Clinical trials: Immune Functions
Intestinal and Immune Function Improved
The Effect of Probiotics on the Improvement of Intestinal and Immune Function
Evaluate the effectiveness and safety of Lactobacillus delbrueckii subsp. bulgaricus LB42 as a food supplement compared to a placebo in improving intestinal and immune functions in healthy adults.
- Trial name
- NCT06873438
- Testing
- Probiotic group
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Polycystic Ovary Syndrom, Metformin
PCOS Patients' Immune Alterations
In this study, the investigators will include PCOS patients and healthy women who meet the trial criteria from the clinical research centers of 3 hospitals, introduce the content of this study to participants, and invite…
- Conditions
- Polycystic Ovary Syndrom, Metformin, Immune Function
- Trial name
- NCT06325969
- Testing
- Detect the immune function of peripheral blood samples
- Where
- China
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Splenic Artery Aneurysm, Immune Function
Clinical Study on Laparoscopic Resection of Splenic Artery Aneurysm With Preservation of Spleen
In this study, researchers examined the changes in related indicators such as immune function, splenic vein,proper hepatic artery, and portal venous hemodynamics following laparoscopic resection of a splenic artery aneurysm.
- Conditions
- Splenic Artery Aneurysm, Immune Function, Hemodynamics
- Trial name
- NCT07053605
- Testing
- laparoscopic resection of splenic artery aneurysm with preservation of spleen
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Northern Jiangsu People's Hospital
Metabolic Effects, Immunosuppressive Agents
Impact of SCFA Supplementation on Gut Microbiome Composition of Kidney Transplant Recipients
This is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effects of high-dose short-chain fatty acid (SCFA) supplementation on the gut microbiome and host metabolome in stable kidney…
- Conditions
- Metabolic Effects, Immunosuppressive Agents, Renal Function, Adverse Events
- Trial name
- RENOBIOME (NCT07024238)
- Testing
- SCFA
- Where
- Slovakia
- Volunteers
- 41 people
- Sponsor
- University Hospital, Martin
Yogurt Intake, Gastrointestinal Immune Function
Yogurt and GI Health
The purpose of this research is to assess mucosal immune function responses in the gastrointestinal (GI) tract to twice-daily yogurt consumption.
- Conditions
- Yogurt Intake, Gastrointestinal Immune Function, Gut Microbiome, Gut Health
- Trial name
- NCT05931471
- Testing
- Yogurt Intervention
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Ketosis, Metabolic, Immune Functions
The Effect of Acute Exogenous Oral Ketone Supplementation on Immune Cells Function and Immune Cells Histone Β-hydroxybutyrylation
To conduct a single-arm pilot study to determine how acute ingestion of an exogenous ketone monoester supplement alters the histone lysine β-hydroxybutyrylation and immune function in healthy human monocytes and lymphocytes.
- Conditions
- Ketosis, Metabolic, Immune Functions, Histone Deacetylase (HDAC) Activity
- Trial name
- Acute_Ketone (NCT06590623)
- Testing
- Ketone Monoester (KE)
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Fasting, Immune Function
The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active Adults
Many individuals engage in fasting for its purported health benefits but the effects of fasting on immune cell and whole body metabolism are not well understood in humans.
- Conditions
- Fasting, Immune Function, Glucose Tolerance
- Trial name
- FASTEX (NCT06737224)
- Testing
- Fasting + Exercise (FAST+EX): fasting + exercise condition, Fasting only (FAST): Non-exercise fasting condition
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Oxidative Stress, Healthy
A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance
This is a prospective, randomized, placebo controlled, double-blind study to assess the effects of a postbiotic blend on exercise induced oxidative stress markers and exercise performance in healthy adult.
- Conditions
- Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness
- Trial name
- PBE (NCT06795425)
- Testing
- Postbiotic Active Lifestyle Blend
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Critical Illness, Intensive Care Unit Delirium
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis.
- Conditions
- Critical Illness, Intensive Care Unit Delirium, Neurocognitive Deficit, Microbiome,immune Function, Critically Ill
- Trial name
- MS-ICU (NCT06749483)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Blood Pressure, Body Composition, Immune Function
Evaluating the Effects of a Synbiotic Versus Probiotic or Placebo on Gut Microbiota and Cardiometabolic Health: A Randomized Double-Blind Placebo Controlled Trial
Accordingly, the purpose of this study is to evaluate the efficacy of 1) supplementation with Synbiotic (Plexus® Triplex), 2) commercially-available Probiotic, or 3) placebo control over 30 days on the gut microbiome…
- Trial name
- GUTRCT (NCT06544915)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Skidmore College
General Health and Wellness, Energy and Vitality
M4C Nutraceutical Intervention Human Health Effects Pilot
This 3 month pilot study will be an unblinded, convenience sampling, nutraceutical intervention trial. Twenty fasted subjects will undergo a baseline health assessment via a questionnaire, baseline clinical chemistries, blood…
- Conditions
- General Health and Wellness, Energy and Vitality, Cognitive Function and Mental Health, Weight Management
- Trial name
- M4C Pilot (NCT06476236)
- Testing
- M4C
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Concordia University Wisconsin
Vitamin D Deficiency, Immune Health
Estimation of the Dietary Requirement for Vitamin D in Ethnic Groups
The aim of this study is to perform a double-blind, randomised, dose-response trial of vitamin D3 supplementation in United Kingdom (UK)-dwelling adults of white European, South Asian, and black African/Caribbean ethnicity to…
- Conditions
- Vitamin D Deficiency, Immune Health, Muscle Function
- Trial name
- NCT06067477
- Testing
- Vitamin D Supplement
- Where
- United Kingdom
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Chronic Lymphocytic Leukemia, Frailty
Investigating the Role of Energy Balance Modification on Health Responses in Chronic Lymphocytic Leukaemia
This randomised control clinical trial aims to investigate the effects of exercise training and diet on physical and functional fitness and immunological and metabolic changes in adults with chronic lymphocytic leukaemia.
- Conditions
- Chronic Lymphocytic Leukemia, Frailty, Muscle Function, Immune Function
- Trial name
- HIT-CLL (NCT06379282)
- Testing
- HIT, EXE+ Nutritional Guidance
- Where
- United Kingdom
- Volunteers
- 132 people
- Sponsor
- University of Surrey
Air Pollution, mHealth Intervention
1/2- Bangladesh Center for Global Environmental and Occupational Health- Bangladesh
Almost 3 billion people worldwide, including 89% people in Bangladesh, are exposed to harmful household air pollutants (HAP) emitted from combustion of biomass (wood, agricultural residue, cow dung, etc.) fuel use for cooking.
- Conditions
- Air Pollution, mHealth Intervention, Cardiopulmonary Function, Immune Function
- Trial name
- GEOHealth-II (NCT05570552)
- Testing
- mHealth based behavioral change communication intervention
- Where
- Bangladesh
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Polycystic Ovary Syndrome, Metformin
PCOS Immune Function Predicts Metformin Efficacy
In this study, the investigators will include PCOS patients who meet the trial criteria, introduce participants to the content of this study, and invite participants to participate.
- Conditions
- Polycystic Ovary Syndrome, Metformin, Immune Function
- Trial name
- NCT06325956
- Testing
- Metformin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Lipid Metabolism, Glucose Intolerance
Twins Nutrition Study (TwiNS): Vegan vs. Omnivore
This study is designed to investigate the health impact of a vegan diet compared to a usual, omnivorous diet. The investigators plan to study these diets in twins, where one twin follows a vegan diet and the other twin follows an…
- Conditions
- Lipid Metabolism, Glucose Intolerance, Weight Change, Body, Microbiome
- Trial name
- TwiNS (NCT05297825)
- Testing
- Vegan diet, Omnivore diet
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Stanford University
Microbiome, Immune Function
Microecology and Immunity in Patients With Anti-MDA5 Antibody Positive Dermatomyositis and Interstitial Lung Disease
The purpose of this study was to analyze the relationship between the microbial community, host immunity and the presence or absence of concurrent rapidly progressive interstitial lung disease patients with anti-MDA5 antibody…
- Conditions
- Microbiome, Immune Function, Anti-MDA5 Antibody Positive Dermatomyositis
- Trial name
- NCT06203249
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese PLA General Hospital
Microbiome, Immune Function
Comparison Study of Manapol and DaltonMax on Immune Function, Microbiome, and Related Variables in Men and Women
The present study will compare the effect of Manapol to DaltonMax on select measures of health. Currently, both ingredients are sold both as a stand-alone dietary supplement and as an active ingredient within various…
- Trial name
- NCT05510050
- Testing
- Aloe Vera Extract 1, Control, Aloe Vera Extract 2
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Enhance Immune Function
The Exploratory Study on the Nicotinamide Mononucleotide (Vital NAD ) to Promote the Rejuvenation of the Peripheral Blood Immune Cells of Adults.
The purpose of this study is to investigate the changes in adult peripheral blood immune cell subpopulations, subpopulations, and cell functional status before and after intervention with Nicotinamide Mononucleotide (Vital NAD )…
- Trial name
- NCT05984550
- Testing
- NMN
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shanghai Cell Therapy Group Co.,Ltd