Clinical trials: Immune Deficiency Disorders
HIV Infections
A Stigma Reduction Intervention at Time of Entry Into Antenatal Care to Improve PMTCT Services in Tanzania
This study will pilot test a brief, scalable intervention called Maisha (Swahili for life), to address HIV stigma for women presenting to antenatal care in Tanzania and male partners who accompany them.
- Trial name
- Maisha (NCT03600142)
- Testing
- Mashia
- Where
- Tanzania
- Volunteers
- 1,539 people, healthy volunteers welcome
- Sponsor
- University of Utah
HIV Infections
Combination Vaccination Before HIV Treatment Interruption
The purpose of this study is to determine if vaccination before a structured treatment interruption (STI) is associated with an improvement in immune function, resulting in a delayed and reduced rebound in the amount of HIV virus…
- Trial name
- NCT00212888
- Testing
- Remune and ALVAC
- Where
- 3 sites in Canada
- Volunteers
- 52 people
- Sponsor
- Ottawa Hospital Research Institute
Staphylococcus Aureus, HIV Infections
Rifabutin Based Therapy for the Eradication of Staphylococcus Aureus Colonization in HIV Infected Adults
DESIGN: This single center, double-blinded, randomized phase II study is being conducted to assess the efficacy of a rifabutin based regimen to eliminate S. aureus colonization in HIV infected individuals.
- Trial name
- NCT00869518
- Testing
- rifabutin plus trimethoprim sulfamethoxazole
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Advanced Malignant Solid Neoplasm, Anal Carcinoma
Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lymphoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery
This phase I trial studies the side effects and best dose of nivolumab when given with ipilimumab in treating patients with human immunodeficiency virus (HIV) associated classical Hodgkin lymphoma that has returned after a period…
- Conditions
- Advanced Malignant Solid Neoplasm, Anal Carcinoma, HIV Infection, Kaposi Sarcoma
- Trial name
- NCT02408861
- Testing
- Biospecimen Collection, Bone Marrow Biopsy, Computed Tomography
- Where
- 34 sites in United States, Australia
- Volunteers
- 79 people
- Sponsor
- National Cancer Institute (NCI)
HIV/AIDS
Patient Actor Training to Improve HIV Services for Adolescents in Kenya
The goal of this study is to develop and evaluate a clinical training intervention utilizing standardized patient actors to improve communication and interpersonal skills of health care workers who serve HIV-infected adolescents…
- Trial name
- SPEED (NCT02928900)
- Testing
- Clinician training intervention
- Where
- 6 sites in Kenya
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Washington
Adolescent Drinking, HIV/AIDS
Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents
The proposed study will test the impact of an economic empowerment intervention on reducing alcohol and drug use (ADU) among adolescents and youth living with HIV (AYLHIV) in poverty-impacted communities in Uganda.
- Conditions
- Adolescent Drinking, HIV/AIDS, Drug Use
- Trial name
- NCT05597865
- Testing
- Economic Empowerment Intervention, Alcohol and Drug Use Risk Reduction Sessions
- Where
- Uganda
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
HIV Infection, Sexually Transmitted Infections
Technology-based Training Tool for PHAT Life
Youth under age 18 involved in the criminal justice system are disproportionately minorities \& affected by substance abuse, mental illness, \& HIV/STI.
- Conditions
- HIV Infection, Sexually Transmitted Infections, Implementation
- Trial name
- PhatLife-II (NCT05339412)
- Testing
- Training Tool for Preventing HIV/AIDS among Teens (PHAT) Life
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
HIV Disease, Bipolar Disorder
Texting to Improve Adherence in HIV+ With Bipolar Disorder
Adherence to combination antiretroviral therapy (ART) is critical for successful HIV viral suppression. Nonadherence to ART poses several potentially serious health consequences, including higher viral loads, faster progression…
- Trial name
- iTAB (NCT02090634)
- Testing
- Psychoeducation, individualized Texting for Adherence Building (iTAB)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of California, San Diego
HIV/AIDS
Suubi4Stigma: Addressing HIV-Associated Stigma Among Adolescents
The study seeks to reduce HIV/AIDS-associated stigma and its negative impact on adolescent health and psychosocial well-being. This study will examine two evidence-informed interventions: 1) group cognitive behavior therapy…
- Trial name
- NCT04528732
- Testing
- Group Cognitive Behavioral Therapy (G-CBT), Multiple Family Group (MFG)
- Where
- 3 sites in United States, Uganda
- Volunteers
- 89 people
- Sponsor
- Washington University School of Medicine
Hiv
HIV-Related Stigma Intervention for Malaysian Clinicians
Key populations at risk of HIV (including men who have sex with men, people who inject drugs, transgender women, and female sex workers) are more likely to be infected with HIV but less likely than members of the general…
- Trial name
- NCT05597787
- Testing
- HIV Connect, Project ECHO for HIV Prevention, Project ECHO for HIV Prevention and Stigma Reduction
- Where
- Malaysia
- Volunteers
- 78 people
- Sponsor
- University of Delaware
HIV Infections, Sexually Transmitted Diseases
Reducing HIV Risk Among Adolescents: Evaluating HEART for Teens
This study evaluates an educational web-based intervention designed to increase adolescent boys' and girls' motivation and skills to engage in safer sexual behavior (HEART: Health Education and Relationship Training).
- Trial name
- NCT03453515
- Testing
- HEART, Growing Minds
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- North Carolina State University
Primary Immunodeficiency Diseases (PID)
Comparison of Intravenous and Subcutaneous Administration of IGIV, 10% in Primary Immunodeficiency (PID) Subjects
The purpose of this study is to evaluate the tolerability of IGIV, 10% given subcutaneously and the pharmacokinetics of immunoglobulin G (IgG) following subcutaneous (SC) treatment with IGIV, 10% in subjects with primary…
- Trial name
- NCT00546871
- Testing
- Immune Globulin Intravenous (Human), 10%
- Where
- 9 sites in United States
- Volunteers
- 49 people
- Sponsor
- Baxalta now part of Shire
Hiv, HIV/AIDS
AllyQuest: Engaging HIV+ YMSM in Care Through Social Networking and Gamification
AllyQuest is a novel, high impact secondary prevention intervention delivered via mobile phones to improve linkage and engagement in care among newly diagnosed HIV+ young men who have sex with men (YMSM).
- Trial name
- AQ (NCT03090958)
- Testing
- AllyQuest
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Hiv
Prospective Cohort Study of Adolescents Living With HIV and Their Caregivers Attending a Psychosocial Programme in Botswana
Adolescents/young adults with perinatally acquired HIV (PAH) face a number of antiretroviral (ART) adherence and well-being challenges.
- Trial name
- NCT03571555
- Testing
- Sentebale Psychosocial Programme
- Where
- Botswana
- Volunteers
- 516 people
- Sponsor
- Royal Holloway University
AIDS
Safety & Efficacy of Dual Therapy With Raltegravir/Lamivudine
A pilot 24-week open-label, randomized, controlled clinical trial to assess the safety, tolerability and efficacy of dual therapy with Raltegravir/Lamivudine combination when replacing standard combination therapy in HIV-infected…
- Trial name
- RALAM (NCT02284035)
- Testing
- Raltegravir/3TC, EFV/TDF/FTC, ATV/r + TDF/FTC or DRV/r + TDF/FTC
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Juan A. Arnaiz
HIV Infections
Implementation a Data-to-Care Strategy to Improve HIV Continuum Outcomes for Out of Care People Living With HIV (PLWH) in Ukraine
The goal of this clinical trial is to study the preliminary effectiveness of a data to care intervention versus standard of care for people living with HIV in Ukraine.
- Trial name
- NCT05821413
- Testing
- Data to care, Standard of Care
- Where
- Ukraine
- Volunteers
- 160 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV Infections
Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine
The purpose of this study is to evaluate the safety and immune response to an HIV clade C vaccine and to an MF59- or alum-adjuvanted clade C Env protein in healthy, HIV-uninfected adults.
- Trial name
- HVTN107 (NCT03284710)
- Testing
- ALVAC-HIV (vCP2438), Bivalent Subtype C gp120/MF59, Bivalent Subtype C gp120 admixed with Al(OH)3 Suspension
- Where
- 6 sites in Mozambique, South Africa and 1 more
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Tobacco Use Cessation
Tobacco Cessation Tailored to Patients Living With HIV (PLWH) in Brazil
The overall goal of this feasibility study is to make adaptations to these evidence-based approaches in collaboration with PLWH and health care providers working with this population, and develop, implement, and evaluate the…
- Trial name
- NCT05560243
- Testing
- Tobacco cessation
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- University of Alabama at Birmingham
Infection, Human Immunodeficiency Virus I
A Trial Comparing GSK1349572 50mg Plus Abacavir/Lamivudine Once Daily to Atripla (Also Called The SINGLE Trial)
The purpose of this trial is to assess the non-inferior antiviral activity of GSK1349572 50 mg plus Abacavir/Lamivudine once daily versus Efavirenz/Emtricitabine/Tenofovir disoproxil fumarate (ATRIPLA® a trade mark of…
- Trial name
- NCT01263015
- Testing
- Dolutegravir, Atripla, Abacavir/Lamivudine
- Where
- 145 sites in United States, Australia and 10 more
- Volunteers
- 844 people
- Sponsor
- ViiV Healthcare
HIV Infection, Infection, Human Immunodeficiency Virus
A Study of an Investigational Regimen Combining FDA Approved HIV Drugs in HIV-Infected Subjects
This is a 24-week study to evaluate the efficacy and safety of a once-daily ritonavir-boosted fosamprenavir regimen (1400mg/100mg QD) to a 200mg ritonavir-boosted fosamprenavir regimen administered either twice-daily or…
- Trial name
- NCT00363142
- Testing
- Half-boosted Fosamprenavir, Full Boosted Fosamprenavir
- Where
- 51 sites in United States, Puerto Rico
- Volunteers
- 211 people
- Sponsor
- GlaxoSmithKline