Clinical trials: Immune Related Disorder
HIV (Human Immunodeficiency Virus), AIDS
Disease Evolution and Risk Factors of AIDS-related Prevalent Cancers
This study aims to investigate the disease progression trends and risk factors of common AIDS-related tumors, including Kaposi sarcoma, lymphoma, lung cancer, and et al., among people living with HIV.
- Conditions
- HIV (Human Immunodeficiency Virus), AIDS, Kaposi Sarcoma (KS), Lymphoma
- Trial name
- NCT07696169
- Volunteers
- 1,000 people
- Sponsor
- Shenzhen Third People's Hospital
Pro-inflammatory Activity, Immunologic Activity Alteration
Pain, Opioids and Pro-Inflammatory Immune Responses
Providing pain management to the patient who abuses prescription opioids presents a clinical challenge, not only due to concerns about "drug-seeking", but because they have increased sensitivity to pain, a phenomenon identified…
- Trial name
- NCT01210066
- Testing
- Fentanyl, Cold pressor test, Fentanyl plus cold pressor test
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Acquired Immunodeficiency Syndrome, HIV Infections
Pulmonary Complications of HIV Infection Study (PACS)
To evaluate the types, incidence, course, and outcome of pulmonary disorders in newly diagnosed cases of Acquired Immune Deficiency Syndrome (AIDS), newly diagnosed cases of AIDS-related complex (ARC) and newly diagnosed…
- Conditions
- Acquired Immunodeficiency Syndrome, HIV Infections, Lung Diseases, Pneumocystis Carinii Infections
- Trial name
- NCT00005273
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Multiple Sclerosis
Evaluate Early Glatiramer Acetate Treatment in Delaying Conversion to Clinically Definite Multiple Sclerosis of Subjects Presenting With Clinically Isolated Syndrome
The primary objective is to assess the effect of treatment with glatiramer acetate (GA) compared to placebo on the time to conversion to CDMS, as determined by Poser criteria (the occurrence of the second clinical attack) during…
- Trial name
- PreCISe (NCT00666224)
- Testing
- Glatiramer Acetate (DB), Glatiramer Acetate (OL)
- Volunteers
- 481 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Sleep Apnea, Allergic Rhinitis
Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study
It has been demonstrated that allergic rhinitis (AR) reduces sleep quality by some components such as nasal obstruction. Pollution and allergen exposure worsening AR, sleep quality is deteriorated.
- Conditions
- Sleep Apnea, Allergic Rhinitis, Allergic Asthma, Pollution Exposure
- Trial name
- POLLAR (NCT03776773)
- Testing
- Pollution exposure
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Asthma, Asthma Attack
ASTHMAXcel Emergency Department Study
This protocol focuses on Phase 1 of a planned two-phase research project. Phase 1 aims to test and adapt a prototype ASTHMAXcelED application for the ED.
- Trial name
- ASTHMAXcel (NCT05013073)
- Testing
- ASTHMAXcel ED Application
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Montefiore Medical Center
Lymphoma
Chemotherapy and Radiation Therapy in Treating Patients With HIV-Related Primary Central Nervous System Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells.
- Trial name
- NCT00003261
- Testing
- methotrexate, zidovudine, neoadjuvant therapy
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Cardiometabolic Syndrome, Hiv
The Role of Ectopic Fat and Heart Attack Risk in HIV
This study is designed to investigate differences between people living with HIV (PLWHIV) and general populations on how the body utilises and stores energy.
- Trial name
- BHIVA (NCT06784154)
- Testing
- Non-interventional
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Meningitis, Cryptococcal, HIV Infections
A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis
To compare the safety and effectiveness of fluconazole and amphotericin B, alone or in combination with flucytosine, as treatment for acute cryptococcal meningitis.
- Trial name
- NCT00002305
- Testing
- Flucytosine, Fluconazole, Amphotericin B
- Where
- 45 sites in United States, Canada
- Sponsor
- Pfizer
Cocaine Use, Cocaine Dependence
rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder
The goal of the study is to investigate the feasibility, safety, and effect of rTMS on mPFC/dACC activity using a combination of fMRI and clinical outcome measures, when used as an augmentation to CBT.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Use Disorder, Cocaine Use Disorder, Moderate
- Trial name
- COAST (NCT05974202)
- Testing
- Active H7-coil repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Cytomegalovirus Retinitis, HIV Infections
A Phase I/II Open-Labelled Trial of Intravitreal Ganciclovir Salvage Therapy for AIDS Patients With Active CMV Retinitis Who Are Intolerant of Systemic Therapy
AMENDED: 04-12-91 Population of patients changed FROM those who are intolerant of systemic therapy with NON-sight-threatening CMV retinitis TO those AIDS patients intolerant of systemic therapy with CMV retinitis.
- Trial name
- NCT00000673
- Testing
- Ganciclovir
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv, Adolescent Behavior
MySTYLE: Online Family-based HIV Prevention for Non-heterosexual Black Adolescent Males in the South
This study will develop and test the efficacy of an online, family-based intervention (MySTYLE) tailored to the relevant sexual health needs of non-heterosexual adolescent males and their parents/caregivers compared waitlist…
- Conditions
- Hiv, Adolescent Behavior, Family Relations, Sexual Orientation
- Trial name
- NCT03487796
- Testing
- MySTYLE, Waitlist Control
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
AIDS-related Kaposi's Sarcoma
A Study of Selumetinib in Patients With Kaposi's Sarcoma
Cancer is a leading cause of death in individuals living with human immunodeficiency virus (HIV), and Kaposi's sarcoma (KS) remains the commonest HIV-associated cancer.
- Trial name
- SCART (NCT01752569)
- Testing
- Selumetinib
- Where
- 6 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Herpes Simplex, HIV Infections
Double-Blind Placebo-Controlled Study Comparing the Combination of 15% SP-303 Gel With Acyclovir Versus Acyclovir Alone for the Treatment of Recurrent Herpes Simplex Virus (HSV) Infections in Subjects With Acquired Immunodeficiency Syndrome (AIDS)
To evaluate the safety of topically applied SP-303 gel and to compare the efficacy of SP-303 gel in combination with acyclovir, relative to acyclovir alone, for the treatment of recurrent Herpes Simplex Virus (HSV) 1 and 2…
- Trial name
- NCT00002186
- Testing
- Crofelemer, Acyclovir
- Where
- 34 sites in United States, Puerto Rico
- Volunteers
- 400 people
- Sponsor
- Shaman Pharmaceuticals
Inflammatory Disease, Immune System Disorder
Cross-condition Validation of the Steroid PRO
Testing a questionnaire about treatment with steroids for skin, lung or gastric conditions
- Conditions
- Inflammatory Disease, Immune System Disorder, Gastrointestinal Diseases, Dermatologic Disease
- Trial name
- NCT06314451
- Testing
- Cognitive Interview
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of the West of England
Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia
Sorafenib in Treating Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndromes, or Blastic Phase Chronic Myelogenous Leukemia
This randomized phase I trial is studying the side effects and best dose of two different schedules of sorafenib in treating patients with refractory or relapsed acute leukemia, myelodysplastic syndromes, or blastic phase chronic…
- Conditions
- Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia, Adult Acute Monoblastic Leukemia
- Trial name
- NCT00217646
- Testing
- Sorafenib Tosylate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Digestive Cancer, Advanced Gynecologic Cancer
Identification of Innovative Biomarkers Related to the Immune System or Tumor Microenvironment to Promote the Efficacy of Immunotherapies
The immune system may be involved in the recognition and destruction of tumor cells or cells undergoing transformation. It is also currently accepted that the quality of immune responses can influence the evolution of cancers…
- Trial name
- HORIZON (NCT06626269)
- Testing
- Blood sample, Tumor tissue
- Where
- 2 sites in France
- Volunteers
- 700 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Diabetes Mellitus, Type 1, Food Habits
High Salt Intake Unrelated to Obesity in Diabetes
People around the world are consuming much more sodium than is physiologically necessary. A number of studies suggest that dietary sodium intake is related to weight gain.
- Trial name
- Diasalt (NCT04256447)
- Testing
- Urinary sodium concentrations
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- University of Campania Luigi Vanvitelli
Asthma in Offspring
Acid-suppressing Drugs Pregnancy Asthma Offspring Study
The purpose of this study is 1. To estimate the association between prenatal exposure to proton pump inhibitors (PPIs) and the risk of asthma during childhood. 2.
- Trial name
- NCT01787435
- Testing
- Risk of asthma in offspring
- Where
- Spain
- Volunteers
- 10,116 people
- Sponsor
- AstraZeneca
Systemic Lupus Erythematosus
IL17 in Systemic Lupus Erythematosus Patients: Association With Disease Activity and Organ Damage
Many laboratory markers can be measured for assessment of Lupus activity as aberrant manufacturing and imbalance of the cytokines of T-helper cell which already have been implicated within autoimmunity pathogenesis as IL-18 and…
- Trial name
- NCT05045417
- Testing
- Serum level of IL-17
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sohag University
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