Clinical trials: Immune Deficiency Disorders
HIV Infections
A Comparative Phase I Clinical Study of HIVAC-1e and Smallpox (Vaccinia) Vaccines in Previously (Vaccinia) Vaccinated and Unvaccinated Volunteers
To determine the physiological and immunological responses in healthy HIV seronegative adult volunteers vaccinated with a) the HIVAC-1e (vaccinia-HIV) vaccine expressing the envelope glycoproteins of HIV and b) the Wyeth smallpox…
- Trial name
- NCT00002261
- Testing
- Smallpox Vaccine, HIVAC-1e, gp160 Vaccine (MicroGeneSys)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
HIV Infections
Interventional Study of Mucosal and Antimicrobial Responses to Repeated Vaginal Applications of Tenofovir Gel in HIV Uninfected Women
Topical microbicides, substances that kill microbes, are being studied to prevent sexual transmission of HIV and other disease-causing agents.
- Trial name
- NCT00594373
- Testing
- Tenofovir gel
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
PlusCare: Mobile Platform to Increase Linkage to Care in Adolescents Living With HIV/AIDS
While major advancements in medical technology over the past decade have significantly improved the life expectancy of persons infected with human immunodeficiency virus (HIV), HIV-positive youth today face new barriers to the…
- Trial name
- NCT03758066
- Testing
- PlusCare
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Dimagi Inc.
Hereditary Angioedema
Study to Determine How BCX4161 is Metabolized and Eliminated by the Body
The purpose of the study is to assess the extent that radioactive dose of BCX4161 taken by mouth ends up in the urine, feces and expired air.
- Trial name
- NCT02218294
- Testing
- BCX4161
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- BioCryst Pharmaceuticals
HIV Infections, Insulin Resistance
Diet, Exercise and/or Rosiglitazone for HIV-Associated Insulin Resistance
The purpose of this study is to determine if, in men and women with excess abdominal fat and insulin resistance, people with HIV infection respond differently than people without HIV to interventions that typically improve body…
- Conditions
- HIV Infections, Insulin Resistance, Obesity
- Trial name
- NCT00264251
- Testing
- Weight loss through diet and exercise, Rosiglitazone insulin sensitizing agent
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Male Circumcision, HIV Prevention
Cohort Field Study to Assess the Safety and Efficacy of the PrePex Device for Non-Surgical Circumcision When Performed by Nurses
A range of observational and epidemiological studies have shown that the lifetime risk of HIV infection can be reduced by 70% through male circumcision.
- Trial name
- NCT01434628
- Testing
- PrePex™ device
- Where
- Rwanda
- Volunteers
- 590 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
HIV Infections, HIV/AIDS
Acceptability and Feasibility of Unsupervised HIV Self-Testing Among Networks of Men
The purpose of this study is to recruit and train men to promote HIV self-testing to their network members in their camps and examine the efficacy of a peer-led HIV self-testing intervention on the uptake of HIV testing among men.
- Conditions
- HIV Infections, HIV/AIDS, Hiv
- Trial name
- STEP (NCT03891407)
- Testing
- Self-Testing Education and Promotion
- Where
- Tanzania
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
HIV Infection
A Pilot Study of Pre-Exposure Prophylaxis (PrEP) to Evaluate Safety, Acceptability, and Adherence in At-risk Populations in Uganda, Africa
This study will evaluate the safety and acceptability of intermittent and daily pre-exposure prophylaxis (PrEP) regimens with FTC/TDF (emtricitabine/tenofovir disoproxil fumarate) in HIV discordant couples, and it will directly…
- Trial name
- NCT00931346
- Testing
- FTC/TDF
- Where
- Uganda
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
HIV Infections
A Crossover Adherence and Acceptability Study Assessing a DPP Capsule for HIV and Pregnancy Prevention
A randomized, crossover study to compare adherence, preference and acceptability of an over-encapsulated dual prevention pill (DPP capsule) containing oral pre-exposure prophylaxis (PrEP) and a combined oral contraceptive (COC)…
- Trial name
- NCT04778527
- Testing
- Dual Prevention Pill, PrEP tablet and a COC as two separate tablets
- Where
- South Africa
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Population Council
HIV Infections, Men
Improving HIV Testing, Linkage, and Retention in Care for Men Through U=U Messaging
This study will evaluate the impact of U=U messaging and counseling on gaps in the HIV care cascade for men, including testing uptake and ART initiation (Aim 1), achieving viral suppression and retention in care (Aim 2) in two…
- Conditions
- HIV Infections, Men, Treatment Adherence
- Trial name
- NCT05602376
- Testing
- U=U testing messaging scripts, U=U adherence messaging scripts
- Where
- 2 sites in South Africa
- Volunteers
- 3,642 people, healthy volunteers welcome
- Sponsor
- Desmond Tutu HIV Foundation
Human Immunodeficiency Virus
Pre-exposure Prophylaxis Implementation in Central-Eastern European Countries
To stem increasing rates of HIV among gay and bisexual men in Central-Eastern Europe, the feasibility, acceptability, and early efficacy of a culturally adapted evidence-based program to introduce pre-exposure prophylaxis (PrEP)…
- Trial name
- NCT05323123
- Testing
- SPARK, HealthMpowerment, PrEP Education
- Where
- 3 sites in United States, Romania
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV Infection
A Pilot Study of PrEP Acceptance Among Young Black MSM
The overarching goal of the proposed study is to determine effective outreach methods designed to recruit and improve acceptance of high-risk HIV-negative YBMSM to initiate PrEP and to identify and modify psychosocial and…
- Trial name
- MI-PrEP (NCT02671591)
- Testing
- MI-PrEP, control condition
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Richard Crosby
HIV Infections, Nutrition Poor
Supplementation Trial of KOKO Plus Among HIV Exposed Children in Accra
The overall aim of the research is to conduct a randomised controlled trial of KOKOPlus in young HIV exposed children attending HIV clinics in Accra, Ghana to test the effectiveness of KOKOPlus over a period of 6 months to…
- Conditions
- HIV Infections, Nutrition Poor, Child Development
- Trial name
- NCT04995874
- Testing
- KOKOPlus protein and micronutrient powder
- Where
- 6 sites in Ghana
- Volunteers
- 649 people, healthy volunteers welcome
- Sponsor
- Noguchi Memorial Institute for Medical Research
Infection, Human Immunodeficiency Virus, HIV Infections
GSK3640254 First Time in Human (FTIH) Study in Healthy Volunteers
Human immuno deficiency virus 1 (HIV-1) infections continues to be a serious health threat throughout the world and development of medicines with new mechanism of action have an important role to play.
- Trial name
- NCT03231943
- Testing
- GSK3640254
- Where
- United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV/AIDS, Tuberculosis
Comparison of Door-to-door Versus Community Gathering to Provide HIV Counseling and Testing Services in Rural Lesotho
The purpose of this trial is to determine if door-to-door is more effective than community gathering in providing voluntary HIV counseling and testing (VCT) in communities in rural Lesotho.
- Conditions
- HIV/AIDS, Tuberculosis, Diabetes Mellitus, Arterial Hypertension
- Trial name
- DoDoPi (NCT01459120)
- Testing
- Door-to-door, Pitso
- Where
- 2 sites in Lesotho
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- SolidarMed
HIV Infections
A Clinical Trial of PGDM1400 and PGT121 and VRC07-523LS Monoclonal Antibodies in HIV-infected and HIV-uninfected Adults
This is a Phase 1 study to evaluate the safety, tolerability, pharmacokinetics and anti-viral efficacy of the PGDM1400 and PGT121 and VRC07-523LS mAbs for HIV prevention and therapy.
- Trial name
- NCT03205917
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
HIV Infections
Evaluating the Safety and Immune Response to an HIV Vaccine Boost Following the Administration of Two HIV Vaccines, in HIV-Uninfected, Healthy Adults (Study Extension to HVTN 073/SAAVI 102)
This is an extension of the HVTN 073/SAAVI 102 study. This study will evaluate the safety and immune response to an HIV envelope protein vaccine boost in people who have previously received the SAAVI DNA-C2 and SAAVI MVA-C…
- Trial name
- NCT01423825
- Testing
- Sub C gp140 Vaccine, MF59C.1 Adjuvant, Sodium chloride
- Where
- 4 sites in United States, South Africa
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Nutrition Intervention in Drug Naive HIV-infected Kenyan Women and Their Children
Many of the 28 million people with immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) estimated to be living in sub-Saharan Africa also suffer from malnutrition.
- Trial name
- HNP (NCT00562874)
- Testing
- Meat Biscuit, Soy Biscuit, Wheat Biscuit
- Where
- Kenya
- Volunteers
- 808 people, healthy volunteers welcome
- Sponsor
- Indiana University
Retention in Care, Hiv
A Mobile Phone SMS Intervention to Increase Retention in HIV Care Among HIV-Positive MSM in Peru (WELTEL PERU)
We will use a web-based system in order to deliver a text messaging-based intervention and assess the efficacy to increase retention in HIV care among HIV+ gay men in Peru.
- Trial name
- NCT05227417
- Testing
- SMS
- Where
- Peru
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Universidad Peruana Cayetano Heredia
Drug Use, Hepatitis
Low Dead-space Injecting Equipment Distribution Program for People Who Inject Drugs in Low- and Middle-income Countries
Implementation and evaluation of a distribution program for low dead-space syringes/needles (LDSS/N) in Armenia, Georgia, and Tanzania, Egypt, Nigeria, Vietnam, India, Ukraine, and South Africa.
- Conditions
- Drug Use, Hepatitis, Hiv
- Trial name
- NCT06395129
- Testing
- Low dead-space syringes/needles, Hepatitis C Antibody Rapid Diagnostic Test, HIV rapid Diagnostic Test
- Where
- 9 sites in Armenia, Georgia and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Médecins du Monde
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