Clinical trials: Immune Health
Arthritis,Rheumatoid
Long Term Effects of an Early Response to Certolizumab Pegol (CZP, Cimzia®) in Rheumatoid Arthritis (RA) Patients
To determine if early clinical response at 12 weeks to Certolizumab Pegol (CZP, Cimzia ®) therapy in adult Rheumatoid Arthritis (RA) patients is a predictor of better long term clinical response at 18 months compared with a lack…
- Trial name
- RA-PROACTIVE (NCT01288287)
- Where
- 22 sites in Ireland, United Kingdom
- Volunteers
- 149 people
- Sponsor
- UCB Pharma
Hepatitis C, HIV Coinfection
Supporting Treatment Outcomes Among PWID
The goal of this study is to improve HCV care continuum outcomes for people who inject drugs (PWID), reduce potential onward transmission to others and improve HIV outcomes among those who are HIV/HCV coinfected.
- Trial name
- STOP-C (NCT04652804)
- Testing
- Low intensity HCV treatment adherence support, Medium intensity HCV treatment adherence support, High intensity HCV treatment adherence support
- Where
- India
- Volunteers
- 3,000 people
- Sponsor
- Johns Hopkins University
Human Immunodeficiency Virus (HIV)
ComBaCaL HIV Prevention TwiCs
This cluster-randomized intervention is embedded in the ComBaCaL (Community-Based Chronic disease care Lesotho) cohort study (EKNZ ID AO_2022-00058, clinicaltrials.gov ID NCT05596773, Lesotho NH-REC ID 210-2022), a platform for…
- Trial name
- CoPrev (NCT07581600)
- Testing
- CoPrev model, Referral to the nearest responsible health facility
- Where
- 2 sites in Lesotho, Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
HIV Infections
HealthcAre sUppoRt fOr Remote HIV pAtients
Adherence to antiretroviral therapy (ART) is crucial for treatment success in HIV+ patients. This study proposes the use of a smartphone application, specifically developed for this project, to monitor ART adherence and assess…
- Trial name
- AURORA (NCT06563284)
- Testing
- AURORA Mobile App
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Asthma in Children, Allergy
Study of Indoor Air Pollutants and Their Impact in Childhood Health and Wellbeing
The number and types of indoor air pollutants in schools is rising, however little is known about the impact of their potentially synergistic interactions, upon schoolchildren health.
- Trial name
- SynAIR-G (NCT05997784)
- Testing
- Performing lung function tests (spirometry and fraction of exhaled nitric oxide (FeNO)), Filling of standardized questionnaires, Using an App on a device
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell
Project to Improve Communication About Serious Illness - Pilot Study
This two-year pilot study will test whether a one-page "Jumpstart Form" will affect goals-of-care discussions in the hospital. This form will be provided to clinicians and will include patient-specific information about…
- Conditions
- Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Disease Chronic, Congestive Heart Failure
- Trial name
- PICSI-P (NCT03746392)
- Testing
- Jumpstart Intervention
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Washington
Diabetes, Type I
Childhood Diabetes
Purpose of the study: To compare three different regimes for children newly diagnosed with type 1 diabetes: (1) traditional hospital based care, (2) intensive psychological support to the family, and (3) home based family…
- Trial name
- NCT00804232
- Testing
- childhood diabetes
- Where
- 2 sites in Sweden
- Volunteers
- 210 people
- Sponsor
- Vardalinstitutet The Swedish Institute for Health Sciences
HIV/AIDS
PlusCare: Mobile Platform to Increase Linkage to Care in Adolescents Living With HIV/AIDS
While major advancements in medical technology over the past decade have significantly improved the life expectancy of persons infected with human immunodeficiency virus (HIV), HIV-positive youth today face new barriers to the…
- Trial name
- NCT03758066
- Testing
- PlusCare
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Dimagi Inc.
HIV/AIDS, STI
Appalachian Partnership to Reduce Disparities (Aim 2)
By combining two strategies (i.e., peer navigation and mHealth) into a complete, culturally compatible, bilingual intervention to increase the use of needed HIV, STI, and HCV prevention and care services among racially/ethnically…
- Conditions
- HIV/AIDS, STI, HCV
- Trial name
- NCT04378439
- Testing
- Peer Navigation, mHealth
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Multiple Sclerosis, Relapsing-Remitting
A Study of Multiple Sclerosis Routine Clinical Practice: Impact on Adherence and Clinical Outcomes of Ofatumumab Treated Patients
This was a retrospective non-interventional study (NIS) of adult (≥18 years) multiple sclerosis (MS) patients on ofatumumab therapy in the United Kingdom (UK) using secondary data.
- Trial name
- NCT06897657
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Novartis Pharmaceuticals
Immunology
A Randomized, Double-Blind, Placebo-Controlled, Parallel Study to Evaluate the Safety of a Bovine Thymus Nuclear Extract
The goal of this trial is to find out if Thymus Nuclear Extract is safe and well-tolerated in healthy men and women by testing three different dose levels and comparing the results to a placebo.
- Trial name
- NCT06795945
- Testing
- TPG1, TPG2, TPG3
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Standard Process Inc.
Asthma
Telecommunications System in Asthma
This project is investigating whether application of a telecommunications system to the care of adult patients with asthma will improve self-management by enhancing compliance with preventive medication regimens and fostering the…
- Trial name
- NCT00232557
- Testing
- TLC-Asthma, TLC-health education
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- US Department of Veterans Affairs
Psychological Stress, Mindfulness
Mechanisms of Mindfulness and Stress Resilience: A Mobile App Mindfulness Training Study
The purpose of this study is to test the active components of mindfulness meditation for reducing psychological stress and improving biomarkers of health.
- Trial name
- NCT02433431
- Testing
- Mindfulness Training, Mindful Attention Only Training, Analytic Thinking Training
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Carnegie Mellon University
HIV Infections, Behavioral Symptoms
Friendship Bench Adaptation to Improve Mental Health & HIV Care Engagement Outcomes Among PLWH and PWID in Vietnam
This project will adapt and pilot a feasible and effective problem-solving therapy designed for low-resource settings to address common mental disorders like depression and anxiety - the Friendship Bench- in a Vietnamese…
- Conditions
- HIV Infections, Behavioral Symptoms, Depression, Anxiety
- Trial name
- VITAL (NCT04790201)
- Testing
- Friendship Bench Delivered by Professional Counselor, Friendship Bench Delivered by Lay Counselor, Enhanced Usual Care
- Where
- Vietnam
- Volunteers
- 77 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV, Substance Use Disorders
The Collaborative Care PrTNER Study
A randomized controlled trial to assess the ability of a Collaborative Care Prevention, Treatment, Navigation, Engagement, Resource (PrTNER) intervention to increase initiation of preexposure prophylaxis (PrEP) (for those at-risk…
- Conditions
- HIV, Substance Use Disorders, Substance Use, AIDS
- Trial name
- PrTNER (NCT06585631)
- Testing
- CC PrTNER
- Where
- 2 sites in United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Rheumatoid Arthritis
Evaluation of a Non-face to Face Multidisciplinary Health Care Model in a Population With Rheumatoid Arthritis
This research work proposes the evaluation of the implementation of a tele-orientation program and tele-consultation to the adult population with RA attended at a specialized rheumatology center in Bogota, Colombia, over a period…
- Trial name
- NCT04768413
- Testing
- Teleconsultation either by phone or by computer consultation. Quantitative and qualitative approaches to analysis, Care modalities. Quantitative and qualitative approaches to analysis
- Where
- 2 sites in Colombia
- Volunteers
- 200 people
- Sponsor
- Fundación Universitaria de Ciencias de la Salud
Obesity
The Symbiont-Restore Study
Within the framework of the Science Foundation Ireland funded Microbe Restore Project, the Symbiont Restore Study is an Investigator-initiated trial which explores the prospective health advantages associated with a particular…
- Trial name
- NCT05942586
- Testing
- Probiotic capsule (L. reuteri PB-W1™), Prebiotic sachet (Prebiotic Blend)
- Where
- Ireland
- Volunteers
- 137 people
- Sponsor
- University College Cork
Multiple Sclerosis
Oral Carnosine for Neuromuscular Performance in Multiple Sclerosis
Low levels of tissue carnosine and mitochondrial dysfunction appears to accompany multiple sclerosis (MS), with oral carnosine might be applicable to tackle impaired bioenergetics and oxidative stress in MS, and perhaps win back…
- Trial name
- CARMUS (NCT03995810)
- Testing
- Carnosine, capsulle, 2 g/day, 8 weeks
- Where
- Serbia
- Volunteers
- 3 people
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Hiv
COMMIT HIV Trial Nepal
Community Healthcare Workers (CHWs), who live in the communities they serve, have the potential to reach patients who poorly engage in their care.
- Trial name
- NCT04462679
- Testing
- COMMIT mHealth application
- Where
- Nepal
- Volunteers
- 86 people
- Sponsor
- Possible
Asthma, Communication
A Patient Advocate to Improve Real-world Asthma Management for Inner City Adults
Few interventions to improve asthma management have targeted low-income minority asthmatic adults and even fewer have focused on the real-world practice where care is provided for these patients.
- Trial name
- HAP2 (NCT01972308)
- Testing
- Patient Advocate, Usual Care
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- University of Pennsylvania
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