Clinical trials: Immune Health
HIV Infections, Adherence, Medication
Supporting Sustained HIV Treatment Adherence After Initiation
The investigators will implement a 24-month fractional factorial design study (Aim 1). The investigators will recruit 510 patients initiating antiretroviral therapy (ART) at three City of Cape Town ART clinics.
- Trial name
- SUSTAIN (NCT05040841)
- Testing
- M1/OTR: Immediate outreach to subject due to unsuppressed viral load test result, M2/PRM: Immediate outreach to subject after a missed pharmacy refill, M3/EAM: Immediate outreach to subject after EAM-identified missed doses
- Where
- 3 sites in South Africa
- Volunteers
- 534 people
- Sponsor
- Boston University
Systemic Lupus Erythematosus
Systemic Lupus Erythematosus in Gullah Health
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies, multiple organ involvement, and diverse clinical symptoms and immunologic manifestations.
- Trial name
- SLEIGH (NCT00756769)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
HIV/AIDS
Antiretroviral Adherence and Quality-of-life Support for HIV+ Patients in India With Twice-daily Interactive Voice Response (IVR) Calls With Health and Mental Health Messaging Compared to Weekly IVR Survey Only Control Condition: The Mobile-messaging Adherence and Support for Health Study, India.
The purpose of this study is to test whether twice-daily Interactive Voice Response (IVR) calls made at the estimated times of patients' antiretroviral (ART) medication dosing and three reminder calls for monthly clinic…
- Trial name
- MASHIndia (NCT02118454)
- Testing
- Daily IVR Calls Intervention, Weekly IVR Survey Only
- Where
- 2 sites in India
- Volunteers
- 400 people
- Sponsor
- University of California, Los Angeles
Type 1 Diabetes
Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes
The main goal is to perform a cost-utility analysis to compare islet cell transplantation versus best medical treatment (defined as Sensor augmented pump therapy) for patients with brittle type1 diabetes.
- Trial name
- STABILOT (NCT02854696)
- Testing
- Islet graft, best medical care
- Where
- 11 sites in France, Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Type 1 Diabetes
Skype for Youth With Poorly Controlled Diabetes
Compared family-based skills training (aka, Behavioral Family Systems Therapy) to youth with poorly controlled type 1 diabetes and their parents either face-to-face or over SkypeTM.
- Trial name
- SKYPE (NCT02274103)
- Testing
- BFST
- Volunteers
- 92 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes (T1D)
Utilizing Community Health Workers as Diabetes Technology Coaches for Children With Type 1 Diabetes Using Automated Insulin Delivery
This study uses community health workers (CHW) as diabetes technology coaches for African American children using automated insulin delivery systems but have an HbA1c of 8% or higher.
- Trial name
- CHWs AID Youth (NCT07154251)
- Testing
- Community Health Worker
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University Hospitals Cleveland Medical Center
Psychological, Stress
Psychological and Lifestyle Factors on Health Outcomes
Psychosocial and lifestyle factors in Army recruits likely contribute to increased susceptibility to infection and injury during basic Army training.
- Conditions
- Psychological, Stress, Immune Health, Vaccination
- Trial name
- NCT04780867
- Testing
- Delayed vaccination
- Where
- United Kingdom
- Volunteers
- 1,188 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
HIV Infections, Drug Use
INTEGRA: A Vanguard Study of Health Service Delivery in a Mobile Health Delivery Unit
The purpose of this study is to determine the efficacy of using a mobile health delivery unit ("mobile unit") to deliver "one stop" integrated health services - particularly medication for opioid use disorder (MOUD) and…
- Conditions
- HIV Infections, Drug Use, Opioid Use, Opioid-use Disorder
- Trial name
- INTEGRA (NCT04804072)
- Testing
- Medication for opioid-use disorder (MOUD) for opioid-use disorder (OUD), HIV testing, HIV treatment for participants living with HIV not already in care
- Where
- 5 sites in United States
- Volunteers
- 447 people
- Sponsor
- HIV Prevention Trials Network
HIV/AIDS and Infections, Drug Abuse
A Community-University Approach to Preventing HIV
Examine the feasibility and acceptability of delivering the S4E intervention to 20 African-American youths between the ages 16-21 in Flint, Michigan.
- Conditions
- HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
- Trial name
- NCT03938077
- Testing
- Storytelling 4 Empowerment
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Alcohol Drinking, Chronic Inflammation
30-to-90 Day Challenge: Effects of Alcohol Cessation on Health Outcomes
The objective for this project is to determine whether how certain behavioral and health functions change in persons with heavy drinking when they stop (or reduce) drinking for 30 days, and whether changes continue for up to 90…
- Conditions
- Alcohol Drinking, Chronic Inflammation, Neurocognitive Dysfunction, Liver Diseases
- Trial name
- NCT03353701
- Testing
- Contingency Management (CM)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Florida
Adrenal Insufficiency, Addison's Disease
Survey in Patients With Chronic Adrenal Insufficiency in Germany
The purpose of this survey is to assess patients with chronic primary or secondary adrenal failure regarding subjective health status, incidence and causes of adrenal crisis, hormone replacement regimens and concomitant endocrine…
- Trial name
- NCT00444119
- Where
- 2 sites in Germany
- Sponsor
- University of Wuerzburg
Chronic Disease, Asthma
Feasibility of Ripple Health Smart Pill Caps in Clinical Settings
The purpose of this research is to determine whether Ripple Health Smart Medicine Bottle Caps can allow for better interface medication administration than traditional pill bottles.
- Trial name
- NCT05192928
- Testing
- Ripple Health Smart Pill Cap
- Where
- 4 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Manan Shukla
Asthma
Observational Assessment of Baseline Asthma Control in African-American Children
To determine if baseline asthma control influences susceptibility to pollutant-induced health effects in African-American children with moderate-to-severe asthma.
- Trial name
- TeenAire (NCT01891630)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Influenza, Human, SARS-CoV-2 Infection
Does Repeat Influenza Vaccination Constrain Influenza Immune Responses and Protection
The objectives of this study are to understand the long-term consequences of repeated annual influenza vaccination among healthcare workers (HCWs) and to use statistical and mathematical modelling to elucidate the immunological…
- Trial name
- NCT05110911
- Testing
- Influenza vaccination: Fluarix Tetra, Vaxigrip Tetra, Fluquadri, Fluad Quad, Afluia Quad, Flucelvax Quad, SARS-CoV-2 vaccination: Comirnaty or Vaxzevria
- Where
- 6 sites in Australia
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Rheumatologic Conditions (JRA,Lupus), Epilepsy
Coping Skills Training (CST) for Children With Chronic Health Conditions
Purpose of the study The purpose of this study is to pilot an adapted Coping Skills Training (CST) intervention for feasibility and preliminary efficacy with a sample of children 8 to 12 years of age and their parents.
- Conditions
- Rheumatologic Conditions (JRA,Lupus), Epilepsy, Spina Bifida, Asthma
- Trial name
- NCT00359775
- Testing
- Coping Skills Training
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Children's Hospital and Health System Foundation, Wisconsin
Osteoarthritis, Arthritis, Rheumatoid
Assessing the Impact of MOVALIS in Osteoarthritis and Rheumatoid Arthritis Patients on Health Related Quality of Life
The objective of the observational study is to examine the effect of MOVALIS (Meloxicam) therapy on Health Related Quality of Life (HRQoL) in the diverse region of Central and Eastern Europe.
- Trial name
- NCT00619177
- Where
- 319 sites in Croatia, Czechia and 3 more
- Volunteers
- 3,569 people
- Sponsor
- Boehringer Ingelheim
Asthma
Outcomes in Patients Taking Fluticasone Propionate/Salmeterol Combination or Other Inhaled Corticosteroids
The objective of this study is to compare healthcare utilization and costs in asthma patients who receive fluticasone propionate/salmeterol combination 100mcg/50mcg ("FSC 100/50") or inhaled corticosteriods in typical clinical…
- Trial name
- NCT01332344
- Testing
- Fluticasone propionate/salmeterol combination, Inhaled corticosteroids
- Volunteers
- 5,180 people
- Sponsor
- GlaxoSmithKline
HIV Infection, HBV Infection
"Pregnancy and Viral Infections: Impact on Pregnant Women and Their Children. French Prospective Cohort"
The VIROPREG study is a French prospective multicenter cohort study that aims to assess the impact of viral infections and antiviral treatments received during pregnancy on maternal and child health.
- Conditions
- HIV Infection, HBV Infection, HDV Infection, HCV Infection
- Trial name
- VIROPREG (NCT07412977)
- Testing
- Blood sampling, Umbilical cord blood sampling, Survey using a questionnaire
- Where
- France
- Volunteers
- 5,160 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Multiple Sclerosis, Telerehabilitation
The Effects of Respiratory-based Telerehabilitaion in Patients With MS
During the pandemic, it is important for people who are isolated in their homes to stay inactive and exercise exercises in order to prevent their complaints from increasing due to inactivity.
- Conditions
- Multiple Sclerosis, Telerehabilitation, Compliance, Patient
- Trial name
- MS (NCT04887051)
- Testing
- pulmonory based home exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dr. Anıl Tosun
Mild Cognitive Impairment, Chronic Inflammation
The Grounded Brain: How Sleeping Grounded Affects Memory and Perceptions
Grounding (Earthing) refers to the practice of contacting the Earth or a properly installed grounding mat with the body. Previous studies on grounding have shown positive effects body-wide inflammation, acute and chronic pain…
- Trial name
- NCT05050812
- Testing
- grounding mat
- Volunteers
- 8 people
- Sponsor
- California Institute of Integral Studies
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