Clinical trials: Immune Deficiency Disorders
HIV Infection, Osteopenia
Effect of HIV Infection and Highly Active Antiretroviral Treatment (HAART) on Bone Homeostasis
Advances in HAART have been a huge success story in the management of HIV infection. However, serious metabolic complications including osteoporosis and bone fractures are increasingly been seen with HAART, and the responsible…
- Conditions
- HIV Infection, Osteopenia, Osteoporosis
- Trial name
- OPG-2 (NCT01020045)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
IgG Deficiency
PNEUMOCELL - Conjugated Pneumococcal Vaccination in Patients With Immunoglobulin G-deficiency
The aim is to study the immune response to conjugated pneumococcal vaccination (Prevenar13) in Immunoglobulin G-deficient patients and healthy controls.
- Trial name
- PNEUMOCELL (NCT01847781)
- Testing
- Prevenar13
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Ebola, HIV/AIDS
Drug-drug Interactions Between Remdesivir and Commonly Used Antiretroviral Therapy
Ebola and HIV are found predominately in the same regions of the world and countries in sub-Saharan Africa are most affected by both diseases. For Ebola, no approved therapies exist.
- Trial name
- RemTLAR (NCT04385719)
- Testing
- Remdesivir
- Where
- Uganda
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Makerere University
HIV Infections
Safety of and Immune System Response to an HIV Vaccine (EP HIV-1090) in HIV Uninfected Adults
The purpose of this study is to test the safety of an HIV DNA vaccine (EP HIV-1090) and to test whether or not the vaccine can stimulate immune system responses in HIV uninfected people.
- Trial name
- NCT00054860
- Testing
- EP HIV-1090
- Where
- 5 sites in United States, Botswana
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infection
Pharmacokinetics of Apricitabine and Tipranavir When Dosed Alone or Together
The aim of the study is to see if apricitabine or tipranavir affect the levels of each other in the blood (pharmacokinetic interaction) when they are dosed together.
- Trial name
- NCT00352066
- Testing
- apricitabine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Avexa
HIV Infections
HIV Prevention in Haitian American Adolescents
There has not been a great deal of research involving Haitian American adolescents and HIV risk reduction. The purpose of the study is to learn better ways to teach teenagers about living healthy by educating these children about…
- Trial name
- NCT00494273
- Testing
- Cognitive Behavioral and Standard Care with Healthy Living
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV Infections
Metabolic Effects of Enfuvirtide in Healthy Volunteers
The metabolic effects of T-20 are not completely known, since the drug is used in combination with other antiretroviral agents. A short-term study in healthy volunteers, with a double-blind crossover design vs.
- Trial name
- NCT00657761
- Testing
- Enfuvirtide
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
HIV Infections
Safety of Acidform Lubricant in HIV-Uninfected Women
Topical microbicides, substances that kill microbes, are being studied to prevent sexual transmission of HIV and other disease pathogens.
- Trial name
- NCT00850837
- Testing
- Acidform Lubricant, HEC gel
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
HIV Pre-exposure Prophylaxis Implementation Study in South Korea
The primary objective of this study is to examine acceptability, patterns of use, rates of adherence, safety , and measured levels of drug when high risk men who have sex with men (MSM) are provided open-label…
- Trial name
- NCT04583267
- Testing
- tenofovir disoproxil fumarate (TDF) 300mg co-formulated with emtricitabine (FTC 200mg) once daily oral administration
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Immunity to Polio Vaccines in Malnourished Infants, Immunity to Polio Vaccines in Non-malnourished Infants
IPV in Moderate to Severe Chronic Malnourished 9-12 Month Old Children in Karachi.
Chronic malnutrition is associated with lack of effective gut immunity which is a possible explanation for why we see polio cases among a proportion of children who have received 7 or more doses of OPV.Our proposed idea is to…
- Trial name
- MIPV (NCT01695798)
- Testing
- Injectable polio vaccine and Bivalent oral polio vaccine
- Where
- Pakistan
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
HIV Infections, Atherosclerosis
Antiretrovirals and Rate of Progression in Carotid Artery Intima-medial Thickness in HIV
It is well known that HIV-infected subjects frequently experience hyperlipidemias, insulin resistance, and visceral adiposity, which are known to increase the risk of atherosclerosis.
- Trial name
- NCT00575939
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Substance Abuse, Intimate Partner Violence (IPV)
SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Families
This study aims to prevent syndemic health conditions by decreasing acculturative stress and promoting resilience via SER Familia (Salud, Estrés y Resilencia en Familias/ Health, Stress, and Resilience in Families), a…
- Conditions
- Substance Abuse, Intimate Partner Violence (IPV), HIV Infections, Depression
- Trial name
- SER Familia (NCT06627764)
- Testing
- SER Familia
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Duke University
Latent Tuberculosis, HIV Infections
Improving Latent Tuberculosis (TB) Diagnosis in Thai Children
The study is a prospective study to improve the diagnosis and management of latent TB in HIV-infected and HIV uninfected children in Thailand.
- Trial name
- TB Px (NCT00947609)
- Where
- 2 sites in Thailand
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- SEARCH Research Foundation
HIV/AIDS
Developing a PrEP Adherence Intervention Targeting At-Risk and Substance Using Women
The purpose of this study is to develop and assess the feasibility, acceptability, and preliminary efficacy on adherence of a community-informed intervention for tenofovir/emtricitabine (TDF/FTC) pre-exposure prophylaxis (PrEP)…
- Trial name
- PEARL (NCT04396678)
- Testing
- PrEP standard of care+behavioral intervention
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Iron Deficiency Anemia
Effects of Oral Iron Supplementation on Vaccine Response in Iron Deficient Kenyan Women
Iron deficiency (ID) anemia (IDA) is a global public health problem, with the highest prevalence in Africa. Vaccines often underperform in low- and middle- income countries (LMIC), and undernutrition, including ID, likely plays a…
- Trial name
- NCT05919472
- Testing
- Oral iron supplementation (pre-treatment), COVID-19 vaccine, MenACWY vaccine
- Where
- Kenya
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nicole Stoffel
HIV Infections, Frailty
Sleep Quality and Frailty Among People Living With HIV
With effective antiretroviral therapy (ART), people living with HIV (PLWH) are living longer and are increasingly experiencing aging-related conditions such as frailty and sleep problems.
- Conditions
- HIV Infections, Frailty, Sleep Quality, Oral Frailty
- Trial name
- NCT07880054
- Testing
- No intervention (observational assessments)
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Sun Yat-sen University
HIV Infections
Safety of and Immune Response to a New HIV Vaccine: HIV CTL MEP
The effectiveness of a vaccine can be improved by using a "prime boost strategy" or by using an adjuvant. A prime boost strategy is the administration of one type of vaccine (the primer) followed by the administration of another…
- Trial name
- NCT00076037
- Testing
- HIV CTL MEP administered with RC529-SE adjuvant, GM-CSF
- Where
- 7 sites in United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Randomized, Double-blinded, Placebo-controlled, Dose-escalation Phase 1 Clinical Trial to Evaluate the Safety and Immunogenicity of Recombinant HIV Envelope Protein BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, in Healthy, HIV-1 Uninfected Adults
This a phase 1 first-in-human clinical trial to evaluate the safety, tolerability, and immunogenicity of BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, in up to 60 healthy adult HIV-uninfected volunteers.
- Trial name
- NCT03699241
- Testing
- BG505 SOSIP.664 gp140, adjuvanted
- Where
- 3 sites in United States, Kenya
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
HIV Infections, Tuberculosis Infection
European Pregnancy and Paediatric Infections Cohort Collaboration: Paediatric Protocol
Across Europe and worldwide, there are many studies following groups (cohorts) of children living with human immunodeficiency virus (HIV) and other infections over time, to monitor their long-term health.
- Conditions
- HIV Infections, Tuberculosis Infection, Hepatitis C, Covid19
- Trial name
- EPPICC (NCT04677842)
- Testing
- ART Therapy
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- PENTA Foundation
Hiv
CHALO! 2.0: A Mobile Technology Based Intervention to Accelerate HIV Testing and Linkage to Preventive Treatment.
While HIV prevalence among Men Seeking Men (MSM) in India is 10-15 times higher than in the general population (4.3% vs 0.3%), current interventions for Indian MSM have limited reach.
- Trial name
- NCT04814654
- Testing
- CHALO! 2.0, Attention-matched control (AMC), Digital coupon only (DCO)
- Where
- India
- Volunteers
- 1,004 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
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