mastocytosis
Analysis of the Role of IgE Proteoforms in Health and Disease
The goal of this observational study is to evaluate the role of IgE proteoforms in healthy volunteers and in patients with type I allergy, patients with chronic spontaneous urticaria, patients with a recent history of…
- Conditions
- Anaphylaxis, Mastocytosis, X-linked Agammaglobulinaemia, Venom Allergy
- Trial name
- IgE-PhD (NCT07328178)
- Testing
- Blood sample collection
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Other Endosseous Dental Implant Failure
Effect of Immediate Placement and Loading of Compressive Versus Conventional Implants
The current study aims to compare immediate placement and loading of compressive versus conventional dental implants after atraumatic extraction regarding the effectiveness, bone resorption and survival of each of them.
- Trial name
- Implants (NCT07601347)
- Testing
- Immediate implant placement and loading
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ahmed Nagi Alghandour
Asthma, Allergic
Tezepelumab and Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma
Asthma is a condition where small inhaled particles can cause inflammation in the lung leading to constriction of airways and wheeze.
- Trial name
- NCT05740748
- Testing
- Tezepelumab
- Where
- 2 sites in Canada
- Volunteers
- 34 people
- Sponsor
- McMaster University
Latent Myofascial Trigger Points, Upper Trapezius Muscle
Immediate Effects of Strain Counterstrain Versus Fascial Distortion Model on Upper Trapezius Latent Trigger Points
This pilot study aimed to compare the immediate effects of two manual therapy techniques, strain counterstrain (SCS) and the fascial distortion model (FDM), on pain-related outcomes and neuromuscular function in individuals with…
- Trial name
- NCT07368426
- Testing
- Strain Counterstrain, Fascial Distortion Model
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kyungnam University
Peanut Allergy
HAL-MPE1 Safety and Tolerability Study
The aim of this study is to confirm safety and tolerability of incremental doses of HAL-MPE1 subcutaneous immunotherapy (SCIT) in peanut allergic adults, and subsequently assess the safety and tolerability in adolescents and…
- Trial name
- NCT02991885
- Testing
- HAL-MPE1
- Where
- 7 sites in United States, Canada
- Volunteers
- 42 people
- Sponsor
- HAL Allergy
Food Allergy
Pectin Intervention Study and Long-term Follow-up in Lipid Transfer Proteins Allergic Patients
Pectins are dietary fibers that have shown a health effect on patients with food allergy, as they are capable of modifying the composition of gastrointestinal microbiota, and producing an immunomodulatory effect.
- Trial name
- PI23/00820 (NCT06558526)
- Testing
- Apple pectin (DE 57%)
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Pacing Therapy, Cardiac Pacing
Immediate Electrophysiological Effects of Different Atrial Pacing Sites on P-Wave Characteristics
This is a prospective, single-center, non-randomized, within-subject interventional study. The purpose is to compare the immediate effects of different atrial pacing sites on atrial electrical activation, as reflected by P-wave…
- Trial name
- Multi-site AP (NCT07603648)
- Testing
- Multi-site short-time pacing
- Where
- 2 sites in China
- Volunteers
- 35 people
- Sponsor
- Shanghai Tong Ren Hospital
Asthma, Allergic, Rhinitis,Allergic
Effects of Intranasal Fluticasone Plus Azelastine on Airway Inflammation in Patients With Asthma & Allergic Rhinitis
Single centre, double-blind, placebo controlled, adaptive design, cross-over trial. The primary objective is to assess the additive effects of using combined intranasal fluticasone propionate plus azelastine nasal spray on airway…
- Conditions
- Asthma, Allergic, Rhinitis,Allergic, Allergy
- Trial name
- MAN06 (NCT02953106)
- Testing
- Azelastine-Fluticasone Nasal
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of Dundee
Postoperative Pain, Edema
Effects of Sterile Kinesio Tape on Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament reconstruction (ACLR) is a surgical tissue graft replacement of the anterior cruciate ligament, located in the knee, to restore its function after an injury.
- Trial name
- NCT04873921
- Testing
- sterile kinesio taping
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Baskent University
Shoulder Pain Chronic
Immediate Effects of TENS and HVPS on Subacromial Pain and Shoulder Movements
This study was performed to investigate the immediate effects of transcutaneous electrical nerve stimulation (TENS) and high voltage pulsed stimulation (HVPS) on resting pain and pain-free range of shoulder motion (pfROM) in…
- Trial name
- NCT03588143
- Testing
- Electrical stimulation
- Volunteers
- 106 people
- Sponsor
- Mehmet Gürhan KARAKAYA
Food Allergy, Food Allergy in Children
Effect of Omalizumab in the Skin of Food Allergy Patients
The goal of this interventional study is to evaluate whether skin barrier abnormalities occur in subjects with a food allergy, as determined by positive oral food challenge (OFC).
- Trial name
- NCT06618963
- Testing
- Omalizumab Injection
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Environmental Exposure
Effects of Pesticide Exposure on Neurodevelopment/Growth/Respiratory Health
Exposure and health study of pesticide and allergen exposures to pregnant women and children. Intervention study is planned after assessment is completed.
- Trial name
- NCT00021658
- Testing
- Pesticide application procedures
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Drug Allergy
Retrospective Study of Immediate Hypersensitivity (IHS) Reactions to Platinum Salts in the University Hospital of Nancy
To assess the efficacy of skin tests with platinum salts in patients suspects with immediate hypersensitivity reactions. All patients adressed in consultation to the Allergy Department of university hospital of nancy for an…
- Trial name
- NCT04920721
- Testing
- no intervention
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Central Hospital, Nancy, France
Parkinson's Disease With End of Dose Wearing Off
Effects of Carbidopa/Levodopa/Entacapone on Motor Function and Quality of Life in Patients With Parkinson's Disease
To assess motor function and quality of life (QoL) in Parkinson's disease (PD) subjects with end-of-dose wearing off, comparing immediate and delayed switch to carbidopa/levodopa and entacapone.
- Trial name
- NCT00219284
- Testing
- Carbidopa/levodopa/entacapone
- Where
- 42 sites in United States, Puerto Rico
- Volunteers
- 359 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
Effects of Interleukin (IL)- 4R-alpha Inhibition on Respiratory Microbiome and Immunologic Correlates in Severe Asthma
The overall goal of this study is to understand biological responses related to dupilumab treatment among severe asthma patients. Not all asthma is the same, and characteristics of asthma vary from person to person.
- Trial name
- NCT05036733
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Chronic Spontaneous Urticaria (CSU)
Effects of Diet and Oxidative Stress on Disease Severity and Response to Omalizumab in Chronic Spontaneous Urticaria
Chronic spontaneous urticaria (CSU) is an immune-mediated skin disorder characterized by pruritic wheals and/or angioedema. This study aims to evaluate the relationship between diet-derived antioxidant capacity and oxidative…
- Trial name
- NCT07431658
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Temporomandibular Joint Disorders, Bruxism
Mandibular Muscle Energy Technique in Patients With Mandibular Joint Pathology and Bruxism
This is a randomized, controlled, double-blind clinical trial. The main objective is to evaluate the immediate effect of the mandibular muscle-energy technique on pain, functionality and kinesiophobia in subjects suffering from…
- Conditions
- Temporomandibular Joint Disorders, Bruxism, Pain Threshold, Kinesiophobia
- Trial name
- NCT05594511
- Testing
- Muscle-energy mandibular technique
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Salamanca
Acute Ischemic Stroke
Research Into the Effect of a Clot-dissolving Agent and Its Inhibitor
Single-chain urokinase-type plasminogen activator (pro-urokinase) is a highly effective thrombolytic drug. At pharmacologic concentrations however, pro-urokinase is converted to urokinase - a non specific thrombolytic, limiting…
- Trial name
- NCT01694381
- Testing
- M5, C1-inhibitor
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- TSI, LLC
Asthma
Phase I Pharmacokinetic Study (BF-BLOCK)
The objective of the study is to assess if charcoal prevents the absorption of budesonide and formoterol via GI track. The assessment will be based on comparing the pharmacokinetic parameter area under the concentration-time…
- Trial name
- BF-BLOCK (NCT01423305)
- Testing
- Budesonide/formoterol capsule., Budesonide/formoterol capsule for oral adm.
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orion Corporation, Orion Pharma
Pain, Asthma
The Effect of Vibration on Pain During Subcutaneous Heparin Injection
Aim: The aim of this research will to examine the effect of the local vibration technique applied to the injection site during subcutaneous low molecular weight heparin (LMWH) injection.
- Conditions
- Pain, Asthma, Pulmonary Disease, Chest Disorder
- Trial name
- NCT06469112
- Testing
- Vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Uludag University
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