Clinical trials: Immediate Effect
Asthma
Anti-histamines and Methacholine Challenges.
The asthmatic airway is identified and studied using inhaled agents such as histamine and methacholine. The use of antihistamines prior to the test will inhibit the test result if histamine is used to cause airway constriction.
- Trial name
- NCT01985789
- Testing
- Diphenhydramine, cetirizine, desloratadine
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Don Cockcroft
Carpal Tunnel Syndrome (CTS), Muscle Stiffness
Immediate Effects of Paraffin Wax Therapy on Forearm and Hand Muscle Stiffness and Pain in Carpal Tunnel Syndrome
This randomized controlled trial aims to investigate the immediate effects of paraffin wax therapy on muscle stiffness and pain among patients diagnosed with Carpal Tunnel Syndrome (CTS).
- Trial name
- Paraffin-CTS (NCT07260448)
- Testing
- Paraffin Wax Therapy, Rest Period (No Treatment)
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Erzurum Technical University
Seasonal Allergic Rhinitis
Effects of Orotic Acid Derivatives With or Without Glutathione on Allergic Rhinitis
The purpose of this study is to learn if two nutritional supplements, Orotic Acid and Glutathione will have any effect on the immune system response and if there will be any effect on the symptoms of seasonal allergies.
- Trial name
- NCT00227058
- Testing
- Orotic acid and Glutathione-(Nutritional Supplements)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Asthma, Recurrent Cough
Spirometry and Methacholine Challenge Test in Asthmatic Children Age 3-6years
Rational: The possible contribution of methacholine challenge test via spirometry to the clinical diagnosis of young children with various respiratory symptoms, the most appropriate spirometry index, and the proper cutoff point…
- Trial name
- MCH-preschool (NCT00550758)
- Testing
- Methachoine, spirometry
- Volunteers
- 84 people
- Sponsor
- Rambam Health Care Campus
Asthma
Effect of an Inhaled Corticosteroid on Airway Gene Expression in Asthma
The purpose of this study is to determine whether an inhaled corticosteroid (fluticasone) alters the expression of any gene expressed in the lining of the airways of asthmatics.
- Trial name
- NCT00187499
- Testing
- Inhaled fluticasone 500 ug BID for 8 weeks
- Where
- United States
- Sponsor
- University of California, San Francisco
Asthma
GSK2190915 Neutrophilic Asthma Study
The purpose of this study is to investigate the effect on repeat doses of GSK2190915 in asthmatic patients with a high percentage of neutrophils in their sputum.
- Trial name
- NCT01471665
- Testing
- GSK2190915 100mg
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- GlaxoSmithKline
Atopic Dermatitis
Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis
The primary objective of the study is to evaluate the pharmacokinetics (PK) of multiple cytochrome P450 (CYP450) substrates alone and in combination with rocatinlimab in participants with moderate to severe atopic dermatitis (AD).
- Trial name
- NCT05891119
- Testing
- Caffeine, Metoprolol, Midazolam
- Where
- 7 sites in United States
- Volunteers
- 21 people
- Sponsor
- Amgen
Asthma
Effect of Dietary Supplements With Fish Oil on Mannitol-induced Airway Sensitivity & Inflammation in Persons With Asthma
We wish to investigate the effects of 3 weeks of orally administered fish oil supplements on the airway sensitivity (provoking dose to cause a 15% fall in FEV1, PD15) to inhaled mannitol (AridolTM).
- Trial name
- NCT00526357
- Testing
- omega-3 fatty acid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Firestone Institute for Respiratory Health
Asthma
The Effect of BIIL 284 BS on Induced-sputum Variables in Patients With Bronchial Asthma
Study to evaluate the anti-inflammatory effect of BIIL 284 BS compared with placebo in patients with asthma
- Trial name
- NCT02249312
- Testing
- BIIL 284 BS
- Volunteers
- 38 people
- Sponsor
- Boehringer Ingelheim
Asthma, Vitamin D Deficiency
A Study to Investigate the Effect of Vitamin D3 Supplementation on Asthma Symptoms in Adults With Asthma (VITDAS)
Asthma is a disease characterised by chronic inflammation of the airways leading to symptoms including periods of shortness of breath, wheezing and a tight chest due to airway narrowing in affected patients.
- Conditions
- Asthma, Vitamin D Deficiency, Nutritional Deficiency, Inflammation
- Trial name
- VITDAS (NCT04117581)
- Testing
- Vitamin D3
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Chester
Tetraplegia, Asthma
Exhaled Levels of Nitric Oxide
Previously it was observed that individuals with tetraplegia have reduced baseline airway caliber and exhibit non-specific airway hyperresponsiveness (AHR).
- Trial name
- NCT00753948
- Testing
- N-Nitro L-arginine-methylester (L-NAME)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Asthma, Allergic Rhinitis
Effect of Omalizumab (Xolair) in Treatment of Patients With AERD and Allergy Asthma
Double blind protocol treatment of 2/3 of the patients with omalizumab and 1/3 placebo administer for 4 months. Patients selected for the study must have both aspirin exacerbated respiratory disease and allergic asthma and…
- Trial name
- NCT00286416
- Testing
- omalizumab (Xolair)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Scripps Clinic
Dental Implants, Osteoprotegerin
The Effect of Local Melatonin Application Around Immediately Placed Implants in the Maxillary Premolar
Background: Immediate implants provide ideal three-dimensional positioning compared to conventional implants. There may be a gap between the surface of the implant and the bone walls of the socket when it is inserted into a…
- Conditions
- Dental Implants, Osteoprotegerin, Melatonin
- Trial name
- NCT07103564
- Testing
- Immediately placed implant in maxillary premolars with local melatonin application, Immediately placed implant in maxillary premolars without local melatonin application
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Hams Hamed Abdelrahman
Spasticity as Sequela of Stroke
Immediate Effect of Johnstone's Pressure Splint Added to Stretching on the Spasticity in Cerebrovascular Disease.
TITLE: Immediate effect of Johnstone's Pressure Splint added to Stretching on the spasticity of elbow flexors and wrist in Cerebrovascular Disease (CVD).
- Trial name
- NCT03675958
- Testing
- Johnstone's Pressure Splint, Stretching
- Volunteers
- 20 people
- Sponsor
- Universidad Industrial de Santander
Lower Extremity Muscular Power Performance Output
The Immediate and 24-hour Effects of Body Tempering Versus Foam Rolling on Lower Extremity Muscular Power During the Vertical Jump and Standing Long Jump Tests
The goal of this clinical trial is to examine the effects of body tempering on healthy volunteers between the ages of 18-39. The main question it aims to answer is will the intervention have an impact on immediate or 24-hour…
- Trial name
- NCT06646926
- Testing
- Body tempering, Foam rolling self-myofascial release
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Muscle Soreness
Effect Kinesio Taping on Acute-onset Muscle Soreness and Calf Muscle Extensibility Among Endurance Athletes
In recent years, athletes have frequently utilized Kinesio tape (KT) to enhance their performance. Despite widespread use, data regarding its efficacy and mechanism of action is lacking among healthy endurance athletes.
- Trial name
- NCT05564585
- Testing
- Kinesio Taping
- Where
- Saudi Arabia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- AMIR IQBAL
Atopic Dermatitis
The Effect of Gladskin on Disease Severity and the Skin Microbiome, Including Staphylococcus Aureus, in Patients With Atopic Dermatitis
Colonization with Staphylococcus aureus is related to inflammation in atopic dermatitis. Gladskin is a product for topical use containing the proprietary enzyme Staphefekt SA.100, which has the ability to specifically lyse the…
- Trial name
- NCT02840955
- Testing
- Staphefekt SA.100
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Asthma, COPD
Anti-viral Effects of Azithromycin in Patients With Asthma and COPD
The purpose of this study is to investigate the anti-viral effects of low-dose AZM treatment in patients with asthma and COPD with an exacerbation history.
- Conditions
- Asthma, COPD, Exacerbation Copd, Asthma; Eosinophilic
- Trial name
- AZIMUNE (NCT04319705)
- Testing
- Azithromycin
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Hypogonadism
The Effect of Various Amounts of Fat on PK of Oral Testosterone Undecanoate
A Phase 2, open-label, randomized, cross-over, pharmacokinetic study designed to determine the effect of meals of various amounts of fat given immediately prior to dosing on the pharmacokinetics of oral testosterone undecanoate.
- Trial name
- NCT02921386
- Testing
- Oral Testosterone Undecanoate
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Clarus Therapeutics, Inc.
Rhinitis, Allergic, Perennial and Seasonal
A Study to Assess Intranasal Repeat Dose Effect of Levocabastine in the Subjects With Allergic Rhinitis
This study will be a randomized, double blind, placebo controlled, 3-way cross over design in allergic rhinitis subjects. Subjects will receive repeat doses of intra-nasal levocabastine for 7 days in each period and the duration…
- Trial name
- NCT01949051
- Testing
- Levocabastine
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- GlaxoSmithKline
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