Clinical trials: Immune Deficiency
HIV Infections
A Phase IIA Trial to Evaluate the Safety and Immunogenicity of a DNA HIV-1 Vaccine Followed by an MVA HIV-1 Vaccine in HIV-uninfected Volunteers
The purpose of this study is to evaluate the safety and tolerability of plasmid DNA and recombinant MVA (Modified Vaccinia Virus Ankara) in a prime-boost regimen.
- Trial name
- NCT01371175
- Testing
- DNA.HIVA, MVA.HIVA
- Where
- 2 sites in Kenya, United Kingdom
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Human Immunodeficiency Virus, Treatment
First in Human Study of TLC-ART 101 (ACTU 2001)
This study is a prospective, open-label, single-site, first-in-human study of a long-acting, injectable combination antiretroviral therapy platform, with a pharmacologically-guided adaptive design for dose escalation…
- Conditions
- Human Immunodeficiency Virus, Treatment, Antiretroviral Therapy
- Trial name
- NCT05850728
- Testing
- TLC-ART
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections
Safety of and Immune Response to a DNA Vaccine and a Recombinant HIV-1-MVA Vaccine, Separately and in Combination, in Healthy Adults
The purpose of this study is to determine the safety of and immune response to two experimental vaccines, designed for use in combination, for the prevention of HIV infection in healthy adults.
- Trial name
- NCT00428337
- Testing
- EP-1233, MVA-mBN32
- Where
- 3 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Implementation and Delivery of Cabotegravir Long Acting Injection for PrEP in a Community Pharmacy Setting.
The goal of this demonstration project or observational study is to evaluate the feasibility and acceptability of a pharmacist-managed cabotegravir long acting injectable for PrEP program in a community pharmacy setting.
- Trial name
- IDCaPP (NCT05867212)
- Testing
- Cabotegravir Injection [Apretude]
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kelley-Ross & Associates, Inc.
HIV Infection
Statin Adjunct Therapy Among ART-treated Adults in Sub-Saharan Africa: Atorvastatin and Rosuvastatin Equivalence Trial
This study will determine whether 36 months of daily atorvastatin or rosuvastatin have equivalent effects in reduction of immune activation, inflammation and immune aging, when given as adjunct therapy among patients receiving…
- Trial name
- STAR (NCT03037372)
- Testing
- ART, Atorvastatin, ART, Rosuvastatin, ART, No statin
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Makerere University
Influenza
Further Investigation of an Intramuscular Influenza Vaccine (Multimeric-001)
This is a multi-center, randomized, two stage, double-blind, placebo-controlled administration study comprising 200 healthy participants.
- Trial name
- NCT01146119
- Testing
- Multimeric-001, 500 mcg, Adjuvanted PBS, PBS and TIV 15%
- Where
- 2 sites in Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- BiondVax Pharmaceuticals ltd.
HIV Disease
Safety and Efficacy of (α1Proteinase Inhibitor, α1PI) in HIV Disease
Our primary objective is to further characterize the mechanism by which alpha-1PI regulates CD4 counts. HIV-1 infected patients will be initiated on PROLASTIN®-C (Alpha-1 Proteinase Inhibitor [Human], Grifols Biotherapeutics…
- Trial name
- NCT01731691
- Testing
- α1 Proteinase Inhibitor
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Institute for Human Genetics and Biochemistry
Human Immunodeficiency Virus
Mater-Bronx Rapid HIV Testing Project.
In the M-BRiHT study we aim to implement a programme of opportunistic HIV screening in the Emergency Department, Mater Misericordiae University Hospital.
- Trial name
- M-BRiHT (NCT01778374)
- Testing
- No participant choice of counselor, Participant choice of counselor
- Where
- Ireland
- Volunteers
- 17,000 people, healthy volunteers welcome
- Sponsor
- University College Dublin
HIV Infections
Safety and Efficacy of a Three-Dose Regimen of an Adenoviral HIV Vaccine (MRKAd5 HIV-1 Gag/Pol/Nef) in HIV Uninfected South African Adults
The purpose of this study is to determine the safety, efficacy, and tolerability of a three-dose regimen of an adenovirus-based HIV-1 vaccine in healthy South African adults.
- Trial name
- NCT00413725
- Testing
- MRKAd5 HIV-1 gag/pol/nef
- Where
- 5 sites in South Africa
- Volunteers
- 801 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Safety of and Immune Response to a Modified Vaccinia Ankara (MVA) HIV Vaccine in HIV Uninfected Adults
The purpose of this study is to determine the safety and the immune responses to the HIV vaccine candidate, MVA-CMDR. This vaccine was designed to induce immune responses to three HIV "passenger" genes encoded with the viral…
- Trial name
- NCT00376090
- Testing
- MVA-CMDR
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Drug Interactions, Human Immunodeficiency Virus
Pharmacokinetic Interactions Between an Herbal Medicine (African Potato) and Antiretroviral Agents (Lopinavir/Ritonavir)
The study is being conducted to evaluate whether African potato, an herbal medicine, can be used together with anti-HIV medicines without affecting the amounts of the anti-HIV medicines in the blood.
- Trial name
- AP6142 (NCT01227590)
- Testing
- Kaletra (lopinavir/ritonavir), African Potato (hypoxis obtusa)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV, HIV Infections
Video-based Counseling & Rapid HIV Testing for Teens
This study evaluated the educational effectiveness of a youth-friendly pre-test video (derived from a previous qualitative study) and compared it with in-person HIV pre-test counseling.
- Trial name
- NCT00836550
- Testing
- Video, in-person HIV pre-test counseling
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- North Bronx Healthcare Network
HIV Infections
Evaluating the Safety and Serum Concentrations of a Human Monoclonal Antibody, VRC-HIVMAB075-00-AB (VRC07-523LS), Administered in Multiple Doses and Routes to Healthy, HIV-uninfected Adults
The purpose of this study is to evaluate the safety, tolerability, and serum concentrations of a human monoclonal antibody, VRC-HIVMAB075-00-AB (VRC07-523LS), administered in multiple doses and routes to healthy, HIV-uninfected…
- Trial name
- NCT03387150
- Testing
- VRC07-523LS
- Where
- 7 sites in United States, Switzerland
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv
A Study to Evaluate the Safety and Immunogenicity of 2 Doses of 100µg BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, Given to a Population of Adults Who Have Received 3 Doses of 300µg BG505 SOSIP.GT1.1 gp140 Vaccine, Adjuvanted
An Open-Label Study to Evaluate the Safety and Immunogenicity of 2 Doses of 100µg BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, given to a Population of Adults in Good General Health Who have Received 3 doses of 300µg BG505…
- Trial name
- NCT05983874
- Testing
- BG505 SOSIP.664 gp140 Vaccine, Adjuvanted (3M-052 AF plus alum) Dosage
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
HIV Infections
Project Minority AIDS Prevention: Reaching Black and Hispanic MSM About PrEP and TasP Using Social Media
This project has the potential to improve the implementation science of treatment as prevention and pre-exposure prophylaxis uptake as a public health strategy for reducing new HIV infections in the United States.
- Trial name
- MAP (NCT03404531)
- Testing
- Social Media Messages Intervention Group, Website Only Group
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Brown University
HIV Infections, Sexually Transmitted Diseases
Increasing Engagement and Improving HIV Outcomes Via HealthMPowerment
The overall goal of this 3-arm randomized trial is to test whether a network-driven online intervention tailored for intersectional stigma amelioration can elicit online social support, promote intervention engagement, and…
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Stigma, Social
- Trial name
- NCT03678181
- Testing
- Information Resources, Social Support, HIV Testing
- Where
- 3 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV, Sexually Transmitted Infections
Addressing Proven Factors in HIV Prevention for Latino Youth
This study tests the effectiveness of the bilingual Health and Success program, which aims to support Latino parents and schools in their efforts to promote the academic success and healthy choices of youth, with the goal of…
- Trial name
- NCT01633879
- Testing
- audio-CD parent education, health and success parent and school
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Education Development Center, Inc.
Cryptococcal Meningitis
Vietnam Cryptococcal Retention in Care Study (CRICS) Federal Financial Report
CRICS financial report for the first budget year of the study
- Trial name
- NCT02955862
- Testing
- Vietnam Cryptococcal Retention in Care Study (CRICS)
- Where
- Vietnam
- Volunteers
- 1,177 people, healthy volunteers welcome
- Sponsor
- National Hospital for Tropical Diseases, Hanoi, Vietnam
Human Immunodeficiency Virus (HIV), Hepatitis C (HCV)
Persuasive Health Communication Intervention for HIV/HCV
A major impediment to emergency department (ED)-based HIV/HCV screening success is that often ED patients at risk for, or later diagnosed with, HIV and HCV decline testing.
- Trial name
- NCT05968573
- Testing
- Video Format with Captions, Video Format without Captions, Health Educator
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of South Florida
HIV Infections
Effectiveness of Communication Technology in Disseminating HIV Prevention Training to Non-governmental Organizations
This study will compare the effectiveness of face-to-face training versus Web-based training seminars in disseminating HIV prevention interventions to nongovernmental organizations in Eastern Europe and Central Asia.
- Trial name
- NCT00698529
- Testing
- Face-to-face training, Distance training, Popular Opinion Leader (POL)
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
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