Clinical trials: Immune Health
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive
Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis: A Trans-regional Digital Health Effort Unlocking the Potential of Artificial Intelligence and Data Science in Health Care
The Clinnova-Multiple Sclerosis (MS) study is part of the Clinnova program (NCT06526364; NCT06235684 and NCT05733702), which seeks to advance precision medicine and the digitalization of healthcare through high-quality…
- Conditions
- Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive, Clinically Isolated Syndrome, Primary Progressive Multiple Sclerosis
- Trial name
- Clinnova-MS (NCT07280871)
- Testing
- Cohort
- Where
- Luxembourg
- Volunteers
- 100 people
- Sponsor
- Luxembourg Institute of Health
Non-Small Cell Carcinoma of Lung
Aspects of Quality of Life During Adjuvant Oncological Treatment for Locally Advanced Lung Cancer Which Include Immune Checkpoint Inhibitor.
Current oncological treatment for patients with locally advanced lung cancer comprise adjuvant immunotherapy (immune checkpoint inhibitors-ICI) as an additional one-year treatment after chemoradiotherapy which increases overall…
- Trial name
- NCT07754409
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Göteborg University
Hypertension, Diabetes Mellitus
Clinical Decision Support for Medication Management and Adherence
This three-year, grant funded project will be conducted by the Division of Clinical Informatics in the Department of Community and Family Medicine at Duke University Medical Center.
- Conditions
- Hypertension, Diabetes Mellitus, Stroke, Myocardial Ischemia
- Trial name
- NCT00979225
- Testing
- Medication Management report, Care manager email notices
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Duke University
Asthma
Efficacy and Safety Study of Mepolizumab Adjunctive Therapy in Participants With Severe Eosinophilic Asthma on Markers of Asthma Control
This is a multi-centre, placebo-controlled, double-blind, parallel-group study to evaluate the efficacy and safety of mepolizumab adjunctive therapy in participants with severe eosinophilic asthma on markers of asthma control.
- Trial name
- NCT02281318
- Testing
- Mepolizumab, SOC
- Where
- 144 sites in United States, Argentina and 17 more
- Volunteers
- 556 people
- Sponsor
- GlaxoSmithKline
Multiple Sclerosis
Oral Carnosine for Neuromuscular Performance in Multiple Sclerosis
Low levels of tissue carnosine and mitochondrial dysfunction appears to accompany multiple sclerosis (MS), with oral carnosine might be applicable to tackle impaired bioenergetics and oxidative stress in MS, and perhaps win back…
- Trial name
- CARMUS (NCT03995810)
- Testing
- Carnosine, capsulle, 2 g/day, 8 weeks
- Where
- Serbia
- Volunteers
- 3 people
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
HIV/AIDS and Infections, Sexual Behavior
Evaluation of 3T, a Sex-Positive HIV/STI Mobile App Intervention for Young Black Men Ages 14-19 Attracted to Men
This study features a 2-arm randomized controlled trial with approximately 300 young black men who have sex with men (YBMSM) to assess the effectiveness of the 3T mobile app.
- Conditions
- HIV/AIDS and Infections, Sexual Behavior, Health Knowledge, Attitudes, Practice
- Trial name
- NCT04135443
- Testing
- 3T Tune in! Turn on! Turn up!, General Health Materials Website
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- ETR Associates
Microbial Colonization, Immune System Diseases
Biodiversity Interventions for Well-Being
Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities, which weakens the functionality of the urban ecosystems and the well-being of citizens.
- Conditions
- Microbial Colonization, Immune System Diseases, Well-Being, Psychological, Nature, Human
- Trial name
- BIWE (NCT06353035)
- Testing
- Rewilding
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Natural Resources Institute Finland
Cancer
Study to Measure and Enhance the Health Related Quality Of Life in Cancer Patients
The ME-Q study aims to validate a patient reported outcome tool called FACT-ICM, which measures health related quality of life (HRQOL) in patients receiving immune checkpoint modulator (ICM) therapy.
- Trial name
- ME-Q (NCT05248425)
- Testing
- Nurse Monitoring
- Where
- Canada
- Sponsor
- University Health Network, Toronto
HIV Infections, Smoking Cessation
Motivation and Patch Treatment for HIV-positive Smokers
The purpose of this study is to develop and evaluate a brief, clinic-based smoking cessation treatment for an HIV+ population. We compared two treatments, a brief advice and follow-up plus nicotine patch treatment(Standard Care…
- Trial name
- Positive PATHS (NCT00551720)
- Testing
- Standard Care, Motivational Enhancement
- Where
- 5 sites in United States
- Volunteers
- 444 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
HIV Infections, Substance Use
Reducing HIV: Safer Sex Skill Building in Pregnant Drug Abusing Women
This study will examine safer sex skills building (SSB), a targeted behavioral HIV prevention and risk reduction group intervention in two samples of pregnant drug abusing women.
- Trial name
- NCT00619320
- Testing
- Safer Sex Skills Building (SSB)
- Where
- 2 sites in United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Type 1 Diabetes, Osteoporosis
Bone Health in Youth With Type 1 Diabetes
This is an observational study of children and young adults ages 6-20 years with type 1 diabetes and age- and race-matched controls.
- Trial name
- NCT02140424
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Allergic Reaction
Analysis of Adverse Events in Anesthesia Using Artificial Intelligence
The interest of health databases in anesthesia is no longer to be demonstrated. The aim of this research was to develop a natural language processing approach to establish a classification of adverse events observed during the…
- Trial name
- ADVENTURE (NCT05185479)
- Where
- France
- Volunteers
- 9,559 people
- Sponsor
- University Hospital, Strasbourg, France
HIV/AIDS, HIV-1-infection
Effect of Reducing Nucleotide Exposure on Bone Health (ReNew)
This is an open-label, randomized pilot study to assess the effect on bone mineral density (BMD) of a switch from a tenofovir alafenamide-containing antiretroviral regimen to dolutegravir/lamivudine vs.
- Conditions
- HIV/AIDS, HIV-1-infection, Osteopenia
- Trial name
- ReNew (NCT03549689)
- Testing
- Dolutegravir (DTG) 50MG/lamivudine (3TC) 300MG FIXED DOSE COMBINATION (FDC), Current tenofovir alafenamide (TAF)-containing ART regimen
- Where
- 10 sites in United States
- Sponsor
- Philip Grant
Asthma
Digital Adherence Monitoring of Inhalative Therapy in Real- Life Conditions
This study is designed as a multicenter, observational, non-interventional, open label, 26-week study in order to observe how asthma control changes under treatment with Mometasone Fuorat/Indacaterol/ Glycopyrronium (MF/IND/GLY)…
- Trial name
- ADITION (NCT04656223)
- Testing
- MF/IND/GLY plus sensor system, FDC therapy
- Where
- 26 sites in Germany
- Volunteers
- 434 people
- Sponsor
- Novartis Pharmaceuticals
Healthy
Galactooligosaccharide, Immune Strength, and Digestive Health
The purpose of this research study is to determine whether a functional fiber, galactooligosaccharide, can help maintain immune strength and digestive health in undergraduate students who are undergoing an academic stress (i.e.…
- Trial name
- NCT01137760
- Testing
- Sucrose, Galactooligosaccharide
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- University of Florida
Asthma
Family-Focused, Stress-Reduction Program to Improve the Health Care of Urban Children With Asthma
Stress and anxiety can negatively affect children with asthma. Reducing the stress of asthmatic children and their families may lead to improved asthma care and fewer asthma symptoms in the children.
- Trial name
- ASPIRE (NCT00384813)
- Testing
- Project ASPIRE Home-Based Family Intervention, Project ASPIRE Enhanced Treatment As Usual
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Emory University
HIV/AIDS
The Wise App Trial for Improving Health Outcomes in PLWH
The overall goal of this study is to design a user-centered design app linked to a smart pill box for people living with HIV (PLWH) and evaluate its effects in a randomized controlled trial.
- Trial name
- WiseApp (NCT03205982)
- Testing
- Wise app with medication adherence reminders, Wise app with fitness reminders
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Type 1 Diabetes (T1D)
Cognitive Function and Mental Health in Children and Youth With Type 1 Diabetes (T1D)
The Hirabai Cowasji Jehangir Medical Research Institute (HCJMRI), Pune, a Center of Excellence in type 1 diabetes (T1D), has extensive experience in studying prospective cohorts with high follow-up rates.
- Trial name
- DMBCOG (NCT07164768)
- Where
- India
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hirabai Cowasji Jehangir Medical Research Institute
Multiple Sclerosis
Probiotic Intervention for People With Multiple Sclerosis
The goal of this single-arm, mixed methods trial is to learn if it is feasible and acceptable to take a probiotic for 12-weeks in people with Multiple Sclerosis.
- Trial name
- NCT07304713
- Testing
- Probiotic
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- Sheffield Hallam University
Asthma in Children, Allergy
Study of Indoor Air Pollutants and Their Impact in Childhood Health and Wellbeing
The number and types of indoor air pollutants in schools is rising, however little is known about the impact of their potentially synergistic interactions, upon schoolchildren health.
- Trial name
- SynAIR-G (NCT05997784)
- Testing
- Performing lung function tests (spirometry and fraction of exhaled nitric oxide (FeNO)), Filling of standardized questionnaires, Using an App on a device
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
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